Obituary Professor James Boyer Brown MELBOURNE_ Nov 4 Medianet by absences

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									                      Obituary: Professor James Boyer Brown

MELBOURNE, Nov. 4 /Medianet International-AsiaNet/ --

The scientific and medical community mourns the loss of our esteemed colleague and
good friend Emeritus Professor James Boyer Brown AM, MSc (NZ), PhD (Edin), MSc
(Melb), DSc (Edin), FRANZCOG (Ad Eundem), Life Member Fertility Society of
Australia, Life Member Endocrine Society of Australia, who passed away on Saturday
31st October 2009, aged 90.

Born 7 October 1919 in New Zealand and educated at Auckland University College
(MSc – First Class Honours in chemistry), James Brown was manpowered to the
laboratories at the Auckland Hospital early in the Second World War. He rationalised
the sterilisation procedures at the hospital, qualified in bacteriology, haematology and
histology and built up the biochemistry laboratory from some simple backroom tests to
the type of facility that exists today. He also set up the blood bank, the monitoring of
blood electrolytes and the production of sterile solutions for peritoneal lavage (the
precursor of renal dialysis).

During the war, chemicals that were required for the new tests were often in short
supply so he developed methods for synthesising or regenerating them, using
techniques that often required innovative use of materials available. One example of his
innovative skills was the production of ampoules of blood-typed sera for the Pacific
forces using a home-made freezer. The ability to innovate was a skill that he used to
great advantage right throughout his life and he was constantly searching for better
ways of doing things.

After the war in 1947, he developed an interest in endocrinology and reproduction and
started a small animal breeding surgery, set up bioassays for urinary gonadotrophins
and oestrogen (the female hormone) and concluded that the most important
requirement in human reproduction was the development of a highly accurate method
for timing ovulation in women, similar to the phenomenon of oestrus in animals.
Measurements of the oestrogens seemed to be the answer and he received a National
Research Scholarship to work in Edinburgh under Professor Guy Marrian FRS, one of
the discovers of oestrogens.

His aim was to develop a chemical method for measuring the oestrogens in the urine
and was given a position in the newly established Clinical Endocrinology Research Unit
in Edinburgh, later to be appointed its Assistant Director. Notwithstanding Marrian's
attempts at dissuading him from this project, Brown persisted and the essential
problems were solved within a few months but a fully validated method was not
published until 1955. This published paper has been cited over 1000 times and was
awarded a full Citation Classic by the Institute for Scientific Information.

Using this new method of measurement, Brown confirmed the elegant patterns of
oestrogen production throughout the menstrual cycle which had been shown previously
using labour intensive bioassays. This work led to a PhD and The Lancet requested the
privilege of publishing the results obtained during the menstrual cycle, conception,
pregnancy, lactation and return to fertility. His method was the `gold standard’ for
measuring these hormones for almost 20 years until superseded by
radioimmunoassays on blood. He also collaborated with Arnold Klopper in developing a
urinary preganediol assay in non-pregnant women which was awarded a half Citation
Classic.

Possibly one of the greatest contributions made by Brown in his early days in Edinburgh
was the use of human gonadotrophin for the induction of ovulation. Working with
colleagues there they purified these hormones and later developed the International
Standard Reference Preparation facilitating their widespread usage. The Edinburgh unit
was the second in the world to use human gonadotrophins for ovulation induction in
humans but Brown, later working in Melbourne, would properly rationalise their usage.

In 1962 he accepted an appointment as First Assistant in the Department of Obstetrics
and Gynaecology at the University of Melbourne under Professor Lance Townsend.
This was despite many attractive offers from the USA including one from Dr Gregory
Pincus, the originator of the oral contraceptive pill. It was here that he showed his true
genius and, in conjunction with his colleagues at the Royal Women's Hospital, he
revolutionised the use of gonadotrophins for the safe induction of ovulation. He refined
the his method for measuring urinary oestrogen making it effectively a routine test which
could be performed in a few hours, thereby enabling these drugs to be used in a safe
manner and all but eliminating the risk of high order multiple pregnancies which had
been a feature of this treatment up until that time. This was the first time that this
approach had been used and led to him developing the threshold theory of ovarian
follicle stimulation which stands unchallenged today in reproductive medicine.

He further modified his rapid assay method to enable urinary oestrogen to be measured
during pregnancy which was used to great effect by obstetricians as a test of placental
function and fetal well-being during pregnancy.

During a sabbatical year in 1970, Brown gained a D.Sc. from the University of
Edinburgh and delivered 63 lectures and demonstrations in Europe and the USA.

Notwithstanding the advent of radioimmunoassay, the laboratory continued to be world
renowned for its urinary assays and attracted large contracts, principally from Harvard
University for studying risk factors in breast cancer and from Family Health International
for studying the return of fertility during breast feeding. The work with Harvard won the
Prix Antoine Lacassagne from Paris as the most important contribution to the study of
breast cancer for that year.

In 1971 he was given a Personal Chair in the Department of Obstetrics and
Gynaecology at the University of Melbourne and was a member of the IVF team led by
Carl Wood. His work and understanding of ovarian function has been linked to the
development of the early techniques for egg pick up in IVF and were used in the first
successful IVF pregnancy in Britain.

Brown retired from the University in 1985 and was accorded the title of Emeritus
Professor. Nonetheless he continued to work in the field. He had established in 1962, a
close working and personal relationship with Drs John and Lyn Billings who developed
the concept of fertility recognition through the changes in cervical mucus secretion,
forming the basis of Natural Family Planning. He validated their findings and continued
to work closely with them especially in his latter years when he developed the Home
Ovarian Monitor – a kit that can be easily used at home even by those without any
laboratory training, to check their hormonal status. This was a quantum leap from his
early methods where one fully trained worker could do only 10 assays per week!
Working with the Billings, the availability, simplicity and low cost of this facility has
enabled him to study literally hundreds of thousands of cycles in women in various
stages of their reproductive lives and develop a theory of ovarian function which takes
account of these findings.

Right up to the time of his death Brown continued to work on various scientific projects
and was involved with the World Health Organisation's Special Programme of Research
in Human Reproduction.

Perhaps his professional life could best be summed up by a closing editorial comment
made in 2003 in response to a letter he had published in Fertility and Sterility, the
Journal of the American Society for Reproductive Medicine:

``...In these days of hype, grossness and glitz, Dr Brown is a model of scientific practice
who is even more imposing by the low profile that he has been able to keep over the
last two decades. Perhaps these are the ideals and values for which we need to renew
our subscription.’’

McDonough, P. Fertility and Sterility 2003; 80, (3): 677-678

James Brown is survived by his wife Wendy and their four children.

Prizes and awards

1958 American Cancer Society Fellowship
1970 Runner-up in award for having made the most important contribution in
endocrinology in the British Commonwealth
1978 Senior Organon Prize (joint winner with Henry Burger)
1981 Lecture Laurentian Hormone Conference USA
1981 Fellow (Ad Eundem) Royal Australian and New Zealand College of Obstetricians
and Gynaecologists
1986 Prix Antione Lacassagne, Paris, in conjunction with Harvard colleagues
2003 Member of the Order of Australia (AM) ``for service to clinical research into
women's health and reproductive issues and the development of the Home Ovarian
Monitor’’.


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For more information and interviews, contact:
Dr Adrian Thomas
Billings Life Australia
+61 3 9802 2022
www.woomb.org

SOURCE: Ovulation Method Research and Reference Centre of Australia Ltd

								
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