Faculty Resume Name: FAZAL SUBHAN Personal: Department of Pharmacy, University of Peshawar. Phone No: 091-9216750 Email: Fsubhan2000@yahooo.com Experience 1. June 2003 to-date; Employer Department of Pharmacy University of Peshawar, Peshawar, N.W.F.P, Pakistan. Designation: Associate Professor 2. 1987 to 2003; Employer Department of Pharmacy ; University of Peshawar, Peshawar, N.W.F.P, Pakistan.; Designation: Lecturer 3. 1986 to 1987; Employer Department of Pharmacy; Gomal University D. I, Khan, N.W.F.P, Pakistan; Designation: Lecturer 4. 1985 to 1986; Employer Redex Drug House Labs. Faisalabad, Pakistan. Designation: Quality Control Incharge: Honors and Awards First Class First Position in Master of Pharmacy (Pharmacology). COT Scholarship for Ph.D. studies abroad. Overseas Research Scholarship (ORS) award for the Year 1997&98 (U.K Higher Education Research Award for Overseas Students). Member of the drug court HEC recognised supervisor Memberships N.A Graduate Students Postdocs Undergraduate Students Honor Students M.Phil. 6 (Three M.Phil. students have completed experimental work) Ph.D. 3 Scholars Service Activity Teaching the subject of Pharmacology to the scond and third professional B-Pharmacy students. Supervising and teaching to M.Phil./Ph.D. Scholars in the field of Pharmacology. Brief Statement of Research Interest MECHANISMS OF DRUG ACTION GROUP: Research is focused on the mechanism of action of drugs. Both behavioral and biochemical techniques are used to study the mechanism of action of opioids including morphine, heroin, CNS active plants, antidepressants and other novel antipsychotic drugs. Mostly, animal paradigms are employed for testing novel drugs and herbal substances for analgesia, antidepressant, anxiolytic, anti-addictive properties and abuse potential of drugs. Neurotransmitter such as dopamine, adrenaline, serotonin and their metabolites are measured in the brain areas of interest using HPLC coupled with Electrochemical Detector. Aim of the research group is to develop suitable remedy/formulations for the clinical management of pain, depression, addiction and other psychiatry problems. Publications Fazal Subhan., Hutcheson, D.M., Pache, D.M., Sewell, R.D.E. 1997. RB 1000 and the CCKB antagonist, CI 988 fail to affect a morphine interoceptive cue. Psychopharmacology, (Supp) 11, 3. Fazal Subhan., Pache, D.M., Sewell, R.D.E. 1998. CCKB receptor antagonism attenuates naloxone-induced morphine withdrawal conditioned place aversion and escape behaviour. J. Pharm. Pharmacol., 50 (Supp). 205. Hutcheson, D.M., Fazal Subhan., Pache, D.M., Maldonado, R., Fournie-Zaluski, M.C., Roques, B.P., Sewell., R.D.E. 2000. Analgesic doses of the enkephalin degrading enzyme inhibitor RB 120 do not have discriminative stimulus properties. Eur. J. Pharmacol., 401, 197-204. Fazal Subhan., Deslandes, P.N., Pache, D.M., Sewell, R.D.E. 2000. Do antidepressants affect motivation in conditioned place preference ? Eur. J. Pharmacol., 408, 257-263. Fazal Subhan., Pache, D.M., Sewell, R.D.E. 2000. Potentiation of opioid-induced place preference conditioning with the selective serotonin reuptake inhibitor, fluoxetine. Eur J Pharmacol., 390, 137-143. Fazal Subhan., Pache, D.M., Spencer, P.S.J., Sewell, R.D.E. 1999. Effect of the selective serotonin reuptake inhibitor, fluoxetine, on the rewarding properties of opioids as assessed by conditioned place preference. J. Pharm. Pharmacol. 51 (Supp) 14 Fazal Subhan., Pache, D.M., Sewell, R.D.E. 2000. CCKb receptor antagonism attenuates negative motivational properties and somatic physical signs of morphine withdrawal Pharmacology reviews and Communications (UK) 11 (1). 27-37. Fazal Subhan., Azmat Rasheed., Mohammad Arfan. 1996. Effect of Ajuga bracteosa on some of the biochemical parameters in rabbits. Hamdard Medicus, (3) XXXIX, 84-89. Azmat Rasheed., Mahbub Alam., Fazal Subhan. 1987. Pharmacokinetics of N-methylisatin-3-thiosemicarbazone in rabbits. Pakistan, Vet. J. 7 (4) 142-144. Azmat Rasheed., Mohammad Riaz., Fazal Subhan., Saqib Javid. 