Diabetes Treatment Among VA Patients With Comorbid Serious Mental

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							Diabetes Treatment Among VA Patients
With Comorbid Serious Mental Illness
Sarah L. Krein, Ph.D., R.N.
C. Raymond Bingham, Ph.D.
John F. McCarthy, Ph.D., M.P.H.
Allison Mitchinson, M.P.H.
Jonathan Payes, M.A.
Marcia Valenstein, M.D., M.S.




                                                                                          I
Objective: Patients with serious mental illnesses, such as schizophrenia,                      ndividuals with serious mental ill-
bipolar disorder, and other psychoses, may be less likely to receive ad-                       nesses, such as schizophrenia,
equate care for chronic medical conditions than patients without seri-                         bipolar disorder, and other psy-
ous mental illness. The quality and outcomes of diabetes care were                        choses, represent a high-risk patient
compared in an observational study among patients with and without                        subpopulation, with complex, ongoing
serious mental illness. Methods: National data were studied for 36,546                    treatment service needs. Many of
individuals receiving care within the U.S. Department of Veterans Af-                     these individuals also have comorbid
fairs (VA) health care system. Widely used diabetes quality-of-care                       medical illnesses and are at increased
measures and intermediate outcomes were compared for patients with                        risk for poor health outcomes. High
diabetes and serious mental illness and age-matched patients with dia-                    rates of morbidity and mortality have
betes who did not have a serious mental illness. Patients’ use of health                  been reported among patients with se-
services was also examined. Results: During fiscal year 1998, patients                    rious mental illness and have some-
with diabetes and serious mental illness were as likely as patients with                  times been attributed to health system
diabetes alone to have their hemoglobin A1c, low-density lipoproteins                     characteristics, including inadequate
(LDL), and cholesterol measured; both groups had comparable A1c,                          integration of the delivery of psychi-
LDL, and cholesterol values. Patients with diabetes and serious mental                    atric and nonpsychiatric services. Pa-
illness had more outpatient visits, both primary care and specialty vis-                  tients with serious mental illness also
its, and made more multiclinic visits, including visits to both primary                   may be at increased risk for poor out-
care and mental health services on the same day. Conclusions: In the                      comes because of decreased access to
VA, patients with diabetes and serious mental illness appear to receive                   providers or poorer health habits and
diabetes care that is comparable with the care that other patients with                   treatment adherence.
diabetes receive, possibly because of increased levels of contact with                       The U.S. Department of Veterans
the health system and the VA’s integration of medical and mental health                   Affairs (VA) health care system pro-
services. (Psychiatric Services 57:1016–1021, 2006)                                       vides the ideal context for examining
                                                                                          characteristics of health services treat-
                                                                                          ment among large samples of patients
                                                                                          with serious mental illness. The VA in-
                                                                                          formation system is regarded as one of
                                                                                          the best in the nation, and VA admin-
                                                                                          istrative data include detailed diagno-
                                                                                          sis and treatment measures. Moreover,
Dr. Krein is affiliated with the Center for Practice Management and Outcomes Re-          the VA has transformed itself over the
search, Department of Veterans Affairs Ann Arbor Healthcare System, and with the          past decade, substantially enhancing
Department of General Medicine, University of Michigan. Dr. Bingham is with the           its integration of services. We evaluat-
Transportation Research Institute, University of Michigan. Dr. McCarthy and Dr.           ed the hypothesis that patients with se-
Valenstein are with National Serious Mental Illness Treatment Research and Depart-
                                                                                          rious mental illness are less likely to re-
ment of Veterans Affairs, Ann Arbor, and with the Department of Psychiatry, Univer-
sity of Michigan. Ms. Mitchinson is with the Center for Practice Management and Out-
                                                                                          ceive adequate treatment for nonpsy-
comes Research, Department of Veterans Affairs Ann Arbor Healthcare System. Mr.           chiatric illnesses. Specifically, we com-
Payes is with the Department of Psychiatry, Case Western Reserve University, Cleve-       pared processes of care for diabetes
land, Ohio. Send correspondence to Dr. Krein at HSR&D Center of Excellence,               and intermediate disease outcomes
HSR&D/SMITREC, Department of Veterans Affairs, P.O. Box 130170, Ann Arbor,                (hemoglobin A1c levels), which influ-
Michigan 48113-0170 (e-mail, skrein@umich.edu).                                           ence later health outcomes (for exam-
1016                                                      PSYCHIATRIC SERVICES   ♦ ps.psychiatryonline.org ♦ July 2006 Vol. 57 No. 7
ple, risk of blindness) among VA pa-           Methods                                      Measures
tients with diabetes with and without          Study design and setting                     Indicators of diabetes management.
serious mental illness.                        Approval for this study was obtained         Our selection of diabetes process and
   As a chronic condition requiring            from the institutional review board at       outcome measures for the analysis was
ongoing care and often complex treat-          the Ann Arbor VA Healthcare System.          based on recommended clinical stan-
ment, diabetes can pose substantial            Data were obtained from two VA               dards for diabetes management.
management challenges for patients             health services registries: the National     Specifically, we used the set of meas-
