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Stein ease flu symptoms

VIEWS: 17 PAGES: 8

Stein ease flu symptoms

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									                      University of California, San Diego



                      H e a lt h w i s e
                      The Sam and Rose Stein Institute for Research on Aging                                 N OV E M B E R 2 0 0 4 • Vol. 24, No. 11


  FREE PUBLIC LECTURE                                                    Key Facts About the Flu
                                                                          From the Centers For Disease Control
  New Understanding of Pain                       About Flu: Influenza (commonly called “the flu”) is a contagious respiratory illness
  Development and its Response                caused by influenza viruses. Infection with influenza viruses can result in illness ranging
  to Treatment
                                              from mild to severe and life-threatening complications. An estimated 5 percent to 20 per-
                                              cent of U.S. residents get the flu each year: an average of 114,000 people are hospitalized
                                              for flu-related complications and 36,000 Americans die each year from complications of flu.
                                                  Symptoms of Flu: Symptoms of flu include fever (usually high), headache, extreme
                                              tiredness, dry cough, sore throat, runny or stuffy nose, and muscle aches. Gastro-intes-
                                              tinal symptoms, such as nausea, vomiting, and diarrhea, are much more common among
                                              children than adults.
                                                  Spread of Flu: The main way that influenza viruses are spread is from person to per-
  Dr. Tony L. Yaksh                           son in respiratory droplets of coughs and sneezes. (This is called “droplet spread.”) This
  Department of Anesthesiology
                                              can happen when droplets from a cough or sneeze of an infected person are propelled
  Wednesday
                                              (generally up to 3 feet) through the air and deposited on the mouth or nose of people
  November 17, 2004, 6:00 P.M.
  Garren Auditorium                           nearby. Though much less frequent, the viruses also can be spread when a person touches
  Basic Science Building                      respiratory droplets on another person or an object and then touches their own mouth
  University of California, San Diego         or nose (or someone else’s mouth or nose) before washing their hands.
                                                  Scientific studies show that adults can shed virus from 1 day before developing symp-
  NEXT MONTH                                  toms to up to 7 days after getting sick. Young children can shed virus for longer than 7

  What You Should Know about                  days. In general, however, more virus is shed earlier in the illness than later.
  Chronic Lung Disease                                                                 Preventing Flu
                                                  Vaccination: The single best way to prevent the flu is to get vaccinated each fall. In the
  Dr. Andrew Ries
  Department of Medicine                      absence of vaccine, however, there are other ways to protect against flu.
                                                                                                                       continued on page 7
  Wednesday
  December 8, 2004, 6:00 P.M.
  Garren Auditorium                                     PUBLIC LECTURE                  How We Defend                11/11          8:00 P.M.
  Basic Science Building                                SERIES UCSD-TV                  Ourselves from
  University of California, San Diego                   SCHEDULE                                                     11/12        10:00 P.M.
                                                                                        Infections
                                                        Lectures air on Cox Commu-
                                                                                        Dr. Michael Karin            11/16          6:00 P.M.
  No reservations required                              nications San Diego, channel
                                                        66; Cox North County, chan-                                  12/9           8:00 P.M.
  Free parking will be provided for
                                                        nel 69; Time Warner Cable,
  SIRA contributing members. Please
  call (858) 534-6299 TWO WEEKS                         channel 18; Del Mar TV 66,                                   12/10        10:00 P.M.
  BEFORE THE LECTURE to receive your                    or UHF (without cable),
  free parking permit. All other lecture                channel 35.                                                  12/14          6:00 P.M.
  attendees must buy a permit at the
  parking kiosk on Gilman Drive or                                                      Ethics of Health             11/25          9:00 P.M.
  park at the metered sites.                                                            Care Reform
                                                                                                                     11/26        11:00 P.M.
   Healthwise is available online                                                       Dr. Lawrence Schneiderman
         at sira.ucsd.edu.                                                                                           11/30          7:00 P.M.


