Syringe Exchange Research Update 2008 by Andamicrophone


									                                          Syringe Exchange Research Update
                                              Harm Reduction Coalition

                                        Syringe Exchange Research Update
                                            Harm Reduction Coalition
                                                   August 2008

          This overview and annotated bibliography summarizes key recent research on syringe exchange
          programs in the United States and related data on injection drug users, HIV, and hepatitis C
          published after 2006. Findings continue to support the effectiveness of syringe exchange,
          corroborated by declines in HIV incidence and hepatitis C prevalence among injection drug users
          in the U.S. Additional research characterizes dynamics and mediators of injection-related risk,
          assesses coverage levels of syringe exchange programs, and examines the role and impact of
          ancillary services at syringe exchange sites such as HIV testing, hepatitis B vaccination, and
          referral to substance abuse treatment.


          The majority of research on the effectiveness of syringe exchange programs (SEPs) in the United
          States was conducted and published in the 1990s. These findings have been summarized in
          numerous reports and reviews, and provide conclusive evidence that syringe exchange reduces
          injection-related HIV risks (e.g. syringe sharing) without increasing drug use among SEP
          participants, nor do SEPs result in other negative consequences (e.g. improperly discarded
          syringes, crime). The most recent and comprehensive review of evidence for the effectiveness of
          syringe exchange was conducted for the World Health Organization and published in 2004 as
          part of WHO’s “Evidence for Action” series. A 2006 article synthesized the findings related to
          HIV prevention (Wodak and Cooney, “Do Needle Syringe Programs Reduce HIV Infection
          Among Injecting Drug Users: A Comprehensive Review of the International Evidence”). A 2008
          commentary provides context for these assessments, describing lessons for programs and
          policymakers on HIV prevention for injection drug users (Des Jarlais and Semaan, “HIV
          Prevention for Injecting Drug Users: The First 25 Years and Counting”).

          A 2007 report in the CDC’s Morbidity and Mortality Weekly offers a current snapshot of SEPs
          in the United States based on a 2005 national survey, with an analysis of size and scope of
          programs, services offered, and funding sources (CDC, “Syringe exchange programs -- United
          States, 2005”). Recent epidemiological studies have attempted to quantify and describe the
          injection drug user population in the United States, estimating roughly 1.5 million injection drug
          users nationally (Brady JE, et al., “Estimating the prevalence of injection drug users in the U.S.
          and in large U.S. metropolitan areas from 1992 to 2002”). Additionally analyses describe
          injection drug users as an “aging population” (Armstrong GL, “Injection drug users in the United

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States, 1979-2002: an aging population”), and note declines in the numbers of black injection
drug users relative to white injectors (Cooper HL, et al., “Estimating the Prevalence of Injection
Drug Use among Black and White Adults in Large U.S. Metropolitan Areas over Time [1992-
2002]: Estimation Methods and Prevalence Trends”; Broz and Ouellet, “Racial and ethnic
changes in heroin injection in the United States: implications for the HIV/AIDS epidemic”).

Mounting epidemiologic data points to an overall decline in new HIV infections among injection
drug users (IDUs) over the past 20 years in the United States, with parallel but more modest
decline in hepatitis C rates. The newly released revised HIV incidence estimates from the CDC
projected that in 2006, injection drug use accounted for 6,600 HIV infections in the 50 U.S.
states and Washington, DC (excluding Puerto Rico), with an additional 2,100 new infections
among men who have sex with men (MSM) who also report injecting drugs. The authors note:
“Overall, HIV incidence among individuals exposed through IDU has decreased approximately
80% in the United States. Over that time, those exposed through IDU have reduced needle
sharing by using sterile syringe available through needle exchange programs or pharmacies and
have reduced the number of individuals with whom they share needles.” (Hall et al., “Estimation
of HIV Incidence in the United States”). Similar declines in hepatitis C prevalence among IDUs,
though lesser in magnitude, have been reported in several U.S. cities with SEPs (e.g., Amon et
al., “Prevalence of hepatitis C virus infection among injection drug users in the United States,

Given that the fundamental questions about the effectiveness of SEPs in HIV prevention have
long been considered resolved by the scientific and public health communities in the United
States, much of the recent research on syringe exchange by U.S. researchers has shifted to focus
on international settings, particularly in countries in Asia, Eastern Europe and the former Soviet
Union where explosive HIV/AIDS epidemics are driven by injection drug use. A few new U.S.-
based studies provide additional corroboration of the evidence base supporting syringe exchange
and contribute to knowledge on factors influencing injection-related risks, and one recent
directly demonstrated the effectiveness of SEPs in reducing HIV risk (Huo and Ouellet, “Needle
exchange and injection-related risk behaviors in Chicago: a longitudinal study”). Other studies
have evaluated ancillary services provided by SEPs and related health benefits (HIV testing,
entry to substance abuse treatment).