and health care providers. Conditions          Psychosis Registry (18) and the              ures (both technical process and inter-
associated with reduced functioning,           Healthcare Analysis and Information          mediate outcome) proposed for dia-
especially mental, cognitive, and              Group/QUERI-DM (Quality En-                  betes care monitoring and quality im-
emotional functioning, may particu-            hancement Research Initiative for Di-        provement through the Diabetes
larly complicate diabetes treatment            abetes Mellitus) diabetes registry (19).     Quality Improvement Project (21).
and worsen health and other out-               We examined data for patients receiv-        The indicators used for this study were
comes. For example, several previous           ing care in fiscal year (FY) 1998 (Octo-     the percentage of patients who had at
studies have reported that depression          ber 1, 1997–September 30, 1998). Se-         least one hemoglobin A1c level ob-
is associated with poorer adherence            rious mental illness was operationally       tained in the past year, the hemoglobin
to dietary and self-management rec-            defined as having a diagnosis in one of      A1c level and the percentage of pa-
ommendations (1,2), poorer glycemic            five ICD-9-CM (20) mental health di-         tients with a high-risk hemoglobin A1c
control (3), greater social and voca-          agnostic categories: all diagnoses of        level (A1c ≥9.5 percent) based on the
tional impairments (4), and increased          schizophrenia except latent schizo-          last value obtained, the percentage of
health care cost and utilization of            phrenia, schizoaffective disorder,           patients who had a low-density
services (2,5–8).                              bipolar disorder, other nonorganic           lipoprotein (LDL) cholesterol meas-
   Diabetes is a prevalent condition           psychoses, paranoid states, and affec-       ure in the past year, the LDL level and
among patients with schizophrenia              tive psychoses. The National Psychosis       the percentage of patients with high-
(9–11), and second-generation an-              Registry contains utilization data, in-      risk LDL values based on the most re-
tipsychotic medications commonly               cluding diagnoses and procedures for         cent test using a cutoff of 130 mg/dl,
used to treat psychosis may further in-        inpatient stays and outpatient visits.       and the percentage of patients who
crease patients’ risk for diabetes                The FY 1998 diabetes registry con-        had a total cholesterol test (because an
(12–15). Among VA patients who re-             tains pharmacy, laboratory, and utiliza-     LDL level could not be calculated for
ceived a diagnosis of serious mental ill-      tion information for individuals with        some patients because of elevated
ness in a given year, one in five also re-     diabetes who used VA health services         triglyceride levels). For quality meas-
ceived a diagnosis of diabetes. Serious        during the fiscal year. Patients with di-    ures related to having had a test in the
mental illnesses may cause additional          abetes were identified as those who re-      past year, higher percentages indicat-
difficulties in diabetes management            ceived a prescription for insulin, an oral   ed higher quality, whereas for meas-
and make positive outcomes harder to           hypoglycemic agent, or blood glucose         ures based on test values, such as
achieve. However, two recent studies           monitoring supplies or who had at least      mean A1c value, lower values or per-
(16,17) found little evidence of poorer        one inpatient encounter or two outpa-        centages indicated better quality.
quality of diabetes care for patients          tient encounters with a diabetes-relat-         Inpatient and outpatient utilization.
with a co-occurring serious mental ill-        ed diagnosis code (ICD-9-CM codes            Inpatient utilization measures includ-
ness. These studies focused only on            250.0–250.9, 357.2, 362.0, and 366.41).      ed the number and percentage of pa-
the receipt of recommended care                   The two registries were used to           tients with at least one inpatient stay
processes, such as having a foot senso-        identify two mutually exclusive groups       and the average length of stay per pa-
ry exam, or on a single intermediate           of patients. The first group included        tient. Outpatient care was measured
outcome (A1c). In addition, they did           18,273 patients with both diabetes and       by the total number of outpatient visits
not explore mechanisms that might ac-          a comorbid serious mental illness in         and the average number of visits per
count for or promote good-quality              FY 1998. The second group consisted          patient. An outpatient visit was de-
care for these patients.                       of a randomly selected age-matched           fined as all outpatient encounters oc-
   In this study, we compared large            set of 18,273 patients with diabetes         curring on the same day, and each vis-
national samples of patients who had           who did not have a diagnosis of serious      it was classified according to the types
diabetes and a serious mental illness          mental illness. To screen out individu-      of clinics visited by the patient: pri-
with patients who had diabetes and             als who might have used the VA to re-        mary care only; mental health care
no diagnosis of mental illness using           ceive medication only, all patients          only; specialty care only; or a multi-
several diabetes-specific process              needed to have had at least one pri-         clinic visit, which was a visit to more
measures and intermediate out-                 mary care or mental health care visit        than one type of clinic on the same
comes. We also examined inpatient              during the year to be included in the        day—for example, visits to both pri-
and outpatient health care utilization         study. Also, because the utilization         mary care and mental health care clin-
and patterns of care to better under-          part of the study primarily focused on       ics. Primary care included general in-
stand how the organization of care             ambulatory care, patients with an in-        ternal medicine, diabetes clinic, geri-
delivery might influence these proc-           patient stay longer than 150 contigu-        atrics clinic, and primary care. Mental
esses and outcomes.                            ous days were excluded.                      health care included encounters for
PSYCHIATRIC SERVICES   ♦ ps.psychiatryonline.org ♦ July 2006 Vol. 57 No. 7                                                     1017
Table 1
Diabetes care processes and intermediate outcomes stratified by treatment regimen for 36,546 Veterans Affairs patients

