Course Outline BIOCHEMISTRY 4200 (Proteins and Nucleic Acids) Spring Semester 2005 Department of Chemistry and Biochemistry Lecture: Tu, Th 16:30 h – 17:45 h D633 University of Lethbridge Lab: M 13:00 h – 15:30 h E770 Lecturer: Hans-Joachim Wieden firstname.lastname@example.org E868 UH Ph: 329 2303 Office Hours: M 13:00 h – 15:00 h W 9:00 h – 11:00 h or by appointment Lab Instructor Michelle Duke email@example.com E856 UH Ph: 329 2088 th Textbook: Lehninger Principles of Biochemistry, 4 Ed. 2004 By D.L. Nelson and M. M. Cox Prerequisits: Chemistry 2410, 2710, Biochemistry 3020 General Information Biochemistry 4200 will deal with the biochemistry of proteins and nucleic acids including protein-ligand and protein-protein interactions; membrane proteins, enzyme mechanisms, and modification of gene expression and rapid kinetics. Laboratory projects will involve the purification and characterization of enzymes and DNA. Reference material will consist of textbook chapters, selected research articles, and specific internet resources. Reference material will be posted weekly. Copies of all reference material will be made available. The midterm exams will deal with material covered in the lectures prior to the exam. The final exam will be comprehensive, but there will be an emphasis on the more recent material. Lecture Outline The course will be separated into three sections of roughly equal size. For each section, a topic will be introduced, several example systems will be studied and underlying methodologies will be discussed. I. Biophysical Methods Modern research tools and techniques for studying macromolecular function. II. Macromolecular Interactions Structure and function of representative enzymes. III. Omics Genomic, proteomics, metabonomics, and others. Laboratory Outline Will be provided or discussed in lab Course Outline Grade Composition: rd Midterm Exams 50min 15% Feb 3 (tentative date, 2 weeks notice) th 50min 15% Mar 10 (tentative date, 2 weeks notice) Final Exam 180min 40% Date set by registrar Laboratory 30% TOTAL 100% Please Note : Failure to attend a Midterm exam will normally result in a score of zero, unless you have a good reason for being absent (Instructors discretion). In the case of illness, a medical certificate must be presented. In either case, the final exam will be pro-rated to reflect the missed Midterm exam. A missed final exam will normally result in a score of zero. Only the Dean (or Associate Dean) of Arts & Science can authorize a "make-up" final exam. A passing grade must be achieved in both the lecture and laboratory component of the course in order to obtain credit.
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