DERMATOLOGIC MANIFESTATIONS OF GASTROINTESTINAL DISEASES

Document Sample
DERMATOLOGIC MANIFESTATIONS OF GASTROINTESTINAL DISEASES Powered By Docstoc
					  DERMATOLOGIC
MANIFESTATIONS OF
GASTROINTESTINAL
    DISEASES


Micheline Maamari Chalouhi,MD
case1   case2
case1   case2
             ESOPHAGUS

• Dysphagia
• 1-Diseases extending to the esophagus
• 2-connective tissue diseases
• 3-cancer
Candida
Pemphigus vulgaris
• Autoimmune
• Sore throat,
  dysphagia
Systemic sclerosis
• Crest
• Lower 2/3
• 90%
• Premature
  fullness,reflux
  dysphagia,abdominal
  pain
Plummer vinson
• (paterson kelly)
  syndrome
• Postcricoidal web
• Koilonychia
• Sore tongue angular
  stomatitis
• Iron deficiency
cancer

• Tylosis
         Gastrointestinal Bleed
Hereditary hemorrhagic
  telangiectasias
• AD
• Vascular
  dilatation:oral, nasal,
  GI
• Epitaxis(1)
• Severe GI bleed (2)
  first decade
       Gastrointestinal Bleed
Ehlers-Danlos
• Type 3 & 4 collagen
  defect
       Gastrointestinal Bleed
Pseudoxathoma
  elasticum
    Gastrointestinal Bleed
Kaposi sarcoma(HHV8)
• Endothelial &
   lymphoreticular cells
• GI: 50-80%
   cutaneous
• 100% oral
• stomach,esophagus,
SI
               Polyposis
Gardner’s syndrome
• AD(defect ch 5)
• Epidermoid
  cysts,fibromas,
  lipomas,osteomas
• adenomatous polyps
  colon
• Carcinoma
                 POLYPOSIS
Canada cronkhite
  syndrome
• Macular
  hyperpigmentation
• Alopecia(rapid onset)
• Nail atrophy
  (onycholysis,
   triangular deformity)
                 POLYPOSIS
Cowden disease
• AD
• Skin tags,acral
  keratoses,oral fibroma
• Breast,thyroid,cervical
  ,colon cancer
                POLYPOSIS
Muir-torre
• Sebaceous gland
  tumors
• Visceral
  malignancies(colon,ki
  dney,uterus…)
                POLYPOSIS
Peutz-jegher’s
  syndrome
• AD
• Hamartomatous
  polyps(jejunum)
• Lips,buccal
  mucosa,gingiva,..
• Ovary,thyroid,cervix
  CA
INFLAMATORY BOWEL DISEASES


pyoderma gangrenosum
• 50%PG have UC
• 10% UC have PG
• Severity & extent of
  ulceration are
  Linked to the activity
  of the disease
INFLAMATORY BOWEL DISEASES


Granulomas
INFLAMATORY BOWEL DISEASES


Erythema nodosum
INFLAMATORY BOWEL DISEASES


Aphtous ulcers
PANCREATITIS
acute
pancreatic fat necrosis
Signs of specific GI tumors
Stomach
• Pernicious anemia
• Vitiligo
• Alopecia areata
Signs of specific GI tumors
Small bowel
• Carcinoid
• Release of serotonin
  & bradykinin
• Hepatic metastasis
• Paroxysmal
• Telangiectasia,
  plethora….
Signs of specific GI tumors
Large bowel
• Paget
• Intense pruritis
• Glandular adnexal ca
  or regional internal ca
Signs of specific GI tumors
Glucagonoma
• APUD
• Necrolytic migratory
  erythema
    Paraneoplastic signs

Dry skin
• Eczema craquele
  malabsorption
     Paraneoplastic signs
Dermatomyositis
• Early sign
• Life saving
     Paraneoplastic signs
Acanthosis nigricans
      Paraneoplastic signs
sister Mary Joseph
   nodule
        Paraneoplastic signs
Lesser trelat
Thank you……..

				
DOCUMENT INFO
Shared By:
Categories:
Stats:
views:979
posted:4/11/2008
language:English
pages:34