                                                     Diabetes and serious      Diabetes only                               Diabetes and ser-
                                                     mental illness (N=18,273) (N=18,273)                                  ious mental illness
                                                                                                                           versus diabetes only

Treatment and measure                                N                  %            N                     %               Pooled SE         Effect sizea

No hypoglycemic medication                           3,605                            2,667
  HbA1c measured in the past year                    2,308              64            1,709                 64               .48              .00
     HbA1c value (mean±SD)b                          6.8±1.68                          7.2±1.74                             1.72             –.22
     HbA1c >9.5 percent                                                  7                                  10               .28             –.08
  LDL measured in past yearc                           944              26             728                  27               .44             –.03
     LDL value (mean±SD mg/dl)d                      118±34.58                        119±33.53                            34.12             –.03
     LDL >130 mg/dl                                                     35                                  37               .48             –.03
  Cholesterol measured in the past year              1,694              47            1,253                 47               .50              .00
Oral agents only                                     8,963                            9,453
  HbA1c measured in the past year                    6,213              69            6,123                 65               .47              .10
     HbA1c value (mean±SD %)b                        7.5±1.91                          7.8±1.92                             1.92             –.15
     HbA1c >9.5 percent                                                 13                                  16               .35             –.07
  LDL measured in the past year                      3,108              35            3,274                 35               .48              .00
     LDL value (mean±SD mg/dl)d                      118±35.05                        118±33.29                            34.16              .01
     LDL >130 mg/dl                                                     33                                  32               .47              .02
  Cholesterol measured in the past year              5,736              64            5,672                 60               .48              .08
Insulin                                              5,705                            6,153
  HbA1c measured in the past year                    3,960              69            4,005                 65               .47              .09
     HbA1c value (mean±SD %)b                        8.4±2.18                          8.5±2.13                             2.16             –.09
     HbA1c >9.5 percent                                                 25                                  27               .44             –.03
  LDL measured in the past year                      1,935              34            1,907                 31               .47              .06
     LDL value (mean±SD mg/dl)d                      118±41.55                        117±37.12                            39.41              .01
     LDL >130 mg/dl                                                     33                                  32               .47              .03
  Cholesterol measured in the past year              3,765              66            3,507                 57               .49              .18
a   Cohen’s d was used to estimated the effect size for differences in independent means, and Cohen’s h was used as an estimate of the effect size for dif-
    ferences in independent proportions (22).
b   Values range from 3.0 to 22.3, with higher values indicating poorer HbA1c control.
c   Low-density lipoprotein. To convert LDL cholesterol to millimoles per liter, multiply by .02586.
d   Values range from 47 to 217, with higher values indicating poorer LDL control.



