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					22 t u f t s m e d i c i n e w i n t e r 2 0 1 0
                                                                                       Where do our memories come from?
                                                                         Where do they go? This young neuroscientist
                                                                         is examining brain molecules for the answers




the nest of memory
b y j ac q u e l i n e m i t c h e l l i l l u s t r at i o n b y j o s e p h da n i e l f i e d l e r


your school song; your mother’s perfume;         brain surgery to relieve his severe epilepsy.     Every time Brenda Milner, a cognitive neu-
that sweatshirt you wore in college. These          The procedure, in one sense, was a suc-        roscientist who worked with H.M. for years
things can all evoke powerful memories.          cess. Removing sections of H.M.’s left and        after his surgery, entered his room at the
Like photographs, memories are the archives      right medial temporal lobes put an end to         Connecticut long-term care facility where
of all our experiences. But also like photo-     his seizures. But after the surgery, H.M., who    H.M. lived until his death, she had to rein-
graphs, memories can fade over time. Despite     died in 2008 at the age of 82, never formed       troduce herself to him, despite the fact that
decades of research, how the brain stores        another new memory—striking evidence              they had met dozens of times.
memories and then retrieves and discards         that the medial temporal lobes are one place          What H.M. hadn’t lost, however, was
them remains something of a scientific mys-      the brain warehouses experiences. “His            his ability to acquire new skills, called pro-
tery. Leon Reijmers, an assistant professor of   memory was frozen in time,” Reijmers says         cedural or motor memories. In a series of
neuroscience at the medical school, is work-     of H.M., who psychologists and neurologists       memory tests, Milner asked H.M. to sketch
ing to make sense of it all.                     studied extensively for five decades. “That       complex geometric figures while watching
   He is building on work that goes back         was the first time researchers got a clue about   his hand move across the paper in a mirror—
nearly six decades, to the amazing case of       where memories are stored in the brain.”          a task even normal adults have trouble mas-
Henry Gustav Molaison.                              H.M.’s plight also provided evidence           tering. With practice, H.M. became better
   Nineteen hundred a nd f if t y-t hree         that there are several categories of mem-         and better at it, although he had no memory
was the last year Molaison remembered,           ory that reside in different regions of the       of doing it previously. “At one point he said to
although he lived for 55 more. In 1953,          brain. H.M. had lost his capacity for what        me, after many of these trials, ‘Huh, this was
the 27-year-old Connecticut native, who          scientists would come to call episodic            easier than I thought it would be,’ ” Milner
would go down in medical history simply as       memory—memories of events, like meet-             told the New York Times in 2008. H.M.’s abil-
“H.M.,” underwent radical, experimental          ing new people or having a conversation.          ity to complete the tasks suggested that these


                                                                                                             w i nt e r 2 010 tufts medicine 23
procedural memories were stored in the             impairment, researchers have discovered           Making M eMories
undamaged regions of his brain.                    that some regions of the brain are associ-        At Tufts, Reijmers is building on the tech-
    In the aftermath of H.M.’s surgery, neu-       ated with certain kinds of memories. For          niques first described in the Science paper
rologists spent much of the 20th century           example, the amygdala, an almond-shaped           to investigate what exactly goes on in a
creating lesions in localized sections of ani-     structure, is known to process emotions           neuron when it’s storing common human
mal brains, and then trying to figure out          and store memories associated with strong         memories, such as making a new acquain-
what abilities were impaired by that dam-          emotions, like fear.                              tance or a enduring a harrowing cab ride
age. For the past 15 years or so, says Reijmers,      But Reijmers wanted to zoom in even            to the airport. The current model for mem-
researchers have used fMRI machines to             closer on how, exact ly, memories are             ory formation says that the connections
watch what happens in healthy, intact human        formed. To do that, Reijmers, then at the         among neurons—called synapses—get
brains during a variety of tasks, including
memorization.
    A new member of Tufts’ up-and-coming               “Once we identify a set of neurons
neuroscience department, Reijmers has pio-
neered the development of genetic tools that       that store specific memories,
allow him to pinpoint the location of memo-
ries in the brain down to specific neurons.
                                                         we want to manipulate them—
His groundbreaking work recently earned             make them fire or make them keep quiet”
him a prestigious $1.5 million, five-year
grant from the National Institutes of Health.             and see what happens. — L e on R e i j m e r s
The NIH Director’s New Innovator Awards,
offered to just 55 scientists this year, are
intended to spur novel research with poten-        Scripps Research Institute in La Jolla, Calif.,   stronger with experience; that is, the neu-
tial wide impact as well as support creative,      and his colleagues built a better mouse,          rons become more efficient at transmitting
young scientists.                                  known as the TetTag mouse, which allows           information. But scientists don’t yet know
    “What we want to do is go beyond descrip-      researchers to see the very neurons involved      by what means synapses become stronger.
tive studies,” says Reijmers, who works with       in memory formation.                                 Neuroscientists suspect synapses gain
colleague Lax Iyer, an expert in computa-              As he described in an August 2007 arti-       strength in one of several ways, Reijmers
tional biology, and biochemist Larry Feig          cle in the journal Science, Reijmers created      says. Neurons—composed of a cell body
[see story, page 26], among others. “Once we       the TetTag mouse by splicing a so-called          w ith arm-like ex tensions ca lled den-
identify a set of neurons that store specific      reporter gene into the mouse’s DNA. When          drites—could increase the number of con-
memories, we want to manipulate them—              the TetTag mouse’s neurons fire during the        nections, or synapses, among each other
make them fire or make them keep quiet”            process of storing or retrieving a memory,        by growing more dendrites. Or, neurons
and see what happens, Reijmers says. In addi-      that reporter gene expresses a protein that       could increase production of neurotrans-
tion to revealing the basic mechanisms of          scientists can easily detect and image.           mitting chemicals. Or, they might sprout
memory, the research could pave the way for        The resulting picture is, in fact, a map of       more receptors for those neurotransmit-
new therapies for memory disorders such as         the mouse’s brain that literally highlights       ters. Whichever process is at play here, it
Alzheimer’s disease or post-traumatic stress       which neurons are involved in memory              requires protein growth. “Over time,” says
disorder.                                          formation.                                        Reijmers, “if we can see which proteins
    “This is really the leading edge of neuro-         Reijmers used classical conditioning to       are synthesized, we can figure out how the
science,” says Philip Haydon, the Annetta          provide his TetTag mice with memories.            brain makes new memories.”
and Gustav Grisard Professor and chair             Through mild shocks to the paws, the spe-            Proteins, the building blocks of the cell,
of the department of neuroscience at the           cially engineered mice quickly learned to         are the main ingredients in almost every-
medical school. “He is able to focus on the        fear being placed in a certain box, an emo-       thing in the body. Our genes tell our cells
very specific molecules used in the process        tion they display by freezing like statues.       what proteins to make and whether those
of memory formation. I don’t know of any-          In the 2007 proof-of-concept experiment,          proteins become structures, like skin and
one else working on this.”                         Reijmers was able to show that neurons in         hair, or chemicals like the neurotrans-
                                                   the TetTag mouse’s amygdala were indeed           mitters serotonin and dopamine. Now
a b e t ter Mouse Model                            the ones implicated in storing this spe-          that Reijmers’ team knows which neu-
To study how the brain stores memories,            cific fear memory. Moreover, the number           rons to look at, the investigators can find
scientists first must figure out where the         of neurons involved matched up to the             out which genes they express and, in turn,
brain—among its hundred billion cells—             strength of the memory, as indicated by the       which proteins they are synthesizing dur-
stores memories. In the half-century since         mouse’s freezing behavior.                        ing memory storage. That data will reveal
H.M.’s surgery and subsequent memory                                                                 whether the neurons are producing more


