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									        DuPont
Translating science to societal
             value


         Ganesh Kishore
    Chief Biotechnology Officer
          December 4 2006
DuPont’s Vision


          To be the world’s most dynamic science company,
               creating sustainable solutions essential
              to a better, safer, healthier life for people
                              everywhere.
 DuPont – A 204 Year History of Innovation
                E. I. du Pont                                    Maturity                          Agriculture
                                                                                                   & Nutrition
                                     Maturity                                                        $6.4B
                                                        Growth
                                                                                Coatings
                                                                                                                    Performance
                          Growth                                                 & Color
            Maturity                                                                                                 Materials
                                                          Chemistry,           Technologies
                                                Birth                            $6.2B                                   $6.8B
   Growth                                                 Biology. . .
                                                          Knowledge -
                                                                                                 Total Revenue
                       Birth       Chemistry,              Intensive                                 $28B
 Birth                             Energy                 Solutions
         Explosives
                                                                                                              Electronic &
                                                                                       Safety &
                                                                                                             Communication
                                                                                      Protection
                                                                                                              Technologies
                                                                                         $5.2B                   $3.5B
1802 1830 1850 1900 1925 1945 1990 2000 2050 2090
                                                                               The 5 Platforms of DuPont
                Our Core Values                                             2010 Goals …
            The Foundation …                                                • 25% of revenues from businesses not
                                                                              requiring depletable raw materials
            •     Safety & Health                                                      Today at 17%
            •     Environmental Stewardship
                                                                            • 10% of energy needs derived from
            •     Ethics                                                      renewable sources
            •     Respect for People                                                  Today at 5 ½ %
Driving Productivity in R&D

More technical effort on growth.
 - Clear technology goals
 - Install a disciplined innovation process
 - Shift business unit resources from
   “sustain” to “grow”
 - Focus on critical few

More patents; more end use patents.

Faster product development cycles.
 Project Selection and Execution
             Criteria
Market Relevance
Technology Uniqueness
Commercialization Feasibility

Continuously validated through life of project
Special emphasis on Market Relevance prior to project
 initiation
    Global R&D Accelerates Growth
     China R&D Center,                          Wuppertal, Germany
             Shanghai



                                                                 1999
                                                     Taiwan Technical Center
                                      2005
Korea Technical
Center, Seoul
                                                                        2004
                                                    Utsunomiya, Japan

                                      2005
(Located at Korean Institute of Science &    2000
Technology)
 Biotechnology Offers Significant Growth Potential
       Throughout the Crop and Value Chain
Value Chain
           Farm &
Crop        Feed
           Chemicals
                                       Non-Plant Based   Health, Wellness, Flavor
            Energy      Processing
                                         Ingredients            & Texture
            Labor


            Corn                                                                             C
                           Farm                           Food and                           O
            Soy
            Rice                                            Fitness                          N
                                                                                             S
           Canola            and                                                             U
              .                                                                              M
              .                                 Fuel and Fiber                               E
              .             Feed                                                             R


                                 Chemicals, Enzymes, Microbes
                                                                                                 Processes
                    Traits & Germplasm – Cost Effective Introgression                            & Products

            ‘Omics (Geno, Transcripto, Proteo, Metabolo, Pheno) – Informatics - Transformation   Enabling
                                                                                                 Competencies
DuPont Businesses in Agriculture and Nutrition
                Chemistry                        The Solae Company
                                                       $1.1B
   Herbicides                   Fungicides
                                                                                          Food &
     $1.5B                        $0.4B                                                  Nutrition
                 Insecticides                     Soy Protein & Lecithin
                    $0.4B                              Ingredients


                   Input                           Grain             Food      Food
                                       Growers
                 Providers                       Processors          Mfg.      Sales



                          Corn Seed
                            $2.0B

                           Soy Seed
                            $0.5B
                                                                      Qualicon
       Pioneer
                                                                Bunge Biotech Alliance
                                                                                         Health
                        Other Seeds
        $2.7B             $0.3B                                    8th Continent         Science
                                                                       $0.3B
                Genetics
Our Crop Genetics Businesses are Leveraging Advancements in Biotech

                                                                                              Biotech
                                                                                              Biotech
                                   Breeding
                                   Breeding                                                                   Traits Agrobacterium Gene Gun
                                                                                                               Traits
                            • ↑ productivity                                                            •   Pest protection
                            • ↑ reliability                                                             •   Stress alleviation
                            • ↑ quality                                                                 •   Superior nutrient use
                                                                                                        •   Enhanced nutrient density
                                                                                                        •   Elevated safety
Pioneer has been breeding
Pioneer has been breeding                                                                               •   Processor friendly
     corn since 1926
      corn since 1926
180

