Curriculum vitae for Patrik Brundin Personal data Name Patrik Brundin Date of birth December 26, 1961 Position title Professor of Neuroscience Institution and Location Degree Year(s) Field of Study Lund University, Sweden M.D. 1992 Medicine Lund University, Sweden Ph.D. 1988 Medical Science Lund University, Sweden B.Sc. 1983 Medicine United World College of the Atlantic, Wales I.B. 1980 Natural sciences Professional Positions 2000 Appointed professor in Neuroscience at Lund University, Sweden. 2000-2000 Professor of Experimental Neuropathology at Copenhagen University, DK 1999 Permanent position as Associate professor of Neuroscience at Lund University. 1998 Lecturer in Experimental Medicine at Lund University. 1995-1998 Swedish Medical Research Council research position. 1994 License to practice medicine (läkarlegimitation). 1994 Neurology, clinical training (3 mo.). 1992-1994 80% clinical internship, 20% research associate. 1990-1992 Clinical program Lund Medical School. 1988-1990 Post-doctoral position at the Dept of Medical Cell Research, Lund University. 1983-1988 Graduate student (supervisor Anders Björklund). 1981-1988 Various junior teaching positions. Honors, Awards, Other Professional Activities 2002-today Coordinator of the EC-sponsored Marie Curie Training Site on “Neurodegeneration, cell rescue and brain repair”. 2001-today Coordinator of the EC-sponsored Concerted Action on “Early Pathogenetic Markers for Slow Neurodegenerative Diseases”. 1996-2001 Dissertation of 7 PhD students and 1 Master student. 1987-today Participation in clinical trials with intracerebral grafts in 19 Parkinsonian patients. 2001 Awarded the Catedra Santiago Grisolía Chair Prize, Valencia, Spain. 2001 Presented with The Outstanding Young Persons of the World Award for research and academic leadership by the Swedish Junior Chamber. 2000 Coorganiser of the international conference entitled "The role of mitochondria in apoptosis and neurodegeneration", June 2000. 1999 Chairman of the Gordon conference entitled "CAG triplet repeat disorders" July 15-20, 2001 Mount Holyoke College, MA, USA. 1999 Awarded Dr Eric K. Fernström Foundation's Prize to Young Swedish Scientists. 1999 Harvard Macy Program for Leaders in Medical Education, Boston, USA. 1999 Chairman of Research Strategy 2000 Group, Medical Faculty, Lund. 1999 Organizer of the international conferences entitled "CAG triplet repeat expansion. in neurologic disease" and "The future of neural grafting in Parkinson's disease" at Wallenberg Neuroscience Center, Lund University, Sweden. 1999-today Editorial board of Experimental Neurology. 1998-today Editorial board of Neuroscience. 1998-today Section editor for neuroscience in Cell Transplantation. 1997-2000 Chairman of the "Experimental Work" Group in the EU-sponsored Concertation of the European strategies for intervention in Parkinson's disease with special emphasis on functional neurosurgery (NIPD). 1997 Project evaluation committee for the National Network in Neuroscience, Sweden. 1997-1999 Chairman of the Neurobiology Club in Lund. 1995 Founder of the Section for Neuronal Survival, Lund University. 1994-today Member of the editorial board of Cell Transplantation. 1994 Awarded the Swedish Medical Research Council grant for young promising scientists. 1994-today President of NECTAR (Network for European CNS Transplantation and Restoration). 1994 New Investigator lecture award, Montreal Neurology Institute. 1990 Member of the local organizing committee for the international Fernström symposium on Intracerebral transplantation in movement disorders: experimental basis and clinical experiences". 1990-today Member of over 25 thesis review committees. 1989 Presented with the Oscar II award for best medical thesis in Lund 1988-1987. Selected peer-reviewed publications (in chronological order) (Publications selected from 135 original papers and 60 review articles/book chapters/commentaries) 1. Isacson O, Brundin P, Kelly PAT, Gage FH and Björklund A (1984) Functional neuronal replacement by grafted striatal neurons in ibotenic acid lesioned rat striatum. Nature 311: 458-460. 