24 t u f t s m e d i c i n e w i n t e r 2 0 1 0
                                                                                                    ways to reduce the fear behavior, research
                                                                                                    that could be invaluable to people suffering
                                                                                                    from post-traumatic stress disorder. At its
                                                                                                    essence, PTSD is not a mental illness but a
                                                                                                    memory disorder that affects about five mil-
                                                                                                    lion Americans every year.
                                                                                                        Reijmers’ work in this area could also play
                                                                                                    a crucial role in developing new therapies for
                                                                                                    memory-loss disorders such as Alzheimer’s
                                                                                                    disease, the most common cause of demen-
                                                                                                    tia. Once he and his colleagues isolate the
                                                                                                    proteins involved in memory storage, they
                                                                                                    may be able to determine which proteins are
                                                                                                    implicated in memory loss. Those proteins,
                                                                                                    in turn, could be promising targets for new
                                                                                                    treatments to stave off cognitive decline in
                                                                                                    Alzheimer’s patients.
                                                                                                        Researchers have already implicated
                                                                                                    a toxic protein called amyloid beta in
                                                                                                    Alzheimer’s disease. The protein is the main
                                                                                                    component of the plaques that eventually
                                                                                                    destroy the brains of Alzheimer’s patients
                                                                                                    and cause memory impairment. But it’s not
                                                                                                    known how the protein damages the brain,
                                                                                                    says Reijmers, who has received a two-year
                                                                                                    grant from the Alzheimer’s Association to
                                                                                                    use the TetTag mouse to find out. “We’ll
                                                                                                    inject the protein into the mouse and watch
                                                                                                    what happens,” says Reijmers. “If we can see
                                                                                                    how amyloid beta impairs memory, then we
                                                                                                    can think about ways to counter the effect,
                                                                                                    even restore memory capacity.”
neurotransmitters, building more recep-            erased from the brain or just suppressed?”           “It’s really an exciting project. We now
tors or creating more synapses, or some               Images from the TetTag mouse brain            know that the physiological mechanism of
combination of the three.                          should reveal all. If the fear-memory neurons    memory [formation and loss] can be altered,”
                                                   are active, and the mouse does not freeze,       says Giuseppina Tesco, who was appointed
er asing th e past                                 that would indicate some kind of memory          an assistant professor of neuroscience and a
What’s happening, exactly, when you can’t put      suppression. On the other hand, if placing       clinical faculty member at the medical school
a name to a face, when no amount of prompt-        the mouse in the box ceases to activate the      last May. Tesco and Reijmers met at a neuro-
ing reminds you of your computer password,         neurons involved in storing the fear mem-        science conference and talked about collabo-
or when you find your car keys in the freezer?     ory, that would indicate that the memory has     rating before either of them came to Tufts.
What’s going on inside neurons when memo-          been deleted entirely from the brain.            Now Tesco runs Tufts’ Alzheimer’s Disease
ries fade? Reijmers will pursue a second line of      In a separate series of experiments,          Research Laboratory, where she and her col-
research using the TetTag mouse model and          Reijmers’ team will train the lab mice to fear   leagues are studying the molecular chain
fear conditioning to find out.                     a specific musical tone while isolating the      reactions that produce the toxic amyloid beta
    Once the mice have learned to fear the         neurons associated with that lesson. “What       protein in the brain—a process that depends
shock-box, Reijmers’ team—including one            happens when we activate those neurons in        on two specific enzymes.
postdoc who started work in Reijmers’ lab          the absence of the tone? Will the mouse feel         If Tesco and her colleagues can tinker with
last summer and one who will arrive this           fear without the stimulus?” Reijmers asks.       genetics and brain chemistry in such a way
winter—will keep placing them in the box,          “Or what happens when you play the note,         that inhibits one or both of those enzymes,
but stop administering a shock. “Eventually,       but keep the neurons from firing? Will the       they should be able to block the production
they’ll lose the fear and stop the freezing        mouse act afraid or not?”                        of the poisonous amyloid beta. That, in turn,
behavior,” says Reijmers. “But what is the            Depending on what the data indicate, the      could ultimately yield a treatment or even a
neuronal mechanism at play? Are memories           second phase of the study will try different     cure for Alzheimer’s. tm


                                                                                                              w i nt e r 2 010 tufts medicine 25
on campus                                   medical school news




            Rosenblatt steps down;
            beRman named inteRim dean                                                         A New Twist
                                                                                              on Heredity
         I
              n late december, dean michael                                 to lead this
               rosenblatt announced that he                                 remarkable
               would be stepping down to be-                                school, one
               come executive vice president                                of the ‘jewels’   Educated mice prove that nurture can
            and chief medical officer at the                                of american       shape nature by Herb Brody
            pharmaceutical giant merck & co.                                medicine.”




