Agenda ARVO Summer Eye Research Conference Ocular inflammation

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					                    ARVO Summer Eye Research Conference 2008

                      “Ocular Autoimmunity and Inflammation”

                                       July 31- August 2, 2008
                                        Monterey, California

Wednesday, July 30, 2008

4:00 pm – 7:00 pm            Registration

5:00 pm – 7:00 pm            Welcome reception

Thursday, July 31, 2008

7:00 am – 8:30 am     Registration and Continental breakfast

Session I: Immune Response in the Eye
              Moderators: Rachel Caspi, PhD and Jerry Niederkorn, PhD

8:30 am – 8:45 am            Welcome and Meeting Information            Rachel Caspi, PhD
                                                                        Justine Smith, MBBS, PhD
                                                                        Course Directors
8:45 am – 9:30 am            Mechanisms of Immune Privilege
                             Joan Stein Streilein, PhD

9:30 am – 10:00 am           Impact of Ocular Immune Privilege on Corneal Transplantation
                             Jerry Niederkorn, PhD

10:00 am –10:30 am           Angiogenesis in Eye Disease: The Role of Immune Privilege
                             Thomas Ferguson, PhD

10:30 am – 10:45 am          Coffee Break

10:45 am – 11:15 am          Regulatory Functions of Ocular Resident Cells
                             Koh-Hei Sonoda, MD, PhD

11:15 am – 11:45 am          Ocular Neuropeptides and Induction of Regulatory T Cells
                             Andrew Taylor, PhD

11:45 am – 12:00 pm          Specific Inhibition of Corneal Lymphangiogenesis Increases Allograft
                             Romulo Albuquerque, DDS, MS

12:00pm– 12:15 pm            Modulation of Innate Immune Functions by Extracellular Matrix
                             Shukti Chakravarti, PhD

12:15 pm – 2:00 pm           Lunch/ Poster Session
Session II: Animal Models of Ocular Inflammation and Autoimmunity
              Moderators: Bahram Bodaghi, MD, PhD and Robert Nussenblatt, MD, MPH

2:00 pm – 2:45 pm            The EAU Model as a Template for Basic and Clinical Studies
                             of Uveitis
                             Rachel Caspi, PhD

2:45 pm – 3:15 pm            TCR/neo-Ag Transgenic Models to Study Ocular Inflammation
                             Bahram Bodaghi, MD, PhD

3:15 pm – 3:45 pm            The AIRE KO Mouse: Lack of Central Tolerance Precipitates
                             Spontaneous Uveitis
                             Mark Anderson, MD, PhD

3:45 pm – 4:00 pm            Coffee break

4:00 pm – 4:30 pm            The EAAU Model Reveals the Role of the Complement System in
                             Ocular Inflammation
                             Nalini Bora, PhD

4:30 pm – 5:00 pm            A New Mouse Model to Examine Immunopathological
                             Mechanisms in AMD
                             Chi-Chao Chan, MD

5:00 pm – 5:15 pm            IRBP T Cell Receptor Transgenic Mice: A New Model of Spontaneous
                             Reiko Horai, PhD

5:15 pm – 5:30 pm            Anterior Uveitis Accompanies Joint Disease in a Murine Model of AS
                             Holly Rosenzweig, PhD

Friday, August 1, 2008

7:30 am – 8:30 am     Continental Breakfast

Session III: Mechanisms of Inflammation and Autoimmunity 1
              Moderators: Andrew Dick, MD and Dale Gregerson, PhD

8:30 am – 8:45 am            Review and meeting updates               Rachel Caspi, PhD
                                                                      Justine Smith, MBBS, PhD

8:45 am – 9:30 am            Dendritic Cell and T Cell Interactions in Ocular Inflammation
                             John Forrester, MD, FRCSE, FRCSG, FRCOphth

9:30 am – 10:00 am           Immunoregulatory Role of γδ T Cells in the Generation of Il-17+
                             Uveitogenic T Cells in Mouse EAU
                             Deming Sun, MD

10:00 am – 10:30 am          Oxidative Stress In Experimental Autoimmune Uveitis (EAU)
                             Narsing Rao, MD

10:30 am – 10:45 am          Coffee Break
10:45 am – 11:15 am          Transcriptional Regulation Of Inflammation And Ocular Diseases
                             Charles Egwuagu, MPH, PhD