Important new analyses on syringe exchange and injection drug use in the U.S. have examined
questions of coverage (how many syringes are exchanged and how many people are reached,
relative to need based on estimated size of injection drug user population).Coverage is an
emerging concept in SEP research that attempts to calculate the extent of syringe exchange
(whether measured by proportion of IDUs reached, or numbers of syringes distributed relative to
need) necessary to make an impact on HIV transmission rates. The World Health Organization
recommends that SEPs strive to reach at least 60% of IDU populations, while the U.S. Public
Health Service has long recommended using one new syringe for each injection. However, these
levels of coverage have never been met in the United States – even in localities with well-
established SEPs with strong community and government support. In large part, the coverage
gap reflects the impact of the federal funding ban in constraining resources that limit the sites
and hours of operation of SEPs. However, epidemiologic data suggests that even more modest
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syringe coverage levels can have a significant impact on HIV epidemics among IDUs, though
higher coverage levels – associated with the availability of government funding for SEPs -- are
correlated with lower HIV risks and greater decreases in AIDS diagnoses among IDUs.

Annotated Bibliography


Wodak A, Cooney A. Do needle syringe programs reduce HIV infection among injecting drug
users: a comprehensive review of the international evidence. Subst Use Misuse. 2006;41(6-

See also:
Wodak A. Lessons from the first international review of the evidence for needle syringe
programs: the band still plays on. Subst Use Misuse. 2006;41(6-7):837-9.

Des Jarlais DC, Semaan S. HIV prevention for injecting drug users: the first 25 years and
counting. Psychosom Med. 2008 Jun;70(5):606-11.

Centers for Disease Control and Prevention (CDC). Syringe exchange programs -- United States,
2005. MMWR Morb Mortal Wkly Rep. 2007 Nov 9;56(44):1164-7.

Hall HI, et al. Estimation of HIV incidence in the United States. JAMA. 2008 Aug 6;300(5):520-

Amon JJ, et al. Prevalence of hepatitis C virus infection among injection drug users in the United
States, 1994-2004. Clin Infect Dis. 2008 Jun 15;46(12):1852-8.

Brady JE, et al. Estimating the prevalence of injection drug users in the U.S. and in large U.S.
metropolitan areas from 1992 to 2002. J Urban Health. 2008 May;85(3):323-51.

Armstrong GL. Injection drug users in the United States, 1979-2002: an aging population. Arch
Intern Med. 2007 Jan 22;167(2):166-73.

Cooper HL, et al. Estimating the Prevalence of Injection Drug Use among Black and White
Adults in Large U.S. Metropolitan Areas over Time (1992-2002): Estimation Methods and
Prevalence Trends. J Urban Health. 2008 Aug 16. [Epub ahead of print]

Broz D, Ouellet LJ. Racial and ethnic changes in heroin injection in the United States:
implications for the HIV/AIDS epidemic. Drug Alcohol Depend. 2008 Apr 1;94(1-3):221-33.
                             Syringe Exchange Research Update
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Risk and Impact

Huo D, Ouellet LJ. Needle exchange and injection-related risk behaviors in Chicago: a
longitudinal study. J Acquir Immune Defic Syndr. 2007 May 1;45(1):108-14.

       A study of 901 Chicago IDUs compared changes in risk between those recruited from an
       SEP and those recruited from an area with no SEP coverage; all study participants
       received a standard behavioral HIV prevention intervention. SEP use substantially
       reduced the likelihood of syringe sharing, and the impact of SEP participation on risk
       reduction was greater than the effect of the behavioral intervention alone.

Neaigus A, et al. Greater drug injecting risk for HIV, HBV, and HCV infection in a city where
syringe exchange and pharmacy syringe distribution are illegal. J Urban Health. 2008

       Compared injection risk and infection rates among 526 IDUs in New York City (where
       syringe exchange and pharmacy sale are legal) to Newark, NJ (where both forms of
       syringe access have been illegal until a recent change in New Jersey law allowing syringe
       exchange). Newark IDUs had substantially higher rates of HIV, hepatitis B, and hepatitis
       C infection compared to New York City IDUs (26% vs. 5%, 70% vs. 27%, and 82% vs.
       53%, respectively). Newark IDUs were also more likely to report sharing syringes and
       less likely to obtain syringes from SEPs or pharmacies than NYC IDUs.

