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Curriculum Vitae Umbilical Cord

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					                                  Curriculum Vitae
Albert A. Rizvanov
Work address 1:      Kazan State University,
                     Faculty of Biology and Soil Sciences, Department of Genetics,
                     Kremlevskaya St 18, Kazan, 420008, Tatarstan, Russia
                     Phone: +7 843 231 5182 (work)
                     Fax: +7 843 2315241

Work address 2:      Yeditepe Universitesi
                     Muhendislik Fak. Genetik ve Biyomuhendislik Bolumu
                     Inonu Mah. Kayisdagi Cad.
                     26 Agustos Yerlesimi, 34755 Kadıkoy - Istanbul, Turkey

E-mail: rizvanov@gmail.com

Education :
- Ph.D. in Cell and Molecular Biology, University of Nevada, Reno, USA (2003).
- Diploma (M.S.) with Honor in Microbiology/Biology, Kazan State University, Kazan,
Russia (1996)

Employment:
2009-current         Associate Professor, Department of Genetics and Bioengineering,
                     Yeditepe University, Turkey (faculty webpage)
2007-current         Senior researcher, Kazan State Medical University, Kazan, Russia
2007-current         Visiting faculty, Associate Professor, Department of Genetics and
                     Bioengineering, Yeditepe University, Turkey (faculty webpage)
2007-current         Leading scientist, head of Division of Biological Methods of
                     Analysis, Regional Center of Collective Use, Kazan, Russia
                     (Division’s webpage)
2006-current         Associate Professor, director of “Molecular genetics laboratory”,
                     Faculty of Biology and Soil Sciences, Department of Genetics,
                     Kazan State University, Russia (faculty webpage)
2003-2006            Post doctoral fellow, Department of Microbiology, University of
                     Nevada, Reno, USA
1996-2003            Graduate research assistant, Cell and Molecular Biology Program,
                     University of Nevada, Reno, USA
Areas of interest:
Gene and stem cell therapies for regenerative medicine
Molecular neurobiology
Molecular virology (retroviruses, hantaviruses, cytomegaloviruses)
Nano- materials and nano-technologies for biomedical applications.

Grants:
2009-2011    Russian Federal Agency for Science and Innovations government contract
FCP 02.740.11.0302 “Investigation of fundamental mechanisms of pathogenesis of
neurodegenerative diseases and development of new therapeutic approaches for their
treatment” – co-investigator.
2009-2010       Contract (EZN) with Ministry of Education and Science of Russian
Federation code 1.4.09 (registration №01200952944) “Mechanisms of reprogramming of
human somatic and stem cells into induced pluripotent stem cells” - principal
investigator.
2009-2010       Russian Foundation for Basic Research grant RFFI 09-04-12047
“Molecular mechanisms of various myocardium, nervous tissue and skeletal muscle
sensitivity to 6-metylurazil derivates – an approach for generation of a novel class of
acetylcholinesterase therapeutic inhibitors with tissue specificity” – co-investigator.
2009 Grant of Tatarstan Academy of Science for young scientists № 11-9/2009 (Г)
“Development of novel biomedical therapies for treating chronic arterial insufficiency of
lower extremities using cell and gene-cell technologies” – co-investigator.
2009 grant “50 Best Innovation Ideas of Tatarstan” in nomination “Innovative Project
by the Young” – “Development of short interfering RNA for gene therapy and
prophylactics of HIV infection” интерферирующих РНК для использования в генной
терапии и профилактике ВИЧ-инфекции» – co-investigator.
2008-2010       Russian Foundation for Basic Research grant RFFI 08-04-01680-а
“Dedifferentiation of haematopoietic stem cells from human umbilical cord blood into
pluripotent cells using genetic modification by transcription factors Oct4, Sox2, cMyc
and Klf4” - principal investigator.
2007-2010       NATO reintegration grant NR.RIG.983007 “Combination gene and stem
cell therapy for treating neurodegenerative diseases” – principal investigator.
2007-2009       Russian Foundation for Basic Research grant RFFI 07-04-00746-a
“Stimulation of axon regeneration in central and peripheral nervous system at use gel
scaffold for stem cells, self-assembling supramolecular systems, VEGF and xymedon” –
co-investigator.
2007-2008       Russian Foundation for Basic Research grant RFFI 07-04-12097
“Selective inhibitors of acetylcholine esterase: molecular mechanisms of tissue- and
organ-specific sensitivity to 6-methyluracyl derivatives” – co-investigator.
2006-2008       Russian Foundation for Basic Research grant RFFI 06-04-49396-a
“Axonal transport and intra-axonal protein synthesis at the gravitational unloading
condition” – co-investigator.
2007 Grant of Tatarstan Academy of Science for young scientists № 11-25 / 2007 (Г)
“Study of intracellular mechanisms of HIV pathogenesis using RNA interference” –
principal investigator.
2007 Russian Federal Agency for Science and Innovations government contract FCP
02.512.11.2052 “Cell therapy using genetically modified stem cells from umbilical cord
blood on a model of transgenic G93A mice, expressing phenotype of amyotrophic lateral
sclerosis” – co-investigator.
2006-2007 Russian Foundation for Basic Research grant for Leading Scientific Schools
“Pre- and postsynaptic mechanisms of plasticity in a system motor neuron-skeletal
muscle” НШ-4444.2006.4 – co-investigator.
Awards:
2009 Kazan State University Award for scientific projects
2009 Tatarstan Government Award for outstanding young scientists
2008 Kazan State University Award for scientific projects by young scientists

