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Animal Models in Immunology

VIEWS: 180 PAGES: 5

  • pg 1
									Animal Models in Immunology
Adam Brown and Teresa Fulk

Nude Mouse

• Discovered in 1962. • Is hairless, and more importantly, lacks a thymus. • Homozygous for recessive trait called “nu” • Immunodeficient since it can’t produce T-cells and lymphocytes. • This allows for implantation of human tumor cells into mouse without rejection.

Scid Mouse
• Def. “A laboratory animal that, lacking an enzyme necessary to fashion an immune system of its own, can be turned into a model of the human immune system when injected with human cells or tissues.”

• Discovered in 1983. • S.C.I.D. – Severe combined immune deficiency • Found to be more immunodeficient than nude mice • Used as a blank slate immune system. • Used in oncology, immunology, infectious disease, rejection of tissue transplants.

Transgenic or Knock-out Mouse
• Mouse that has DNA artificially transmitted into it. • Are produced from genetically engineered embryos. • Through breeding, strains of mice created with desired traits.

References
• http://www.immunecentral.com/immunesystem/iss29.cfm • http://www.vetmed.ucdavis.edu/Animal_Alternati ves/cancer.htm • http://home.comcast.net/~john.kimball1/BiologyP ages/N/NudeMouse.html • http://darwin.bio.uci.edu/~tjf/tmf_tgms.html • http://www.uac.arizona.edu/VSC443/rodentmod els/rodentmodel06.html • http://www.accessexcellence.org/RC/VL/GG/tran sgenic.html


								
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