11:15 am – 11:45 am          Killing Neurons – or Not: Immunomodulation On-Demand
                             Dale Gregerson, PhD

11:45 am – 12:00 pm          Lipopolysaccharide-induced Iris Pigment Epithelial Cells Secretion of
                             Cytokines is Mediated By TLR4 Activation
                             Jeanie Chui

12:00 pm – 12:15 pm          Delivery of Interferon-γ by an Adenovirus Vector Blocks Herpes
                             Simplex Virus Type 1 Reactivation in vitro and in vivo Independent of
                             RNase L and Double-Stranded RNA-Dependent Protein Kinase
                             Daniel Carr, PhD

12:15 pm – 2:00 pm           Lunch/ Poster Session

Session IV: Mechanisms of Inflammation and Autoimmunity 2
             Moderators: Jayakrishna Ambati, MD and James Rosenbaum, MD

2:00 pm – 2:45 pm            Toll like Receptor-3 and AMD
                             Jayakrishna Ambati, MD

2:45 pm – 3:15 pm            Investigation of Autoimmune Retinopathy, with Comparative Studies
                             of CAR, MAR, and Non-neoplastic Autoimmune
                             Retinopathy with and without Cystoid Macular Changes
                             John Heckenlively, MD

3:15 pm – 3:30 pm            Immunization with Recoverin Induces Autoimmune Retinopathy in
                             LPR mice
                             Ying Lu, PhD

3:30 pm – 3:45 pm            Coffee Break

3:45 pm – 4:15 pm            Autoimmune Mechanisms in Glaucoma
                             Franz Grus, MD PhD

4:15 pm – 4:30 pm            Effects of Serum and Antibodies of Glaucoma Patients on Protein
                             Profiles of Retinal Ganglion Cells
                             Katharina Bell

4:30 pm –4:45 pm             Glaucoma & AMD Share Key Molecular Players
                             Luis Vazquez, PhD

Saturday, August 2, 2008

7:30 am – 8:30 am     Continental Breakfast

Session V: Ocular Imaging in Health and Disease
             Moderators: John Forrester, MD and Paul McMenamin, PhD
8:30 am – 8:45 am         Review and Meeting Updates                 Rachel Caspi, PhD
                                                                     Justine Smith, MBBS, PhD

8:45 am – 9:30 am         Imaging Ocular Inflammation in Real Time
                          James Rosenbaum, MD

9:30 am – 10:00 am        Resident and Migrant Ocular Dendritic Cells
                          Paul McMenamin, PhD

10:00 am – 10:15 am       Investigating the Role of CX3CR1 and Resident Versus Hematogenous
                          Cell Contributions in the Early Pathogenesis of EAU
                          Jelena Kezic, Bsc with Hons

10:15 am – 10:30 am       Coffee Break

10:30 am – 11:00am        Migration of Effector T Cells in Uveitis
                          Gerhild Wildner, PhD

11:00 am – 11:30 am       Tracking Inflammatory Cell Recruitment in Corneal Inflammation
                          Victor Perez, MD

11:30 am – 11:45 am       Dynamic Imaging of Retinal Microglia in Explant Tissue Using Time-
                          lapse Confocal Microscopy
                          Wai Wong, MD, PhD

11:45 pm – 1:00 pm        Lunch

Session VI: New Therapeutic Approaches
             Moderators: Victor Perez, MD and Justine Smith, MBBS, PhD

1:00pm – 1:45 pm          Age-Related Macular Degeneration as an Immunologically
                          Driven Disease
                          Robert Nussenblatt, MD, MPH

1:45 pm – 2:15 pm         Longitudinal Data Analysis of Immunosuppression for Posterior
                          Uveitis: What Can We Learn From Clinical Practice Data
                          Douglas Jabs, MD, MBA

2:15 pm – 2:30 pm         Combined Intravitreal Bevacizumab and Triamcinolone Acetonide for
                          the Treatment of Refractory Uveitic Macular Edema
                          Karina Quinones, MD

2:30 pm –2:45 pm          Coffee Break

2:45 pm – 3:15 pm         New Approaches to Immunotherapy of Clinical Uveitis
                          Andrew Dick, MD

3:15 pm – 3:45 pm         New Methods of Local Drug Delivery for Inflammatory
                          Eye Disease
                          Scott Whitcup, MD

3:45pm – 4:00 pm          Closing remarks / Meeting Adjourns

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