                                                                                              T
                rosenblatt has been dean of                                 but, he also
            tufts School of medicine for six          Harris Berman         noted, “the                        he popular understanding of genetics
            years, significantly longer than          nature of this [new] opportunity                         boils down to the defining power of
            the average tenure of a medical           and its timing seems right.”                             DNA. Mom’s and Dad’s genes are passed
            school dean. “the school is in a              berman, the school’s in-                             along to their children, and the DNA
            strong position thanks to his lead-       terim dean, received a b.a. from        instructions within those genes mean the children are
            ership,” tufts President lawrence         harvard college, his medical de-        either blessed or cursed with particular characteristics.
            S. bacow and Jamshed bharucha,            gree from columbia University’s         It has long been known that people differ from each
            provost and senior vice president,        college of Physicians and               other, for the most part, because the content of the four
                                    said in a joint   Surgeons, and did most of his           building blocks of DNA that make up genes differs
                                    statement in      postgraduate training, including a      slightly from one individual to another. These differ-
                                    which they        fellowship in infectious disease,       ences are acquired from one’s parents, who acquired
                                    announced         at tufts-new england medical            them from their parents. But recent findings shine a
                                    that Vice         center (now tufts medical               light on another side of the inheritance process.
                                    dean harris       center). he also served for 17              Larry Feig, a professor of biochemistry at the medi-
                                    berman            years as ceO of tufts health            cal school and a member of the biochemistry and neu-
            Michael Rosenblatt would lead             Plan. in 2003, he was appointed         roscience programs at the Sackler School of Graduate
            the school as interim dean.               dean of public health and profes-       Biomedical Sciences, has discovered that young mice
                rosenblatt’s “accomplish-             sional degree programs at tufts         that frolic in a cage filled with stimulating objects
            ments are many, and we are                medical School. last year he was        not only get smarter—they also pass at least part of
            proud to have had him in the              named vice dean for academic            their increased brain power on to their offspring. The
            administration,” bacow and                and clinical affairs, as well as a      research supports a growing body of evidence that an
            bharucha said in their statement.         professor of public health and          organism’s traits can be acquired not only through dif-
            “during his deanship, he has              community medicine.                     ferences in DNA that have been passed on for many
            worked to recruit outstanding                 “dr. berman is an accom-            generations, but also by biochemical alterations that
            faculty, forge closer ties with our       plished medical leader, and             occur in response to a parent’s environment.
            clinical affiliates, improve the          we are delighted that he has                Unearthing new forms of inheritance was not Feig’s
            facilities for faculty research and       accepted this new challenge,”           original goal. He and his team had set out to investigate
            student life and learning, and            said bacow and bharucha in              the biochemical machinations that lead to cancer. They
            advance diversity.”                       their statement. “With the help         knew that when a certain gene continually produced
                in a farewell letter to the           of the deans, faculty and staff,        growth-promoting proteins, tumors would result. To
            medical school community,                 we expect this to be a smooth           gain insight into how that gene operates, they created
            rosenblatt wrote, “the decision           transition for tufts School of          some mice lacking the gene—knockout mice, as they are
            to leave tufts has not been easy          medicine.”                              known. Such mice had weak memories. The research-
            for me because of the wonderful                                                   ers wondered if stimulation would help the mice over-
            students, faculty and staff . . .                                                 come their neurological deficit. So they took 15-day-old
            it will always be one of the great                                                females (early adolescents, by mouse standards) out of
            honors and satisfactions of my                                                    their no-frills lab cage and gave them a two-week holiday
            life to have had the opportunity                                                  in a rodent wonderland full of toys, running wheels and


