Curvitae JHU promotion inflammation

Document Sample
Curvitae JHU promotion  inflammation Powered By Docstoc
					___________________________                                                May 26, 2005

Cristiana Stellato, M.D., Ph.D.
Current appointment

July 2000-           Assistant Professor of Medicine, Division of Clinical Immunology, The Johns
                     Hopkins University School of Medicine.

Personal data

Contact address:       The Johns Hopkins Asthma and Allergy Center
                       5501 Hopkins Bayview Circle
                       Baltimore, MD 21224
                       Room 1A.12A
                       Telephone: (410) 550-6981
                       Fax: (410) 550-2090
                       e-mail: stellato@jhmi.edu

Education and training

1974–79      High school (field: humanistic) at the Liceo Classico Statale “Adolfo Pansini”, Naples,
             Italy. Graduate July 31, 1979 (score 57/60).

1980–88      School of Medicine and Surgery, University of Naples Federico II, Naples, Italy. M.D.
             degree, October 3, 1988 (score 110 cum laude/110).

1986–88      Intern, Department of Medicine (Chairman: Prof. Mario Condorelli), University of Naples
             Federico II, Naples, Italy.

1988–91      Resident, Division of Allergology and Clinical Immunology (Director: Prof. Mario Ricci),
             University of Florence, Florence, Italy.

1990         Visiting scientist, Division of Clinical Immunology (Director: Lawrence M. Lichtenstein,
             M.D., Ph.D.), The Johns Hopkins University, Baltimore, Maryland (March 22–June 22).

1991–96      Ph.D. school of Broncho-pneumology (Coordinator: Prof. Paolo Altucci; Tutor: Prof.
             Gianni Marone), Second University of Naples, Caserta, Italy. Ph.D. Degree Oct. 1996

1990–93      Postdoctoral fellow, Division of Clinical Immunology and Allergology (Director: Prof.
             Gianni Marone), University of Naples Federico II, Naples, Italy.

1992         Visiting scientist, Johns Hopkins Asthma and Allergy Center, Division of Clinical
             Immunology (Director: Lawrence M. Lichtenstein, M.D., Ph.D.), The Johns Hopkins
             University, Baltimore, Maryland (July 1–September 30).




                                                                                                        1
1993–97    Postdoctoral fellow, Johns Hopkins Asthma and Allergy Center, Division of Clinical
           Immunology, The Johns Hopkins University, Baltimore, Maryland (Mentor: Dr. Robert P.
           Schleimer).

Professional Experience

1997-99    Visiting Assistant Professor, Johns Hopkins Asthma and Allergy Center, Division of
           Clinical Immunology, The Johns Hopkins University, Baltimore, Maryland.

1998-      At-term Professor, Division of Clinical Immunology and Allergology (Director: Prof.
           Gianni Marone), University of Naples Federico II, Naples, Italy.

Publications

     Peer-Reviewed Articles

1.   Stellato C., de Paulis A., Cirillo R., Mastronardi P., Mazzarella B., Marone G.: Heterogeneity of
     human mast cells and basophils in response to muscle relaxants. Anesthesiology 1991; 74:1078-
     1086.

2.   Stellato C., Casolaro V., Ciccarelli A., Mastronardi P., Mazzarella B., Marone G.: General
     anaesthetics induce only histamine release selectively from human mast cells. British Journal of
     Anaesthesia 1991; 67:751-758.

3.   Stellato C., de Paulis A., Ciccarelli A., Cirillo R., Patella V., Casolaro V., Marone G.: Anti-
     inflammatory effect of cyclosporin A on human skin mast cells. Journal of Investigative
     Dermatology 1992; 98:800-804.

4.   Stellato C., Cirillo R., de Paulis A., Casolaro V., Patella V., Mastronardi P., Mazzarella B.,
     Marone G.: Human basophil/mast cell releasability. IX. Heterogeneity of the effects of opioids
     on mediator release. Anesthesiology 1992; 77:932-940.

5.   de Paulis A., Stellato C., Cirillo R., Ciccarelli A., Oriente A., Marone G.: Anti-inflammatory
     effect of FK-506 on human skin mast cells. Journal of Investigative Dermatology 1992; 99:723-
     728.

