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What does it look like to be a Direct thrombin inhibitor and why is that important

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What does it look like to be a Direct thrombin inhibitor and why is that important Powered By Docstoc
					Indirect vs Direct Thrombin Inhibition

Indirect inhibition by heparin requires the presence of antithrombin (AT), the actual inhibitor. Heparin (long yellow strand) binds to AT, causing a shape change that increases the ability of AT to inhibit thrombin.
Hirsh J et al. Chest. 2001;119(1 suppl):64S-94S. Weitz JI et al. Thromb Res. 2002;106:V275-V284.

Direct inhibition with Angiomax® (bivalirudin) inhibits thrombin directly with high affinity and specificity.
It requires no cofactor, and acts alone. Bivalirudin’s effectiveness is not affected by variability in the concentration of a co-factor like AT.
Gibson CM, 2006

www. Clinical trial results.org


				
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