Fostering healthy aging by supporting advances in patient care through innovative research, training, and education
   Something to Think About
                                                                                                      RECENT DONORS
   We Need Purpose to Feel Fulfilled                                                                    TO THE SIRA
   By J. Adam Milgram, Editor and Executive Director                                                    We would like to express our deep
                                                                                                  appreciation for all those listed, as well as the
   We humans are functioning beings,             order to function well. Our value is derived     anonymous donors, who chose to support the
made to move, to act, to do, to work, and so     in part by being useful to others, to soci-       research, education, and patient care at the
on. In fact, if we do not use our bodies,        ety, not just to ourselves. It is insufficient    Sam and Rose Stein Institute for Research
move, exercise, our bodies will atrophy and      to be just active, although that may help                          on Aging.
eventually waste away. The use it or lose it     the body function. But plain activity does                        Donations
cliché so popular these days is also so true.    not satisfy our psychological, existential,                  Jean & Vincent Ardito
We are learning that this saying does not        and spiritual natures. That require more                   James & Evelyn Paccione
only apply to our bodies, but to our minds       meaningful activity. We need greater satis-
as well. While the research is still inconclu-   faction than endless rounds of golf, card                       New Member

sive, there is some merit to the relationship    games, or just having a good old leisurely                      Elaine M. Brody

between using our minds and the avoidance        time. No, we need more than that to keep                    Clarence (Clancy) Borns

of brain disease. Learning, for example,         us fulfilled, vital, healthy, and fully func-      Leonard & Patricia Fabricatore, Trustees

facilitates the creation of synapses—new         tioning. This issue is particularly challeng-                    Tom Gaughan

connections in the brain to keep it function-    ing for those who are disabled and who
                                                                                                                Member Level
ing better, perhaps healthier.                   may have chronic, debilitating diseases
                                                                                                            Anne & George Lanman
   Related to this functioning idea, is the      that severely limit them. While these con-
                                                                                                             Fred & Christine Stalder
sense of the individual’s continued func-        ditions do not necessarily stop everyone
                                                                                                                 Phil & Swanson
tioning in the world in some purposeful,         from a continued life of purpose and
                                                                                                              Ingeborg M. Ehricke
meaningful way. One of the issues facing         value, it is most sad to see some just wait-
                                                                                                               Edith Nierenberg
retiring and older persons in general, is        ing for death to claim them.
                                                                                                            Of the Edith Nierenberg
the need to reinvent oneself, rebirth one-          In my understanding, each of us is born                   Revocable TST DTD
self into new forms of functioning—new           for a purpose, a role, perhaps more than                           Rudolf Ott
endeavors, new work, and new activities.         one, and the light of that purpose(s)                     Benjamin & Jaye Fairchild
Psychologically, if we do not have a pur-        guides us through life. It is said “blessed is               Mary Louise Zernicke
pose for living, life becomes meaningless.       he/she who has found one’s life purpose.”
                                                                                                                 Sandra Barstow
In fact, it can facilitate depression and        I cannot comprehend that long life should
                                                                                                            Andrew G. Castiglione &
other negative mental states, even leading       necessarily deprive one of our purpose(s)                     Phyllis J. Pascoe
to suicide. Individuals who reveal vitality      and our value in and to life. In this ever                  Verle & Janice Peterson
and zest for life are usually those who are      dynamic life, our purpose changes as we               Leland & Mignon G. Zimmerman
imbued with a mission, a reason for living.      advance in age. Here too, there are those
   In that vein, I am reminded of                who have skills and talents, but are not                           Sponsor
                                                                                                               Virginia Rutherford
Nietzsche’s   famous     saying,   “If   man     used, not valued for whatever reason, not
                                                                                                                 Louise D. Kasch
(woman) has a why to live, he/she can            discovered to be of value. In that regard,
always find a how to live.” It is this why to    our society does not appear to know how
live that enabled Victor Frankel, the            to value its older people, its disabled and
famous developer of Logo Therapy, to             frail people. We lack the sight, perhaps we
endure years in a nazi concentration camp.       lack the eyes of the heart to discover the
                                                                                                      In Memory of M. Powell Lawton
He indicated that those who survived             indelible value and meaningfulness of our                       Elaine M. Brody
tended to be those who found meaning             elders. (Your comments are welcome,                  In Memory of William John Prsha
and purpose in being, usually in helping         amilgram@ucsd.edu).                                             Marie Alice Prsha
others. We humans need to be used in



                                                                       2
                                                                                                                Vol. 24, No. 11 November 2004



                                Seniors Dispel Myths About Sedentary Lives
                                                  University of Alberta, September 9, 2004

