BIOLOGY COURSE OUTLINE FALL MEET THE INSTRUCTORS Dr Francis

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					     BIOLOGY 401A COURSE OUTLINE                 FALL 2008


1) MEET THE INSTRUCTORS

♦ Dr. Francis Choy:

  ♦ Professor in the Department of Biology and a member of the Centre for Biomedical
    Research (CBR).

  ♦ Expertise is in molecular genetics and enzymology, specifically the metabolic and
    molecular bases of lysosomal storage diseases. Using Gaucher disease and Sanfilippo
    syndrome (which result from an inherited deficiency of glucocerebrosidase and N-
    acetyl glucosaminidase, respectively) as models, my research is focused on the
    genotype/phenotype correlation for better prognosis and diagnosis; and recombinant
    protein expression for enzyme replacement therapy.

  ♦ My Lab and Office are in Cunningham 062. You can reach me at the following
    numbers;

           Office (062a):          721-7107
           FAX:               721-7120
           E-mail:                 fchoy@uvic.ca


♦ Dr. Johan de Boer:

  ♦ Professor in the Department of Biology and a member of the Centre for Biomedical
    Research (CBR).

  ♦ Boer’s research relates to the initiation and prevention of cancer by nutrition. He uses
    rodent models to study the genotoxicity of dietary and environmental carcinogens and
    how nutritional compounds can modulate the mutagenicity and alter gene expression.
     Bacterial and mammalian cell culture systems do not properly mimic an animal with
    its many different tissues and complicated metabolic systems, thus strains of transgenic
    mice have been developed and are used for the evaluation of mutagenicity of chemical
    compounds, the effect of ageing on mutation, and the study of mutation in tumours.

  ♦ Lab and Office are in Petch 041B. You can reach Dr. de Boer at the following number:
          Office:                  472-4079
          FAX:               472-4075
          E-mail:                  wjdboer@uvic.ca

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Guest Lecturer:
Dr. Patrick MacLeod, Director, Medical Genetics, Victoria General Hospital.
E-mail. patrick.macleod@viha.ca


2) WHAT IS THIS COURSE ABOUT?

 This course is designed to give you an understanding of the application of genetic and
molecular biological principles to research and industry; it is about the “Tools and Rules” of
Biotechnology.


3) WHERE AND WHEN

♦ Tuesday, Wednesday, and Friday, 9:30 pm to 10:20 am, ECS Room 124


4) STRUCTURE AND ORGANIZATION OF THE COURSE

♦ The course will be given by Drs. Francis Choy, Johan DeBoer, and guest lecturer Dr.
  Patrick MacLeod

♦ There is No Textbook for this course, but all lectures, the Problem Sets, and the answers
  to the Problem Sets can be downloaded from the Biol 401A Blackboard site at:
  http://blackboard.uvic.ca/webct/entryPageIns.dowebct


5) THE GRADING SYSTEM

      2 Mid-term exams           30% each X 2 = 60%
      1 Final Exam                    40%
                                100%

5.1) Mid-Term Exams

♦ The two mid-term exams will be held on

   September 30- Lectures presented September 03 to September 26
   November 4 - Lectures presented October 1 to 31

♦ The 2nd mid-term is NOT accumulative, i.e. you are responsible for all lecture materials
  covered in the n2d section


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5.2) The Final Exam

♦ The final exam will be cumulative and cover all topics presented in the course. The format
  will be announced late in the semester.


6)      THE GRADING SYSTEM

     Final Grades will be assigned on the basis of the following scale:

     A+        A         A-        B+        B          B-       C+         C       D       F
90-        85-       80-       75-        70-         65-     60-         55-     50-     0-
100%       89.9%     84.9%     79.9%      74.9%       69.9%   64.9%       59.9%   54.9%   49.9%

     Although these minimum standards will not be raised, the instructors reserve the right to
     lower this scale at their discretion. An “E” grade will not be assigned and Supplemental
     Exams will not be allowed.




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BIOLOGY 401A               TENTATIVE LECTURE SCHEDULE                    FALL 2007
Wednesday   September 03       Introduction and DNA Enzymes I                   Dr. Choy
Friday      September 05       DNA Enzymes II                                   Dr. Choy
Tuesday     September 9        Biotechniques I                                  Dr. Choy
Wednesday   September 10       Biotechniques II                                 Dr. Choy
Friday      September 12       DNA Enzymes III                                  Dr. Choy
Tuesday     September 16       DNA Enzymes IV                                   Dr. Choy
Wednesday   September 17       Protein Expression System I                      Dr. Choy
Friday      September 19       Protein Expression Systems II                    Dr. Choy
Tuesday     September 23       Protein Expression Systems III                   Dr. Choy
Wednesday   September 24       Transgenic Animal Models in Research I           Dr. Choy
Friday      September 26       Review and catch-up                              Dr. Choy

Tuesday     September 30       - FIRST MID-TERM TEST

Wednesday   October 1          Transgenic Animal Models in Research II            Dr. Choy
Friday      October 3          Transgenic Animal Models in Research III           Dr. Choy
Tuesday     October 7          Current (& cool) techniques in Genome Analysis I Dr. Choy
Wednesday   October 8          Current (& cool) techniques in Genome Analysis II Dr. Choy
Friday      October 10         Current (& cool) techniques in Genome Analysis III Dr. Choy
Tuesday     October 14         Bioethics                                          Dr. Choy
Wednesday   October 15         Guest Lecture on Rett syndrome                     Dr. MacLeod
Friday      October 17         Cloning systems I                                  Dr. de Boer
Tuesday     October 21         Cloning systems II                                 Dr. de Boer
Wednesday   October 22         Cloning systems III                                Dr. de Boer
Friday      October 24         Cloning strategies I                               Dr. de Boer
Tuesday     October 28         Cloning strategies II                              Dr. de Boer
Wednesday   October 29         Cloning strategies III                             Dr. de Boer
Friday      October 31         Stem cell technology and review                    Dr. de Boer

Tuesday     November 4     - SECOND MID-TERM TEST

Wednesday   November 5         Genetically Modified Organisms                   Dr. de Boer
Friday      November 7         Forensics                                        Dr. de Boer
Tuesday     November 11        NO CLASS: Reading break
Wednesday   November 12        NO CLASS: Reading break
Friday      November 14        Bioinformatics I                                 Dr. de Boer
Tuesday     November 18        Bioinformatics II                                Dr. de Boer
Wednesday   November 19        Genomics and proteomics                          Dr. de Boer
Friday      November 21        Genome projects                                  Dr. de Boer
Tuesday     November 25        PCR applications                                 Dr. de Boer
Wednesday   November 26        Big Blue system                                  Dr. de Boer
Friday      November 28        History of biotechnology                         Dr. de Boer

Tuesday     December 2         Review and catch-up




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