Drugs Courseoutline 93-mdf by katiebelonga



                                  THE UNIVERSITY OF MICHIGAN
                   (An introduction to the neuropsychopharmacology of drug abuse)

                                   COURSE OUTLINE, WINTER 2003

Instructor:       Professor Terry E. Robinson
Office:           4024 East Hall (EH)
Office Hours:     Tues. 10:45-11:45, or by appointment (Phone: 763-4361)
Lecture:          Tues. and Thurs., 4 - 5:30, 1324 EH

       Assistants:          Susan Ferguson (smfergus@umich.edu) and
                            Anna Samaha (asamaha@umich.edu)
                            4045 EH (Phone: 763-1304)
       Office Hours: During scheduled sessions prior to exams or by appointment

Course Description
This course provides a basic introduction to the neuropsychopharmacology of drug abuse and addiction,
and has a strong natural science (neuroscience) orientation. Prerequisites include Psychology 330
(Introduction to Biopsychology) and an interest in biological approaches to the study of behavior.
Introductory Biology and Chemistry are also recommended. The acute and long-term effects of selected
drugs of abuse on behavior, mood, cognition and neuronal function are discussed, and material from
studies with humans is integrated with basic studies on the neurobiological basis of drug action and drug
abuse -- including detailed coverage of synaptic transmission and the distribution, regulation and
integration of brain neurotransmitter systems. The focus is on addictive or illicit drugs, and all the major
classes are discussed, including: opiates (heroin, morphine, opium), sedative - hypnotics (alcohol,
barbituates, chloral hydrate), anxiolytics (benzodiazepines), psychomotor stimulants (amphetamine,
cocaine), marijuana, hallucinogens (LSD, mescaline), hallucinogenic-stimulants (MDA, MDMA), and
dissociative anaesthetics (PCP).

A lecture format is used, with required readings from a text. The class is intended primarily for juniors
or seniors concentrating in biopsychology, biology or the biomedical sciences (eg., pre-med).

Required Text
RS Feldman, JS Meyer & LF Quenzer, Principles of Neuropsychopharmacology, Sinauer, 1997.

You can also access Powerpoint Presentation files at the following address:
This site provides the outline of each lecture and most of the illustrations used in lecture. These can be
printed either showing all the images, or in outline format. It is highly recommended you do this and
then use the hardcopy in lecture to take additional notes. I find that the “Print What” option for
“Handouts - 3 slides per page” works best. With 1 slide per page you have way too much paper and with
more than 3 slides per page there is not enough room for your notes.

Exams and Grading
The course grade will be based on the outcome of three multiple choice/short answer type exams. The
first exam will be on Jan. 30 and will cover material presented up to that time. The first exam will be
worth 30% of the final grade. The second exam will be on Mar. 18 and will cover material presented
since the first exam, and through the Mar. 11 lecture on marijuana. The second exam will be worth 35%
of the final grade. The third exam will be on Apr. 15. The third exam also will be worth 35% of the
final grade and will cover material presented since the second exam (i.e., it will not be cumulative).
Grades will be based only on performance on the exams. There will be NO opportunity to re-take an
exam or to write a paper to “improve” a grade (i.e., the grade is based on performance, not effort). In
past years the average grade in this class has been B-.


            Introduction to Psychopharmacology
    7       Principles of Pharmacology. I. Drug nomenclature & classification
    9       Principles of Pharmacology. II. Pharmacokinetics
    14      Principles of Pharmacology. III. Pharmacodynamics
    16      Principles of Behavioral Pharmacology. Measurement of drug reward.

            Introduction to Synaptic Transmission

    21      Synaptic transmission. I. Synapses
    23      Synaptic transmission. II. Neurotransmitters
    28      Synaptic transmission. III. Receptors and Signal Transduction

    30      EXAM #1 (30% of final grade)

            The Neuropsychopharmacology of Selected Drugs of Abuse
    4       Psychostimulants. I. Pharmacology of amphetamines and cocaine
    6       Psychostimulants. II. Mechanism of action - Catecholamine transmitters
    11      Psychostimulants. III. Mechanism of action - Catecholamine transmitters
    13      Psychostimulants. IV. Amphetamine Neurotoxicity
    18      Opiates. I. Pharmacology and behavioral pharmacology
    20      Opiates. II. Mechanism of action - Peptide neurotransmitters
    25-27   Spring break
    4       Opiates. III. Mechanism of action - Endogenous opioid peptides and receptors
    6       Nicotine & Acetylcholine neurotransmission
    11      Mind-altering drugs. I. Marijuana
    13      Sedative-hypnotics and anxiolytics. I. Alcohol