   Despite reports that herald seniors as           The survey looked at such factors as               A small group of retired men and women
weak, frail burdens to society, our aging pop-   income, living arrangements, time spent on         also continued to hold paid jobs. More than
ulation is breaking those stereotypes, says a    unpaid work, active and passive leisure and        5 per cent of retired men and 4 per cent of
University of Alberta researcher in a new        self-care activities and quality of life. The      retired women spent nearly four hours per
Statistics Canada study that finds most older    findings showed that older people do not fit       day on paid work. This group of men was
Canadians to be active, happy contributors       the stereotype of being “sick, weak, frail,        among the most at-risk of those making a
to society.                                      powerless, sexless, passive, alone, unhappy        seamless transition to retirement. The study
   “Warnings found in media headlines and        and failing,” said Fast, who also leads a $2.3-    found that they were almost as time-stressed
delivered by politicians about disasters to be   million study titled “Hidden Costs/Invisible       as their full-time employed counterparts and
visited upon society because of population       Contributions:    The      Marginalization   of    much less likely than other men at this stage
aging have blown things way out of propor-       ‘Dependent’ Adults” funded by Social               of life to report being happy with their qual-
tion,” said Dr. Janet Fast, from the U of A’s    Sciences and Humanities Research Council           ity of life.
Department of Human Ecology. “Our find-          of Canada.                                            However, Fast said she was surprised to
ings contradict stereotypes of the sedentary,       “Most of even the oldest of the old are         see that those few men who were forced to
unproductive, and dependent retiree couch        very much engaged in life and differ little        live with someone other than their spouse
potato. Yes, those who have made the transi-     from younger seniors on many quality of life       because of transitions such as widowhood
tion to retirement are spending more time        measures,” she said.                               or poor health were happier than expected.
watching television, but they’re spending           The researchers found that retirees spent          “This group of men were presumed to
even more time on active leisure and unpaid      more time on unpaid productive activities          be the most socially isolated, to feel
work. They’re also happy about being busy,       (volunteer, care, and domestic work), leisure,     trapped in a daily routine, to feel they had-
happier than their employed counterparts.”       and self-care than their employed counter-         n’t accomplished what they wanted in the
   Fast and Judith Frederick, a senior analyst   parts. This evidence contradicts previous find-    day and to have time on their hands they
with Statistics Canada, investigated how         ings that have been unclear about volunteer        didn’t know what to do with,” said Fast.
Canadians spend their time during later life     work. Overall, 3.2 million retirees spent          “Yet, they were almost as likely as married
transitions from paid work to retirement, to     about 5 billion hours on unpaid productive         men to say they were happy, so they seem
widowhood, and to loss of independence.          activity annually. The estimated economic          to have adapted to their new circum-
The study uses data from Statistics Canada’s     value of these contributions to our society is     stances.”
1998 General Social Survey on time use.          $60.2 billion each year in Canada.



Social and Environmental Factors Play Role in Aging
   WASHINGTON—Why do some older people experience a                         examine frailty and the protective role of positive emotions in the
rapid decline in their physical and functional health while some            largest minority population in the United States.
of their peers remain healthy and active? While your genes and                 Study authors Glenn Ostir, Ph.D., Kenneth Ottenbacher, Ph.D.,
overall physical health play a role, new research shows how                 and Kyriakos Markides, Ph.D., followed the participants for seven
psychosocial factors can also play an important role. Two                   years and assessed frailty by measuring the participants’ weight
studies report on this in the September issue of Psychology and             loss, exhaustion, walking speed and grip strength. Positive affect
Aging, a journal published by the American Psychological                    (positive emotions) was measured during the study period by ask-
Association (APA).                                                          ing the participants how often in the last week “I felt that I was
   In the first study, researchers at the University of Texas Medical       just as good as other people,” “I felt hopeful about the future,”
Branch at Galveston found a link between positive emotions and              “I was happy,” and “I enjoyed life.”
the onset of frailty in 1,558 initially non-frail older Mexican                The overall incidence of frailty increased almost eight percent
Americans living in five southwestern states—Texas, California,             during the seven-year follow-up period, but those who scored
Arizona, Colorado and New Mexico. This was the first study to                                                              continued on page 5



                                                                        3
Healthwise
                                                                                                                        Interview
     Interview with Dr. Tony L. Yaksh
     UCSD Department of Anesthesiology