mental illness treatment (individual                  timates of effect size were used to aid              and serious mental illness group) with
and group), substance abuse treat-                    in data interpretation. Cohen’s d (22)               a mean age of 58±12 years. A higher
ment and rehabilitation, intensive case               was used to estimate effect sizes for                proportion of those in the diabetes-
management, and intensive individual                  the ANOVA models, and odds ratios                    only group were married (29 percent
programs. Specialty care included en-                 (ORs) (23) represented the effect size               compared with 21 percent). Among
counters at clinics offering specialized              for chi square tests. Small, medium,                 patients with an identified race or eth-
care, such as dermatology, ophthal-                   and large effects were .20, .50, and                 nicity classification, those in the dia-
mology, and neurology. Outpatient en-                 ≥.80 for Cohen’s d; 1.2, 1.5, and ≥2.0               betes-only group were slightly more
counters that did not fall into one of                for positive ORs; and .83, .67, and ≤.5              likely than patients with comorbid se-
the three classes, such as visits for lab-            for negative ORs. All comparisons of                 rious mental illness to be classified as
oratory tests, were disregarded.                      diabetes care processes and interme-                 white (69 percent compared with 64
                                                      diate outcomes were stratified by                    percent) and less likely to be classified
Statistical analysis                                  treatment regimen as a proxy for dis-                as Hispanic (8 percent compared with
Group comparisons were initially con-                 ease severity. Specifically, patients                11 percent) or black (22 percent com-
ducted using one-way analysis of vari-                were categorized as to whether they                  pared with 24 percent). Within the di-
ance (ANOVA) and chi square tests.                    were treated without any hypo-                       abetes and serious mental illness
Because of the large sizes of the                     glycemic agents (indicating milder dis-              group, 73 percent were diagnosed as
groups being compared in this study,                  ease), treated with oral hypoglycemic                having schizophrenia, 18 percent as
however, conventional tests of statisti-              agents only, or treated with insulin (in-            having bipolar disorder, and 9 percent
cal significance were not necessarily                 dicating more severe disease).                       as having another type of psychosis.
clinically meaningful, as small differ-
ences were often statistically signifi-               Results                                              Quality of diabetes care
cant. Thus, instead of using statistical              The study sample was predominantly                   Table 1 presents the comparison of di-
significance as a primary tool in identi-             male (97 percent in the diabetes-only                abetes care processes and intermedi-
fying potentially important results, es-              group and 96 percent in the diabetes                 ate outcome measures between the
1018                                                                    PSYCHIATRIC SERVICES    ♦ ps.psychiatryonline.org ♦ July 2006 Vol. 57 No. 7
Table 2
Utilization of inpatient and outpatient health care services among patients with diabetes only and patients with diabetes and
a comorbid serious mental illness

                                                        Diabetes only                                         Diabetes and serious
                                                        (N=18,273)                                            mental illness(N=18,273)

Type of utilization                                     N                  %              Mean±SD             N                   %         Mean±SD

