ATMOSPHERIC PRESSURE AIR PLASMA TREATMENT OF HUMAN BLOOD PLASMA by uwn15494

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									ATMOSPHERIC PRESSURE AIR PLASMA TREATMENT OF HUMAN BLOOD
        PLASMA: A KINETIC MODEL OF COAGULATION*

Kevin Quann, Gregory Fridman, Alexander Fridman, Alexander Gutsol, Victor Vasilets,
                                 Gary Friedman
                  Plasma-Medicine Lab, Drexel Plasma Institute,
         Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104.

We observe that Floating Electrode Dielectric Barrier Discharge (FE-DBD) electric
plasma is able to significantly hasten human blood plasma clot formation and influence
normal blood protein concentrations. Here, a better understanding of influence of FE-
DBD is needed and we propose a first step in this direction – an explanation of influence
of FE-DBD on ion concentrations in blood plasma.
    The presented model compares normal blood coagulation rate with blood undergoing
e-plasma treatment by assuming linear relationship between ion concentrations in blood
plasma and positive radical production by e-plasma at the surface of blood. Electric
plasma is effective in increase of Ca2+ concentration through a redox mechanism:
                      [Ca   2+
                                    ]     +
                                                         [
                                 R 2- + H (H2O) ←⎯ ⎯Ca → H + R 2-
                                                        ⎯
                                                 kCa |k −
                                                                    ]
                                                                    −
                                                                    (H2O)
                                                                                 2+
                                                                            + Ca (H2O)
This mechanism is provided by hydrogen ions generated in air plasma through a
sequence of ion-molecular processes.




             Prothrombin kinetics: two-fold decrease in clot formation time




 Uniform FE-DBD treatment of blood plasma (top: FE-DBD electrode; bottom: blood).
________________________________
* This work was supported by Defense Advanced Research Project Agency (DARPA)
Award #W81XWH-05-2-0068.

								
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