Editor: Good morning, Dr.Yaksh. Tell us a little bit about how you          sensory experience such as light touch or prioprioception. This
came to study pain and a little about your background.                      of course stands in contrast to spinal local anesthetics which
                                                                            produce a block of virtually all somatosensory information and
Dr. Yaksh: Well, I received my Ph.D. in neurobiology and then as I
                                                                            motor outflow. This degree of specificity argues that there is a
had gone to ROTC, I went into the Army and was stationed at
                                                                            high degree of functional encoding of afferent output, which
Edgewood Arsenal Maryland. Another individual there was study-
                                                                            occurs at the spinal level. It is now appreciated that virtually all
ing the systemic actions of opiates and one day in a hallway con-
                                                                            of the pain states that arise from tissue and nerve injury have
versation we posed the question of where in the brain did
                                                                            as their underlying mechanisms changes in spinal encoding.
morphine act to produce analgesia? At the time no one had a
                                                                            Consider the intense sensation associated with warm bathwater
clue. I had initiated studies to “microinjection map” morphine for
                                                                            on an area of sunburned skin. Similarly, after injury to the
its analgesic actions in primates. These led then to a series of
                                                                            peripheral nerve there is spontaneous pain and an exaggerated
studies later at the University of Wisconsin where we discovered
                                                                            pain sensation generated by light touch. Again, all of these
the analgesic effects of morphine at the spinal level. I continued
                                                                            “miscodings” are now attributed to changes in the way the
these studies for eleven years eventually moving
                                                                            spinal cord generates a sensory output to the brain.
to the Department of Anesthesiology at UCSD.
                                                                            Third, since our initial experiments , there has been increasing
Editor: What was the importance of these spinal opiate effects?
                                                                            focus on the pharmacology and biochemistry of these spinal
Dr. Yaksh: Those observations provided the unexpected insight
                                                                            systems. There has been literally an explosion in spinal drug
that morphine with an action limited to the spinal cord would
                                                                            targets coincident with our growth in understanding spinal
produce a potent and selective analgesia. The preclinical work led
                                                                            pain processing. Thus, for example, we know that morphine
within two years to the implementation at Mayo of spinal opiate
                                                                            works by an action on the spinal terminals of “pain” fibers to
delivery to manage acute post operative pain. Shortly thereafter
                                                                            block the release of the transmitters from that fiber. We now
Burton Onofrio and I collaborated at Mayo and demonstrated
                                                                            know that other inhibitory receptors are also on those termi-
the first use of spinal morphine in managing cancer with placed
                                                                            nals and that the spinal delivery of those agonists will indeed
spinal catheters and implanted pumps in humans. It was impor-
                                                                            produce a powerful non-opioid analgesia.
tant because giving drugs spinally allowed you to regulate specif-
                                                                            Editor: What are the next steps in your particular research?
ically pain processing at the spinal cord level permitting you to
avoid the brain effects such as sedation, respiratory depression,           Dr. Yaksh: From a research perspective, there is an ever evolv-
changes in hormone and blood pressure, etc.                                 ing growth in our understanding of systems that encode pain
                                                                            and how these systems are altered in development and after
Editor: So there was the clinical side and then there is the issue of
                                                                            injury. Particularly exciting at the moment is the role of non
the spinal mechanisms revealed by these studies?
                                                                            neuronal cells such as microglia and astrocytes in altering the
Dr. Yaksh: Yes. Interestingly enough, in some ways I think that
                                                                            communication between neurons. This focus is clearly an
the implications arising from these spinal opiate studies have
                                                                            important component of the events that transpire after
even greater consequences than the initial and current use of
                                                                            chronic tissue and nerve injury and we have a strong effort
spinal morphine. First, before the mid 1970s no one routinely
                                                                            in this area.
gave spinal drugs in animal models. Our work in the spinal cord
                                                                            From a broader perspective, I would note that we all talk
required the development of a robust and simple approach to
                                                                            about how much things have improved in pain management.
delivering drugs spinally and we developed some models that
                                                                            However, we still have problems, which have proven extremely
allowed that to be done routinely. Secondly, the observations
                                                                            difficult to address. There are people that have diabetic
with spinal morphine suggested that the encoding of pain infor-
                                                                            neuropathies that are difficult to treat. States such as
mation was subject to an unexpectedly detailed modulation. One
                                                                            fibromyalgia, musculoskeletal pain and the like are complex to
could by activating spinal opiate receptors specifically prevent the
                                                                            diagnose and even more complex to treat. All one has to do is
processing of pain information, but not other components of the


