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www.renalandurologynews.com JUNE 2010 Renal & Urology News 15 ■ ATC, San Diego Reports from the 2010 American Transplant Congress. Renal & Urology News editor Jody A. Charnow provided news coverage. Mortality Risk Linked to DGF Duration NODAT The longer graft function is delayed, the greater the risk of death Linked to Low THE DURATION of delayed graft function (DGF) affect mortality risk dard criteria donor kidneys; 50.6% of those who received donation Magnesium among renal transplant recipients after cardiac death (DCD) donor RAPID NEW-ONSET diabetes after surviving 90 days after transplantation, kidneys; and 34.4% of subjects who transplantation (NODAT) may be more a study found. received expanded criteria donor likely to occur in renal transplant Each added day of DGF is associ- (ECD) kidneys. recipients who experience hypomag- ated with a 2% increased risk of death, Patients who received DCD kidneys a nesemia in the ﬁrst three months after researchers reported. In addition, each 3.56 times signiﬁcantly increased odds surgery, according to researchers. added day of DGF is associated with of having DGF. Recipients who had The ﬁnding emerged from a study a 4% increased risk of acute rejec- coronary artery disease had a signiﬁcant tion within six months following 81% increased odds. Each one-year of 16 renal transplant recipients transplantation. It is possible that the increment in donor age was associated conducted by researchers at North impact of duration of DGF on patient with a 2% increased odds. Shore-Long Island Jewish Health death may be mediated through the Among subjects with DGF, having Systems and Hofstra Medical School effects of acute rejection, the investiga- a DCD kidney was associated with a in Manhasset, N.Y. All patients were tors stated. signiﬁcant twofold increased likelihood on a triple drug protocol consisting of The study, led by transplant neph- of having an additional day of DGF. Deepa Jayaram, MD mycophenolate sodium, tacrolimus, rology fellow Deepa Jayaram, MD, Each one-year increment in recipient and prednisone. of the University of Michigan in age at transplant was associated with a kidneys to older recipients, Dr. Jayaram NODAT developed in three patients Ann Arbor, included 683 renal trans- signiﬁcant 2% increased odds of having said. The ﬁndings also support the need within the ﬁrst three months post- plant recipients, of whom 180 (26.4%) an additional day of DGF. for efforts to reduce the duration of had DGF. The mean and median dura- Knowledge of the factors that inﬂu- DGF and the need for early diagnosis transplant. These patients had a tion of DGF was 11.9 and ﬁve days, ence the risk and duration of DGF and treatment of acute rejection in mean hemoglobin A1c (HbA1c ) level respectively. DGF occurred in 21.4% could be of prognostic value particu- patients with DGF in an attempt to of 8.1; the remaining 13 patients of the 513 patients who received stan- larly in the allocation of ECD and DCD improve clinical outcomes. ■ (controls) had an HbA1c of 5.1. At three months, blood magne- sium levels were 1.3 mg/dL in Low-Dose Fluconazole Prophylaxis Safe
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