New flaxseed review by ProQuest


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									                                                                                                  410 inform July 2010, Vol. 21 (7)

        groups of people were to self-medicate more
        with green exercise,” added Barton.              Vitamin E and liver                               that liver enzyme levels considered normal
                                                                                                           are actually elevated. Healthy levels are <30
             A challenge for policy makers is that
        policy recommendations on physical activity
                                                         disease                                           U/L for a man and <20 for a woman.”
                                                                                                                In the Pioglitazone or Vitamin E for
        are easily stated but rarely adopted widely as   Vitamin E has been shown effective in treat-      NASH Study (PIVENS), investigators ran-
        public policy, Pretty noted, adding that the     ing nonalcoholic steatohepatitis (NASH),          domly assigned 247 nondiabetic adults with
        economic benefits could be substantial.          an obesity-associated chronic liver disease       biopsy-confirmed NASH to receive vitamin
             Policies that suggest active living         that can lead to cirrhosis, liver cancer, and     E, pioglitazone, or placebo. Vitamin E func-
        point to the need for changes to physical,       death. NASH also is related to or a part of       tions as an antioxidant whereas pioglitazone
        social, and natural environments, and are        type 2 diabetes, lipid disorders, and cardio-     improves the sensitivity of cells to insulin,
        more likely to be effective if physical activ-   vascular disease.                                 a hormone that controls both sugar and fat
        ity becomes an inevitable part of life rather          The often asymptomatic condition            metabolism.
        than a matter of daily choice.                   affects 2–50/0 of the population, although an          After 96 weeks of treatment, vitamin
                                                         additional 10–200/0 of the population has fat     E improved all features of NASH with the
                                                         in their livers but no inflammation or liver      exception of the amount of scar tissue in the
        New flaxseed                                     damage, a condition called “fatty liver” that
                                                         is a precursor to NASH. There is no estab-
                                                                                                           liver; 430/0 of those treated with vitamin E
                                                                                                           met the primary end point of the trial, which
        review                                           lished treatment.
                                                               The government-funded multicenter
                                                                                                           was a composite of the scores for several
                                                                                                           features of NASH indicative of disease
        A new review paper explores the role of          study was organized by the Nonalcoholic           activity, compared with only 190/0 of those
        flaxseed as an antioxidant that may protect      Steatohepatitis Clinical Research Network         who received a placebo. Pioglitazone also
        against cancer and diabetes. The new             of the National Institute of Diabetes and         improved many features of NASH and met
        research appears in Comprehensive Reviews        Digestive and Kidney Diseases, and is the         the primary end point in 340/0 of individu-
        in Food Science and Food Safety (9:261–          largest ever placebo-controlled randomized        als who received it but fell short of statisti-
        269, 2010).                                      trial of treatment for NASH. Results were         cal significance. Pioglitazone treatment led
             “Flaxseed has been the focus of             published in the New England Journal of           to an average weight gain of 10 pounds (4.5
        increased interest in the field of diet and      Medicine (362:1675–1685, 2010).                   kg) over the 96-week duration of this study.
        disease research due to the potential health           Beginning in the late 1990s, study of       Liver enzyme tests, which are commonly
        benefits associated with some of its bio-        vitamin E for NASH was pioneered in pilot         used to assess liver injury, also improved
        logically active components,” according to       trials by Joel Lavine, now a faculty member       in those who received either pioglitazone
        researchers from the School of Food Science      at the Department of Pediatrics at Colum-         or vitamin E.
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