Burt RD, et al. Trends in hepatitis B virus, hepatitis C virus, and human immunodeficiency virus
prevalence, risk behaviors, and preventive measures among Seattle injection drug users aged 18-
30 years, 1994-2004. J Urban Health. 2007 May;84(3):436-54.

       Analyzed studies of young IDUs in Seattle, WA over the course of a decade for changes
       in infection rates and risk. Hepatitis B and hepatitis C rates declined substantially (from
       43% to 15%, and from 68% to 32%, respectively) and HIV prevalence remained very low
       (2-3%). While no trends were observed in overall injection-related risks, the proportion
       reporting SEPs as their primary syringe source increased significantly from 48% in 1994
       to 68% in 2004.

Coffin PO, et al. Safe syringe disposal is related to safe syringe access among HIV-positive
injection drug users. AIDS Behav. 2007 Sep;11(5):652-62.

       Assessed syringe access and disposal practices among 680 HIV+ IDUs in three U.S.
       cities. Nearly three-quarters had ever visited an SEP. 52% reported safe syringe access
       sources (e.g., obtained from SEP or pharmacy), and 31% reported possibly safe syringe
       access (e.g., obtained from friend who had visited an SEP) vs. 18% reporting unsafe
       syringe sources (e.g. bought from street dealer). IDUs who had ever visited an SEP and
       those obtaining syringes from safe sources were significantly more likely to dispose of
       their syringes safely.
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Des Jarlais DC, Braine N, Friedmann P. Unstable housing as a factor for increased injection risk
behavior at US syringe exchange programs. AIDS Behav. 2007 Nov;11(6 Suppl):78-84.

       Analysis of participants of 15 moderate-to-large sized SEPs across the U.S. with at least
       50 survey subjects reporting recent unstable housing or homelessness. Unstably housed
       IDUs were twice as likely to report syringe sharing as stably housed IDUs participating in

Des Jarlais DC, et al. Residual injection risk behavior, HIV infection, and the evaluation of
syringe exchange programs. AIDS Educ Prev. 2007 Apr;19(2):111-23.

       Surveyed participants of 6 large SEPs across the U.S. Between 10% and 27% of SEP
       participants at each program reported recent syringe sharing. Programs with higher HIV
       rates among participants had lower proportions of recent syringe sharing.


Bailey SL, et al. Perceived risk, peer influences, and injection partner type predict receptive
syringe sharing among young adult injection drug users in five U.S. cities. Drug Alcohol
Depend. 2007 Nov;91 Suppl 1:S18-29.

Golub ET, et al. Distributive syringe sharing among young adult injection drug users in five U.S.
cities. Drug Alcohol Depend. 2007 Nov;91 Suppl 1:S30-8.

Thiede H, et al. Prevalence and correlates of indirect sharing practices among young adult
injection drug users in five U.S. cities. Drug Alcohol Depend. 2007 Nov;91 Suppl 1:S39-47.

       These three papers report findings on injection-related risk from a large survey of young
       adult IDUs in five U.S. cities (Collaborative Injection Drug Users Study III/Drug Users
       Intervention Trial, or CIDUS/DUIT). The research found high levels of receptive syringe
       sharing (over half injected with a syringe that had previously been used by someone
       else), distributive syringe sharing (nearly half gave another IDU a syringe that they had
       previously used), and indirect sharing (over half reported sharing of injection equipment
       other than syringes, such as cookers and cotton, or splitting drugs with a common
       syringe). However, 76.9% reported obtaining most of their syringes from SEPs or
       pharmacies, and this group was significantly less likely to report receptive syringe
       sharing or distributive syringe sharing than those IDUs obtaining syringes primarily from
       other sources. Despite the levels of injection-related risk reported, only 2.8% were HIV
       positive – a rate well below the overall average HIV prevalence among IDUs across the 5
       cities – and 34.3% had been infected with hepatitis C (a figure well in range of available
       epidemiological data for this subpopulation, and still lower than most of the hepatitis C
       prevalence rates reported for the general IDU population). Also of note, a subsequent
       behavioral intervention component of the study (DUIT) successfully resulted in further
       reducing injection-related risks among participants.
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Tempalski B, et al. Correlates of syringe coverage for heroin injection in 35 large metropolitan
areas in the US in which heroin is the dominant injected drug. Int J Drug Policy. 2008 Apr;19
Suppl 1:S47-58.

