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ABSTRACTS
Medical
ZEEL vs. DICLOFENAC
U. Maronna, M. Weiser, P. Klein
that of the conventional anti- trointestinal side effects such as;
Comparison of the efficacy rheumatic agent Diclofenac. nausea, diarrhea, gastrointestinal
and tolerance of Zeel comp. This was demonstrated in a hemorrhage, and even the deve-
and Diclofenac for the oral double-blind equivalence study lopment of gastrointestinal ulcers.
treatment of gonarthrosis: carried out by the Institute for Moreover, the length of therapy
results of a double-blind Antihomotoxic Medicine and and the dosage is limited despite
equivalence study. Orale Basic Regulatory Research in the side effects. This is why there
Behandlung der gonarthrose Baden-Baden, Germany. is an increased interest, on the
mit Zeel comp - ergebnisse part of doctors and patients, to
einer doppelblinden Aquiva- Diclofenac is one of the non- find an alternative with compara-
lenzstudie versus Diclofenac.
steroidal anti rheumatic agents ble efficacy for the treatment of
Orthopädische Praxis. 2000;36 (5). (NSARs) most frequently used rheumatic joint disease that is
worldwide. NSARs are recog- devoid of these side effects.
For the treatment of degenerative nized as being effective for Because the nature of rheumatic
arthritis of the knee (gonarthro- gonarthrosis and other rheumatic disease is chronic, a product like
sis), the homeopathic complex conditions. However, when Zeel comp. is an appealing substi-
preparation Zeel comp (tablets) Diclofenac is taken for long peri- tute.
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displays an efficacy comparable to ods of time there is risk of gas-
HOMEOPATHIC REMEDIES FOR RHEUMATIC DISEASE
The homeopathic complex preparation Zeel comp. is a natural remedy for rheumatic conditions. In a
comparative study with the widely used allopathic drug Diclofenac, for the treatment of joint arthrosis,
121 patients with gonarthrosis participated in a multi centric, random, double-blind comparative study.
Medical
ABSTRACTS
STUDY DESIGN
Men and women suffering from ment as "good" and "very good" From this study and the anecdotal
medium to severe gonarthrosis (Diclofenac group: 51%) (Fig. 2). evidence of years of clinical use of
for at least six months, participat- The tolerance of the two test Zeel comp., researchers recom-
ed in this multi centric study preparations was assessed by both mend that further studies be car-
from thirteen orthopedic prac- patient groups as "good" and ried out to determine whether an
tices. Patients received test prepa- "very good" in 85% of the cases. agonist or an additive action exists
rations for ten weeks: 60 patients between the homeo-
Figure 1
received one tablet of Zeel comp. pathic medication
and a Diclofenac placebo 3 times and the NSAR drug.
a day; 61 patients took one tablet Interesting new
of Diclofenac 25 and a Zeel treatments could
comp. placebo tablet 3 times a emerge from the
day. The identity of the medica- combination of the
tion was concealed from physi- two preparations.
cians and patients in keeping For example, with
with the double-blind frame- severe forms of
work. The efficacy of the medica- gonarthrosis, a com-
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tion was measured by WOMAC bination treatment
(Western Ontario and McMaster would be a more tol-
Colleges) arthrosis index, in Change in the WOMAC arthrosis index after 2, 4, 6, erable option, since
and 10 weeks' treatment.
which the parameters: pain, stiff- the additional
ness, and physical activity are administration of
It has been well established that the
assessed after 2, 4, 6, and 10 the antihomotoxic complex prepa-
therapeutic effectiveness of
weeks. ration reduces the dose of
Diclofenac is based on its inhibi-
Diclofenac and, with efficacy
According to the data, both Zeel tion of cyclooxygenase - a catalyst
maintained, the risk of severe side-
comp. and Diclofenac signifi- in the prostaglandin pathway. The
effects could be substantially
cantly improved the symptoms of exact mechanism of Zeel is still
reduced.
gonarthrosis. After a period of 2 undetermined; In
and 4 weeks, a marked improve- vitro investigation
Figure 2
ment in pain, stiffness and physi- suggests that Zeel
cal activity occurred, first, in the comp. inhibits
Diclofenac group. After 6 weeks, activity of elastase.
there was no longer any differ- This enzyme is
ence between the two groups and released during the
statistical analysis of the data inflammatory
revealed the therapeutic equiva- response and
lence of the two test medications attacks the articular
(Fig. 1). Overall, 47% of patients cartilage which is
from the Zeel comp. group rich in proteogly- Overall assessment (opinion of patients) of the efficacy
assessed the efficacy of the treat- cans. of the treatment after 10 weeks.