6.   Stellato C., Beck L.A., Gorgone G.A., Proud D., Schall T.J., Ono S.J., Lichtenstein L.M.,
     Schleimer R.P.: Expression of the chemokine RANTES by a human bronchial epithelial cell line:
     Modulation by cytokines and glucocorticoids. Journal of Immunology 1995; 155:410- 418.

7.   Schwiebert L.A., Beck L.A., Stellato C., Bickel C.A., Bochner B.S., Schleimer R.P.:
     Glucocorticosteroid inhibition of cytokine production: Relevance to antiallergic actions. The
     Journal of Allergy and Clinical Immunology 1996; 97:143-152.

8.   Stellato C., de Crescenzo G., Patella V., Mastronardi P., Mazzarella B., Marone G.:
     Human basophil/mast cell releasability. XI. Heterogeneity of the effects of contrast media
     on mediator release. The Journal of Allergy and Clinical Immunology 1996; 97:838-850.


                                                                                                        2
9.    Beck L.A., Stellato C., Beall L.D., Schall T.J., Leopold D., Bickel C.A., Baroody F., Bochner
      B.S., Schleimer R.P.: Detection of the chemokine RANTES and endothelial adhesion molecules
      in nasal polyps. The Journal of Allergy and Clinical Immunology 1996; 98:766-778.

10.   Stellato C., Collins P., Ponath P. D., Soler D., Newman W., LaRosa G., Li H., White J.,
      Schwiebert L.M., Bickel C., Liu M., Bochner B.S., Williams T.J., Schleimer R.P.: Production of
      the novel C-C chemokine MCP-4 by airway cells and comparison of its biological activity to
      other C-C chemokines. Journal of Clinical Investigation 1997;99:926-936.

11.   Stellato C., Atsuta J., Bickel, C., Schleimer, R.P. An in vitro comparison of commonly used
      topical glucocorticoid (GC) preparations. The Journal of Allergy and Clinical Immunology
      1999;104:623-629.

12.   Stellato C., Matsukura S., Fal A., Plitt J., Brummet M. E., White J., Beck L., Proud D.,
      Schleimer R.P.: Differential regulation of epithelial-derived C-C chemokine expression by IL-4
      and the glucocorticoid budesonide. Journal of Immunology 1999; 163;5624-5632.

13.   Matsukura S., Stellato C., Plitt J.R., Bickel C., Miura K., Georas S.N., Casolaro V., Schleimer
      R.P. Activation of eotaxin gene transcription by Nuclear Factor Kappa B (NF-kB) and Signal
      Transducer and Activator of Transcription 6 (STAT6) in human airway epithelial cells. Journal
      of Immunology 1999;163:6876-6883.

14.   Arima M., Plitt J., Stellato C., Bickel, C., Motojima S., Makino S., Fukuda T., Schleimer R.P.
      Expression of interleukin 16 by human epithelial cells. Inhibition by dexamethasone. American
      Journal of Respiratory Cellular and Molecular Biology 1999;21:684-692.

15.   Lee S.C., Brummet M.E., Shahabbudin S., Woodworth T., Georas S., Leiferman K., Gilman S.,
      Stellato C., Gladue R., Schleimer R.P., Beck L.A.: Cutaneous injection of human subjects with
      Macrophage Inflammatory Protein-1 induces significant recruitment of neutrophils and
      monocytes. Journal of Immunology 2000;164:3392-33401.

16.   Stellato C., Brummet M.E., Plitt J.R., Shahabuddin S., Baroody F., Liu M.C., Ponath P.D., Beck
      L.A. Cutting Edge: Expression of the CC Chemokine Receptor CCR3 in Human Airway
      Epithelial Cells. Journal of Immunology 2001; 166:1457-1461.

17. Matsukura S., StellatoC., Georas S.N., Casolaro V., Plitt J.R., Miura K., Kurosawa S., Schindler
    U. and Schleimer R.P. IL-13 upregulates eotaxin expression in airway epithelial cells by a
    STAT6-dependent mechanism. American Journal of Respiratory Cellular and Molecular
    Biology. 2001;24:755-761.