26 t u f t s m e d i c i n e w i n t e r 2 0 1 0                                                                          PhOtOS: JOdi hiltOn (leFt), melOdy kO
nesting materials. These indulged mice showed mark-
edly improved memory, just as Feig had hoped.
    The surprise came several weeks after the mice were
returned to their standard, spartan living conditions.
When they and their less-favored counterparts became
pregnant and gave birth, babies born to mothers who
had enjoyed the enriched environment possessed a dis-
tinct mental advantage, even though their genetic profile
said they shouldn’t. “When my postdoc first told me the
result, I said, ‘Get out of here!’ I didn’t believe it,” Feig
recalls. It was as though his colleague had claimed that a
girl who learns German in high school will give birth to
children who have a propensity for German.
    The type of mental test investigated is known as fear
conditioning. If a mouse is given a mild electric shock in
its cage, the memory of that experience will often cause
it to freeze when it is returned to its cage. Ordinary mice
typically exhibit this freeze behavior for about a week.
Knockout mice, with their weaker memories, lose the
response more quickly. But sure enough, adolescent
knockout mice that spent time in an enriched environ-
ment showed almost the normal duration of fear con-
ditioning—and so did their offspring. “He got a huge               It’s not entirely clear how the process works. Feig     DNA doesn’t
effect, and showed that it was transmitted to the next gen-     conjectures that the enriched environment triggers a       have to be the
                                                                                                                           last word in
eration,” says Klaus Miczek, the Moses Hunt Professor           hormonal change. Even though the mice are missing          inheritance,
of Psychology at Tufts, who consulted with Feig’s group.        the gene that normally aids learning and memory, this      says Larry Feig.
“It’s quite stunning—your jaw drops when you see it.”           hormonal change may turn on another gene that then
    The results, taken as a whole, are the first to “dem-       pumps out memory-boosting proteins.
onstrate that the benefits of an early enriched environ-           When the mouse is returned to its humdrum labo-
ment on memory can be passed along without a direct             ratory cage, its body keeps churning out the proteins,
nurturing effect,” notes Tania Roth, a neurobiologist at        because the hormone responsible remains in its blood-
the University of Alabama at Birmingham
who has done related research.
    The work of Feig’s team adds to knowl-            W
                                                    “ henmypostdocfirsttoldmetheresult,
edge of a broader concept called epi-
                                                      Isaid,‘Getoutofhere!’Ididn’tbelieveit.”         
genetics—the idea that the amount of a
particular protein a gene produces can be           — L a r ry Fe ig
altered for the lifetime of an animal, and          
even in their future offspring. Epigenetics may explain,         stream. If the mouse gets pregnant long after its happy
for example, why children with identical genetic anoma-         holiday, the hormone could be passed along to the fetus,
lies sometimes have entirely different diseases. In one of      whose genes it affects in the same way.
the best understood examples of epigenetic inheritance,            Are there implications for human inheritance? Roth,
McGill University researchers showed that rats whose            the Alabama researcher, thinks it “very likely” that the
mothers had an unusually high tendency to lick and              epigenetic effect Feig has found exists in humans or
groom their young grew up to be “high touch” moth-              other primates. Szyf, of McGill, concurs, remarking
ers themselves. “Even though the external signal”—the           that Feig has uncovered “a very basic thing—and basic
stimulating environment—“is gone, the impact on gene            things are common.” Feig himself, though, is more con-
expression is still there,” explains Moshe Szyf, a McGill       servative, cautioning that the effect could prove to be
pharmacology professor and epigenetics specialist.              “unique to mice.”


PhOtO: JOhn SOareS                                                                                             w i nt e r 2 010 tufts medicine 27
    on campus



   Thirty-five Years and Counting
   in late november, representatives from baystate medical                       Dean Michael Rosenblatt told attendees that year after year,
   Center and Tufts Medical School gathered in Springfield, Mass.,            Tufts medical students rank Baystate first out of all the Tufts
   to celebrate the 35-year alliance of the two institutions. With a          teaching hospitals.
   formal affiliation dating back to 1974, Baystate was named the                Robert Emery, ’73, a graduate of the first Tufts class at Baystate
   western campus of the medical school in 1988, and now serves as            and now a cardiothoracic surgeon in Minneapolis, traveled from
   its largest teaching site.                                                 Minnesota for the occasion. He shared reflections of his days at
                                                                                         Baystate as well as fond memories of time spent at the
                                                                                         hospital with his father, Robert Emery, ’46, a general
                                                                                         surgeon who served on staff at Springfield Hospital,
                                                                                         the precursor to Baystate Medical Center.
                                                                                            The day’s celebration was hosted by Mark Tolosky,
                                                                                         president and CEO of Baystate Health, and Lawrence
                                                                                         S. Bacow, president of Tufts University. Other partici-
                                                                                         pants included U.S. Rep. Richard Neal, D-Springfield,
                                                                                         Mayor Domenic Sarno and Dr. Hal Jenson, dean of
                                                                                         the western campus of Tufts School of Medicine. Dr.
                                                                                         Ethel Weinberg was also recognized for her role as
                                                                                         Baystate’s first academic leader.


                                                                                           Baystate Health Trustee Howard Trietsch, left;
                                                                                           Mark R. Tolosky, president and CEO of Baystate
                                                                                           Health; Tufts President Lawrence S. Bacow; and
                                                                                           U.S. Congressman Richard E. Neal, D-Springfield.




        Meet the Class of 2013
        WHO THEY ARE                               TOP FEEDER SCHOOLS                         WheRe theY CaMe fRoM
        completed                                  tufts                 33
        applications            7,361              boston college        10
        Offered admission               555        brown                  7                              california
        enrolled                        200                                                                14%
                                                   cornell                7
                                                   bowdoin                6           new york
        GENDER                                     harvard                6               11%
        male                           113         Uc berkeley            6                                                       new england

                                                                                                                                  45%
                                                                                 new Jersey
        Female                            87       University of maine    5
                                                                                     5%
                                                   brandeis               5
        PROGRAM ENROLLMENT                         colby                  5
        m.d.                        168                                                          Other
                                                                                                 25%
        m.d./m.P.h.                       17
        m.d./m.b.a.                      10
        m.d./Ph.d.                         3
        m.d./m.S.e.                        2




28 t u f t s m e d i c i n e w i n t e r 2 0 1 0                                                                  PhOtO: dOn treeger OF the rePUblican neWSPaPer
                                                                                                wHITe CoAT
                                                                                                CeremoNY
                                                                                                Students in the Class of 2013 celebrate
                                                                                                the beginning of their medical training at
                                                                                                the White Coat Ceremony, which took place
                                                                                                on October 3, 2009, at the Cutler Majestic
                                                                                                Theatre. In addition to receiving their white
                                                                                                coats, the students stood together to recite
                                                                                                the modern Hippocratic Oath. This year’s
                                                                                                keynote speaker was Dr. Nancy Rappaport,
                                                                                                ’88, the author of a new book, In Her Wake,
                                                                                                about her mother’s suicide. For more on
                                                                                                Rappaport, turn to page 10.




