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Antiviral Drugs0 by benbenzhou

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Antiviral Drugs

Description:    Viruses are microorganisms that are as varied in type as the plants and animals of the macroscopic
                world. A particularly virulent virus can infect and kill a human host, which is 10 million times larger.
                The human immune system is the first line of defense against any infectious organism. However,
                sometimes this protection proves inadequate to the viral challenge. In this situation humans
                attempt to provide additional aid in retarding viral reproduction through the use of antiviral drugs
                until an overwhelmed immune system is able to cope with the infection. This type of self-help is the
                object of antiviral drug research.

                Antiviral Drugs by John Driscoll provides up-to-date information on the classification, history,
                structure, preclinical development, bioactivity, pharmacology, and effectiveness of the 72 most
                important antiviral agents. A carefully researched collection of over 400 references places details of
                definitive recent antiviral research at the readers fingertips. An appendix contains for each drug an
                at-a-glance, detailed sketch, which includes chemical structure and molecular formula,
                identification numbers, synonyms, physical properties, toxicities, and manufacturers. Introductory
                chapters describe where viruses fit into the world of microorganisms, explore the unique properties
                of DNA and RNA viruses, and show how new antiviral drugs are discovered and developed into
                useful medicines.

                About the author
                John S. Driscoll earned a PhD in chemistry from Princeton University and after eight years as
                Research Group Leader in private industry, he joined the National Cancer Institute (NCI), National
                Institutes of Health, in Bethesda, MD where he initiated an intramural research program for the
                discovery of new anticancer drugs. From 1980 to 1983, he was Associate Director, Developmental
                Therapeutics Program for the NCI where he was responsible for managing preclinical intramural and
                extramural anticancer drug discovery and development. Dr Driscoll returned to experimental
                science as NCIs Chief of the Laboratory of Medicinal Chemistry. His laboratory conducted research
                in drug design, organic synthesis, analytical chemistry, biochemistry, pharmacology, and
                information technology in the area of new anticancer and anti-HIV drug discovery. He retired from
                the NCI after publishing over 140 scientific papers and obtaining numerous patents.



Contents:       Preface.
                 Acknowledgements.
                 How to Use This Book.
                 List of Tables.
                 List of Figures.
                 Abbreviations.
                 Table of Antiviral Drugs.


                Chapter 1: Infectious Microorganisms. .

                 Microbes.
                 Prions.
                 Viruses.

                References for Chapter 1. .



                Chapter 2: Antiviral Drug Discovery and Development. .

                 Preclinical Drug Discovery.
                 Clinical Drug Development.
            References for Chapter 2. .



            Chapter 3: Antiviral Drugs. .

            Drug Organization.
            Drugs Effective Against DNA Viruses.
            Drugs Effective Against RNA Viruses.
            Drugs for the Treatment of RNA Retroviral Diseases.
            Drugs for the Treatment of RNA Non-retroviral Diseases.
            Prospects for Future Antiviral Drugs.
            Information Resources.

            References for Chapter 3. .


            Appendix: Antiviral Drug Chemical Data.
            CAS Registry Number Index.
            Main Index.




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