Acute Exposure Guideline Levels AEGL

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					Acute Exposure Guideline Levels
            AEGL

              Paul S. Tobin, Ph D
             tobin.paul@epa.gov
     U.S. Environmental Protection Agency
Short-term exposure limits (10 min. to 8
                    hrs.)
 Three defined health effect threshold
 levels (discomfort, disability, death) –
       disability is an action level
  Intended for acutely toxic chemicals
   Applicable to accidental chemical
                 releases
Applicable to chemical terrorist activities
                 CHARACTERISTICS OF AEGLs
                        HAZARD ASSESSMENT

  Threshold Levels                 Effects


DEATH                           Increasing likelihood of death

  AEGL-3



DISABLING            • Impairment of ability to escape
                     • Increasing severity of irreversible or
                          other serious long-lasting effects
   AEGL-2

                       •Increase in notable discomfort
DISCOMFORT             •Increasing severity of reversible effects
                       (with or without signs/symptoms)
    AEGL-1

                     Increasing complaints of objectionable
DETECTABILITY
                     odor, taste, sensory irritation or other
                     mild, non-sensory or asymptomatic
                     effects
AEGL “Vulnerable”/ “Safe” Zones




         Release site




          Death
         (AEGL-3)


         Disability
         (AEGL-2)

        Discomfort
         (AEGL-1)


       DETECTABILITY
      FEDERAL ORGANIZATIONS WITH AEGL APPLICATIONS

    ASTDR                        COAST                             DOD                                DOE
                                 GUARD

Medical Management Guidelines   CHRIS Manual                   Restoration                     Safety Orders
Toxicology Profiles                                            DOA-Chem Demil                  Environmental Mgmt
Emergency Response                                             Emergency Programs              Fixed Facilities




      DOT                                                                                             EPA
                                                       AEGLs
                                                       AEGLs
Emergency Response Guidebook                                                                 OPPT/Risk Assessments
PIH Classification                                                                           CEPPO CAA 112 (r)
Emergency Planning                                                                           CAMEO
                                                                                             OSWER Superfund
                                                                                             OAQPS CAAA 112 (b)




                                                                                                 NIEHS
     FEMA                           NIOSH                            OSHA

                                                                                            Training of Superfund
DOA Chem Demil Support          IDLH Revisions                 Process Safety Regulations   Site Workers
Chemical Emergency Training     New IDLH Values
                                Respirator Selection
        COMPREHENSIVE PEER REVIEW PROCESS
            AEGL DEVELOPMENT PROCESS
                          to NAC/AEGL Committee Concurrence

        Non-published,         Published                Other                          Special
      Non-peer Reviewed        Literature         Data / Information                   Toxicity
         Industry Data          Search                Sources                          Studies




AEGL Development                      Technical                  Distribute Draft or
  Team - ORNL                          Support                   Proposed TSDs /
Scientist, Chemical                  Documents                       AEGLs to
                                                                                                    DRAFT
Manager, Chemical                      (TSDs)                       Committee
    Reviewers                                                         Members


                                                                    NAC/AEGL
                                                           Committee Meeting to Discuss
                                                             Draft or Proposed AEGLs




                                                                   NAC/AEGL
                                                                   Committee
                                NO                                Consensus on
                                                                    Proposed
                                                                     AEGLs

                                                                                                  PROPOSED
                                                                        Y ES
     COMPREHENSIVE PEER REVIEW PROCESS
         AEGL DEVELOPMENT PROCESS
                                 to final publication by NAS

                                                              Y ES


                                                         FR Publ ication
          Major Changes



          NAC/AEGL
          Committee
                                                             Major
         Consensus on
                                       Y ES               Comments/
          Revisions to
                                                           Issues?
           Proposed
            AEGLs


                                                              NO
          Minor Changes

                                                         Interim AEGLs
                                                                                   INTERIM

                                        NAS-NRC AEGL                       NAC/AEGL
                                         Subcommi ttee                     Committee


FINAL
                                                                              NO
 NAS-NRC                                NAS-NRC AEGL
Publi cation of           Y ES           Subcommi ttee
Final AEGLs                              Concurrence
                            NAC/AEGL Committee
                                        INDUSTRY
      FEDERAL                       (Arch Chemicals, Dow
1. Agency for Toxic                                                  ORGANIZATIONS
                                    Chemical, Honeywell)
   Substances and                                               1.    ToxPath Inc.
   Disease Registry                                             2.    National Fire
   (ATSDR)                                                            Protection
2. Environmental                                                      Association (NFPA)
   Protection Agency                                            3.    American College of
   (EPA)                                                              Occupational and
3. Department of                                                      Environmental
   Transportation (DOT)                                               Medicine (ACOEM)
4. Department of Energy                                         4.    Association of State
   (DOE)                                                              and Territorial Health
5. Department of Defense                                              Officials (ASTHO)
   (Army/Navy/Air Force)                                        5.    International Center
6. National Institute for
   Occupational Safety
                                  NAC/AEGL                            for Environmental
                                                                      Technology
   and Health (NIOSH)             Committee                     6.    American Industrial
                                                                      Hygiene Association
                                                                      (AIHA)




         STATE                            INTERNATIONAL                   ACADEMIC
      (Massachusets,                        (The Netherlands,              (Oregon State
     Texas, California,                     Germany, Canada)                 University)
        Wisconsin)
            AEGL Methodologies




     1993                              2001
Publications of the National Academy (NAS) Press
Publication of Final AEGLs by the National Academy
                     (NAS) Press




                  Volume 4
         AEGL website




http://www.epa.gov/oppt/aegl/
             Results
Final, Interim and Proposed AEGL Chemicals
 Output through May 2008

 •   38 Final
 •   190 Interim
 •   9 Proposed
 •   20 Holding
 •   60 Remaining
    International Harmonization
• EPA Chemical Emergency Provisions followed
  Bhopal even in Dec 1984 (methyl isocyanate
  gas)
• European Economic Community Chemical
  Emergency Provisions followed Seveso in 1976
  (Dioxin solid)
• Harmonization must include consideration of
  chemical lists (tox + volatility cutoffs?) and acute
  exposure values (AEGLs = Global Values?)