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					                                         PROLIEF (blue) & PHOTOPROLIEF (green)

WOMEN:

As a female fetus our female sexual hormones including progesterone (P) are produced only by our adrenal glands and
not by our ovaries. This is sufficient at that time.

When we go into puberty and menstrual cycling and our reproductive years, our sexual female hormones are produced
by the adrenal glands and also the ovaries. The switch over is what causes some personality changes in us.

Likewise when we make the change into menopause, our body goes through mood and personality changes as we move
back over to producing our sexual hormones only from our adrenal glands again and no longer from our ovaries. In the
case of some women, the progesterone produced by only our adrenal glands is not enough and we experience
menopausal symptoms such as severe mood changes, hot flashes etc. Even for women who have had a full
hysterectomy and no longer have ovaries, they still need the boost in progesterone to maintain body harmony/balance
as they body is still following a hormonal pattern even if they are no longer cycling.



THE TWO ROADS TO PROGESTERONE – IS IT ENOUGH?

Our body has two pathways to produce hormones as follows. The balanced “sexual pathway” which is favorable. And
the “stress pathway” which is not preferable but which our body will always favor as a survival mechanism. In our
modern world with ever more stress this is the reason more and more women are experiencing hormonal imbalance,
personality changes and in difficulty in becoming pregnant. Our natural hormonal homeostasis is affected by stress. See
Fig.1.

When we are stressed and our body chooses the “stress pathway”, we produce Cortisol which, in normal doses, is acts
as a natural anti-inflammatory but too much of it produces weight gain. Cortisol also acts as a natural anti-allergen but
too much leads to hot flashes as our body is triggered to counter allergens. As a consequence pre-menopausal and
menopausal women may even develop allergic reactions they never experienced before as their body surges with
cortisol and overreacts to supposed allergens. Similarly such women will sometimes experience joint pains as an
overreaction to inflammation. Their blood pressure may drop for the first time in their lives (dizzy spells). A lack of
libido will be a result of stress causing the production of too much DHEA which leads to too much cortisol and estrogens
and reduces testosterone levels which are key to libido.

These are all results of deficient progesterone and excessive levels of estrogens, particularly estriol. Adding
progesterone will counter these effects.



ESTROGEN DOMINANCE AND PROGESTERONE DEFICIENCY

They key is not only to increase progesterone but in doing so, to maintain a healthy balance in the ratio of estrogens as
follows.

                                                    6/30/2007                                                     Page 1 of 5
Estradiol: Should be 10% of the total estrogens. This is the estrogen often in prescription estrogen treatments but if it is
in too high a dose, it can put the ratio out of balance. If you have too little Estradiol it affects the limbic brain resulting in
extreme mood swings and irritiablity.

Estriol: Should be 80% of the total estrogens. This estrogen is a natural cancer preventative.

Estrone: Should be at 10% of total estrogens and it also a natural cancer preventative.



The natural phyto (plant – soy based) estrogens in Prolief and Phytoprolief (they both contain them but in different
dosages) naturally convert to the natural ratio balance of necessary estrogens.

        Fig.1

                    STRESS PATHWAY
                                                                                                      SEXUAL PATHWAY

                                                              Adrenal Gland




                   Pregnostrone              Progesterone                                            Male Androgen




                      DHEA                      Cortisol                                             Testosterone




                   Estrone 10%                Aldesterone
                                                                                                       Estrogens




                   Estrodiol 10%




                    Estrol 80%




                                                       6/30/2007                                                      Page 2 of 5
SUGGESTIONS:

To establish if you are progesterone deficient contact your OB-Gyn or go to Dr. John Lee’s site www.johnleemd.com
where you can order a do-it-yourself home hormone testing kits. Cost approx $85. It is a simple oral inner cheek scrape
test that Dr. Lee will analyze.

All women can use either Prolief (blue – milder) or Phytoprolief (green – stronger). The treatment can be refined by a)
the individual product or product combination used; b) the dosage; and c) the time of day applied. The dispenser doses
20mg. If you only need less dosage, pump out 20mg and keep aside in a cup. Apply by dividing into quarters accordingly
(see below) and apply according to your needs. You do not have to pump 20mg and use it all.

