Immunology and Cancer by AmnaKhan

VIEWS: 303 PAGES: 36

									Immunology and Cancer
and Some Concepts on Non-Immunological Host-Response in Cancer

Folder Title: CxImmuno
Updated: April 12, 2007

General Concepts on Host-Response in Cancer (Part 1)
Does the Host Respond to Prevent Oncogenesis? Does the Host Respond to Limit Neoplastic Growth and Progression? If So, How Does the Host Respond? What Exactly Is the Host Recognizing? • To Prevent Oncogenesis • To Limit Growth and Progression

General Concepts on Host-Response in Cancer (Part 2)
Is the Appearance and Growth of Cancer Related to Weakened Host Response? Genetically Weakened? Environmentally Weakened? Physiologically or Pathologically Weakened? Can Host Response Actually Facilitate Tumor Appearance and Enhance Tumor Growth and Progression? Can the Recognition and Response Mechanisms be Mobilized, Enhanced, and Directed for Cancer Management and Cancer Therapy? Can They Be Used in Cancer Prevention?

Non-Immunological Host-Responses in Cancer
Anti-carcinogenic Effects: Deactivation, Elimination DNA Repair Mechanisms Genetically-directed Apoptosis (May Function in Anti-tumor Immunity Also) Differentiation-inducing Factors Oncolytic Cytokines (May Function in Anti-tumor Immunity Also) Hormonal Responses Anti-Angiogenesis Factors Affecting Tumors Psychological Factors (May Function in Anti-tumor Immunity Also)

Non-Specific Innate Natural Immunity vs Specific Adaptive Immunity in Cancer
Innate Natural Immunity Specific Adaptive Immunity No Specific Antigen Recognition Specific Antigen Recognition Not Antibody-dependent Can Involve Antibodies No Antigen-specific T-Cell Receptor Uses T-Cell Receptors Not MHC-Restricted MHC-Restricted (Recognizes Altered-self) No Memory Response Exhibits Immunlogical Memory No Priming & Second-set Response Enhanced Secondary Responses No Clonal Selection & Expansion Involves Clonal Selection and Expansion of T- and B-Cells

Cells and Factors in the Natural Immune Response in Cancer
Natural Killer (NK) Lymphocytes • Non-B-Cell, Non-T-Cell "Null" Lymphocytes • Activated by Interferon Activated Macrophages • Includes Splenic MPh's, Liver Kupfer Cells, Alveolar (Lung) MPh's, Brain Glial Cells, and others Granulocytes (Polymorphonuclear Leucocytes) • Neutrophils, Eosinophils, Basophils, Tissue Mast Cells Activated Non-Antigen-Specific T-Cells • Lymphokine-activated Killer Cells (LAK) Cytokines • Tumor Necrosis Factor (TNF), Interferons • Interleukins (e.g. IL-2)

Potential Tumor Antigen Targets (from Pitot, Lecture 24, OnLine)


Pitot, OnLine Lecture 24


Vaccination of Mice with Irradiated Killed Tumor Cells

Figure 15.17 The Biology of Cancer (© Garland Science 2007)

p. 673

Figure 15.3b The Biology of Cancer (© Garland Science 2007

p. 658)

Figure 15.12d The Biology of Cancer (© Garland Science 2007) p. 666

MHC Class I Modulation and Escape from T-Cell Lysis

from Kuby, Immunology


To top