Inpatient care
  Inpatient staya                                           3,225           17.6                                  6,953            38.1
  Length of stay (mean±SD days)b                                                           8.2±11.4                                          12.0±15.9
Outpatient visits per patient
  Primary care only                                      18,166             99.4c          4.8±3.9             18,175              99.5c      5.8±5.5
  Mental health care only                                 3,617             19.8           2.1±11.6            17,602              96.3c     17.9±35.3
  Specialty care only                                    13,825             75.7           4.2±5.7             14,873              81.4       5.3±7.9
  Multiclinic                                             6,539             35.8           2.2±2.7             12,533              68.6       3.5±5.9
  Total visits per patient (mean±SD)d                                                     16.4±18.2                                          36.7±40.1
Total outpatient visits                                299,530            100                                 670,070             100
  Primary care only                                     76,143             25.4                                77,095              11.5
  Mental health care only                               34,188             11.4                               292,379              43.6
  Specialty care only                                   64,655             21.6                                71,461              10.7
  Multiclinic                                           14,186              4.7                                43,717               6.5
  Othere                                               110,358             36.8                               185,418              27.7
a   OR=2.8 for between-group comparison with approximate 95 percent CI based on Woolf’s method of 2.67–2.94.
b   Cohen’s d=.26 for between-group comparison.
c   High percentages are an artifact of sampling criteria that included a high proportion of patients with these types of care.
d   d=.62 for between-group comparison.
e   Includes visits for ancillary services such as laboratory tests or physical therapy




two patient groups stratified by dia-                  ness. Otherwise, within each treat-                   than patients with solely diabetes and
betes treatment regimen. Only one                      ment stratum, the two groups of pa-                   received both more inpatient and
difference in the quality-of-care meas-                tients had very similar amounts of dia-               outpatient services. Patients with dia-
ures and intermediate outcomes be-                     betes care and levels of control.                     betes and serious mental illness were
tween patients with diabetes and those                                                                       2.8 times more likely than the dia-
with diabetes and serious mental ill-                  Utilization of inpatient                              betes-only group to have had an inpa-
ness reached a small effect size.                      and outpatient care                                   tient stay and also had a slightly
Among patients who did not receive                     Differences in inpatient and outpa-                   longer length of stay when hospital-
hypoglycemic medications (who pre-                     tient health care utilization between                 ized. Patients with comorbid serious
sumably had less severe diabetes), pa-                 the two groups are shown in Table 2.                  mental illness also made far more vis-
tients with only diabetes had slightly                 Patients in the diabetes and serious                  its to outpatient care. On average, pa-
higher A1c levels than their counter-                  mental illness group had more total                   tients with diabetes and serious men-
parts who also had a serious mental ill-               contact with the health care system                   tal illness had more than double the



Table 3
Multiclinic visits by type for patients with diabetes with and without comorbid serious mental illness
                                                                           Diabetes only                                    Diabetes and serious
                                                                           (N=6,539)                                        mental illness (N=12,533)

Type of visit                                                              N                          %                     N                     %

Multiclinic outpatient visits per patient                                   6,539                                           12,533
  Primary care and mental health care                                       1,094                     16.7                   6,137                49.0
  Primary care and specialty care                                           4,840                     74.0                   2,986                23.8
  Mental health care and specialty care                                       520                      8.0                   2,927                23.3
  Primary care, mental health care, and specialty care                         85                      1.3                     483                 3.9
All multiclinic outpatient visits                                          14,186                                           43,717
  Primary care and mental health care                                       2,756                     19.4                  19,060                43.6
  Primary care and specialty care                                           9,274                     65.4                   8,567                19.6
  Mental health care and specialty care                                     1,812                     12.8                  14,056                32.2
  Primary care, mental health care, and specialty care                        344                      2.4                   2,034                 4.6