See Fig. 2 to understand a typical “cycling” woman’s monthly hormonal cycle. Perimenopausal (in 40 year old range),
menopausal and women post-hysterectomy (surgical menopausal) follow the same hormonal pattern the only
difference is that they are often not producing enough progesterone for their needs through only their adrenal glands.
This is why they are in more need of a supplement like Pro/Phytoprolief. In Fig 2 you can see the time 10-12 days before
the next cycle (luteral phase) is where most women experience mood swings or imbalance when the progesterone
climbs and should exceed estrogen but often does not (progesterone deficiency and therefore estrogen dominance).
This is when to add progesterone.

These are examples of dosage but this can be tailored to specific needs as you establish your own pattern/mood and
therefore needs.

E.g. 1: For cycling women with low imbalance/progesterone deficiency: Prolief 5mg at night only during luteral phase.

E.g. 2: For cycling women with increased imbalance: Prolief 5-10 mg at night only during luteral phase.

E.g. 3: For perimenopausal women, cycling women with severe imbalance: 10-20 mg Prolief at night during luteral phase
only and if needed a lesser dose at night during the rest of the month.

E.g. 3: Surgical and postmenopausal women: 20mg Prolief at night and 10-20 mg Prolief a.m. during luteral cycle and if
needed Prolief during the rest of the month and only at night and possibly in lesser doses. For more severe cases this
dosage pattern could be done including only Phytoprolief or combining the two products to tailor needs.

You must establish a pattern for yourself depending on how you feel. It will take a few months to feel the balance
returning as the hormones self-regulate. It does not happen overnight. Any changes you make need to be gradual and
given time to take effect. Sudden changes are not recommended.

Apply product to soles of feel; inner upper arm; inner upper thigh. Wash hands after use. Rotate the areas you use to
apply the cream for better affect.


                                                  6/30/2007                                                  Page 3 of 5
Do not over use the product as a severe dose e.g. 2 X 20mg pump per day of either product (and especially Phytoprolief)
will result in too much progesterone which causes depression. Progesterone has a calming effect on the brain this is
why we apply the product (and particularly the stronger Phytoprolief) at night.

Remember stress is against you all the time. The more stress you endure, the more estrogen and therefore cortisol you
will produce which will override and lower your progesterone.

                  Fig. 2

                                                                                     Luteral Phase
                                      Oval Phase                                     (progesterone
                                                                                         should
                                                                                         exceed
                                                                                       estrogen)




                                                                Apply cream
                                                                 in this time
                                                                    where
                                                                progesterone
                                                                   is often
                                                                deficient and
 Hormone Levels




                                                                   estogen
                                                                  dominant.
                                                                 This is the
                                                                “mad mood”
                                                                    phase




                                                                10 -12 days
                                      Days                      before next                                Start of next
                                                                  period                                      period

                           Estrogen

                            Progesterone




MEN:

Men go through their own body life changes called an “andropause”. Women have estrogens. Men have androgens.
Women have a mensal cycle (monthly). Men have a diurnal (day/night) cycle of hormones (see Fig 3). Because
progesterone is the key to testosterone production, a fall in progesterone in men results in a drop in testosterone with

                                                   6/30/2007                                                    Page 4 of 5
its own effects e.g. depression and lack of sex drive. Men can also use Prolief to boost progesterone and therefore
testosterone. Men experience a surge of testosterone in the morning (typically 4-6am) and are often more sexually
aroused at this time. Progesterone/Prolief is therefore supplemented at night to add to their natural nightly self-
generation of testosterone.




 Typical Male Diurnal Testosterone Cycle
                                                                     Fig. 3



                                                   Te
                                                 reg sost
                                                    en ero
     Testosterone Level




                                                      era ne
                                                          ted na
                                                             ov tual
                                                               ern ly
                                                                  igh
                                                                      t




                          4-6 am   Time          12-2 pm                       12 pm




SELF EDUCATION READING:

“Screaming to be Heard” by Dr. Elizabeth Vlit

“What your Doctor May Not Tell You About Menopause” by Dr. John R. Lee, M.D. www.johnleemd.com




                                                  6/30/2007                                                  Page 5 of 5

				
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