Center of Excellence Tumor and Cancer Virus Immunology

Center of Excellence Tumor [and Cancer Virus] Immunology Kathy Zoon August 21, 2003 1 Mission: • The re-engineered IRP will support basic research and translate that research to eliminate death and suffering due to cancer Action: • Four Centers of Excellence will be established to accomplish this mission: – – – – Advanced Biomedical Technology Molecular Epidemiology Molecular Oncology Tumor Immunology 2 Center of Excellence Elements: • Promote an integrated transdisciplinary (basic, clinical, epidemiologic) research collaboratory approach (incl. between ICs and with academia, other government agencies, pharmaceutical industry) [Break down walls] • Perform high-risk, high-payoff, long-term basic (discovery) and translational (development and delivery) research [What can the CoE do that cannot or will not be done by others outside?] • Exploit new technologies and core infrastructure • Make better use of NIH Clinical Center and collaborate with other outside cancer clinical centers • Place more emphasis on recruitment, training and 3 mentoring of fellows Center of Excellence in Tumor [and Cancer Virus]Immunology Focus: Immunology-based therapeutics development • Vaccines • Intratumoral therapies • Cytokine therapies • Adoptive transfer immunotherapies • Stem cell transplantation • Cancer viruses e.g., HIV,HPV 4 Center of Excellence in Tumor [and Cancer Virus] Immunology Structure: Consolidation of groups of excellence • Vaccine Working Group • Biologics Working Group • Clinical Immunotherapies Working Group • Immunology Faculty • HIV Working Groups • Enlist participation from immunologists in other ICs or outside NIH, e.g. FDA • Other interdisciplinary expertise needed (intramural or extramural) • SAIC Clinical Support Laboratory • Clinical Product Review Committee 5 Potential Participants • Metabolism Branch • Surgery Branch • Experimental Transplantation and Immunology Branch • Experimental Immunology Branch • Laboratory of Tumor Immunology and Biology • Laboratory of Experimental Immunology • Laboratory of Immunobiology • Laboratory of Immune Cell Biology • Laboratory of Molecular Immunoregulation • Laboratory of Molecular Biology • Many others 6 Center of Excellence in Tumor Immunology Operational Vision: Function: • Umbrella organization • Facilitate cross-fertilization of expertise, experience, knowledge, ideas • Promote interest in immune-based therapies • Foster new immune-based therapies (e.g., cytokines, monoclonal antibodies, etc.) through clinical trials • Establish a bridge between immunologists and oncologists • Incorporate new technology discoveries (genomics, proteomics, imaging) into clinical studies 7 • “Play to our strengths” Center of Excellence in Tumor Immunology “Experiment in Progress”: • Pilot programs in tumor immunology • Identify strengths and weaknesses • Identify how the expertise in CCR can help each other • Engage the appropriate pharmaceutical industry partners (e.g., CRADA mechanism) • Enlist the support of the NCI extramural program (e.g., CTEP, BDP) • Seek collaborations with other Intramural (e.g., CCR Molecular Oncology) or Extramural Centers of Excellence, Cooperative Groups, SPORES, Consortia, FDA etc. 8 Center of Excellence in Tumor Immunology Anticipated Accomplishments: • Enhance the interaction of CCR laboratories with the extramural community • Provide more coordination in translational/clinical research between the intramural and extramural communities • Demonstrate “value added” to the extramural communities by the CCR • Accelerate development of new cancer therapies, particularly combination therapies • Exploit emerging technologies to access more knowledge of the mechanisms involved in these therapies 9 Matrix Approach: Intersection of Science Area and Cancer Site 10 Center of Excellence: Tumor [and Cancer Virus] Immunology • Proposed name ( see above) • Proposed mission: To accelerate basic research and the discovery, development and delivery of products for the prevention or treatment of cancer or virus infections that lead to cancer 11 Center of Excellence Tumor [and Cancer Virus] Immunology • Structure: – Steering committee • Chair, Principal Deputy Director, CCR • Proposed Members and Adjunct Steering Committee Members • Proposed Functions of the Committee 12 Proposed Steering Committee and Adjunct Steering Committee Members • Steering Committee: Tom Waldmann, Ira Pastan, Steve Rosenberg, Jeff Schlom, Jay Berzofsky, Doug Lowy, Bob Wiltrout, Allan Hildesheim, Joe Oppenheim, Bob Yarchoan, Ron Gress, Al Singer, John Wigginton, Jeff Lifson, and Kathy Zoon (chair). • Adjunct Steering Committee: Neil Goldman, Steve Creekmore, Dale Shoemaker, and Betty Fitzpatrick • Proposed Project manager: Orkand contract 13 Proposed Functions • Umbrella organization • Facilitate cross-fertilization of expertise, experience, knowledge, ideas • Promote interest in immune-based prevention and therapies • Foster new immune-based vaccines and therapies (e.g., cytokines, monoclonal antibodies, etc.) through clinical trials • Establish a bridge between immunologists, virologists and oncologists • Incorporate new technology discoveries (genomics, proteomics, imaging) into clinical studies • Regulatory Support • Contract Support for product development 14 • Assay development (CSL) Special Issues of Consideration • Technology Transfer and Intellectual Property Issues will be addressed in order to facilitate the mission of the Center 15 Develop Strategic Objectives 16 Potential Resources • • • • Clinical Product Review Committee SAIC Clinical Support Laboratory Support from Director, CCR Project Manager, Orkand 17 Next Steps • Draft Charter • Finalize Steering Committee and Adjunct Steering Committee Members • Meeting Schedule • Web Site • Other Issues 18