(1) THE UNIVERSITY OF MICHIGAN PSYCHOLOGY 436: DRUGS OF ABUSE, BRAIN and BEHAVIOR (An introduction to the neuropsychopharmacology of drug abuse) COURSE OUTLINE, WINTER 2003 Instructor: Professor Terry E. Robinson Office: 4024 East Hall (EH) Office Hours: Tues. 10:45-11:45, or by appointment (Phone: 763-4361) Lecture: Tues. and Thurs., 4 - 5:30, 1324 EH Assistants: Susan Ferguson (firstname.lastname@example.org) and Anna Samaha (email@example.com) 4045 EH (Phone: 763-1304) Office Hours: During scheduled sessions prior to exams or by appointment Course Description This course provides a basic introduction to the neuropsychopharmacology of drug abuse and addiction, and has a strong natural science (neuroscience) orientation. Prerequisites include Psychology 330 (Introduction to Biopsychology) and an interest in biological approaches to the study of behavior. Introductory Biology and Chemistry are also recommended. The acute and long-term effects of selected drugs of abuse on behavior, mood, cognition and neuronal function are discussed, and material from studies with humans is integrated with basic studies on the neurobiological basis of drug action and drug abuse -- including detailed coverage of synaptic transmission and the distribution, regulation and integration of brain neurotransmitter systems. The focus is on addictive or illicit drugs, and all the major classes are discussed, including: opiates (heroin, morphine, opium), sedative - hypnotics (alcohol, barbituates, chloral hydrate), anxiolytics (benzodiazepines), psychomotor stimulants (amphetamine, cocaine), marijuana, hallucinogens (LSD, mescaline), hallucinogenic-stimulants (MDA, MDMA), and dissociative anaesthetics (PCP). A lecture format is used, with required readings from a text. The class is intended primarily for juniors or seniors concentrating in biopsychology, biology or the biomedical sciences (eg., pre-med). Required Text RS Feldman, JS Meyer & LF Quenzer, Principles of Neuropsychopharmacology, Sinauer, 1997. You can also access Powerpoint Presentation files at the following address: (https://coursetools.ummu.umich.edu/2003/winter/psych/436/001.nsf). This site provides the outline of each lecture and most of the illustrations used in lecture. These can be printed either showing all the images, or in outline format. It is highly recommended you do this and then use the hardcopy in lecture to take additional notes. I find that the “Print What” option for “Handouts - 3 slides per page” works best. With 1 slide per page you have way too much paper and with more than 3 slides per page there is not enough room for your notes. Exams and Grading The course grade will be based on the outcome of three multiple choice/short answer type exams. The first exam will be on Jan. 30 and will cover material presented up to that time. The first exam will be worth 30% of the final grade. The second exam will be on Mar. 18 and will cover material presented since the first exam, and through the Mar. 11 lecture on marijuana. The second exam will be worth 35% (2) of the final grade. The third exam will be on Apr. 15. The third exam also will be worth 35% of the final grade and will cover material presented since the second exam (i.e., it will not be cumulative). Grades will be based only on performance on the exams. There will be NO opportunity to re-take an exam or to write a paper to “improve” a grade (i.e., the grade is based on performance, not effort). In past years the average grade in this class has been B-. (3) LECTURE TOPICS AND SCHEDULE Introduction to Psychopharmacology Jan. 7 Principles of Pharmacology. I. Drug nomenclature & classification 9 Principles of Pharmacology. II. Pharmacokinetics 14 Principles of Pharmacology. III. Pharmacodynamics 16 Principles of Behavioral Pharmacology. Measurement of drug reward. Introduction to Synaptic Transmission 21 Synaptic transmission. I. Synapses 23 Synaptic transmission. II. Neurotransmitters 28 Synaptic transmission. III. Receptors and Signal Transduction 30 EXAM #1 (30% of final grade) The Neuropsychopharmacology of Selected Drugs of Abuse Feb. 4 Psychostimulants. I. Pharmacology of amphetamines and