Cardiovascular Events Halt Study of Testosterone Gel by ProQuest


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									                                                                                                                                                  AUGUST 2010       Renal & Urology News 9

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                                                       Short Takes                                                                               Cardiovascular Events Halt
Acupuncture May Ease
Hot Flashes from ADT
                                                                             pants in the Atherosclerosis Risk
                                                                             in Communities study. Daniel J.
                                                                                                                                                 Study of Testosterone Gel
Acupuncture may be an effective                                              Brotman, MD, of Johns Hopkins Hos-
treatment for hot flashes in men
receiving androgen deprivation
                                                                             pital in Baltimore, and colleagues
                                                                             found that over a median follow-up of
                                                                                                                                                 A    study of testosterone supplementation in older men was terminated
                                                                                                                                                      after daily application of a testosterone gel was associated with a signifi-
                                                                                                                                                 cantly increased risk of cardiovascular (CV) adverse events.
therapy (ADT) for prostate cancer                                            16 years, subjects aged 45-64 years                                   The study involved 209 men aged 65 years and older (mean age 74 years) who
(PCa), according to findings pub-                                             with higher resting heart rates had a                               had limitations in mobility and a total serum testosterone level of 100-
lished online in Urology. Tomasz                                             twofold increased risk of eventually                                350 ng/dL. At baseline, subjects had a high prevalence of hypertension, dia-
M. Beer, MD, of Oregon Health and                                            developing kidney failure; those with
                                                                                                                                                 betes, hyperlipidemia, and obesity. During the course of the study, the testosterone-
                                                                                                                                                 treated men had significantly greater improvements in strength but also higher rates
Science University in Portland, and                                          a lower beat-to-beat variability in heart
                                                                                                                                                 of cardiac, respiratory, and dermatologic events than those taking a placebo.
colleagues studied 22 PCa patients                                           rate had a 1.5-fold increased risk,
                                                                                                                                                 CV-related adverse events occurred in 23 treated men versus five placebo
who were on ADT and underwent                                                according to findings published online                               recipients, Shehzad Basaria, MD, and colleagues reported online in The New
acupuncture with electrostimulation                                          in the Journal of the American Society                              England Journal of Medicine.
biweekly for four weeks, then weekly                                         of Nephrology.
for six weeks. The primary endpoint
was a reduction in hot flash score af-
ter four weeks of therapy. After four
                                                                             CKD, Low Income
                                                                             Linked in Blacks
                                                                                                                                                 PSA Testing Found to Reduce
weeks, nine patients (41%) achieved
the primary endpoint. The research-
                                                                             Low socioeconomic status (SES) in-
                                                                             creases blacks’ risk of developing CKD
                                                                                                                                                 Prostate Cancer Mortality
ers noted that numerous placebo-                                             nearly twofold, but does not increase
controlled trials have shown a 25%
response rate to placebo treatment
                                                                             the risk in whites, according to a re-
                                                                             cent report in the American Journal of
                                                                                                                                                 D    eaths from prostate cancer (PCa) fell by almost half after 14 years of
                                                                                                                                                      biennial screening, according to data from a Swedish study. Among 7,578
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