baystate wins copd gRant


D
           r. peter lindenauer, director       North Carolina, Chicago, Illinois                           “We are excited to be able to
           of the Center for Quality of Care   and Washington to build a data                          build a toolkit that will be more
           Research and an associate pro-      warehouse of COPD patients and                          powerful than anything done
           fessor of medicine at Baystate      apply systematic analysis to their                      previously,” says Lindenauer, who
Medical Center, says doctors have suffered     conditions, treatment patterns                          calls the NIH award an “endorse-
from a dearth of reliable data on the best     and outcomes. The six sites will                        ment” of Baystate’s recent efforts
treatment for chronic obstructive pulmo-       share a $7.4 million grant from the                     to strengthen research at the
nary disease, or COPD, which currently         National Institutes of Health over Peter Lindenauer     medical school’s western campus.
ranks as the nation’s fourth leading cause     the next two years. Lindenauer is                       Collectively, the six grant recipi-
of death.                                      the study and site PI. Drs. Mark Tidwell      ents hope to compile and track the medi-
   To answer that need, Baystate has joined    and John Landis, both assistant professors    cal histories of at least 20,000 patients with
forces with colleagues at Kaiser Permanente    of medicine at Baystate, will assist him in   emphysema, chronic bronchitis or smoker’s
Northwest Region and the universities of       carrying out the ambitious study.             lung that share the COPD umbrella.




                                                           faCelift foR M&V


                                                         I
                                                              F yOU haVen’t Walked alOng harriSOn aVenUe recently, yOU might nOt recOgnize
                                                               the former garment factories that were turned into a lab complex for the
                                                               medical school in the early 1950s. the m&V and Stearns buildings are
                                                               undergoing complete facelifts, centered on the installation of large, energy-
                                                           efficient windows.
                                                               the first floor of Stearns has been renovated to house the department of
                                                           community medicine and the growing m.S. in biomedical Sciences and Public
                                                           health degree programs, as well as student study rooms and lounges. a
                                                           glassed-in, sidewalk-level entry to Stearns showcases an inviting lobby.
                                                               in addition to the physical changes, the buildings also have a new name—
                                                           the biomedical research and Public health building—that better reflects the
                                                           range of activities housed there.



PhOtOS: alOnSO nichOlS                                                                                      w i nt e r 2 010 tufts medicine 29
    university news                                       the wider world of tufts




                  homegrown Sabbatical
   Computer scientist Carla Brodley creates new frontiers for collaboration
   in her own backyard by Marjorie Howard




                  P                  rofessor carla brodley was due for a sabbatical from the              The results, which included two draft
                                     department of computer science when she had an intriguing         papers and a funded grant for further
                                     notion: instead of working on just her own research or visiting   research, were so positive that Brodley is
                                     another university, maybe she could spend a semester or two       continuing the work, and connecting oth-
                    in a different school or department right at Tufts.                                ers in her department with researchers
                       If one of Tufts’ goals is for faculty to collaborate, she thought, it would     on the health sciences campus in Boston.
                    make sense to get to know people outside of her own turf, the School of            She’s also helping medical school research-
                    Engineering. Perhaps there were ways her skills could be put to use. Perhaps       ers develop a computer program that fac-
                    there were projects she could help with—if only she knew about them and            ulty throughout the university might use
                    other faculty knew about her. With a longtime interest in medical applica-         to find possible collaborators on campus.
                    tions for her work, she was especially interested in making a connection with
                    the medical school.                                                                Th e Power of Lu nch
                       She presented her idea to Provost Jamshed Bharucha, who approved it. Thus       Brodley began her sabbatical with a cou-
                    was born a new program that Brodley calls the “interdisciplinary sabbatical.”      ple of brown-bag lunches at the medical
                    Last year she spent two semesters at Tufts School of Medicine, collaborating       school, where she talked about her work,
                    on research projects for which her specialized computer science skills proved      namely research connected with data min-
                    timely and invaluable.                                                             ing and machine learning. Data mining


                       Carla Brodley, a faculty member
                       in Tufts School of Engineering,
                       spent two semesters at the
                       medical school, collaborating on
                       research projects for which her
                       specialized computer science
                       skills proved invaluable.