Publications:

      1. Lagarkova MA, Shutova MV, Bogomazova AN, Vassina EM, Glazov EA,
Zhang P, Rizvanov AA, Chestkov IV, Kiselev SL. Induction of pluripotency in human
endothelial cells resets genome-wide promoter methylation and induces X chromosome
reactivation. Human Molecular Genetics. 2009. Under review.
      2. Rizvanov A.A., Yalvaç M.E., Shafigullina A.K., Salafutdinov I.I., Blatt N.L.,
Sahin F., Kiyasov A.P., Palotás A. Interaction and self-organization of human
mesenchymal stem cells and neuro-blastoma SH-SY5Y cells under co-culture conditions:
a novel system for modeling cancer cell micro-environment. Current Cancer Drug
Targets. 2009. Under review.
      3. M.E. Yalvac, A.A. Rizvanov, E. Kilic, F. Sahin, M.A. Mukhamedyarov, R.R.
Islamov, A. Palotás. Potential role of dental stem cells in the cellular therapy of cerebral
ischemia. Current Pharmaceutical Design. 2009. V.15. In print.
      4. Yalvac ME, Ramazanoglu M, Rizvanov AA, Sahin F, Bayrak OF, Salli U,
Palotás A, Kose GT. Isolation and characterization of stem cells derived from human
third molar tooth germs of young adults: implications in neo-vascularization, osteo-,
adipo- and neuro-genesis. Pharmacogenomics Journal. 2009. DOI:10.1038/tpj.2009.40.
In print.
      5. Mikhailova EO, Balaban NP, Mardanova AM, Rudakova NL, Ilyinskaya ON,
Rudenskaya GN, Rizvanov AA, Sharipova MR. Purification of a subtilisin-like serine
proteinase from recombinant Bacillus subtilis during different phases of growth. Annals
of Microbiology. 2009. Vol. 59, Issue: 2, Pages: 301-307.
      6. Rizvanov AA, Mukhamedyarov MA, Palotás A, Islamov RR. Retrogradely
transported siRNA silences human mutant SOD(1) in spinal cord motor neurons. Exp
Brain Res. 2009 May;195(1):1-4.
      7. Yalvac ME, Ramazanoglu M, Gumru OZ, Sahin F, Palotás A, Rizvanov AA.
Comparison and Optimisation of Transfection of Human Dental Follicle Cells, a Novel
Source of Stem Cells, with Different Chemical Methods and Electro-poration.
Neurochem Res. 2009 Jul;34(7):1272-7.
      8. R.P. Naumova, T.V. Grigoryeva, A.A. Rizvanov, J.V. Gogolev, N.V.
Kudrjashova, A.V. Laikov. Diazotrophs Originated from Petrochemical Sludge as a
Potential Resource of Waste Remediation. World Applied Sciences Journal. 2009 Vol.6
(2): P.154-157
      9. T.I. Abdullin, O.V. Bondar, A.A. Rizvanov, I.I. Nikitina. Carbon nanotubes
based biosensors for DNA structure characterization // Applied Biochemistry and
Microbiology. 2009. – Vol. 45. – №2. – P.229–232.
      10. V.A. Anokhin, E.V. Golovin, A.A. Rizvanov. The preintegration complex of
human immunodeficiency virus as a potential object of gene therapy for HIV infection //
Infectious diseases (Russian) – 2008. – V.6. - №4. – P.46-50.
       11. R.R. Islamov, A.A. Rizvanov, A.P. Kiyasov Strategy in gene-stem cell therapy
of amyotrophic lateral sclerosis // Neurological Bulletin. 2008. – V.40. – №4. – P.91-101.
       12. Rizvanov AA, Kiyasov AP, Gaziziov IM, Yilmaz TS, Kaligin MS, Andreeva
DI, Shafigullina AK, Guseva DS, Kiselev SL, Matin K, Palotás A, Islamov RR. Human
umbilical cord blood cells transfected with VEGF, L1CAM do not differentiate into