       Assessed syringe coverage per heroin injector in cities with SEPs. Average coverage was
       estimated at only 3 syringes per 100 injections, though coverage rates varied widely.
       Cities with older SEP programs and larger MSM populations had greater syringe
       coverage. Government funding (city, county, and/or state) was associated with higher
       coverage levels, supporting arguments to lift the federal funding ban on SEPs.

Heimer R. Community coverage and HIV prevention: assessing metrics for estimating HIV
incidence through syringe exchange. Int J Drug Policy. 2008 Apr;19 Suppl 1:S65-73.

       Compared syringe coverage through SEPs (percentage of IDUs reached, or percent of
       syringes provided per injection) in two cities: Chicago, IL and New Haven, CT. In both
       cities, programs generally reached less than 10% of their estimated IDU populations each
       month, and had low levels of coverage compared to syringe need. Coverage rates were
       higher in Chicago, where SEPs had less restrictive exchange policies than in New Haven.
       Despite modest coverage levels, the proportion of AIDS diagnoses attributed to IDUs
       declined by 21.7% in New Haven and by 41.4% in Chicago, suggesting a significant
       impact on HIV transmission.

Bluthenthal RN, et al. Examination of the association between syringe exchange program (SEP)
dispensation policy and SEP client-level syringe coverage among injection drug users.
Addiction. 2007 Apr;102(4):638-46.

       Evaluated the impact of different syringe dispensation policies on achieving adequate
       syringe coverage (defined as one new syringe per injection) for SEP participants (24
       SEPs in California, 1576 IDUs). Results: IDUs were most likely to obtain adequate
       numbers of syringes from programs with the least restrictive policies (unlimited needs-
       based distribution models, vs. limited and/or one-for-one exchange models).

Bluthenthal RN, et al. Higher syringe coverage is associated with lower odds of HIV risk and
does not increase unsafe syringe disposal among syringe exchange program clients. Drug
Alcohol Depend. 2007 Jul 10;89(2-3):214-22.

       Evaluated the impact of syringe coverage (defined as one new syringe per injection) on
       HIV risk and unsafe syringe disposal among SEP participants (24 SEPs in California,
       1577 IDUs). Results: IDUs with the highest levels of syringe coverage were least likely
       to share syringes, while IDUs with the lowest levels of syringe coverage were most likely
       to share syringes. Coverage levels did not have an impact on rates of safe syringe
       disposal – i.e., IDUs receiving more syringes were no more likely to dispose of their
       syringes unsafely than IDUs receiving the fewest syringes.
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Other Services/Health Benefits

Heimer R, et al. Assessment of HIV testing of urban injection drug users: implications for
expansion of HIV testing and prevention efforts. Am J Public Health. 2007 Jan;97(1):110-6.

       Surveyed HIV testing rates among 1543 IDUs in five cities. Overall, 93% of IDUs had
       ever been tested for HIV; among those not reporting a positive HIV test, 90% had been
       tested for HIV within the past 3 years. SEP participants were more likely both to have
       ever been tested and to have been tested recently.

Heinzerling KG, et al. Human immunodeficiency virus and hepatitis C virus testing services at
syringe exchange programs: availability and outcomes. J Subst Abuse Treat. 2007

       Surveyed 24 California SEPs. 62% provided both HIV and hepatitis C testing; 21%
       offered only HIV testing; 17% had no testing services available. Utilization of HIV and
       hepatitis C testing by SEP participants varied, but was greater in programs operating with
       official legal authorization.

Hu Y, et al. Economic evaluation of delivering hepatitis B vaccine to injection drug users. Am J
Prev Med. 2008 Jul;35(1):25-32.

       Assigned 1,964 IDU participants in SEPs in Chicago, IL and Hartford and Bridgeport,
       CT to two different hepatitis B vaccination schedules. Hepatitis B vaccination through
       SEPs was found to be feasible and cost-saving.

Neufeld K, et al. A comparison of 1-year substance abuse treatment outcomes in community
syringe exchange participants versus other referrals. Drug Alcohol Depend. 2008 Sep 1;97(1-

       Compared the results of substance abuse treatment among 324 methadone maintenance
       patients referred from SEPs vs. other referral sources. While those referred from SEPs
       were more likely to screen positive for opioid and cocaine use during treatment and less
       likely to complete 12 months of treatment when compared to patients referred from other
       sources, those differences were attributed to the greater baseline addiction severity among
       SEP referrals. When baseline factors were factored in to the analysis, outcomes did not
       differ significantly between SEP referrals and referrals to treatment from other sources.

Prepared by the Harm Reduction Coalition, August 2008

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