                                                                        4
                                                                                                           Vol. 24, No. 11 November 2004
Interview continued
look at somebody who is suffering from advanced rheumatoid arthritis
                                                                             Social and Environmental Factors
and you can only say to yourself that there must be a better way.
To the extent that people have uncontrolled pain, we can only say that
                                                                             Play Role in Aging continued from page 3
means we have not arrived where we want to be. I should say that             high on positive affect were significantly less likely to
every area of biology and translational biology, whether it be spinal        become frail. Each unit increase in baseline positive affect
injury or pain or chronic hypertension, we need only look at the prob-       score was associated with a three percent decreased risk of
lems our clinical colleagues face to realize how far we have to go.          frailty after adjusting for relevant risk factors.

Editor: In closing, is there anything further you’d like to say about           The precise reason for this happening was beyond the scope

your work.                                                                   of the current study, but the researchers speculate that positive
                                                                             emotions may directly affect health via chemical and neural
Dr. Yaksh: It is clearly one example of what is the current trend in
                                                                             responses involved in maintaining homeostatic balance. Or a
research in medicine—to see a growing alliance between the basic
                                                                             more indirect process may be at work, according to the authors,
scientist and clinician. We do our research here because it is the
                                                                             with positive emotions affecting health by increasing a person’s
human problem that concerns us.
                                                                             intellectual, physical, psychological and social resources.
                                                                                In the second study, researchers Thomas Hess, Ph.D., Joey
                                                                             Hinson, M.A., and Jill Statham, B.A., from North Carolina
  Successful Aging Research Coordinator                                      State University investigated how negative stereotypes about
                                                                             aging influences older adults’ memory. Their study involved
     We are pleased to announce
                                                                             193 participants and two experiments, each with a younger
  Jennifer Reichstadt, M.S., has joined
                                                                             (17–35 years old) and older (57–82 years old) group of adults.
  the staff at UCSD’s Stein Institute for
                                                                             Participants were exposed to stereotype-related words in the
  Research on Aging (SIRA) as our
                                                                             context of another task (scrambled sentence, word judg-
  research coordinator. In this newly
                                                                             ment) in order to prime positive and negative stereotypes of
  appointed     position,   her   primary
                                                                             aging. This involved either words reflecting negative stereo-
  responsibility is organizing and coordi-
                                                                             types about aging (brittle, complaining, confused, cranky,
  nating all facets of SIRA’s new longitu-   Jennifer Reichstadt, M.S.       feeble, forgot, senile, etc.) or words reflecting positive views
  dinal study on successful aging.
                                                                             of aging (accomplished, active, alert, dignified, distin-
     Jennifer has a master’s degree in gerontology from the
                                                                             guished, knowledgeable, successful, etc.)
  University of Arizona and has gained professional experience
                                                                                Results show memory performance in older adults was
  in multiple settings. Most recently, she was the Older Adult
                                                                             lower when they were primed with negative stereotypes
  Program Coordinator for a San Diego County-funded
                                                                             than when they were primed with positive stereotypes. In
  Screening, Brief Intervention, and Referral (SBIR) substance use
                                                                             addition, age differences in memory between young and
  program. She has also worked for the Senior Health & Wellness
                                                                             older adults were significantly reduced following a positive
  Center in Oregon, recognized as a model clinic by the Hartford
                                                                             stereotype prime, with young and older adults performing at
  Foundation; University of Arizona’s Center on Aging, for a
                                                                             almost identical levels in some situations.
  grant-funded Older Persons Emergency Network (OPEN) proj-
                                                                                The study also provides evidence that older adults can
  ect; and Northern Arizona University’s Gerontology Institute,
                                                                             control the effect of negative stereotype activation but only
  which provided oversight to the Senior Companion and
                                                                             when the primes are relatively subtle. In contrast, when the
  Retired and Senior Volunteer Programs.
                                                                             stereotype primes are relatively blatant, memory perform-
     Jennifer is very honored and excited to be a part of SIRA. Her
                                                                             ance tends to be negatively affected.
  experience and enthusiasm and her desire to help improve the
                                                                                The results of this study add to a growing list of findings
  quality of life for older adults of today and of the future repre-
                                                                             that implicate the importance of the social environment in
  sents an excellent match with her new position. If you have any
                                                                             how it affects older peoples’ memory performance, accord-
  questions for Jennifer, personally, or related to SIRA’s successful
                                                                             ing to the authors. If older people are treated like they are
  aging studies, please contact her at (858) 534-1226 or
                                                                             competent, productive members of society, then they per-
  jreichst@ucsd.edu.
                                                                             form that way too.



