Longeve T Ginkgo Ext

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					               Longeve-T
         For Long Lasting Beauty

                                                  With increased age we commonly have a decrease in general
                                                  sense of health and wellbeing, including decreases in strength,
                                                  flexibility, mobility and collagen formation. Common symptoms
                                                  of ageing include a decrease in antioxidant defence, anti-
                                                  inflammatory mechanisms, cognitive function, visual acuity, bone
                                                  mineral density, general immune function and skin integrity. This
                                                  highlights the need for nutraceutical support which can help to
                                                  reduce the symptoms of ageing.

                                                 •	 Possesses antioxidant properties
                                                 •	 May help support healthy ageing
                                                 •	 May assist healthy visual acuity
                                                 •	 May promote healthy cognitive function
      Pack Size: 60 tablets
 Recommended Dose: 2 tablets daily               •	 May help support healthy immune function
                                                 •	 May help support healthy bone and cartilage
                                                    formation and maintenance

Formulation
 Ascorbic acid                       125mg     Calcium pantothenate                   25mg   Curcuma longa rhizome
 Vitamin C (as calcium ascorbate)   33.08mg    Iodine (as potassium iodide)        37.5mcg   ext. dry conc.                       50mg
                                                                                              equiv. turmeric rhizome dry            1g
 d-alpha tocopherol succinate           50IU   Zinc (as citrate)                     7.5mg    equiv. curcumin                     20mg
 Vitamin D3 (as cholecalciferol)       500IU   Selenium (as selenomethionine)      37.5mcg   Vitis vinifera ext. dry conc.        20mg
                                                                                              equiv. grapeseed dry                 2.4g
 Vitamin K1                         42.5mcg    Manganese (as amino acid chelate)       1mg    equiv. procyanidins                 18mg
 Thiamine HCl                           5mg    Chromium (as picolinate)            12.5mcg   Bacopa monnieri ext. dry conc.       40mg
 Riboflavin                           2.5mg    Boron (as borax)                    500mcg     equiv. brahmi plant dry            800mg
                                                                                              equiv. bacosides as bacoside A      18mg
 Riboflavin 5-phosphate                 5mg    Choline (as bitartrate)                50mg
                                                                                             Polygonum cuspidatum
 Nicotinic acid                         5mg    Inositol                             60.5mg   ext. dry conc.                       25mg
 Nicotinamide                        17.5mg    alpha lipoic acid                      20mg    equiv. polygonum cuspidatum root     2.5g
                                                                                              equiv. resveratrol                   5mg
 Pyridoxine HCl                         5mg    Betacarotene                            2mg
                                                                                             Pomegranate ext. dry conc.           25mg
 Pyridoxal 5-phosphate                  5mg    Lutein                                  2mg    equiv. pomegranate seed dry         1.25g
 Calcium folinate                   100mcg     Ginkgo biloba ext. dry conc.           40mg    equiv. ellagic acid                 10mg
 Cyanocobalamin                     100mcg       equiv. ginkgo biloba leaf dry          2g
                                                 equiv. ginkgoflavonglycosides       4.8mg
 Biotin                                 1mg      equiv. ginkgolides & bilobalide     1.2mg




