Hematologic Neoplastic disorders by sammyc2007

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									HEMATO-ONCOLOGY
“Neoplasia of Hemopoietic system”

Dr. VM Shashidhar Senior Lecturer in Pathology Fiji School of Medicine

Normal Blood Film:

Haematological Neoplasia:
Leukemia
Acute & Chronic  Myeloid & Lymphoid


Lymphoma
Hodgkins & Non-Hodgkins  High grade & Low grade


Premalignant Conditions
Myeloproliferative syndromes (MPS)  Myelodysplastic syndromes (MDS)


Leukemia Classification
Acute Leukemias:
Myeloid - M0, M1, M2, M3, M4, M5, M6, M7  Lymphoid - L1, L2, L3.


Chronic Leukemias:
Myeloid - CML  Lymphoid- CLL, PLL, HCL,


Leukemia - Clinical Features
Anemia (low RBC) Fever - Infections (low WBC) Bleeding tendency (low PLT) Tender bones, lymphadenopathy, organomegaly Gum hypertrophy etc. (organ infiltration)

AML-M5 - Gum Hypertrophy:

ALL:Cervical Lymphadenopathy

Organomegaly

Mediastinal Lymphnodes-ALL

ALL-Acute Lymphocytic Leuk.
Common in Children. FAB classification L1, L2 & L3 B cell, Tcell & histiocytic types. CD10 +ve, Pre B cell type common. Lymphadenopathy, bleeding tendency Moderate Hepatosplenomegaly

ALL-L3

AML-Acute Myeloid Leuk.
Malignancy of myeloid progenitor cells. Adults common Hepatosplenomegaly moderate No significant lymphadenopathy Bleeding tendency Gum bleeding common in M5/M4 FAB classification - M0 to M7.

AML-M2 - with maturation

AML-M3 - Auer Rods

AML-M3 - Promyelocytic

AML-M4 - Myelomonocytic

AML-M5b - Monoblastic Leuk

AML-M6 : Erythroleukemia

Chronic Myeloid Leukemia
Middle age 40-60y Philadelphia chromosome, t(9:22) Leucocytosis (>50x109/L), abnormal cells Marked splenomegaly Anemia, Bleeding Hypermetabolism, Hyperuricemia- gout, renal impairment.

Chronic Myeloid Leukemia:

Chronic Myeloid Leukemia:

Chronic Lymphocytic Leukemia
Elderly age Marked lymphoid proliferation Non functional, excess life span. Spleen, lymph node & liver enlargement Common B cell (CD5 +ve) Immunodeficiency, infections. Anemia, thrombocytopenia at later stages. Rare types are HCL,PLL, T-CLL

CLL

CLL – Blood Film

Hodgkins Lymphoma:
Lymphadenopathy, painless, firm Pel-Ebstein fever, Eosinophilia, Reed-Sternberg cells - B lymphocytes Histological Types:
Lymphocyte predominant.  Nodular Sclerosis.  Mixed cellularity.  Lymphocyte depleted.


Hodgkins lymphoma

Non-Hodgkins Lymphoma:
According to cell type  T cell NHL  B cell NHL  Miscellaneous NHL According to Clinical grade  Low grade NHL  High grade NHL  Intermediate grade NHL
Ex: Lennert’s lymphoma is a low grade Tcell NHL. Burkitt’s lymphoma is a high grade B cell NHL

NHL- Histologic types

Diffuse - & - Follicular

NHL- Histologic types

Small – Intermed. – Large

Myeloma – Bone Marrow

Burkitt’s Lymphoma L.N.

CML - Blood Film

Basophils

Thank You...


								
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