                                                                         5
Healthwise
                                                                                       Be A Part of Science
 Biomarkers in Aging, MCI, and                 removed from the lower part of the back.           If you participate, you will either
      Alzheimer’s Disease                      The spinal taps are done to measure the         receive:
                                               biomarker proteins. Subjects will receive       • 12 sessions of anxiety management
   Dr. Galasko at the UCSD Alzheimer’s
                                               up to $200 compensation per year of the            training from the CALM study team
Disease Research Center is conducting a
                                               study for undergoing the spinal taps.           • Or treatment as usual from your regu-
study to measure the levels of a number of
                                               Subjects are not required to have a spinal         lar health care provider.
different proteins (called biomarkers) in
                                               tap each year if they choose not to do so.         Anxiety management will help you learn
cerebrospinal fluid (CSF) and in blood. The
                                               If you are interested in participating, call    relaxation techniques, problem-solving
purpose of the study is to find out
                                               Helen Vanderswag, RN, at (858) 622-5805.        skills, and how to let go of past and present
whether levels of these proteins are
altered in people who have normal cogni-                                                       experiences that make you anxious.

tive ability, mild memory problems, or
                                                  Are you at risk for Developing                  Possible benefits include:
                                                        Type 2 Diabetes?                       • $80 for four assessments over a
early Alzheimer’s Disease (AD). We aim to
study these markers in detail to determine     • Are you concerned about developing               16-month period
which combination of biomarkers is most           Type 2 Diabetes due to a family history,     • You and your health care provider will
helpful to indicate whether people with           high blood sugar, or being over-                receive information about your symp-
mild memory problems are at high risk of          weight?                                         toms, which may lead to better care
worsening over time, or progressing to         • Have you ever been told that you are             for you
AD. We will also test blood to find which         at an increased risk for developing          • You may receive anxiety management
form of a gene called Apolipoprotein E            Type 2 Diabetes?                                training at no cost to you
(APOE) an individual may have. Studies            Dr. Mudaliar at the VA Medical Center        • You may experience relief of your anx-
suggest that this gene may influence the       in La Jolla is currently screening volunteers      iety symptoms
risk of developing AD.                         (Vets and Non-Vets) for the ACTOS NOW              For more information, please call
   Recruitment is now underway to enroll       study. This study looks at an investigational   Yvonne Chan or Arianna Peñalba at (858)
subjects in one of the following cate-         use of the drug Pioglitazone to determine       552-8585 ext. 2270 or Dr. Wetherell at
gories:                                        if the drug can prevent or delay the devel-     (858) 552-8585 ext. 2752.
1) healthy adults without memory prob-         opment of Type 2 Diabetes.
   lems, between ages 40–90                       Subjects who qualify will receive:             Chronic Obstructive Pulmonary
2) individuals with Mild Cognitive             • study related medical care by board                     Disease Study
   Impairment (MCI), between ages 60–90           certified physicians
                                                                                                  Our clinic is conducting a clinical
3) individuals with early AD, between          • counseling with a certified diabetes
                                                                                               research study for men or women who
                                                  educator
   ages 60–90
                                                                                               have chronic obstructive pulmonary dis-
                                               • compensation up to $600
   The study will last five years and each                                                     ease (COPD). This study is comparing the
year will involve a two-day (non-consecu-         If interested, please call Alana Clark at
                                                                                               long-term effects of two marketed prod-
tive) visit.                                   (858) 552-8585 ext. 2884.
                                                                                               ucts on the composition (makeup) of
   During the first visit, participants will                                                   bones, in order to measure bone gain or
undergo brief physical and neurological
                                               Controlling Anxiety in Later-life
                                                                                               loss in patients with COPD.
                                                      Medical Patients
examinations and will be asked a series of                                                        You may be able to participate if you:
                                                    (The CALM Study)
questions that are designed to evaluate                                                        • are at least 40 years of age
memory, thinking capacity, and mood.              Dr. Julie Wetherell and her colleagues       • have COPD (such as emphysema or
They will also undergo laboratory (blood       are conducting a study to see whether              chronic bronchitis)
and urine) tests. The second visit will con-   anxiety management training helps               • have a smoking history or are a
sist of further blood work and undergoing      older adults. You may be eligible if you           current smoker
a spinal tap. Spinal taps, or lumbar punc-     are at least 60 years old, have a health        • do not have asthma
tures, are routine neurological outpatient     care provider, and often feel tense, wor-
tests in which a small amount of fluid is      ried, or anxious.                                                   continued from page 7