PSYCHIATRIC SERVICES      ♦ ps.psychiatryonline.org ♦ July 2006 Vol. 57 No. 7                                                                     1019
number of outpatient visits per per-        diabetes care over the past several           grated health care system that pro-
son compared with diabetes-only pa-         years (24–26). Our overall findings of        vides comprehensive access to health
tients (36.7 compared with 16.4; Co-        comparable diabetes care processes            care across the full spectrum of health
hen’s d=.62, a moderate effect size).       and A1c values were somewhat unex-            needs. In many areas this integration
                                            pected, given prior research that has         includes the actual physical integration
Type of outpatient care                     demonstrated a clear negative effect of       of health care services, which allows
Table 2 also shows the types of outpa-      concurrent depression on diabetes out-        patients with diabetes and comorbid
tient care received by each patient         comes (2,3), even though our findings         serious mental illness to visit multiple
group. Notably, patients with diabetes      are consistent with two recent studies        clinics, receive treatment for both con-
and serious mental illness not only had     of individuals with diabetes and comor-       ditions, and have their prescriptions
more total contact with the health sys-     bid serious mental illness (16,17). Al-       filled during a single visit day.
tem and more mental health visits than      though the causal processes underlying           Integration also may be achieved
patients with diabetes alone, they also     these results remain unclear, this study      through better communication among
had more primary care, medical spe-         offers some possible explanations.            providers and referrals across special-
cialty, and multiclinic visits than did        Patients with diabetes and serious         ties. The VA maintains an electronic
patients with diabetes only. On aver-       mental illness had much more contact          patient record system that contains
age, patients with diabetes and serious     with the health care system than pa-          both medical and mental health care
mental illness had 1.0 more visit to pri-   tients with diabetes alone. Patients          records for all patients treated at that
mary care than patients with diabetes       with diabetes and serious mental ill-         medical center. Seamless access to pa-
only (mean of 5.8 visits compared with      ness used more inpatient care than pa-        tients’ records gives providers greater
4.8), 1.1 more specialty medical visits     tients with diabetes only and had much        insight into their patients’ needs and
(mean of 5.3 compared with 4.2), and        higher levels of outpatient use, both of      potential conflicts between different
1.3 more multiclinic visits (mean of 3.5    which, even if not focused specifically       aspects of their care, which creates op-
compared with 2.2).                         or solely on diabetes treatment, pro-         portunities for improving treatment.
   The frequency of multiclinic visits      vide an increased opportunity to com-         In addition, primary care providers
made by the patients with diabetes          plete important diabetes care process-        can often refer patients for subspecial-
and serious mental illness is especially    es. Patients who also had serious men-        ty care and mental health providers
striking, with a total of 43,171 multi-     tal illness not only had a greater num-       can refer their patients for medical
clinic visits, compared with 14,186 for     ber of total outpatient visits, they also     care without requiring the patient to
the diabetes-only group. On a per-pa-       had more primary care and specialty           travel to another facility or burdening
tient basis, 69 percent of those in the     medical visits than patients with dia-        the patient with the stresses of recon-
group with diabetes and serious men-        betes only. Patients with diabetes and        ciling conflicts that arise from referrals
tal illness had a multiclinic outpatient    serious mental illness made, on aver-         outside their health care system.
visit, compared with 36 percent in the      age, 36.7 outpatient visits compared             We note several study limitations.
diabetes-only group, and nearly half of     with 16.4 visits for those with diabetes      First, this analysis was based on a pop-
the multiclinic visits for patients with    only. They had one additional primary         ulation of patients who were using the
diabetes and serious mental illness in-     care visit, 1.1 additional specialty med-     VA health care system. This popula-
volved both primary care and mental         ical care visits, and 1.3 more multiclin-     tion was primarily male and likely had
health services (Table 3).                  ic visits during the year compared with       a poorer health status than populations
                                            visits for those with diabetes only.          in other health care settings (27). Thus
Discussion                                     The substantial number of visits in-       these results may not be generalizable
In general, patients with multiple          volving multiple types of health care         to all populations. Second, with the ex-
chronic conditions, especially diabetes     providers is especially noteworthy. In        ception of age and type of mental
and comorbid serious mental illness,        particular, 69 percent of patients with       health condition, this analysis did not
have challenging health care needs and      comorbid serious mental illness had           take into account specific sociodemo-
subsequently may be more likely to re-      visits involving multiple types of clinic     graphic factors, such as race, that may
ceive poorer-quality diabetes care and      encounters, compared with 27 percent          affect diabetes outcomes or utilization.
have poorer outcomes. However, in           of those with diabetes only, and nearly          However, in a separate analysis we
this large-sample study, diabetes care      50 percent of multiclinic visits for this     compared treatment utilization by the
