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									RT-240 Pediatrics and
Neonatology
Class #1 Embryology


        Respiratory Therapy Program
        Allegany College of Maryland
            Cumberland, Maryland




Terminology (Fertilization)
  Zygote
  Gametes
  Testes
  Ovaries
  Gametogenesis
  Spermatogenesis
  Oogenesis




Fertilization
  Blastomeres
  Morula
  Erythroblast
    Embryo
    Amnion
    Yolk sac
  Trophoblast
    Placenta
    Chorion




                                       1
Implantation of the Morula
 Endoderm
   GI, mouth, pharynx, lung and liver
 Ectoderm
   CNS, PNS, eyes, ears, nose, and
   appendages
 Mesoderm
   Connective tissue, cartilage, bone heart
 The embryo begins to grow!




Intrauterine Life/Respiratory
Development
 Two phases
   Embryonic
   Fetal
 Embryonic stage
   “primitive development stage”
   1st five weeks of gestation
 Pseudoglandular stage
   6th-16th weeks of gestation
   Dichotomous branching




Intrauterine Life/Respiratory
Development
 Canalicular stage
   16th week -26th weeks
   Respiratory units appear at the 16th week
 Terminal Sac stage
   27th week – 40 weeks
     Saccular 28-36 weeks
     Alveolar 36-term




                                               2
Pulmonary Surfactant
 Major surfactant is called lecithin
 Second type of surfactant is called
 sphingomyelin
 Methyltransferase system
   24 – 28 weeks
 Phosphocholine transferase system
   35th week




Amniocentesis
 Amniotic fluid is removed and
 analyzed…
   Chromosomal matching
   Lung maturity (l/s ratio)
     1:1 90% RDS (Steroids)
     2:1 5% RDS
     1.5:1 50% RDS
   Gender
 Complications




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