cocaine 6 Psychostimulants. II. Mechanism of action - Catecholamine transmitters 11 Psychostimulants. III. Mechanism of action - Catecholamine transmitters 13 Psychostimulants. IV. Amphetamine Neurotoxicity 18 Opiates. I. Pharmacology and behavioral pharmacology 20 Opiates. II. Mechanism of action - Peptide neurotransmitters 25-27 Spring break Mar. 4 Opiates. III. Mechanism of action - Endogenous opioid peptides and receptors 6 Nicotine & Acetylcholine neurotransmission 11 Mind-altering drugs. I. Marijuana 13 Sedative-hypnotics and anxiolytics. I. Alcohol 18 EXAM #2 (35% of grade; NOTE only covers material through Mar. 11) 20 Sedative-hypnotics and anxiolytics. II. Barbiturates and benzodiazepines 25 Sedative-hypnotics and anxiolytics. III. Mechanism of action - GABA neurotransmission 27 Mind-altering drugs. II. Phencyclindine & Glutamate neurotransmission Apr. 1 Mind-altering drugs. III. Hallucinogens (LSD, mescaline, etc.) 3 Mind-altering drugs. IV. Mechanism of action - Serotonin neurotransmission Theories of Addiction 8 Theories of Addiction. I. 10 Theories of Addiction. II. 15 EXAM #3 (35% of final grade) (4) (5) DETAILED READING ASSIGNMENTS (from Feldman et al.) All readings listed below are required unless listed as optional. For Exam 1 Pharmacokinetics. Chap. 1, pp. 1-12; pp. 17-20 (Inactivation & Elimination) Pharmacodynamics Chap. 1, pp. 12-17 (Drug Binding); pp. 21-25 (Tolerance & Sensitization) Optional: Chap. 2, Part I (Neurochemical Techniques) Behavioral Pharmacology. Chap. 2, Part II, pp. 57-73 (Techniques in Behavioral Pharmacology) Synapses Chap. 6, pp. 185-197 (Synapses) Optional Review: (You are expected to already know the basic material in the following sections) - Chap. 3, pp. 75-78 (Neurons); pp. 88-90 (Dendrites); pp. 90-93 (Axons); pp. 95-103 (Membranes); Chap. 4 (Basic overview of neuroanatomy). Neurotransmitters Chap. 6, pp. 197-208 (Neurochemistry of Synaptic Transmission); pp. 224-225 (Termination) Receptors and Signal Transduction Chap. 6, pp. 208-215; pp. 225-227 (Autoreceptors) Optional: pp. 215-224 (cGMP, Calmodulin, etc.) For Exam 2 Psychostimulants Chap. 13, Amphetamine, pp. 549-551 (Intro. & Basic Pharmacology); pp. 556-566 (Behavioral & Physiological Effects); Cocaine, pp. 568-570 (Basics); pp. 573-579 (Behavior & Physiology) Psychostimulants - Mechanisms Chap. 8, Part I (Catecholamines), pp. 277-301 (Basics); Part II (Dopamine), pp. 303-313; Chap. 13, pp. 552-556 (Mech. Amphetamine Action); pp. 570-573 (Mech. Cocaine Action) Optional: Chap. 8, Part III (Norepinephrine) Psychostimulants - Mechanisms Chap. 13, pp. 566-567 (Neurotoxicity); Chap. 9, pp. 358-359 (Serotonin Neurotoxins) Opiates - Pharmacology Chap. 12, Part I, pp. 495-498 (General Pharmacology) Opiates - Mechanisms Chap. 11, Peptide Neurotransmitters, pp. 455-463; Chap. 12, Part II, Opiate Receptors, pp. 498-508; Chap. 12, Part III, Endogenous Opioid Peptides, pp. 508-514; pp. 523-525 (Localization of Effects) Nicotine Chap. 14, Part I, Nicotine, pp. 591-611; Chap. 7, Acetylcholine, pp. 235-239; pp. 252-254 (Nicotinic Receptors) Psychedelics - Marijuana Chap. 17, Part I, Marijuana and the Cannabinoids, pp. 731-750. For Exam 3 Sedative-Hypnotics - Alcohol Chap. 15, Alcohol, pp. 625-634; pp. 649-650 (Withdrawal). Sedative-Hypnotics - Barbiturates & Benzodiazepines Chap. 16, Part I, pp. 673-678 (Anxiolytics); Part II, pp. 678-680 (Barbiturates); pp. 682-686 (Abuse & Dependence); Part III, pp. 686-688 (Benzodiazepines). Sedative-Hypnotics - Mechanisms Chap. 10, Part II, GABA, pp. 417-431; Chap. 15, pp. 634-637 (Neuromolecular Effects of Alcohol); Chap. 16, pp. 680-682 (Synaptic Effects of Barbiturates); pp. 689-691 (Mechanisms). Psychedelics - PCP Chap. 17, Part II, Phencyclidine, pp. 750-764; Chap. 10, Part I, Glutamate, pp. 391-405. Psychedelics - LSD Chap. 17, Part III, LSD, pp. 765-780; Chap. 9, Serotonin, pp. 345-352; pp. 361-366 (Anatomy) Theories of Addiction Chap. 12, Part IV, Opiate Dependence and Abuse, pp. 530-538; Chap. 8, Catecholamines, pp. 319-323, (Role of DA in Motivational Processes); Chap. 13, pp. 579-585 (Is There a Common Mechanism ...).
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