30 t u f t s m e d i c i n e w i n t e r 2 0 1 0                                                                                photo: alonso nichols
uses software to detect and analyze patterns
in large amounts of information. Machine
learning is related to data mining: it uses
software to teach machines how to recognize      Federal stimulus Funds
such patterns, and how to make decisions
based on data.                                   buoy research at tuFts
    The lunches quickly paid off. She con-
nected with Joseph Lau, ’78, a professor of      scientists at tufts university have secured 75 awards from 241 univer-
medicine and director of the Tufts Evidence-     sity proposals submitted for funding under the american recovery and
based Practice Center, which uses data           reinvestment act of 2009.
gained from clinical research conducted              the funded investigators represent 23 academic departments from the
around the world to determine the most           schools of arts and sciences, dental medicine, engineering and medicine,
effective treatments.                            the friedman school of nutrition science and policy, the cummings school
    There are vast numbers of abstracts to       of veterinary medicine, the sackler school of Graduate Biomedical sciences
pore over, says Lau, who notes that “this is a   and the Jean mayer usda human nutrition research center on aging.
fairly boring exercise for a human. It would     altogether, the awards total $16.9 million for the first year of funding, with
be nice to have a computer to do this work—      grants for the second year expected to reach $30 million.
or at least help out.”                               of the 75 awards to tufts, more than 50 were obtained by faculty at the
    Enter Brodley. She and Lau, together with    school of medicine, said naomi rosenberg, dean of the sackler school. in
Christopher Schmid, professor of medicine,       addition, she said, medical school faculty based at tufts medical center
and Tom Trikalinos, assistant professor of       and tufts’ other affiliated hospitals received funding for another 40 research
medicine, and computer science graduate          projects.
student Byron Wallace, have developed soft-          philip haydon, the annetta and Gustav Grisard professor and chair of
ware that screens abstracts for key words or     neuroscience, secured a $1.65 million faculty recruitment grant from the
phrases. That could save researchers many        national institute of neurological disorders and stroke. the newly es-
hours. “Once we have this program success-       tablished faculty recruitment award program is designed to mitigate the
fully done, it will reduce the work to a quar-   reduction in faculty positions due to the current economic downturn. the
ter or less of human time,” Lau says.            two-year grant will facilitate the hiring of new faculty for secure, tenure-track
    “I was working on this before,” says         or equivalent positions.
Lau, “but she [Brodley] is an expert in              two teams of investigators were awarded rc2 grants, also known
this area and could pinpoint exactly what        as Grand opportunity or “Go” grants, meant to lend generous, short-term
needs to be done, what is feasible, what         support to high-impact ideas. Beverly rubin, associate professor of
research questions are remaining; she’s          anatomy and cell biology, and her colleagues received a two-year, $1.6
been extremely helpful.”                         million grant to study the relationship between obesity and exposure to
    Brodley is so pleased with the results of    the controversial plastics ingredient Bisphenol a (Bpa). ana soto, profes-
her sabbatical that she plans to spend one       sor of anatomy and cell biology, and her team were awarded $1.84 million
day a week at the medical school to con-         over two years for an investigation into the effect of Bpa exposure on fetal
tinue her work. In addition, she is bringing     development.
in a postdoctoral student to help develop the        also part of the stimulus funding, two teams of tufts scientists have
computer program that would encourage            won competitive challenge grants from the nih, which is seeking to focus
interdisciplinary collaborations.                on areas where an influx of funds would quickly advance research in signifi-
    The program, she says, reviews faculty       cant ways. examples include specific knowledge gaps, scientific opportuni-
members’ papers to determine if one per-         ties, new technologies, data generation and research methods.
son’s essential topic might become another           larry a. feig, professor of biochemistry, received a $1 million, two-year
person’s minor topic. “If people are work-       grant to determine if and how connections in the developing teenage brain
ing on the same main topic,” she says, “they     affect adolescent behaviors. the nih also awarded paula minihan, an
already know about each other. It’s more         assistant professor of public health and community medicine at tufts
useful to suggest that people work with          medical school, and John morgan, an assistant professor of public health
someone they are not familiar with.”             and community service at tufts dental school, $925,000 over two years
    Bharucha, the Tufts provost, is delighted    to study oral health in adults with developmental disabilities, identifying
with the results of the interdisciplinary sab-   factors that hinder daily care and regular dental visits.
batical and is encouraging others to propose
their own. “It can help us bridge the schools,
which is a goal of mine,” he says.


                                                                                                       w i nt e r 2 010 tufts medicine 31
    beyond bounda r i e s                                           providing the means for excellence




  Sackler Center
  Is Reborn
   By Lauren Katims




  T                  ransformation was the theme on october 22,
                     2009, as more than 500 alumni, students, faculty,
                     staff and friends gathered in Boston to celebrate the
                     unveiling of the newly renovated Arthur M. Sackler
   Center at the medical school. “Being here for this wonderful event,
   surrounded by alumni and friends, brings back lots of memories of
   being on campus, even though it has been completely transformed,”
   said David Rosenthal, ’63, vice president of the Tufts University
   Medical Alumni Association.
       Students conducted tours of the center’s eight f loors, which
   include a fitness center, four learning communities with small study
   rooms for working on team projects and problem-based learning
   assignments, a café and student lounge, three library floors, admis-
   sions offices and interview rooms.
       Lee Gerson, ’12, said he’s proud to show off his school to his
   friends and family when they visit. “Since I spend so much time at
   school as it is, it’s nice to have the ability to relax and exercise in such
   a comfortable and welcoming environment,” he said.
       These transformational renovations were made possible by
   Overseer Steven Jaharis, ’87, and his father, Michael Jaharis, chair of
   the medical board of overseers and of the Jaharis Family Foundation,
   whose $15 million gift toward the renovation of the Sackler Center,
   the creation of the new Clinical Skills and Simulation Center, and
   financial aid is the largest gift in the history of the school. As part of
   their gift, they established the Jaharis Scholarship Challenge, toward
   which Tufts is raising an additional $7.5 million for scholarships.
   (See story, page 35).
       Steven Jaharis said when this opportunity was presented to him,
   it really “hit home for me … .When I was a student, I daydreamed
   of having a real student center. Now it’s gratifying to see it done and
   used well.”
       Students say one of their favorite aspects of the new building
   are the learning communities, which they report have significantly
   enhanced their academic experience over the past year. A network
   of clinical teachers and mentors, who are assigned to specific small
   groups of students throughout the four years of medical school, sup-
   port the learning communities.                                                    Unveiling the new Sackler Center are Tufts
       Tufts President Lawrence S. Bacow expressed appreciation for the              President Lawrence S. Bacow, left, and Alfred
   visionary leaders and philanthropists, who, like Arthur Sackler, had              Tauber, A69, M73, a Tufts trustee who named
                                                                                     the new fitness center in honor of his father,
   blazed new trails in decades past. “The new student center,” Bacow
                                                                                     Laszlo Tauber. At right, Steven Jaharis, ’87,
   said, “represents how each generation at Tufts University School of               Bacow, Tauber and Dean Michael Rosenblatt.
   Medicine helps the next.”


32 t u f t s m e d i c i n e w i n t e r 2 0 1 0                                                                               Photos: alonso nichols
                                                   Robert Heller,
                                                   ’13, left, talks
                                                   about the new
                                                   space with
                                                   Bonnie Dunlap,
                                                   A06P, and Ronald
                                                   Dunlap, ’75,
                                                   A06P.




Left, Professor Emeritus Robert Kennison, ’60, reviews a timeline of
school history for students and guests. Above, Ameer Shah, A07, M13,
center, leads a tour for Sangita Gupta, ’00, left, his mother, Sabera
T. Shah, an ophthalmologist who practices in Boston, and Veena
Jayadeva, a student at MIT’s Sloan School. Below, Joyce Field Pastor,
J95P, and Bruce M. Pastor, ’68, J95P.