    18      EXAM #2 (35% of grade; NOTE only covers material through Mar. 11)

    20      Sedative-hypnotics and anxiolytics. II. Barbiturates and benzodiazepines
    25      Sedative-hypnotics and anxiolytics. III. Mechanism of action - GABA neurotransmission
    27      Mind-altering drugs. II. Phencyclindine & Glutamate neurotransmission
    1       Mind-altering drugs. III. Hallucinogens (LSD, mescaline, etc.)
    3       Mind-altering drugs. IV. Mechanism of action - Serotonin neurotransmission

            Theories of Addiction

    8       Theories of Addiction. I.
    10      Theories of Addiction. II.

    15      EXAM #3 (35% of final grade)

All readings listed below are required unless listed as optional.
For Exam 1
        Chap. 1, pp. 1-12; pp. 17-20 (Inactivation & Elimination)
        Chap. 1, pp. 12-17 (Drug Binding); pp. 21-25 (Tolerance & Sensitization)
        Optional: Chap. 2, Part I (Neurochemical Techniques)
Behavioral Pharmacology.
        Chap. 2, Part II, pp. 57-73 (Techniques in Behavioral Pharmacology)
        Chap. 6, pp. 185-197 (Synapses)
        Optional Review: (You are expected to already know the basic material in the following sections) -
        Chap. 3, pp. 75-78 (Neurons); pp. 88-90 (Dendrites); pp. 90-93 (Axons); pp. 95-103 (Membranes);
        Chap. 4 (Basic overview of neuroanatomy).
        Chap. 6, pp. 197-208 (Neurochemistry of Synaptic Transmission); pp. 224-225 (Termination)
Receptors and Signal Transduction
        Chap. 6, pp. 208-215; pp. 225-227 (Autoreceptors)
        Optional: pp. 215-224 (cGMP, Calmodulin, etc.)

For Exam 2
         Chap. 13, Amphetamine, pp. 549-551 (Intro. & Basic Pharmacology); pp. 556-566 (Behavioral
         & Physiological Effects); Cocaine, pp. 568-570 (Basics); pp. 573-579 (Behavior & Physiology)
Psychostimulants - Mechanisms
         Chap. 8, Part I (Catecholamines), pp. 277-301 (Basics); Part II (Dopamine), pp. 303-313;
         Chap. 13, pp. 552-556 (Mech. Amphetamine Action); pp. 570-573 (Mech. Cocaine Action)
         Optional: Chap. 8, Part III (Norepinephrine)
Psychostimulants - Mechanisms
         Chap. 13, pp. 566-567 (Neurotoxicity); Chap. 9, pp. 358-359 (Serotonin Neurotoxins)
Opiates - Pharmacology
         Chap. 12, Part I, pp. 495-498 (General Pharmacology)
Opiates - Mechanisms
         Chap. 11, Peptide Neurotransmitters, pp. 455-463; Chap. 12, Part II, Opiate Receptors, pp. 498-508;
         Chap. 12, Part III, Endogenous Opioid Peptides, pp. 508-514; pp. 523-525 (Localization of Effects)
         Chap. 14, Part I, Nicotine, pp. 591-611;
         Chap. 7, Acetylcholine, pp. 235-239; pp. 252-254 (Nicotinic Receptors)
Psychedelics - Marijuana
         Chap. 17, Part I, Marijuana and the Cannabinoids, pp. 731-750.

For Exam 3
Sedative-Hypnotics - Alcohol
         Chap. 15, Alcohol, pp. 625-634; pp. 649-650 (Withdrawal).
Sedative-Hypnotics - Barbiturates & Benzodiazepines
         Chap. 16, Part I, pp. 673-678 (Anxiolytics); Part II, pp. 678-680 (Barbiturates);
         pp. 682-686 (Abuse & Dependence); Part III, pp. 686-688 (Benzodiazepines).
Sedative-Hypnotics - Mechanisms
         Chap. 10, Part II, GABA, pp. 417-431; Chap. 15, pp. 634-637 (Neuromolecular Effects of
         Alcohol); Chap. 16, pp. 680-682 (Synaptic Effects of Barbiturates); pp. 689-691 (Mechanisms).
Psychedelics - PCP
         Chap. 17, Part II, Phencyclidine, pp. 750-764; Chap. 10, Part I, Glutamate, pp. 391-405.
Psychedelics - LSD
         Chap. 17, Part III, LSD, pp. 765-780; Chap. 9, Serotonin, pp. 345-352; pp. 361-366 (Anatomy)
Theories of Addiction
         Chap. 12, Part IV, Opiate Dependence and Abuse, pp. 530-538; Chap. 8, Catecholamines, pp. 319-323,
         (Role of DA in Motivational Processes); Chap. 13, pp. 579-585 (Is There a Common Mechanism ...).

To top