18. Matsukura S., Kokubu F., Kuga H., Kawaguchi M., Ieki K., Odaka M., Suzuki S., Watanabe S.,
    Takeuchi H., Adachi M., Stellato C., Schleimer R.P. Differential regulation of eotaxin
    expression by IFN- in airway epithelial cells. The Journal of Allergy and Clinical Immunology
    2003;111:1337-44.

19. Atasoy U, Curry S, Lopez de Silanes I, Shyu A-B, Casolaro V, Gorospe M, Stellato C.
    Regulation of eotaxin gene expression by TNF and IL-4 through messenger RNA stabilization:
    Involvement of the RNA binding protein HuR. Journal of Immunology 2003;171:4369-4378.



                                                                                                        3
20. Heller N.M., Matsukura S., Georas S.N., Boothby M.B., Schindler U., Stellato C., Schleimer
    RP.: Assessment of Signal Transducer and Activator of Transcription 6, (STAT6) as a target of
    glucocorticoid action in human airway epithelial cells. Clinical and Experimental Allergy
    2004;34:1690-1700.

21. Heller N.M., Matsukura S., Georas S.N., Boothby M.R., Rothman P.B., Stellato C., Schleimer
    RP.: Interferon- inhibits STAT6 signal transduction and gene expression in human airway
    epithelial cells. American Journal of Respiratory Cellular and Molecular Biology 2004:2004-
    0195OC.

22. Huang J.L., Gao P.S., Mathias R.A., Yao T.C., Chen L.C., Kuo M.L., Hsu S.C., Plunkett B.,
    Togias A., Barnes K.C., Stellato C., Beaty T.H., Huang S.K.: Sequence variants of the gene
    encoding chemoattractant receptor expressed on Th2 cells (CRTH2) are associated with asthma
    and differentially influence mRNA stability. Human Molecular Genetics 2004;13:2691-2697

      Non-Peer-Reviewed Articles

21.   Marone G., Casolaro V., Cirillo R., Stellato C., Genovese A.: Pathophysiology of human
      basophils and mast cells in allergic disorders. Clinical Immunology and Immunopathology 1989;
      50:S24-S40.

22.   Marone G., Casolaro V., Stellato C., de Paulis A., Genovese A.: Immunological and
                                                      +
      pharmacological heterogeneity of human FcRI cells. Journal of Chemotherapy 1991;3:55- 58.

23.   Marone G., Stellato C., Mastronardi P., Mazzarella B.: Non-specific histamine-releasing
      properties of general anesthetic drugs. Clinical Reviews in Allergy 1991; 9:269-280.

24.   Stellato C., Casolaro V., Ciccarelli A., de Crescenzo G., Patella V., Marone G.: Selective
      activation of human mast cells by general anesthetics. Agents and Actions 1992; 32:C19-C194.

25.   Stellato C., de Paulis A., de Crescenzo G., Tatangelo F., Rickler O., Marone G.: Heterogeneity
      of human basophils and mast cells in response to muscle relexants. Agents and Actions 1992;
      32:C195-C198.

26.   Marino O., Casolaro V., Meliota S., Stellato C., Guidi G., Marone G.: Inhibition of histamine
      release from human FcRI+ cells by nimesulide. Agents and Actions 1992; 32:C311-C314.

27.   Stellato C., Casolaro V., Renda A., Genovese A., Marone G.: Anti-inflammatory effect of
      deflazacort. International Archives of Allergy and Immunology 1992; 99:340-342.

28.   Marone G., Stellato C.: Activation of human mast cells and basophils by general anaesthetic
      drugs. Monographs in Allergy 1992; 30:54-73.

29. Marone G., Stellato C., Mastronardi P., Mazzarella B.: Mechanisms of activation of human mast
    cells and basophils by general anaesthetic drugs. Annales Françaises d'Anesthesie et
    Réanimation 1993; 12:116-125.

                                                                                                       4
30.   Marone G., Stellato C., Renda A., Genovese A.: Anti-inflammatory effects of glucocorticoids
      and cyclosporin A on human basophils. European Journal of Clinical Pharmacology 1993;
      45(Suppl. 1):S17-S22.

31.   Stellato C., Marone G.: Mast cells and basophils in adverse reactions to drugs used during
      general anesthesia. Chemical Immunology 1995; 62:108-131.

