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					Program of Symposia Selected for Bratislava Meeting 2007
(Speakers and topics as given by chairs in symposium proposals)

DAY 1 (September 12)

1.   Chairs: Záhradníková Alexandra, Eisner David A. (Bratislava, Slovakia;
     Manchester, United Kingdom)
     CARDIAC EXCITATION-CONTRACTION COUPLING IN HEALTH AND
     DISEASES

      Karin Sipido (Leuven, Belgium):
      Dynamic modulation of Ca current by Ca release in cardiac hypertrophy

      Lars Meier (Goettingen, Germany):
      Role of CaMKII for E-C coupling and hypertrophy/heart failure

      Sylvain Richard (Montpellier, France):
      The Ryanodine receptor connection: from normal to cardiac arrhythmias

      F. Anthony Lai (Cardiff, United Kingdom):
      Mechanisms of dysfunction in mutant ryanodine receptors in cardiac pathology

      Alexandra Zahradniková (Bratislava, Slovakia):
      Regulation and dysregulation of the ryanodine receptor activity: insights from mathematical
      modelling Regulation and dysregulation of RyR activity: Is there a common point?


2.   Chairs: Kolář František, Ravingerová Táňa (Prague, Czech Republic;
     Bratislava, Slovakia)
     MITOCHONDRIA: ROLE IN MYOCYTE INJURY AND PROTECTION

      Enn Seppet (Tartu, Estonia):
      Organization of intracellular energy metabolism in muscle cells: structure – function
      relationships

      Jiří Neužil (Prague, Czech Republic):
      Role of mitochondria in myocyte apoptosis

      Fabio DiLisa (Padova, Italy):
      Mitochondrial dysfunction and ROS formation. Crucial roles in functional and structural
      derangements of the ischemic heart

      Vilma Borutaite (Cambridge, United Kingdom)
      Mitochondria and nitric oxide in cell death and cardioprotection

      Andrew P. Halestrap (Bristol, United Kingdom)
      The mitochondrial permeability transition pore - from molecular mechanism to Cardioprotection

3.   Chairs: Lightman Stafford, Ježová Daniela (Bristol, United Kingdom;
     Bratislava, Slovakia)
     HYPOTHALAMIC-PITUITARY-ADRENOCORTICAL AXIS IN HEALTH AND
     DISEASE

      Lightman S. (Bristol, United Kingdom):
      Pulsatility as a key aspect of HPA regulation




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      Alon Ch. (Rehovot,Israel):
      The role of Urocortin 2 in HPA axis activity and stress-related behaviors
      Filaretova L.P. (St. Petersburg, Russia):
      HPA axis and gastroprotection

      Ježová D. (Bratislava, Slovakia):
      HPA axis and mood disorders

4.   Chair: Symonds Michael E. (Nottingham, United Kingdom)
     UNCOUPLING PROTEINS – DIFFERENT ROLES THROUGH THE LIFE
     CYCLE?

      Bruno Miroux (Paris, France):
      Uncoupling proteins - tissue specific functions?

      Michael Symonds (Nottingham, United Kingdom):
      Differential roles for uncoupling proteins through the life cycle

      Jan Kopecký (Prague, Czech Republic):
      Dietary and developmental regulation of uncoupling proteins

      Karim Echtay (Balamand, Lebanon):
      Uncoupling proteins - what is their physiological role?

      Alison Mostyn (Nottingham, United Kingdom):
      Endocrine manipulation of uncoupling proteins

5.     Chairs: Mysliveček Jaromír, Anna Hrabovská (Prague, Czech Republic,
Bratislava, Slovakia)

     NEW ASPECTS IN PHYSIOLOGY OF CHOLINERGIC SYSTEM

      Uwe Maskos (Paris, France):
      Nicotinic receptors/Novel approaches for the analysis of brain function and deep-brain imaging

      Eric Krejci (Paris, France):
      Acetylcholinesterase anchoring/Genetics and cell biology of cholinergic targeting

      Ezio Giacobini (Geneva,Switzerland):
      Neurodegenerative diseases/Long term and wide indications for cholinergic therapy of
      neurodegenerative diseases

      Anna Hrabovská (Bratislava, Slovakia)
      AChE knockout mice/Receptor adaptation mechanisms in AChE-/- mice

