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Ebola.ppt - Slide 1

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					               Comparative Virology
                  October 2005
KARAN CHOPRA                          MOHAN BOLISETTY
     Virus Classification
        Group: Group V (-)ssRNA.
        Order:Mononegavirales
        Family:Filoviridae
        Genus:Ebolavirus

• Ebola’s natural reservoir is unknown.
• Non human primates have been the source of
  human infections but are not thought to be the
  reservoirs.
                       History
• Named after the Ebola River in the Democratic Republic of
   the Congo (formerly Zaire), near the first epidemics.
• Two species were identified in 1976:
    – Zaire ebolavirus (ZEBOV) and
    – Sudan ebolavirus (SEBOV)
• Case fatality rates of 83% and 54% respectively.
• A third species, Reston ebolavirus (REBOV), was
  discovered in November 1989 in a group of monkeys
  (Macaca fascicularis) imported from the Philippines.
• Ivory Coast ebolavirus – Only one case. Unlucky scientist.
OUTBREAKS
EBOLA Saga
Saga Continues




      http://www.cdc.gov/ncidod/dvrd/spb/mnpages/dispages/ebotabl.htm
         Most Recent
• April 25 – June 16 2005 total of 12
  cases including 9 deaths were
  reported in Etoumbi and Mbomo in
  the Cuvette Quest Region.
     Modes of Transmission

There are 3 modes of
infection:

1. Unsterilized needles
2. Suboptimal Hospital
   conditions
3. Personal contact



                          http://www.ecplanet.com/pic/2003/12/1071257871/ebola.jpg
             Symptoms
•   Onset of fever.
•   Intense weakness.
•   Muscle Pain.
•   Headache.
•   Soar Throat.
•   Vommitting, Diarrhoea.
•   Impaired Kidnay and liver function.
      Is There a Cure?
• There are no known curative
  medications for Ebola.
• However, there have been very
  recent developments in preventative
  medications.
              Vaccines
• In June, Jones and his colleagues, Dr.
  Heinz Feldmann of Winnipeg and Dr.
  Thomas Geisbert at Fort Detrick,
  Maryland announced that they had
  successfully vaccinated monkeys against
  the deadly Ebola virus
• The Ebola vaccine is based on the 1976
  strain of the Zaire species and protects
  from the 1995, but not the other 2 species
  that affect humans.
         Bioterrorism


• Airborne transmission of Ebola Zaire
  has been demonstrated in monkeys
  in a controlled laboratory experiment

• Plum Island…?
          Conclusion
• Even though scientists have recently
  made breakthroughs there is still
  need for extensive research to find
  vaccines and cures for this deadly
  virus.
                  References
•   www.wikipidea.com
•   http://www.cdc.gov/ncidod/dvrd/spb/mnpages/dispages/ebotabl.h
    tm
•   http://www.who.int/mediacentre/factsheets/fs103/en/
•   Hampton, Tracy. Vaccines Against Ebola and Marburg Viruses
    Show Promise in Primates Studies. Maedical News and
    Perspectives. JAMA. Vol. 294 No. 2 July 2005.
• Jones, Steven. Live attenuated recombinant vaccine
  protects nonhuman primates against Ebola and Marburg
  viruses. Nature Medicine. Vol. 11 No. 7 July 2005.

				
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posted:9/28/2010
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