Genome, generally defined as the complete set of chromosomes in haploid cells as a genome or all genes in haploid cells as a genome. However, the results of genome sequencing, gene coding sequences found in the whole genome sequence of only a small part. Therefore, it refers to haploid genome of cells, including coding sequences and non-coding sequences of all DNA molecules. Say more precisely, is the haploid nuclear genome of all DNA molecules within the nucleus; mitochondrial genome is a mitochondrial DNA molecule contains all; chloroplast genome is all of a chloroplast DNA molecules contained.
human genome project more information: www.abpischools.org.uk new horizons in medicine Understanding the human genome can be seen as the key to Sequencing the DNA Diagnostic understanding the mystery of human life itself. The Human Genome 5' Single stranded DNA to be sequenced 3' testing Project set out to identify all of the genes in the human chromosomes A A G C T G A C C T A G C (around 30,000 of them) and to sequence the billions of base pairs which Tests using gene probes are being mixed with make up human DNA. As a result of advances in the technology used to developed to diagnose inherited diseases. As it becomes possible to sequence DNA, the task of producing the complete human genome identify the genes making people was completed two years ahead of schedule! susceptible to problems like heart DNA polymerase A T Limited number disease or cancer, in the future C G of dideoxynucleotide Lots of bases which terminate everyone may be able to plan a A T normal the DNA chain, each with lifestyle to suit their genes. CG nucleotide a different coloured bases fluorescent tag incubated International involvement G G A T C G Right drug, T G G A T C G right place The Human Genome Project has G C been an example of successful Some of the new treatments G T international cooperation, with G G C G developed using knowledge from the T scientists in 18 countries all A A Human Genome Project hit precise T working on sequencing the DNA. C targets in the body, such as cancer C T G G A T C G G cells. Others work best in people with a particular genetic makeup. In future, Many DNA fragments made, all of different lengths as the chain terminating bases are added at random medicines may even switch genes on or off to control disease. Fragments separated by electrophoresis – the shortest fragments travel furthest G C G T T C G A C T G G A T C G T C G Sequence of new complementary strand of DNA The naked A T C G gives us C A T C G gene G G A T C G Gene therapy ‘Human DNA’ by Michael Dunning. T G G A T C G Image from the Novartis and The Daily Telegraph A A G C T G A C C T A G C This is what the human genome Visions of Science Photographic Awards. www.visions-of-science.co.uk In gene therapy the idea is to C T G G A T C G Sequence of original DNA strand looks like – these letters represent overcome genetic diseases by A C T G G A T C G a fragment of gene THC1256444 modifying the faulty DNA which causes which codes for an insulin-like G A C T G G A T C G diseases such as thalassemia and molecule. Each letter is C G A C T G G A T C G cystic fibrosis. Results from the Human equivalent to one nucleotide T C G A C T G G A T C G Genome Project should help scientists base and there are about make progress in this exciting new area T T C G A C T G G A T C G 3 BILLION of them in the of treatments. human genome. Model sequence
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