Flaxseed lignans might play a role in cancer prevention - specifically in breast, prostate, colon, and skin cancers; Soluble fiber and other components of flaxseed fractions could potentially affect insulin secretion and maintenance of steady blood sugar.
410 inform July 2010, Vol. 21 (7) groups of people were to self-medicate more with green exercise,” added Barton. Vitamin E and liver that liver enzyme levels considered normal are actually elevated. Healthy levels are <30 A challenge for policy makers is that policy recommendations on physical activity disease U/L for a man and <20 for a woman.” In the Pioglitazone or Vitamin E for are easily stated but rarely adopted widely as Vitamin E has been shown effective in treat- NASH Study (PIVENS), investigators ran- public policy, Pretty noted, adding that the ing nonalcoholic steatohepatitis (NASH), domly assigned 247 nondiabetic adults with economic benefits could be substantial. an obesity-associated chronic liver disease biopsy-confirmed NASH to receive vitamin Policies that suggest active living that can lead to cirrhosis, liver cancer, and E, pioglitazone, or placebo. Vitamin E func- point to the need for changes to physical, death. NASH also is related to or a part of tions as an antioxidant whereas pioglitazone social, and natural environments, and are type 2 diabetes, lipid disorders, and cardio- improves the sensitivity of cells to insulin, more likely to be effective if physical activ- vascular disease. a hormone that controls both sugar and fat ity becomes an inevitable part of life rather The often asymptomatic condition metabolism. than a matter of daily choice. affects 2–50/0 of the population, although an After 96 weeks of treatment, vitamin additional 10–200/0 of the population has fat E improved all features of NASH with the in their livers but no inflammation or liver exception of the amount of scar tissue in the New flaxseed damage, a condition called “fatty liver” that is a precursor to NASH. There is no estab- liver; 430/0 of those treated with vitamin E met the primary end point of the trial, which review lished treatment. The government-funded multicenter was a composite of the scores for several features of NASH indicative of disease A new review paper explores the role of study was organized by the Nonalcoholic activity, compared with only 190/0 of those flaxseed as an antioxidant that may protect Steatohepatitis Clinical Research Network who received a placebo. Pioglitazone also against cancer and diabetes. The new of the National Institute of Diabetes and improved many features of NASH and met research appears in Comprehensive Reviews Digestive and Kidney Diseases, and is the the primary end point in 340/0 of individu- in Food Science and Food Safety (9:261– largest ever placebo-controlled randomized als who received it but fell short of statisti- 269, 2010). trial of treatment for NASH. Results were cal significance. Pioglitazone treatment led “Flaxseed has been the focus of published in the New England Journal of to an average weight gain of 10 pounds (4.5 increased interest in the field of diet and Medicine (362:1675–1685, 2010). kg) over the 96-week duration of this study. disease research due to the potential health Beginning in the late 1990s, study of Liver enzyme tests, which are commonly benefits associated with some of its bio- vitamin E for NASH was pioneered in pilot used to assess liver injury, also improved logically active components,” according to trials by Joel Lavine, now a faculty member in those who received either pioglitazone researchers from the School of Food Science at the Department of Pediatrics at Colum- or vitamin E.
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