Your Federal Quarterly Tax Payments are due April 15th Get Help Now >>

Pathogenesis and management of pain in osteoarthritis - PowerPoint by dnm98994

VIEWS: 510 PAGES: 34

									  Pathogenesis and
management of pain in

        Topic review
        May 19,2005
 Sasithorn Chabchaisuk MD.
• Osteoarthritis is a common disorder
  of synovial joints.
• Strongly age-related, being less
  common before 40 years,but rising in
  frequency with age, such that most
  people older than 70 years have
  radiological evidence of osteoarthritis
  in some joints.
• The clinical problems associated
  with pathological and radiographic
  – joint pain related to use
  – short-lasting inactivity stiffness of
  – pain on movement with a restricted
  – cracking of joints (crepitus)
• However,correlation between
  radiographic evidence of
  osteoarthritis and the symptomatic
  disease is rather weak.
• Should be studying the cause of
  joint damage, or the causes of pain
  and physical disability in older

1. The relations between joint
   damage and joint pain.
2. The genetics of osteoarthritis.
3. The principles of diagnosis,
   assessment, and management.
1.Joint damage and joint pain
• In the 1960s, John Lawrence and
  colleagues, showed that people with
  radiographic evidence of
  osteoarthritis were more likely to
  have joint pain than were those
  without any such changes, but also
  that severe radiographic changes
  could be present with few or no
• More recent studies have confirmed
  and extended that radiographic
  evidence of joint damage
  predisposes to joint pain, but the
  severity of the joint damage on the
  radiograph bears little relation to
  the severity of the pain
 Risk factors associated with
       joint damage and
        its progression
• Age
• Family history
• Inherited and developmental conditions
  that affect bone or joint growth or
• Joint injuries
• Selected activities
• Obesity
  the balance of risk factors varies according to
    joint site.
Risk factors for progressive joint
    some evidence that it different
 from incident osteoarthritis
    although the problems with
 definitions and cut-off points
 mentioned make it difficult to make
 this distinction.
• Bone density              + or –
   The pathogenesis of joint

Articular cartilage.
  molecular level
• gradual proteolytic degradation of
  the matrix
• increased synthesis of the matrix
  components by the chondrocytes
  morphological changes
• cartilage surface fibrillation
• cleft formation
• loss of cartilage volume
Bone :less well understood,
• development of osteophytes at the
  joint margin
• ossification of cartilage outgrowths
• major changes in the vascularity
  and turnover of the subchondral
• Cytokines and other signalling
  molecules released from the
  cartilage, synovium, and bone
  affect chondrocyte function.
• Role for inflammation in
  osteoarthritis, at least in some
  patients and in some phases of the
• environmental risk factors mentioned
• Studies have stressed the importance of
  muscle weakness, joint instability, and
  malalignment as possible causes of
• Implicit in the concept of osteoarthritis
  disease modification is the idea that
  reduction of structural joint damage will
  translate into symptomatic benefits and
  improved quality of life. This concept
  remains unproven.
    Risk factors for joint pain
    few data are available about the
    risk factors for joint pain.
•   joint pathology
•   radiographic changes
•   various physical activities
•   psychological wellbeing
•   health status
The pathogenesis of joint pain
•   synovitis
•   subchondral bone changes
•   peripheral pain sensitisation
•   central pain sensitisation
    Finally, the experience of pain will
    be modulated by psychological,
    social, and other contextual factors
• neurogenic inflammation can
  contribute to joint damage
• inflammation might be an important
  feature of the process of
• Pain is accompanied by local
  production of substance P and
  cytokines that can interact with
  inflammation pathways and thereby
  make a secondary contribution to
  joint pathology.
2.Phenotypes, genotypes, and

• Osteoarthritis is a multifactorial disease
  with genetic and environmental
• All cases are probably affected by both
  genetics and environment, with a
  continuous distribution between the
  extremes of predominantly genetic or
  predominantly environmental.
• Recent reports have identified
  several chromosomal loci and gene
  variations associated with an
  increased risk for osteoarthritis.
• coding for molecules in the cartilage
  matrix such as collagen types II,
  IX, and XI, COMP, and matrilin-3.
• Many but not all genetic variations
  or mutations are associated with
  variable expression of the
  phenotypes spondyloepiphyseal
  dysplasia (SED) or multiple
  epiphyseal dysplasia (MED).
   Diagnosis and assessment

differentiation from
1. referred pain
2. periarticular (soft-tissue)
3. somatisation (regional pain in the
   absence of any local pathological
• Radiograph
• disease-specific questionnaires
  – Knee injury and osteoarthritis outcome
    score” (KOOS)
  – Western Ontario and McMaster
    Universities osteoarthritis index
   Principles of management
• many elderly people regard
  musculoskeletal aches and pains and
  stiffness as a normal part of the
  aging process, rather than a disease.
• Many never seek medical help.
• It is important not to overtreat
  those who do seek help and advice,
  and that it is inappropriate to
  medicalise most of those with mild
• All patients should be given general
  advice about the disease, lifestyle
  alterations that might reduce
  symptoms, the need to keep fit and
  active, and the need to lose weight
  if they are obese.
• Referral to allied health
  professionals can help with delivery
  of educational and exercise-based
• all patients should be empowered to
  take control of the condition
  themselves through self-help
  measures with proven effectiveness,
  – use of simple analgesics and topical
    agents as well as some nutraceuticals.
• Only if these measures fail should
  interventions that require medical
  – non-steroidal anti-inflammatory drugs,
    physiotherapy, and the use of aids and
• for those in whom other measures
  have failed, are the more invasive
  interventions. For those with severe
  osteoarthritis, joint replacement is
  very effective.
• One of the major problems with the
  practice of evidence-based health
  care for people with osteoarthritis
  is that the evidence only concerns
  single interventions, whereas in
  practice combinations of different
  interventions and packages of care
  involving a mixture of
  pharmaceutical and non-
  pharmaceutical treatments are
• Prevention. Some of the major risk
  factors for joint damage are
  potentially modifiable and, in
  theory, the rate of obesity and
  joint injury could be reduced.
• However, such reductions are
  unlikely to happen; indeed, both
  obesity and injury seem to be on
  the increase, despite knowledge
  that they are detrimental to

To top