160
        Corn Yields                                              b=1.52
                                                                         Biotech
140
        U.S. Average Bu/Ac
120
                                                                               1993
100
                                                                             1988
          Open                       b = 2.85
 80                                                                   1983                                                Biotech
        Pollinated                                            1974
                                                      1970
 60                                                          Single Cross
                     b = 1.17
      b = -0.67                                                Hybrids
 40
                                  1947

 20                 1936             Double Cross
                                       Hybrids
 0
  1920 1925 1930 1935 1940 1945 1950 1955 1960 1965 1970 1975 1980 1985 1990 1995 2000 2005
      DuPont’s Current Biotechnology Business is Built Chiefly on
      Licensed and Co-Developed Traits
                            Licensed (Monsanto)                                                Co-Developed (Dow)
Roundup Ready Soybeans & Corn                                     Insect Resistant Corn
                                            European Corn Borer               Further Protection             Extending the Benefits

                                                                          European
                                                                          Corn Borer                                                 Western
                               (2004)                                                            Fall
Unsprayed           Sprayed                                                                   Armyworm                                    Northern

        (1997)
                                              Bt Corn   Non-Bt Corn       Corn
                                                                        Earworm
                                                    (1999)                                          Black                             Mexican
                                                                                                   Cutworm
Benefits …
• Simple & flexible weed            • Reduced labor
                                                                           Southwestern
  management                        • Reduced energy                        Corn Borer
• Reduced pesticide                 • Greater resource efficiency                                                   Control
                                                                                                                               Chemical Biotech Trait

  application                       • Higher yield                                        (2004)                              Insecticide Protected

                                                                                                                               (2006)
• Conservation or no-tillage        • Improved quality
                                    • Favorable economic returns                   Stacking        3.5                                 3.42
                                                                                                               Trait Retail
        U.S. Conservation                                                     Exponentially          3         Value Added
        Tillage Adoption                                                    Increases Value                    per Acre
           (MM Acres)                                                                              2.5
                                                                                                     2            1.59
                                                 Drought exacerbates
                                                 Drought exacerbates
                                              weed-disease-insect pressure
                                              weed-disease-insect pressure                         1.5
                                                 and chemical injury
                                                  and chemical injury                                1
                                                                                                                                     TRIPLE
                                                                                                                DOUBLE
                                                                                                                 STACK               STACK

                                                                                                         1 = Indexed Value of Single Trait
Delivering Now, Positioning for the Future
            in Ag & Nutrition
                                                                                                Annual
                                                                                              Opportunity
                                                                                                                                                    Status
                                                                                               Revenue
                                                                                                 $ MM
   PTOI
                                        New Genetics                                              > $1100                       2/3 of 2006 N.A. sales
   $900
                                        Herculex®
                                        Herculex® RW +
                                                                                                   > $150                       2006 Launch
                                        Stacks
   $750
                                        Optimum™ GAT™
                                        Optimum™ GAT™                                                                           2006 Regulatory
                                                                                                   > $200
                                        Soy                                                                                     submission
   $600
                                        Stalk Rot Resistance                                        > $25                       Field trials

                                        Seed Production
   $450                                                                                             > $50                       Field trials
                                        Technology

                                                                                                                                2006 Regulatory
                                        High Oleic Soy                                             > $100
                                                                                                                                submission
   $300
                                        Rynaxypyr™
                                        Rynaxypyr™ (E2Y)                                                                        2006 Regulatory
                                                                                                   > $200
                                        Insecticide                                                                             Submission
   $150

                                        Soy Protein Taste                                          > $100                       Development
     $0
   2001*   2002   2003   2004   2005   Herculex insect protection technology by Dow AgroSciences and Pioneer Hi-Bred. Herculex is a registered trademark of Dow AgroSciences LLC.
                 2006 Rich Crop Genetics Pipeline
                       Target Markets
                                                                     Discovery        Phase 1    Phase 2       Phase 3       Phase 4
               Farmer              Consumer                            Gene/Trait     Proof of      Early       Advanced
               Processor           Enabling Technology                                Concept    Development   Development   Pre-Launch
                                                                     Identification
               Anthracnose Stalk Rot Resistance
                      Fungal Disease Resistance
                              Optimum™ GAT™*
                    Corn Rootworm Resistance II
                    Corn Rootworm Resistance III
                         Corn Borer Resistance II
                        Corn Borer Resistance III
Corn