                                       w i nt e r 2 010 tufts medicine 33
    beyond bounda r i e s



   Creating Rooms with Special Meaning


 L
               aszlo tauber, orPhaned at a young              encourage students to make staying healthy      sister, Frances samuels; her husband,
              age in budapest, excelled in gym-               and active a permanent part of their daily      Jeffrey; and an anonymous donor. the
              nastics through discipline and hard             routines.                                       conference room honors the memory of their
              work, winning many junior tourna-                   the tauber Fitness center, which quickly    parents, arthur and Jean rosenblatt, and
   ments across hungary. “i remember he had                   has become a favorite place for medical         their stepfather, david bialer, all holocaust
   a bag of at least 80 or 90 medals,” his son,               students to unwind before and after classes,    survivors, in a place dedicated to improving
   alfred tauber, a69, m73, recalls. but after                is one of 16 spaces that have been named        health and life.
   entering medical school, he was forced by                  in the renovated sackler center as part of a        “my sister and i and our spouses were
   his rigorous schedule of classes to give up                drive to raise scholarship funds for medical    looking for a way to honor our parents and
   gymnastics, a decision he regretted.                       students (see sidebar, page 35).                celebrate their extraordinary lives and their
        “he understood the importance of being                    another space, the rosenblatt-bialer        love of life and family,” says rosenblatt.
   fit, the discipline and endurance it gives                 admissions conference room on the eighth        “when the opportunity came along to name a
   you,” says his son, who made the naming gift               floor of the sackler center, has been named     room at the medical school in their memories,
   for the school of medicine’s new laszlo n.                 by the former dean of the school of medicine,   while at the same time creating funds for
   tauber, m.d., Fitness center, a place that will            michael rosenblatt; his wife, Patricia; his     scholarships, we knew that we had found the




                                                   Above, John Matias, the medical school’s
                                                   associate dean for admissions, gives
                                                   prospective students a glimpse into life at
                                                   Tufts Medical School in the new Rosenblatt-
                                                   Bialer Admissions Conference Room on the
                                                   eighth floor of the Sackler Center. At right,
                                                   Dean Michael Rosenblatt speaks at the
                                                   dedication of the conference room, named
                                                   for his parents and stepfather. Behind him
                                                   are his sister, Frances Samuels, and her
                                                   husband, Jeffrey.



34 t u f t s m e d i c i n e w i n t e r 2 0 1 0                                                                  Photos: alonso nichols, matthew modoono (above)
                                                    Jaharis scholarship
                                                    challenge
right way. an unexpected and most touching
part of the experience has been to have a           through their family foundation, overseer steven Jaharis, ’87,
friend, who knows the story of my parents and       and his father, michael Jaharis, chair of the medical board of
who wishes to remain anonymous, join us in          overseers and of the Jaharis Family Foundation, contributed
donating funds to dedicate the rosenblatt-          $15 million toward the renovation of the sackler center, the
bialer room.”                                       creation of the new clinical skills and simulation center
    after moving to america, arthur and Jean        and financial aid. at the same time, they issued the Jaharis
rosenblatt built a successful tool-and-die          scholarship challenge, under which tufts agreed to raise an
business, re-created a home and raised their        additional $7.5 million to release a portion of the Jaharis gift
family. after arthur rosenblatt passed away,        for scholarships once the construction projects were completed.
their mother expanded the business and                  the alumni and friends listed below have stepped forward
eventually married david bialer, one of the         to support the school of medicine in response to the Jaharis
last people to come through ellis island.           scholarship challenge, an initiative that is transforming medical
    “i can’t describe how wonderful it feels to     education and the quality of life for medical students at tufts.
do this,” says rosenblatt.


                        The new Laszlo N.
                        Tauber, M.D., Fitness       DONORS
                        Center has quickly
                        become a favorite
                                                    Dr. Adel Abu-moustafa, dean       Dr. Sheldon Nankin, ’67,
                        place for students to
                        work off a little stress.
                                                    for international affairs, and    m07P, Sandra Nankin, m07P,
                        Below, Alfred Tauber,       Magda Abu-moustafa                and Dr. Nils Nankin, ’07
                        A69, M73, right, who        Dr. Alphonse F. Calvanese,        Dr. Bruce M. Pastor, ’68,
                        named the space for         ’78, and Debra A. Calvanese       J95P, and Joyce Field Pastor,
                        his father, and Tufts
                                                    The Chasin Family                 J95P
                        President Lawrence S.
                        Bacow with a student.       In memory of Dr. Werner David     Robert and Caro Rock,
                                                    Chasin, ’58                       parents of dr. thomas a. rock,
                                                                                      ’09
                                                    Marguerite Cusson
                                                    In memory of her husband,         The families of Dr. Michael
                                                    Dr. Donald L. Cusson, ’58         and Patricia Rosenblatt,
                                                                                      Jeffrey B. and Frances R.
                                                    Dr. Robert A. Fasoli, ’73,
                                                                                      Samuels and an
                                                    d10P, and Maureen Fasoli,
                                                                                      anonymous donor
                                                    d10P
                                                                                      In memory of Arthur
                                                    Dr. Edward T. Gordon, a44,        Rosenblatt, Jean Rosenblatt
                                                    m47, a72P, m76P, e77P, g77P,      Bialer and David J. Bialer
                                                    and Claire Gordon, a72P,
                                                                                      Dr. David B. Stanton, ’81,
                                                    m76P, e77P, g77P
                                                                                      and family
                                                    Dr. Dan Kaplan, ’56
                                                                                      Dr. Ron Sue, ’81, a06P,
                                                    In loving memory of his
                                                                                      and Penny Sue, a06P
                                                    parents, Joseph and
                                                    Sylvia Kaplan                     Dr. Alfred I. Tauber, a69, m73