      Book Chapters and Monographs

32.   Marone G., Casolaro V., Quinti I., Paganelli R., Spadaro G., Stellato C.: Mast cell and basophil
      activation by human anti-IgE autoantibodies. In: Progress in Allergy and Clinical Immunology
      (W.J. Pichler, B.M. Stadler, C. Dahinden, A.R. Pécoud, P.C. Frei, C. Schneider, A.L. de Weck,
      eds.). Hogrefe & Huber Publishers, Toronto, Lewiston, Bern, Göttingen, Stuttgart, 1989, pp. 125-
      128.

33.   Casolaro V., Stellato C., Spadaro G., Marone G.: Alterations of immunoregulation in allergic
      diseases. In: Immunoregulation and Lymphoproliferative Disorders (F. Dammacco, ed.). Edi-
      Ermes, Milan, 1989, pp. 57-72.

34.   Casolaro V., Stellato C., de Crescenzo G., Triggiani M., Marone G.: Mast cells, basophils and
      their mediators. In: Asthma Treatment. A Multidisciplinary Approach (D. Olivieri, P. Barnes, S.
      Hurd, G. Folco, eds.). Plenum Publishing Co., New York, 1992, pp. 63-79.

35.   Marone G., de Paulis A., Casolaro V., Ciccarelli A., Spadaro G., Patella V., Stellato C., Cirillo
      R., Genovese A.: Are the anti-inflammatory properties of cyclosporin A useful in the treatment
      of chronic asthma? In: Respiratory Allergy: Advances in Clinical Immunology and Pulmonary
      Medicine (G. Melillo, P.M. O'Byrne, G. Marone, eds.). Excerpta Medica, Amsterdam, London,
      New York, Tokyo, 1993, pp. 251-260.

36. Schleimer R.P., Beck L.A., Schwiebert L.M., Stellato C., Bochner B.S.: Inhibition of
    inflammatory cell recruitment by glucocorticoids: Cytokines as primary targets. In: Topical
    Glucocorticoids in Asthma – Mechanisms and Clinical Actions. (R.P. Schleimer, W.W. Busse,
    P.M. O'Byrne, eds.). Marcel Dekker, Inc., New York, 1995, pp. 203-238.

37.   Stellato C., Schwiebert L.M., Schleimer R.P.: Mechanism of action of glucocorticosteroids. In:
      Asthma (P.J. Barnes, M.M. Grunstein, A. Leff, A.J. Woolcock, eds.). Raven Press, New York,
      1996, pp. 1569-1595.

38.   Stellato C., Schleimer R.P.: Glucocorticoid regulation of chemokines. In: Chemokines in
      Allergic Disease (Rothenberg, M. ed.). Marcel Dekker, Inc., New York, 1999, pp. 473 - 507.

39.   Stellato C., Beck L.A.: Expression of eosinophil-specific chemokines by human epithelial cells.
      In: Human Eosinophils: Biological and Clinical Aspects (Marone, G. ed.). S. Karger AG, Basel,
      1999, vol. 76, pp. 156 - 176. 36.

40.   Beck L., Stellato C., Shahabuddin S., Nickel R., Schleimer R.P. The role of chemokines in
      allergic diseases of the airways. In: Inflammatory Processes. Molecular Mechanisms and
      Therapeutic Opportunities. LG Letts and DW Morgan, editors. Birkhauser Verlag, Basel
      Switzerland, 2000, pp.109-120.

                                                                                                          5
41.     Stellato C., Beck L.A. Expression of eosinophil-specific chemokines by human epithelial cells.
        Chemical Immunology 2000;76:156:176.

42.     Stellato C. Blockade of chemokine production/function as an example of glucocorticoid anti-
        inflammatory actions. In: Inhaled Steroids in Asthma—Optimizing effects in the airways. RP
        Schleimer, O'Byrne PM, Szefler SJ, and R Brattsand, editors. Marcel Dekker, New York, NY.
        2002;63:113-136.


Extramural Sponsorship

As Principal Investigator:

      1) NIH RO1 AI44242-01 "Regulation of C-C Chemokines in Human Airway Epithelium‖, from
         4/1/2000 to 3/31/2005, now in 1 year no-cost extension status until 3/31/2006. Direct cost
         175,000 $/year, 90 % effort.