                               Drought Tolerance
                          Nitrogen Use Efficiency
                                 Increased Yield I
                                Increased Yield II
                  Increased Ethanol Production II
                 Increased Ethanol Production III
                                 Improved Feed II
                                Improved Feed III
                     Seed Production Technology
                Asian Soybean Rust Resistance
                             Optimum™ GAT™*
                   Glyphosate ALS Tolerance II
                               Insect Resistance
                     Cyst Nematode Resistance
Soybeans




                                 Increased Yield I
                                Increased Yield II
                                  Improved Feed I
                                 Improved Feed II
               High Oleic + High Stearic Acid Oil
                              High Oleic Acid Oil
                                     Omega-3 Oil
                                  Improved Flavor
                          Improved Functionality
                     Glyphosate Tolerant Cotton
Other Crops




                 Glyphosate ALS Tolerant Cotton
                         Insect Resistant Cotton
                     Nematode Resistant Cotton
                           Insect Resistant Rice
                     Glyphosate Tolerant Canola
              ** Proprietary Pioneer Glyphosate ALS Tolerant trait
                 Proprietary Pioneer Glyphosate ALS Tolerant trait
            Nutrition – Opportunities in Nutrition Create a Critical, Major Growth
            Wave for Next Generation Products
              Prevention vs. Treatment                                                                                 Current Products
       Progression of Symptoms vs. Age
                                                                                                                       Solae Soy Protein
                                                                                                                        •   Isolated soy protein
                                                                                                                        •   Meat Emulsifiers
                                                                                                                        •   Bars & Shakes                                 Low Linolenic Soybean Oil
                                                                                                                        •   Beverages                                     • Trans fat free
                           Symptoms




                                                                            Disease                                                                                       • Eliminates chemical




                                                                                         Cost
                                                                                                                        Qualified Health Claim
                                                                           Management                                                                                       hydrogenation
                                                                                                                              “Heart Health”
                                                           Progression                                                                                                    • Protects HDL level
                                                                                                                            Taste Improvements
                                         Prevention          Delay
                                                                                                                                    Corn                              Seed
                                                                                         Drugs                                         White Corn                         • High oleic sunflower
                                             Nutrients       Years                      Nutrients                                                                         • Oil-modified canola
                                             Behavior                                   Behavior          "Let thy food be thy                                            • Cardio friendly oils
                                                                                                           medicine and thy
  Major Areas of Opportunity                                                                             medicine be thy food.”
                                                         FUTURE                     NOW                       Hippocrates
                                                                                                                                      Future
       High                                                                    Weight Management             (460-377 BC)
                                                                                                                                      Solae Soy Protein                 Nutrium
                                             Alzheimer’s            Joint Health Women’s Health                                        • Superior tasting               • High oleic soy oil
(size and growth, unmet needs)
 MARKET OPPORTUNITY




                                        Macular Prostrate                               Cardiovascular
                                                                                                                                       • Improved texture               • High oleic / high stearate
                                      Degeneration Cancer                   Inflammation                                               • Consistent health efficacy       soy oil
                                                                                                                                                                        • Omega-3 soy oils
                                                                                     Glucose
                                            Parkinson’s Cognitive                   Management
                                                       Dysfunction                                                                        1.0                                      Also in Solae pipeline:
                                                                                                                       Omega-3            0.8      0.90                             SoleCina
                                       Breast              Colon                                                       Intake of          0.6                         Deficiency    High 7S
                                       Cancer              Cancer                                                     EPA-DHA             0.4                                       Mixes with other
                                                                                                                    (Grams per Day)                                   Current
                                                Infant         Enteral/             Aged                                                  0.2                                          proteins
                                               Nutrition       Parental          Malnutrition                                                      Ideal         0.15
                                                                                                                                          0.0                                       Peptides
                                                               Nutrition
        Low
                                      Low                                                       High
                                                 SCIENTIFIC OPPORTUNITY
                                                                        Red = Metabolic Syndrome
                                            Taste ––Texture ––Nutrition ––Convenience ––Cost --Personalization
                                            Taste Texture Nutrition Convenience Cost Personalization
Bio Based Materials – The Right Science at the Right Time
Bio Based Materials




        Enabling Technology and IP Leverage in All Four Areas
Bio-Based Materials – Bio-PDO™ (1,3 Propanediol, 3G)
                                         Genome




                                                                     E.coli has been
                                                   Cell
                                                  Factory            programmed to
                                                                  increase Bio-PDO™
                                                                  production 500-fold
        Economic Production of 3G
In Nature:
two microorganisms
convert glucose
to 3G stepwise
                    Starch     Glucose              Glycerol                3G
                                           Yeast                Bacterium
Biotech Application:
a single microorganism                     Programmed E. coli     OH     OH
to effect the conversion       Glucose
 Sorona® (3GT) – An Advanced Polymer/Fiber