                                                                                                      Be A Part of Science
                                                                     6
                                                                                                                   Vol. 24, No. 11 November 2004



Be A Part of Science             continued
                                                                                                         Belmont Village




                                                       S AV E T H E D AT E
                                                                                    Invites You to a Senior Lifestyles Education Presentation on
   Study staff will review additional crite-
ria with you. You will be asked to come to                                     Spirituality, Aging, and Emotional Well-Being
the clinic for fourteen study visits over                                                 J. Adam Milgram, M.A., Executive Director
approximately three years. All study-                                           The Sam and Rose Stein Institute for Research on Aging, UCSD
related medical evaluations and investiga-
                                                                                         December 8, 2004 from 11:30 A.M. to 1:00 P.M.
tional     medication   are   provided    to
                                                                                                  Belmont Village (Town Hall)
qualified participants at no cost. For more
                                                                                       13075 Evening Creek Drive South, Sabre Springs
information, please contact UCSD Clinical
                                                                                         Space is limited, please RSVP: (858) 486-5020
Trials Center. (888) 827-3247.
                                                                                                          Lunch Provided

Key Facts About the Flu continued from page 1
   Antiviral Medications: Three antiviral          Germs are often spread when a person                   symptoms, particularly fever, without first
drugs (amantadine, rimantadine, and                touches something that is contami-                     speaking to your doctor.)
oseltamivir) are approved and commer-              nated with germs and then touches his                     If, however, your flu symptoms are
cially available for use in preventing flu.        or her eyes, nose, or mouth.                           unusually severe (for example, if you are
All of these medications are prescription                                                                 having trouble breathing), you should
                                                                        Diagnosing the Flu
drugs, and a doctor should be consulted                                                                   consult your health-care provider right
                                                   Tests are available that can determine
before the drugs are used for preventing                                                                  away.
                                                if you have the flu as long as you
the flu.                                                                                                     If you are at special risk from complica-
                                                are tested within the first 2 or 3 days
    Other Habits for Good Health                                                                          tions of flu, you should consult your
                                                after your symptoms begin. In addition,
   The following steps may help prevent                                                                   health-care provider when your flu symp-
                                                a doctor’s examination may be needed
the spread of respiratory illnesses like flu:                                                             toms begin. This includes people 65 years
                                                to determine whether a person has
                                                                                                          or older, people with chronic medical con-
• Avoid close contact                           another infection that is a complication
                                                                                                          ditions, pregnant women, or children.
   Avoid close contact with people who          of the flu.
                                                                                                          Your doctor may choose to use certain
   are sick. When you are sick, keep your
                                                   At Special Risk of Complications                       antiviral drugs to treat the flu.
   distance from others to protect them
                                                               from Flu                                      For more information www.cdc.gov/
   from getting sick too.
                                                   Certain people are at increased risk for               flu/keyfacts.htm, or www.sdchip.org/, or
• Stay home when you are sick                   serious complications from the flu. This                  call Flu Line in San Diego at 877-358-0202.
   If possible, stay home from work,            group includes people age 65 years and
   school, and errands when you are sick.       older and people of any age with chronic
   You will help prevent others from            medical conditions. Pregnant women and
   catching your illness.                       children between 6 months and 23
• Cover your mouth and nose                     months of age also are at increased risk
   Cover your mouth and nose with a             from flu complications.
   tissue when coughing or sneezing. It               What to Do If You Get Sick
                                                                                                                    BROCHURES
   may prevent those around you from                       This Flu Season                                        NIH Consensus Statement
   getting sick.                                   If you develop the flu, it is advisable to                     on Osteoporosis Prevention,
• Clean your hands                              get plenty of rest, drink a lot of liquids,                       Diagnosis, and Therapy.
   Washing your hands often will help           and avoid using alcohol and tobacco. Also,
                                                                                                                  To order, please send email
   protect you from germs.                      you can take medications to relieve the
                                                                                                                  to steininstitute@ucsd.edu
• Avoid touching your eyes, nose, or            symptoms of flu (but never give aspirin to
                                                                                                                  or call (858) 534-6299.
   mouth                                        children or teenagers who have flu-like