      Jacques Mallet (Paris, France):
      Conditional inactivation of the ChAT gene as a novel approach to investigate the physiology of
      cholinergic systems




DAY 2 (September 13)




                                                                                                       2
 6.   Chair: Vassort Guy (Montpellier, France)
      FINE TUNING OF MYOCARDIAL CONTRACTILITY BY MYOFIBRILLAR
      REGULATORY PROTEINS IN CONTROL AND DISEASES

       Alison CAVE (London, United Kingdom)
       Involvement of troponin I in endotoxemia-induced contractile dysfunction

       Ingo MORANO (Berlin-Buch, Germany):
       Targeting essential myosin light chain/actin interaction in transgenic rats

       Olivier CAZORLA (Montpellier, France):
       Role of C-protein versus troponin I during PKA-dependent control of contractility

       Alain LACAMPAGNE (Montpellier, France):
       Regionalisation of MLC-2 phosphorylation and its dephosphorylation in diseases

       Zoltan PAPP (Debrecen, Hungary):
                                 2+
       Mechanisms of action of Ca -sensitizers


 7.   Chairs: Lacinová Lubica, Striessnig Jörg (Bratislava, Slovakia; Innsbruck,
      Austria)
      ROLE OF L-TYPE CALCIUM CHANNELS IN CELLULAR EXCITABILITY

       Jörg Striessnig (Innsbruck, Austria):
       Cav1.4 dysfunction in Congenital Stationary Night Blindness Type 2

       Jutta Engel / Marlies Knipper (Tübingen, Germany):
       Functional role of L-type calcium channels for auditory function

       Matteo Mangoni (Montpellier, France):
       Voltage-dependent calcium channels and cardiac pacemaker activity: From ionic currents to
       genes

       Thomas Kleppisch / Lubica Lacinova (München, Germany; Bratislava, Slovakia):
       Cav1.2 channels in normal and abnormal hippocampal excitability

       Erik Renström (Lund, Sweden):
       L-type calcium channels in pancreatic islets and their role in diabetes

       Norbert Klugbauer (Freiburg, Germany):
       The role of the Cav1.2 L-type calcium channel in smooth muscle and endocrine tissues

8.    Chair: Motta Marcella (Milano, Italy)
      SYNERGISTIC CONTROL OF FOOD INTAKE, ENERGY METABOLISM AND
      REPRODUCTION

       Francois Pralong (Lausanne, Switzerland):
       The neuroendocrine brain and the joined regulation of reproduction and food intake
       MM van Weissenbruch (Amsterdam, Netherlands):
       Nutrition and timing of puberty

       Paolo Magni (Milano, Italy):
       Leptin and other adipokine systems: gender dimorphism and role in reproduction and
       metabolism

       Manuel Tena-Sempere (Cordoba, Spain):



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      Novel peptide systems in the cross-talk of energy metabolism and reproduction: ghrelin and
      kisspeptins

9.   Chairs: Verkhratsky Alexei, Syková Eva (Manchester, United Kingdom;
     Prague, Czech Republic)
     MOLECULAR PHYSIOLOGY OF INTEGRATION IN NEURONAL-GLIAL
     CIRCUITS

      Eva Syková (Prague, Czech republic):
      Role of glia in volume transmission in the CNS

      C. Giaume (Paris, France):
      Gap junctions in glial physiology and pathophysiology

      A. Volterra (Lausanne, France):
      Vesular release of "glio"transmitters and integration in neuronal-glial networks

      H. Kettenmann (Berlin, Germany):
      Physiology and pathophysiology of microglia

      Vladimír Štrbák (Bratislava, Slovakia):
      Cell volume and peptide hormone secretion

      Alexei Verkhratsky (Manchester, United Kingdom):
      Calcium signals and integration in neuronal-glial networks

10. Chair: Zeman Michal, Serge Daan (Bratislava, Slovakia, Grooningen,
    Netherland)
    CIRCADIAN RHYTHMS AND MELATONIN

      Urs Albrecht (Fribourg, Switzerland):
      The Circadian Clock: Rhythm and Blues in the Body

      Serge Daan (Grooningen, Netherlands):
      The circadian rhythm of mice: in the lab and in nature