1992. Blood glucose level and body temperature after concomitant administration of chloramphenicol and aspirin in rabbits. Pakistan, J. Zool. 24 (4) 360-362. Saeed, M., Gilani, A.H., Iqbal, Z., Subhan, F., Jamshid Ali Khan. 2000.Screening of some 4-acetyl-4-phenylpiprridine derivatives for their effects on blood pressure and smooth muscle contraction. Sci. Khyber, 13, 59-62. Fazal Subhan., Nazar ul Islam., Azmath Rasheed., Abdul Subhan Ijaz., Mehboob Alam. 1998. Biochemical and histological effects induced by the antiviral drug, N-methylisatin-3-thio semicarbazone in rabbits. J.Sc. & Tech. Univ. Peshawar. 22,17- 21. Fazal Subhan. 2002.Rewarding properties of serotonin selective reuptake inhibitor, Paroxetine: Behavioural and biochemical correlates.Peshawar University Teachers Association Journal, 9, 27-33. Abdul Subhan Ijaz., Fazal Subhan., Nazar ul Islam., Saeed Ahmad and Arif Ali Rajer. 2002. Synthesis of Pharmacologically active Isatin derivatives. Sci. Khyber 15 (1) 9-16. Fazal Subhan., Amir Zada Khan. and Mohammad Saeed and Ikhtiar Khan. 2002. Effect of chronic treatment of antidepressants on dopamine and its metabolites in the brain areas of nucleus accumbens and striatum: an animal study Sci. Khyber 15 (1) 1-7. Ikhtiar Khan., Gul Nawab., Ijaz Ahmad., Fazal Subahn. 2002. Thyroid hormones level in healthy population of N.W.F.P. Scientific Khyber, 15(1) 9-16. Fazal Subhan., Abdul Matin Khan., Ahmad Yar Sial., Muhammad Azam Zia., Haroon ur Rashid. 2002. Drug dependence-neurotransmitter systems and paradigm for assessment. Pakistan Armed forces Med. Journal, 52, 76-83. Fazal Subhan., Sewell, R.D.E. 1997. Effect of rewarding doses of morphine or fluoxetine on the striatal and nucleus accumbens levels of dopamine and its metabolites: A comparative study. Pak. J. Pharm., 10, 23-34. Fazal Subhan., Rasheed, A., Sewell, R.D.E. 2002 Selective CCK2 receptor antagonist, CI 988 failed to enhance the reinforcing properties of morphine as assessed by drug discrimination paradigm in rats. Pak. J. Pharm., (11-15), 11-17. Fazal Subhan., Mohammad Ibrar., Amir Zada Khan., Mohammad Arfan and Gul Nawab. 2002. Effect of Ajuga bracteosa on serum level of triiodothyronin (t3) and thyroxin (t4) in rabbits. J. Sci. Tech. Peshawar University, 26, 7-9. Mohammad Ibrar., Fazal Subhan., Amir Zada Khan. 2003. Medicinal Plants Cultivation, Collection and Preservation. PUTAJ. 10, 49-56. Anwar. H. GILANI2,4, Arif-ullah KHAN2, Qaiser JABEEN2, Fazal SUBHAN3, Rukhsana GHAFAR3 (2005) Antispasmodic and blood pressure lowering effects of Valeriana wallichii are mediated through K+ channel activation1 Journal of Ethnopharmacology 100, 347-352. Gilani A. H., Khan A Subhan F, Khan M,. 2005. Pharmacological basis for use of St. Jahon’s wart in Gastriintestinal and respiratory disorders. Fundamental & Clinical Pharmacology Journal (France). 19, 695-705. Subhan F, Khan M, Ibrar M. Nazar ul Islam, Gilani A. H., Khan A. 2007. Antagonism of antinociceptive effect of hydro-ethanolic extract of Hypericum perforatum Linn. by a non selective opioid receptor antagonist, naloxone. Pak. Journal of Biological Sciences. 10 (5) 792- 796. Research Grants and Contracts 1. Pharmacological investigation on some indigenous plants/ Hypericum perforatum, potentially useful for depression, pain and addiction. 2. Selective Serotnin Re-uptake Inhibitor (SSRI), fluoxetine, drug dependence and analgesia 3. Biopharmaceutical profile of Risperidone 4. Determination of serum lithium level in fasting and non-fasting patients . (Clinical study) Other Research or Creative Accomplishments Successfully completed courses (Module 1, 2, 3 and 4) of animal handling and experimentation organised by the institute of Biology, University of Wales, Cardiff, UK. Personal animal licence holder authorised to experiment on animals including Rats, Mice, Guinea pigs and Rabbits in UK. Selected Professional Presentations British Pharmaceutical Conference held in September 1999 at Cardiff, UK. British Pharmaceutical Conference held in September 1998 at Eastbourn, UK. BAP/CCNP Conference held in July 1997 at Cambridge, UK.