                                               Practitioner Support
www.bioconcepts.com.au                         1800 077 113                                         www.orthoplex.com.au
  Longeve-T Technical Information
Antioxidants                                            neurological diseases, diabetes, and autoimmune          Bone Density
                                                        diseases exhibit dysregulation of multiple cell
Antioxidants protect the body’s cells and help to       signaling pathways that have been linked to              Vitamin D, boron and vitamin K are all essential for
prevent free radical damage. Several studies have       inflammation.                                            maintaining bone mineral density. A protective role
indicated potential roles for dietary antioxidants                                                               for vitamin K in bone health has been suggested
in the reduction of degenerative diseases such          Resveratrol has been shown to bind to numerous           based on its role as an enzymatic cofactor. Vitamin
as vascular dementia, cardiovascular disease,           cell-signalling molecules such as multi drug             K insufficiency is generally associated with lower
neurodegenerative conditions and cancer.                resistance protein, topoisomerase II, aromatase,         bone mass and increased hip fracture risk.
                                                        DNA polymerase, estrogen receptors, tubulin and
Studies indicate that the antioxidant properties of     F1-ATPase. Resveratrol has also been shown to            Vitamin D3, is a secosteroid hormone that
vitamin E and polyphenols present in green tea may      activate various transcription factor (e.g; NFkappaB),   regulates calcium and bone metabolism, controls
contribute to reducing the risk of cardiovascular       suppress the expression of antiapoptotic gene            cell proliferation and differentiation and exerts
disease by reducing oxidation of low density            products, inhibit protein kinases, induce antioxidant    immunoregulatory activities.
lipoproteins, vascular endothelial cell expression of   enzymes, suppress the expression of inflammatory
pro-inflammatory cytokines, and the expression of                                                                Immune Function
                                                        biomarkers, inhibit the expression of angiogenic
adhesion molecules and monocyte adhesion.               and metastatic gene products, and modulate cell          Several epidemiological and clinical studies have
Resveratrol has been shown to reduce whole-             cycle regulatory genes. (6)                              revealed potential roles for dietary antioxidants in
body oxidative stress levels.(1) Resveratrol inhibits                                                            the age-associated decline of immune function.
                                                        Curcumin may be beneficial in a number of pro-
apoptotic cell death,(2) which may assist in                                                                     Long-term supplementation with vitamin E
                                                        inflammatory conditions due to its potent inhibitory
protection against cardiovascular events such                                                                    enhances immune function in aged animals and
                                                        effect on certain inflammatory mediators, such as
as atherosclerosis and myocardial ischaemic                                                                      elderly subjects.
                                                        NF-kappaB (NFκB), tumour necrosis factor-alpha
reperfusion injury. (3)                                 (TNF-α), Interlukin-1β and Interlukin-6.(7) Curcumin     Vitamin E reverses an age-associated defect in
Pomegranate extracts have been shown to                 also reduces cyclooxygenase (COX-2) expression,          T cells, particularly naïve T cells. This effect of
scavenge free radicals and decrease macrophage          down regulating prostaglandin E2 production.             vitamin E is also reflected in a reduced rate of
oxidative stress and lipid peroxidation in animals;                                                              upper respiratory tract infection in the elderly
and increase plasma antioxidant capacity in elderly     Cognitive Function                                       and enhanced clearance of influenza infection in a
humans. (4)                                             Ginkgo biloba has extensive protective effects on        rodent model.

Curcumin has been identified as a potent superoxide     the central nervous and cerebrovascular systems. As      Curcumin has been shown to exhibit antioxidant,
scavenger through mechanisms including                  a neuroprotective agent it eliminates free radicals,     anti-inflammatory, antiviral, antibacterial, and
modulation of glutathione levels and the inhibition     acts as an antioxidant and a free-radical scavenger,     antifungal activities and thus offer immune support
of inflammatory mediators. (5)                          reduces lipid peroxidation, and is a membrane            against chronic illnesses associated with ageing. (11
                                                        stabilizer and an inhibitor of platelet-activating
Vitamins C, E and beta-carotene all have antioxidant    factor via the terpene ginkgolide. The anti-             Skin Ageing
actions. Vitamin E is a naturally occurring             ischaemic neuroprotective effects of ginkgo have         One of the most visual effects of ageing is the
antioxidant and specifically protects unsaturated       been proven in cerebral and spinal cord ischaemic        loss of skin integrity and decrease in collagen
fatty acids from oxidative damage. Beta-Carotene,       models in animals. (8)                                   formation. Skin ageing is influenced by different
the precursor of vitamin A, scavenges singlet
                                                        Studies into the cognitive effects of Bacopa             factors including genetics and environmental
oxygen and decreases lipid peroxidation. Vitamin
                                                        monniera have found that this herb may improve           irritants such as UV-light exposure (photoageing).
C is a water soluble electron donor antioxidant
                                                        higher order cognitive processes that are critically     Appearance of wrinkles and loss of elasticity and
essential for recycling glutathione.
                                                        dependent on the input of information from our           firmness of the skin are among the main signs of
Many studies have shown that vitamin E, Lipoic acid     environment such as learning and memory. (9)             skin ageing. Such changes are mainly due to an
and the Glutathione peroxidase enzyme system act                                                                 abnormal accumulation of reactive oxygen species.
synergistically to protect the cell membrane.           Folic acid supplementation for 3 years has also been     (12)
                                                                                                                      A placebo controlled study has shown oral
                                                        shown to significantly improve domains of cognitive
Selenium is an essential component of the                                                                        supplementation of antioxidants (including vitamin
                                                        function that tend to decline with age. (10)
intracellular antioxidant system that defends the                                                                E, lutein, selenium and carotenoids) to increase skin
cell and the whole organism against oxidative           Visual Acuity                                            density and thickness and decrease roughness and
damage.                                                                                                          scaling. (13)
                                                        Visual acuity typically declines with age. Oxidative
                                                        damage contributes to this decline. Antioxidants such    References available upon request.
Inflammation
                                                        as lutein, alpha lipoic acid and ginkgo have all been
Extensive research within the last decade has           found to have positive effects in maintaining visual
revealed that most chronic illnesses such as            acuity and delaying the onset of optical conditions.
cancer, cardiovascular and pulmonary diseases,


                    Orthoplex Pty Ltd.                                                                             PO Box 1492 EAGLE FARM QLD 4009
  ABN 86 010 516 775 ACN 010 516 775                                                                               Phone +61 (0)7 3868 0699
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