Enzogenol® is the pine bark extract produced by Enzo

							                  Enzogenol® - Blood Pressure Reduction
                  Enzogenol® is a unique polyphenol complex extracted from New Zealand
                  grown pinus radiata bark. The broad spectrum of flavonoid compounds
                  including the very high content of proanthocyanidins are the basis for the
                  many health benefits Enzogenol® can deliver.
                  Clinical studies have shown that Enzogenol® lowers blood pressure.

     CLINICAL STUDY I.                           Evidence for the effect on systolic blood pressure

                                            Enzogenol® significantly                          Mean Systolic Blood pressure
                                                                                        135

                                            reduced systolic blood                      130
                                                                                        125
                                            pressure by 7 mm Hg




                                                                                mm Hg
                                                                                        120                      p<0.01        p<0.01

• Open label study                          after 6 weeks of                            115

• 24 subjects, age 55-75
                                                                                        110
                                            supplementation in this
• 12 weeks of supplementation:
                                                                                        105
                                                                                        100
    o 480 mg Enzogenol +                    open label study.
                                                                                                Baseline         6 weeks      12 weeks
       240 mg Vitamin C daily


       Two further double-blind, controlled clinical studies verified the finding!

CLINICAL STUDIES II & III: randomised, double-blind, vitamin C-controlled
44 smokers, age 40-67, 12 week supplementation                  42 subjects, age 50-65, 5 week supplementation
Treatment:     480 mg Enzogenol +                               Treatment:      960 mg Enzogenol +
               60 mg Vitamin C daily                                            120 mg Vitamin C daily
Control:       60 mg Vitamin C daily                            Control:        120 mg Vitamin C daily

 Meta-Analysis of
                                       Change in Systolic Blood Pressure from Baseline
 blood pressure                             Study II           Study III                   Meta-Analysis II & III combined
                               4    6 wks       12 wks        +ht      -ht              6 wks     12 wks       6 wks     12 wks
 effects from two                                                                              +ht                   -ht
                               2
 double-blind,
                               0
                       mm HG




 vitamin C-
                               -2
 controlled clinical                 P=0.09

                               -4                 P=0.12                                  P=0.048
 studies proofs that                                         P=0.24
                                                                                                       P=0.056       P=0.03
                                                                                                                                P=0.04
                               -6
 Enzogenol® lowers
                                                                       P=0.21
 systolic blood
                               -8
                                                           Enzogenol + Vitamin C               Vitamin C only
 pressure.

With these results the effect of Enzogenol® to lower systolic blood pressure has
been well established adding to the list of health benefits that Enzogenol® can
deliver for cardiovascular health.




                                              ENZO Nutraceuticals Ltd                                                +64 9 414 1997
                                              Auckland, New Zealand                                                info@enzo.co.nz