      2) NIH RO1 AI060990 ―Role of the RNA-binding protein HuR in Allergic Inflammation‖, from
         4/1/2005 to 12/31/2009, direct cost 250,000/yr, 90% effort.

      3) 2004 AAAAI/Aventis Women Physician in Allergy Junior Faculty Development Award,
         ―Posttranscriptional Gene Regulation in Allergic Inflammation: Role of the RNA-binding
         Protein HuR‖, 40,000/yr for two years (2004-2005).

As Co-investigator:

      1) NIH RO1 AI41463 ―Regulation of IL-4 in cells involved in allergic disease‖, 10 % effort;
         Principal Investigator: Vincenzo Casolaro, M.D., Ph.D.

Teaching and Mentoring Activities
1998-1999       Small group discussion leader ("small group discussions on immediate
                hypersensitivity") for the second year medical students - JHU School of Medicine.

1999 – to date At-term Professor, Division of Clinical Immunology and Allergology (Director:
               Prof. Gianni Marone), University of Naples Federico II, Naples, Italy.

1999            Mentoring for Nikki Buckley, 1st year Ph.D. student of the JHU program in
                Cellular and Molecular Medicine, during a 3-month rotation of laboratory work on
                the effect of glucocorticoids on eotaxin mRNA stability.

1999-2000       Lectures on the Pathophysiology of Asthma for the Pharmaceutical Preceptorship
                Program in the Division of Clinical Immunology.

1999-to date Lectures on chemokine and chemokine receptor biology in the Orientation Conference
             Series for the new postdoctoral fellows in the Division of Clinical Immunology.
2001            Mentoring for Jacqueline Nguyen, student (graduating 2001) at Long Reach High
                School, Technology Magnet Program, during a 3-month rotation of laboratory


                                                                                                         6
               experience on the role of the transcription factor CP2 on transcriptional activation of
               the eotaxin gene.

2001           Mentoring for Naba Bakar, student (graduating 2002) at Dulaney Valley High School,
               during a 3-month rotation of laboratory experience on the role of the CCR3 chemokine
               receptor in promoting gene expression in airway epithelial cells.

2003-05        Mentoring for S. Yukiko Asaki, a student at St. Mary’s College of Maryland, during
               summer rotations (May-August) of laboratory experience on various projects (the role
               of the CCR3 chemokine receptor in promoting proliferation and chemotaxis in airway
               epithelial cells, and studies on IL-13 mRNA turnover).

2004-2005      Mentoring (eight months) for Dr. Nikki Heller, Post-doctoral fellow working on the
               effect of glucocorticoids on endothelial cell chemokine gene expression

2004- to date Mentoring for Dr. Jinshui Fan, Post-doctoral fellow working on posttranscriptional
              regulation of inflammatory genes

Editorial Activities
Peer Review for:       Allergy
                       Anesthesiology
                       American Journal of Respiratory Cell and Molecular Biology
                       Inflammation Research
                       Journal of Allergy and Clinical Immunology
                       Journal of Immunology
                       Journal of Leukocyte Biology

Reviewer for the Wellcome Trust University Award (2000)


Clinical Activities - Certification

1989        Unrestricted licence to practice of Medicine and Surgery in the European Community,
            University of Naples Federico II, Naples, Italy.

1990        Passed the basic and clinical science components of the Foreign Medical Graduate
            Examination in the Medical Sciences (FMGEMS) (Rome, Italy, January 15–16).

1991        European board in Allergology and Clinical Immunology, University of Florence, Florence,
            Italy (October 4; score 70 cum laude/70).

Professional Societies

1997 -      Member, American Academy of Allergy, Asthma and Immunology.

Honors and Awards

1989        Investigator Award, Roussel Institute (Milan, Italy).



                                                                                                         7
1990        Extended Scholarship Award, the UCB Institute of Allergy (Brussels, Belgium).

1992        Research fellowship, National Research Council (CNR, Rome, Italy).

1993        Fogarty International Fellowship, Public Health Service (Bethesda, Maryland).

1995        Finalist, ―The Respiratory 2000 International Young Investigator Award‖, Schering- Plough
            International (Milan, Italy).

1997        The 1997 Cytokine Abstract Award for the Best Abstract for Fellows- in-Training
            presented in the Field of Cytokine Research at the Joint Meeting of American Academy of
            Asthma, Allergy and Immunology/American Association of Immunologists/Clinical
            Immunology Society, S. Francisco, February 21-26.

