ATMOSPHERIC PRESSURE AIR PLASMA TREATMENT OF HUMAN BLOOD PLASMA: A KINETIC MODEL OF COAGULATION* Kevin Quann, Gregory Fridman, Alexander Fridman, Alexander Gutsol, Victor Vasilets, Gary Friedman Plasma-Medicine Lab, Drexel Plasma Institute, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104. We observe that Floating Electrode Dielectric Barrier Discharge (FE-DBD) electric plasma is able to significantly hasten human blood plasma clot formation and influence normal blood protein concentrations. Here, a better understanding of influence of FE- DBD is needed and we propose a first step in this direction – an explanation of influence of FE-DBD on ion concentrations in blood plasma. The presented model compares normal blood coagulation rate with blood undergoing e-plasma treatment by assuming linear relationship between ion concentrations in blood plasma and positive radical production by e-plasma at the surface of blood. Electric plasma is effective in increase of Ca2+ concentration through a redox mechanism: [Ca 2+ ] + [ R 2- + H (H2O) ←⎯ ⎯Ca → H + R 2- ⎯ kCa |k − ] − (H2O) 2+ + Ca (H2O) This mechanism is provided by hydrogen ions generated in air plasma through a sequence of ion-molecular processes. Prothrombin kinetics: two-fold decrease in clot formation time Uniform FE-DBD treatment of blood plasma (top: FE-DBD electrode; bottom: blood). ________________________________ * This work was supported by Defense Advanced Research Project Agency (DARPA) Award #W81XWH-05-2-0068.
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