      Andrew Loudon (Manchester, United Kingdom):
      The tau mutation in mice and hamsters

      Alena Sumova (Prague, Czech republic):
      Clock gene expression during development

      Michal Zeman (Bratislava, Slovakia):
      Clock genes and rhythmic function of cardiovascular system in rats




DAY 3 (September 14)

11. Chair: Tribulová Narcisa (Bratislava, Slovakia)


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    GAP JUNCTIONS IN CARDIOVASCULAR REGULATIONS

      Dhein Stephan (Leipzig, Germany):
      Structure, function and pharmacology of gap junctions

      Weingart Robert (Bern, Germany):
      Basic electrical and diffusional properties of gap junctions

      Kostin Sawa (Nauheim, Germany):
      Gap junctions in diseased human heart

      Oviedo-Orta Ernesto (Guildford, United Kingdom):
      Gap junctions and atherosclerotic plaque development

      van Veen Toon (Utrecht, Netherland):
      Gap junctional communication between myocardial and stem cell-derived cardiomyocytes

12. Chairs: Kemp Paul J., Peers Chris (Cardiff, United Kingdom; Leeds, United
    Kingdom)
    OXYGEN SENSING: FROM FETAL PROGRAMMING TO POSTNATAL
    REMODELLING

      Vaclav Hampl (Prague, Czech Republic):
      Fetal oxygen sensing

      Jean-Marc Pequignot (Lyon, France):
      Hypoxia and cardiorespiratory control

      Constancio Gonzalez (Valladolid, Spain):
      Vascular remodeling

      Joachim Fandrey (Essen, Germany):
      Hypoxic regulation of gene expression

      Chris Peers (Leeds, United Kingdom):
      Hypoxia and Alzheimer`s disease

      A Mark Evans (St Andrews, United Kingdom);
      AMP kinase in hypoxia




13. Chair: Douglas Alison J. (Edinburgh, United Kingdom)
    CONTROL OF PARTURITION: UTERUS OR HYPOTHALAMUS?

      Q.J. Pittman (Calgary, Canada):
      Fever and parturition

      S.L. Meddle (Edinburgh, United Kingdom):
      Perinatal behaviour

      D.K. Grammatopoulos (Warwick; United Kingdom):
      Placenta and uterine hormone mechanisms

      J. Szekerz-Bartho (Pecs, Hungary):
      Peripheral cytokines and labour mechanisms

      A.J. Douglas (Edinburgh, United Kingdom):
      Switching on oxytocin neurones at birth



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14. Chairs: McBain Chris J., King Anne E. (Bethesda, USA; Leeds, United
    Kingdom)
    SPINAL AND CORTICAL INHIBITORY INTERNEURONS: FROM SYNAPSES
    TO NETWORKS

      Chris J. McBain (Bethesda, USA):
      Differential mechanisms of synaptic plasticity control hippocampal interneuron networks

      Anne E. King (Leeds, United Kingdom):
      Spinal dorsal horn networks: implications for somatosensory processing and pain

      Richard Miles (Paris, France):
      Disinhibition induced synchrony in the hippocampus: emergence, threshold and pacemaker
      phenomena

      Rosa Cossart (Marseille, France):
      Maturation of brain networks: from coherent assemblies of gap junction connected intrinsic
      oscillators to synapse-driven network patterns

      Laura Ballerini (Trieste, Italy):
      Interneurons and development of spinal cord network activity; substrates for locomotion

15. Chairs: Brown David A., Shapiro Mark S. (London, United Kingdom; San
    Antonio, USA)
    Kv7 (KCNQ) POTASSIUM CHANNELS THAT ARE MUTATED IN HUMAN
    DISEASES

      G. Loussouam (Nantes, France):
      Kv7.1 (KCNQ1) properties and channelopathies

      H. Lerche (Ulm, Germany):
      Nervous system Kv7 channelopathies

      B. Attali (Tel Aviv, Israel):
      Gating and assembly of Kv7 channels: multi-modular structures

     M.S.Shapiro (San Antonio, USA):
     Regulation of neural Kv7 channels

      Y.Yaari (Jerusalem, Israel):
      Functions of Kv7 channels in central neurons

      H.Hansen (Ballerup, Denmark):
      Kv7 channel modifying drugs




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Description: Cardiovascular Physiology ache