                                                                                7
Community Board of Advisors                                     Membership in SIRA
Muriel E. Baze, M.A.
                                                                Become a member of SIRA (a non-profit organization) today by completing the membership
Dana K. Bezerra
Donald F. Billings, C.F.A. (President)
                                                                form below. Membership in SIRA also makes an exceptionally meaningful gift for friends.
Barbara Giammona                                                Your membership provides needed financial support for SIRA’s programs and services. Your
William Gibbs, Jr.                                              continued health and well-being are important to us. (Dilip V. Jeste, M.D., director)
Susan Hoekenga, MPA                                             Features of SIRA Membership
Natasha Josefowitz, Ph.D.
                                                                • Privileged use of resource library and videotaped lectures
Claudia Laird
                                                                • Twelve issues of the SIRA newsletter, Healthwise
Terrie D. Litwin, M.S.W. (Vice President)
Hasmik Rakijian                                                 • Complimentary parking permits to all Public/Seminar Lecture Series
Gregory D. Stein, M.D., (Secretary/Treasurer)
Ilene E. Swartz                                                 SIRA Membership Form
Joanne Sides Watson
Caroleen L. Williams                                            I would like to support The Sam and Rose Stein Institute for Research on Aging
RADM Raymond G. Zeller, USN (Ret.)                              by becoming a member:
Emeritus Members
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J. Dallas Clark
Pat Hyndman                                                     r $500–999        Benefactor/Corporate    r $1,000+           Director’s Circle
Irwin M. Jacobs, Sc.D.                                          Specify amount $ _____________________              r Renewal           r New Member
Philip M. Klauber
Marvin L. Krichman                                              Membership gift for a friend/relative:
Paul F. Mahoney                                                 Name ________________________________________________r Do not list my name
Mary Ann McCauley
Oscar M. Ruebhausen                                             Address____________________________________________________________________
Dixie Unruh
Honorary Member                                                 r Visa r American Express r MasterCard
Sam S. Stein
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Staff                                                           Please print your name as you would like it to appear in the SIRA newsletter roll of donors.
Director: Dilip V. Jeste, M.D.
Associate Director: J.E. Seegmiller, M.D., professor emeritus   Name ____________________________________________________________________
Executive Director and Editor: J. Adam Milgram, M.A.
                                                                Address____________________________________________________________________
Research Coordinator: Jennifer Reichstadt, M.S.
Administrative Assistant: Coty Benrimoj                         City______________________________ State __________ Zip ____________________
Fund Manager: Bernard Hernandez
Web Master: David Ung (Volunteer)                               Home Phone __________________________ Business Phone ______________________

Please write to us at our address if you wish to have           Email Address ______________________________________________________________
your name removed from the list to receive future               Thank you for your generous support. (Make checks payable to UC San Diego Foundation—SIRA
fund-raising requests supporting The Stein Institute            and mail to Stein Institute for Research on Aging, 9500 Gilman Drive, La Jolla, CA 92093-0664.)
for Research on Aging (SIRA).                                   All membership contributions are tax deductible.

Healthwise Vol. 24, No. 11 November 2004


 University of California, San Diego                                                                                                Non-Profit Org.
 The Sam and Rose Stein Institute for Research on Aging                                                                               U.S. Postage
                                                                                                                                          PAID
 School of Medicine
                                                                                                                                     San Diego, CA
 9500 Gilman Drive, Dept. 0664
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 La Jolla, CA 92093-0664

 ADDRESS SERVICE REQUESTED
 phone: (858) 534-6299
 web site: sira.ucsd.edu
 email: steininstitute@ucsd.edu




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