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www.renalandurologynews.com JUNE 2010 Renal & Urology News 11 ■ NKF, Orlando, Fla. Reports from the 2010 National Kidney Foundation’s Spring Clinical Meetings. ESA Resistance Linked to Variant Hb in Blacks VARIANT HEMOGLOBIN (Hb) globin was associated with a three-fold cular morbidity and mortality so this with venous thromboembolism, sug- phenotypes may be associated with resis- increased odds of ESA resistance, after link should be evaluated, especially in gesting that high-dose ESA use in tance to treatment with erythropoiesis- adjusting for multiple variables. patients with variant Hb, the research- patients with sickle cell trait may have stimulating agents (ESAs) among African Higher doses of ESA have been ers noted. In addition, both ESAs and an augmented risk of thrombotic events, Americans with end-stage renal dis- associated with increased cardiovas- sickle cell trait have been associated the researchers observed. ■ ease (ESRD), according to research- ers. These phenotypes include sickle cell trait (HbAS) and hemoglobin C trait (HbAC). The study, led by Vimal K. Derebail, MD, of the University of North Carolina at Chapel Hill, includ- ed 155 African-American ESRD pa- tients who underwent hemoglobin phenotypin
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