1998        Fellowship from the Pharmacia Allergy Research Foundation.

2004        American Academy of Allergy, Asthma and Immunology/Aventis Women Physician in
            Allergy Junior Faculty Development Award (2 year support).

Invited Talks

September 1997        Great Lakes Pulmonary Conference, Niagara-On the-Lake, Ontario, CA -
                      "Production of C-C chemokines in the airways: potential role in allergic
                      diseases".

February 1998         54th American Academy of Allergy, Asthma and Immunology, Washington, DC,
                      "Pathophysiology of Contrast Media Reactions" in joint AAAAI/EAACI
                      Symposium.

November 1999         1999 Autumn Immunology Conference, Chicago, "Epithelial-derived
                      Chemokines and Asthma".

December 1999         Congress on: The Anti-asthmatic Actions and Selectivity of Inhaled Steroids,
                      Palm Beach, FL, "Blockade of Chemokine Production/function as an Example
                      of Anti-inflammatory actions".

March 2001            57th American Academy of Allergy, Asthma and Immunology, New Orleans,
                      LA, "Effects of Corticosteroids on eosinophil-specific chemokine
                      expression in the airways" in MOA Interest Section Symposium.

January 2003          University of Maryland School of Medicine, Baltimore, MD, Guest Speaker at
                      the Departimental Seminar Series, ―Unraveling the Role of Post-transcriptional
                      regulation in Chemokine Biology: a Study on the CC Chemokine, Eotaxin‖.

July 2003             Congress on: Inhaled Corticosteroids in the Treatment of Asthma and COPD,
                      Le Parker Meridien, New York, NY, ― Posttranscriptional and Non-genomic
                      Effects of Glucocorticoids‖.




                                                                                                       8
May 2004              Frontiers in Medicine Course, Johns Hopkins Asthma and Allergy Center,
                      Baltimore, “Chemokines: multi-tasking molecules in allergic inflammation”.

January 2005          Guest Speaker at the Seminar Series of the Laboratory of Cellular and
                      Molecular Biology, NIA, NIH, Baltimore, ―Understanding Chemokines: Multi-
                      tasking Molecules in Airway Inflammation‖.

March 2005            RNA Focus Group, University of Maryland, Baltimore, ―Posttranscriptional
                      Chemokine Gene Regulation and the RNA-binding Protein HuR in Allergic
                      Inflammation‖.

May 2005              American Thoracic Society 2005 Intl. Conference, San Diego, ―Regulation of
                      Airway Epithelial Chemokine Expression by Alteration in mRNA Stability: The
                      Role of the RNA-binding Protein HuR in Allergic Inflammation‖, in
                      Symposium ―Gene Expression: Beyond Transcription Factors‖.


Invited Reviews and Editorials

Stellato C., Adkinson N.F.: Pathophysiology of contrast media anaphylactoid reactions: new
perspectives of an old problem. Allergy 1998;53:1111-1113.

Beck L.A., Nickel R., Stellato C., Schleimer R.P: Chemokines in allergic diseases. The Journal of
Allergy and Clinical Imunology.1999;104:723-742.

Georas S.N., Beck L.A., Stellato C.: What is eotaxin doing in the pleura? Insights into innate
immunity from pleural mesothelial cells. American Journal of Respiratory Cellular and Molecular
Biology. 2002;26:1-4.

Stellato C.: Posttranscriptional and Non-genomic Effects of Glucocorticoids. Proceedings of
American Thoracic Society. 2004;1:255-263.

Fan J., Heller N.M., Gorospe M., Atasoy U., Stellato C.: The Role of Post-transcriptional Regulation
in Chemokine Gene Expression in Inflammation and Allergy. European Respiratory Journal.
Accepted for Publication.

Esche C, Stellato C, Beck L.: Chemokines: Their Role in Innate and Adaptive Immunity. Journal of
Invesigative Dermatology. Accepted for Publication.




                                                                                                       9

				
DOCUMENT INFO
Shared By:
Categories:
Stats:
views:98
posted:7/25/2010
language:English
pages:9
Description: Curvitae JHU promotion inflammation