2. Brundin P, Nilsson OG, Strecker RE, Lindvall O, Åstedt B and Björklund A (1986) Behavioural effects of human fetal dopamine neurons grafted in a rat model of Parkinson's disease. Exp Brain Res 65: 235-240. 3. Brundin P, Strecker RE, Widner H, Clarke DJ, Nilsson OG, Åstedt B, Lindvall O and Björklund A (1988) Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: immunological aspects, spontaneous and drug-induced behaviour, and dopamine release. Exp Brain Res 70: 192-208. 4. Lindvall O, Brundin P, Widner H, Rehncrona S, Gustavii B, Frackowiak R, Leenders KL, Sawle G, Rothwell JC, Marsden CD and Björklund A (1990) Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease. Science 247: 574-577. Wictorin K, Brundin P, Gustavii B, Lindvall O and Björklund A (1990) Reformation of long axonal pathways in adult rat central nervous system by human forebrain neuroblasts. Nature 347: 556-558. 6. Grabowski M, Brundin P and Johansson BB (1993) Functional integration of cortical grafts in infarcted rat neocortex. Annal Neurol 34: 362-368. 7. Nakao N, Frodl EM, Widner H, Carlson E, Eggerding FA, Epstein CJ and Brundin P (1995) Overexpressing Cu/Zn-superoxide dismutase enhances survival of transplanted neurons in a rat model of Parkinson's disease. Nature Med 1: 226-231. 8. Grasbon-Frodl EM, Nakao N, Lindvall O and Brundin P (1996).Phenotypic development of the human embryonic striatal primordium: a study of cultured and grafted neurons from the lateral and medial ganglionic eminences. Neuroscience 73: 171-183. 9. Grasbon-Frodl EM, Andersson A and Brundin P (1996) Lazaroid treatment prevents death of cultured rat embryonic mesencephalic neurons following glutathione depletion. J Neurochem 67: 1653-1660. 10. Nakao N and Brundin P (1997) Effects of a-phenyl-tert-butyl nitrone on neuronal survival and motor function following intrastriatal injections of quinolinate or 3- nitropropionic acid. Neuroscience 76: 749-761. 11. Barkats M, Nakao N, Grasbon-Frodl EM, Biland-Bleuel A, Revah F, Mallet J and Brundin P (1997) Intrastriatal grafts of embryonic mesencephalic rat neurons genetically modified using an adenovirus encoding human Cu/Zn superoxide dismutase. Neuroscience 78: 703-713. 12. Duan W-M, Widner H, Cameron RM and Brundin P (1998) Quinolinic acid- induced inflammation in the striatum does not impair the survival of neural allografts in the rat. Eur J Neurosc 10: 2595-2606. 13. Schierle GS, Hansson O, Leist M, Nicotera P, Widner H and Brundin P (1999) Caspase inhibition reduces apoptosis and increases survival of nigral transplants. Nature Med 5: 97-100. 14. Hansson O, Petersén Å, Leist M, Nicotera P, Castilho RF and Brundin P (1999) Transgenic mice expressing a Huntington's disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity. Proc Natl Acad Sci USA 96: 8727- 8732. 15. Schierle GS, Leist M, Martinou J-C, Widner H, Nicotera P and Brundin P (1999) Differential effects of Bcl-2 overexpression on fiber outgrowth and survival of embryonic dopaminergic neurons in intracerebral transplants. Eur J Neurosci 11: 3073-308. 16. Piccini P, Brooks DJ, Bjorklund A, Gunn RN, Grasby PM, Rimoldi O, Brundin P, Hagell P, Rehncrona S, Widner H, Lindvall, O (1999) Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient. Nature Neurosci 2:1137-1140. 17. Brundin P, Pogarell O, Hagell P, Piccini P, Widner H, Schrag A, Kupsch A, Crabb L, Odin P, Gustavii B, Björklund A, Brooks DJ, David Marsden C, Oertel WH, Quinn NP, Rehncrona S and Lindvall O (2000) Bilateral caudate and putamen grafts of embryonic mesencephalic tissue treated with lazaroids in Parkinson's disease. Brain 123: 1380-1390. 18. Lotharius J, Barg S, Wiekop P, Lundberg C, Raymond HK, Brundin P (2002). Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line. Journal of Biological Chemistry, in press. 19. Hagell P, Piccini P, Björklund A, Brundin P, Rehncrona S, Widner H, Crabb L, Pavese N, Oertel WH, Quinn N, Brooks DJ, and Lindvall O (2002). Dyskinesias following neural transplantation in Parkinson's disease. Nature Neuroscience 5:627-628.