neurons but transform into vascular endothelial cells and secrete neuro-trophic factors to
support neuro-genesis – a novel approach in stem cell therapy. Neurochem Int. 2008
Dec;53(6-8):389-94.
       13. Kitaeva E.V., Bashirov F.V., Rizvanov A.A., Homyakov E.A., Safin R.R.,
Halikov M.M., Gilmullin F.I., Muginov R.N., Muhutdinova E.R., Hasabova D.R.,
Islamov R.R. The neuroprotective action of action of the PK-Merz connected with
increase in Hsp70 expression into neurons of cerebral cortex of rats after the occlusion of
a middle cerebral artery // Morphological Newsletter. 2008. № 1-2: 66-72.
       14. O.V. Bondar, I.I. Nikitina, R.R. Khazyakhmetova, A.A. Rizvanov, T.I.
Abdullin. Evaluation of DNA integrity using electrochemical biosensors // Scientific
Reports of Kazan State University. 2007. Vol.149(4):106-111.
       15. R. R. Islamov, A. A. Rizvanov, Guseva D.G., Kiasov A.P. Gene and stem-cell
therapy for neurodegenerative diseases. 2007. Cellular transplantology and tissue
engineering. Vol. 2(3): 21-37.
       16. R. R. Islamov, A. A. Rizvanov, Yu. A. Chelyshev, A. K. Murashov. RNA
Interference in the Regulation of Axonal Transport. Uspehi Physiologicheskih Nauk.
2007. Vol. 38(3): 47-56.
       17. Rizvanov AA, Khaiboullina SF, van Geelen AG, St Jeor SC. Replication and
immunoactivity of the recombinant Peromyscus maniculatus cytomegalovirus expressing
hantavirus G1 glycoprotein in vivo and in vitro. Vaccine. 2006 Jan 16;24(3):327-34.
       18. Khaiboullina SF, A.A. Rizvanov, M.R. Holbrook, and S. St. Jeor. Yellow
fever virus strains Asibi and 17d-204 infect human umbilical cord endothelial cells and
induce novel changes in gene expression. Virology. 2005 Nov 25;342(2):167-76.
       19. Deyde VM, Rizvanov AA, Chase J, Otteson EW, St Jeor SC. Interactions and
trafficking of Andes and Sin Nombre Hantavirus glycoproteins G1 and G2. Virology.
2005 Jan 20;331(2):307-15
       20. Khaiboullina SF, Rizvanov AA, Deyde VM, St Jeor SC. Andes virus
stimulates interferon-inducible MxA protein expression in endothelial cells. J Med Virol.
2005 Feb; 75(2):267-75.
       21. Deyde V, Rizvanov A, Otteson E, Brandt S, Bego M, Pari G, Kozel T, St Jeor
S. Identification of a monoclonal antibody from Peromyscus maniculatus (deer mouse)
cytomegalovirus (PCMV) which binds to a protein with homology to the human CMV
matrix protein HCMV pp71. J. Virol. Methods. 2005 Jan; 123(1):9-15.
       22. Albert A. Rizvanov, Svetlana F. Khaiboullina, and Stephen St. Jeor.
Development of reassortant viruses between pathogenic hantavirus strains. Virology.
2004 Oct 1; 327(2):225-32.
       23. Svetlana F. Khaiboullina, Albert A. Rizvanov, Elmer Otteson, Akira
Miyazato, Jaroslaw Maciejewski, and Stephen St. Jeor. Regulation of cellular gene
expression in endothelial cells by sin nombre and prospect hill viruses. Viral Immunol.
2004; 17(2):234-51.
      24. A.A. Rizvanov, A.G.M. Van Geelen, S.P. Morzunov, E.W. Otteson, G.S.
Pari, M.C. Bohlman, and S. C. St. Jeor. Generation of a recombinant Peromyscus
maniculatis cytomegalovirus for expression of a hantavirus glycoprotein. Journal of
Virology. 2003. Nov; 77(22):12203-10

				
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