3GT (Sorona®)                        O                                  O                       O
                          HO                    O       C       O
HO
     C
         C
             C
                 OH
                      +    O
                               C   C
                                      OH
                                            O
                                                    C       C       C
                                                                    O
                                                                        C
                                                                            O
                                                                                C
                                                                                    C
                                                                                        C
                                                                                            O
                                                                                                 C


1,3-Propanediol       Terephthalic Acid    Polypropylene terephthalate
      (3G)                                            (3GT)



     Superior Properties
         Stretch & Recovery
         Softness
         Vibrant Color
         Stain Resistance
         UV & Chlorine Resistance
         Easy Care
Corn has Significant Potential for Biofuels
                                                                                      Ethanol Productivity
                                                                                      18 Gal/Acre

                                                                                  390 Gal/Acre
                                                                                  @ 150 bu/ac grain yield


                                                                                                    100 Gal/Acre


                                  Stover
                                                           The Potential: 30 --50 Billion Gallons
                                                           The Potential: 30 50 Billion Gallons
                                  60
                                                                                                 1200          Stover




                                                                              Gallons per Acre
                                  50
                                                                                                 1000          Grain - Pericarp
                                                          30-50B gal
                                  40                                                                           Grain - Endosperm
                                                                                                 800
                                  30       Corn Acres Available
                                           Million Acres                                         600
                                  20
                                                                                                 400
        Corn Ethanol Produced     10
                                                                                                 200
                Billion Gallons   0                                                                0
                                   2005    2010         2015           2020                             2005        2010      2015   2020
  Integrated Corn Biorefinery Strategy

Sustainable Materials, Chemicals & Energy
                                 Feedstock
                                 Conversion
       Feedstock                                  Fermentation
       Harvest &                                   Production
       Transport




                                                           Separate,
Feedstock                                                   Refine
                                  Produce
Production                    Chemicals & Fuels
To Summarize … An Expectation is Set that Makes the Biotechnology
Vision Strategically Critical for DuPont

             DuPont Vision                                Biotechnology Vision


       To be the world’s most dynamic
          science company, creating                         Unlocking genetic secrets
             sustainable solutions                            to meet societal needs
     essential to a better, safer, healthier                 in a sustainable manner
         life for people everywhere.




                    The best way to predict the future is to invent it.
                                   --- Peter Drucker




                           Put                 Power of          Go Where
                         Science                 One                the
                         to Work                DuPont           Growth is
Plant Sciences, an important
 building block of the future
Agriculture is a major strength of US
economy – traditionally $45 B + trade
surplus
US is not only a producer of 25% of
worlds grain but also a leading
technology developer
Plant sciences will migrate from food
and feed to include fuel, fiber and
fitness – tremendous value addition
Eco Agriculture can be effectively
delivered through plant sciences
Several aspects of plant science
     research are critical
 Pest control through genetics
 Stress resistance to reduce variability
 Nutrient and energy assimilation and
 transformation (N, Water, Light, C)
 Biomass distribution (architecture)
 Metabolic partitioning and distribution
 Process friendly
 Environmental and eco safety
 Human safety and nutrition
Traditionally, plant sciences has been a
    poor cousin of human sciences
 Most investments for scientific and
 technological development by the
 private sector
 Tools borrowed from human and
 microbial sciences
 Food availability not a main stream
 issue
 Poor appreciation of the potential
 No National Institute of Plant Sciences
 Little funding in the competitive
 granting arena in relationship to health
 Global competition in Plant
  Sciences is intensifying
China has made plant sciences a
strategic national priority
Substantial commitment to Plant
Science Centers at Beijing, Shanghai
Focus on rice as a model and
commercial crop
Large US, Europe trained personnel
State of art facilities
Integrated basic and applied research
Expanded investments in plant sciences
 has broad societal and global impact
  Hunger
  Sustainability and eco enhancement
  Disease prevention and better
  management
  Rural economic development and
  industrialization
  New paradigms for new industries
  (tech providers, value chain)
  Global trade harmonization
To accelerate returns on investments, a
 number of breakthroughs are needed
 Technology (current timeframe: 8-15 years)
 - molecular understanding of key physiological
 processes @ cell, tissue, organism and ecosystems
 - early identification of fruitful pursuits
 - transparent, science-based regulatory processes
 Significant private/public sector interaction
 Greater participation of academic community in
 Translation research
 Novel ways of approaching the research component of
 training and education
 Seed money for early stage commercial work
 People – leadership and execution capabilities in multi-
 disciplinary environment
 Social Acceptance and Freedom to practice

								
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