processes and intermediate outcomes         group involved encounters with both           groups with diabetes with an age-
of patients with diabetes and serious       primary care and mental health servic-        matched group of patients with serious
mental illness did not differ apprecia-     es. These results indicate that patients      mental illness alone for each mental
bly from those of patients with diabetes    with diabetes and serious mental ill-         health diagnosis category and found
alone. Performance on several of the        ness not only had more contact with           few effects that appeared to be specif-
measures might be considered poor for       health care providers but also may            ic to a particular type of mental illness.
both groups, as compared with current       have received more intensive and inte-        Also, among patients with staff-identi-
performance and quality standards in        grated outpatient care. Unlike other          fied race and ethnicity information,
the VA (24), although it is important to    health care systems that might provide        modest differences were observed by
recognize that there have been sub-         only medical care and contract out for        race and ethnicity, with those in the di-
stantial improvements in VA-delivered       mental health care, the VA is an inte-        abetes-only group more likely than pa-
1020                                                      PSYCHIATRIC SERVICES   ♦ ps.psychiatryonline.org ♦ July 2006 Vol. 57 No. 7
                                                                                                         tients (ltr). Lancet 1:495, 1989
tients with comorbid serious mental            is paramount to help inform the design
illness to be classified as white (69 per-     of health care systems, both inside and               12. Erle G, Basso M, Federspil G, et al: Effect of
                                                                                                         chlorpromazine on blood glucose and plasma
cent compared with 64 percent) and             outside the VA, that best meet the                        insulin in man. European Journal of Clinical
less likely to be classified as Hispanic       needs of patients with multiple com-                      Pharmacology 11:15–18, 1977
(8 percent compared with 11 percent)           plex chronic conditions.                              13. Hagg S, Joelsson L, Mjorndal T, et al: Preva-
or black (22 percent compared with 24                                                                    lence of diabetes and impaired glucose toler-
                                               Acknowledgments                                           ance in patients treated with clozapine com-
percent).                                                                                                pared with patients treated with conventional
   Also, we were unable to assess the          This study was supported by grant DIB-98-                 depot neuroleptic medications. Journal of
use of health services outside the VA          001 from the Department of Veterans Af-                   Clinical Psychiatry 59:294–299, 1998
system. We used visit-based criteria to        fairs (VA), Health Services Research and              14. Lindenmayer JP, Nathan AM, Smith RC: Hy-
                                               Development Service; by the VA National                   perglycemia associated with the use of atypi-
restrict our analysis to those who had                                                                   cal antipsychotics. Journal of Clinical Psychia-
used the VA system, but this restriction       Serious Mental Illness Treatment Research                 try 62(suppl 23):30–38, 2001
could not ensure that patients did not         and Evaluation Center; and by grant NIH-
                                                                                                     15. Sernyak MJ, Leslie DL, Alarcon RD, et al:
also use services outside the VA. Con-         5060 DK-20572 to Michigan Diabetes Re-                    Association of diabetes mellitus with use of
                                               search and Training. Dr. McCarthy was                     atypical neuroleptics in the treatment of
sequently, if outside use was more like-
                                               funded by Career Development Award                        schizophrenia. American Journal of Psychia-
ly among those with diabetes only, then        Merit Review Entry Program MRP-03-320                     try 159:561–566, 2002
our results may be somewhat overstat-          from the VA Health Services Research and              16. Dixon LB, Kreyenbuhl JA, Dickerson FB, et
ed. Nonetheless, even with more out-           Development program. The authors thank                    al: A comparison of type 2 diabetes outcomes
side use among those with diabetes                                                                       among persons with and without severe men-
                                               the VA Healthcare Analysis and Informa-
                                                                                                         tal illnesses. Psychiatric Services 55:892–900,
only, we feel these results are robust in      tion Group for their assistance with data                 2004
describing the potential benefits of           collection. The views expressed in this arti-
                                                                                                     17. Desai MM, Rosenheck RA, Druss BG, et al:
medical and mental health services in-         cle are the opinions of the authors and not               Mental disorders and quality of diabetes care
tegration. Finally, we examined care           necessarily the supporting agencies.                      in the Veterans Health Administration.
                                                                                                         American Journal of Psychiatry 159:1584–
processes and intermediate outcomes                                                                      1590, 2002
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PSYCHIATRIC SERVICES   ♦ ps.psychiatryonline.org ♦ July 2006 Vol. 57 No. 7                                                                        1021

						
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