                                                    Dr. John M. Leventhal, ’73        The Tufts Medical Alumni
                                                                                      Association
                                                    Dr. Richard B. McElvein, ’51
                                                    In memory of his wife,
                                                    Priscilla McElvein




                                                                                            w i nt e r 2 010 tufts medicine 35
    beyond bounda r i e s



   Dannon                                              Honorine Ward and Barry Goldin

   gift funDs
   immune system
   research
   a gift of $192,800 from the dannon co.,
   Inc. will help researchers at the School of
   Medicine shed light on how certain bacteria
   in yogurt boost the immune system.
      The immune system affects allergic
   reactions to food, is involved in preventing
   diarrheal diseases, and protects against
   intestinal pathogens such as salmonella,
   E. coli, cholera and rotavirus, says Barry
   Goldin, a professor with the Nutrition
   Infection Unit at the School of Medicine.
   “With a better understanding of how it
   works, we can make better organisms and
   vaccines to boost the immune system.”
      Twenty years ago, Goldin and his colleague, Sherwood                   probiotics is being done by researchers at Tufts.
   Gorbach, ’62, a professor of public health and community medi-               The current project came about af ter Goldin and his
   cine at Tufts, discovered a bacterium, lactobacillus GG, which is         collaborator, Honorine Ward, a research assistant professor of
   used in fermenting dairy products, including some yogurts made            medicine, proposed a series of studies on benefits that LGG confers
   by Dannon. LGG is what is called a probiotic, an organism that            to the immune system in the gastrointestinal tract. The Dannon
   conveys health benefits. A significant amount of research into            gift will support their research in this area.




   Bequest Supports Translational Science
   dr. Judith vaitukaitis, J62, has established a  at our school,” said michael rosenblatt,          awards program. Prior to april 2005, she
   $1.5 million bequest that will support clinical former dean of the school of medicine. “her       was the director of the national center for
   and translational science at the school of      contribution will enable the school of medicine   research resources at the national institutes
   medicine.                                                  to support innovative clinical and     of health in bethesda, md. she was respon-
       vaitukaitis is a trustee emerita                       translational research and perhaps     sible for developing critical research technolo-
   of tufts university and currently                          change the practice of medicine        gies and providing cost-effective, multidis-
   serves on the medical school’s                             and health-care policy,” he said.      ciplinary resources for more than 35,000
   board of overseers. in addition to                             “the vaitukaitis endowed Fund      biomedical investigators across the spectrum
   promoting clinical and translational                       will support young tufts investiga-    of nih-supported research activities. her per-
   research, the Judith l. vaitukaitis                        tors, guiding them with her high       sonal commitment to clinical and translational
   endowed Fund will be used by the                           standards and strong commit-           research has grown from her research exper-
   dean of the school of medicine to Judith Vaitukaitis       ment to science, patient-oriented      tise and professional accomplishments.
   support interdisciplinary collaboration be-     research and constantly improving quality of          “her historic guidance of the national
   tween the school of medicine and                care,” rosenblatt said.                           center for research resources and of
   tufts’ other schools and to assist the next         vaitukaitis retired in 2008 as a senior       individual investigators continues to be felt
   generation of scientists beginning their        advisor to the then-director of the national      every day by the faculty, grant recipients and
   research careers.                               institutes of health, elias a. zerhouni. among    patients at tufts,” rosenblatt said. “we feel
       “Judy vaitukaitis has made a commitment     her many contributions, she supported             enduring respect and gratitude for her many
   to provide a lasting foundation for excellence  zerhouni’s clinical & translational science       contributions to the school of medicine.”



36 t u f t s m e d i c i n e w i n t e r 2 0 1 0                                                            Photo: alonso nichols (toP); ernie branson/nih
                                                                           staying connected              alumni news



Continuity and Change
                                          at the big sackler center “transformation               involved with the medical school has been a
                                          Celebration” in late October, we were fortunate to      rewarding two-way partnership for many. If
                                          have the opportunity to sponsor one of the class-       you have considered lending a hand to Tufts
                                          rooms on behalf of the Tufts Medical Alumni             in any way, I urge you to follow through on
                                          Association. On behalf of our organization,             your inclination.
                                          Vice President David Rosenthal, ’63, Secretary-            There is always more to do. I have met
                                          Treasurer Laurence Bailen, ’93, and I dedicated         many successful graduates and affiliates
                                          the room. I met with many alumni who had not            of Tufts while serving as your association
                                          visited the medical school since graduation, and        president. When the bricks and mortar are
                                          they were pleasantly surprised by the changes that      torn down for the next renovation of Tufts
                                          had occurred since then.                                Medical School, what will continue to stand
              By any measure, the cosmetic and functional changes to the interior space           firm is the commitment alumni and stu-
          of Sackler are profound. However, in speaking with today’s medical students,            dents demonstrate for this institution.
          I found a common thread between then and now—a love of learning and the
          dedication of those mentors who have inspired our shared medical tradition.
              Your alumni association plays an important role in sustaining that tradition.
          The Tufts Medical Alumni Association helps sponsor the annual White Coat cer-
          emony and reunion weekend, as well as makes donations to financial aid and other
          worthy student causes and activities. Many alumni mentor medical students with          David Wong, ’87
          their clinical activities and also serve as resources for career opportunities. Being   remiwonda@aol.com
TL_halfpg_AdA_HealthSciMags_Winter10              12/3/09     2:30 PM     Page 1




  T R AV E L T O E X T R A O R D I N A R Y P L A C E S W I T H E XC E P T I O N A L P E O P L E



                                                                                                         From Turkey to Tuscany,
                                                                                                         from Saxony to Saigon, our
                                                                                                         journeys feature intellectual
                                                                                                         inquiry with lectures and explo-
                                                                                                         ration. There’s a perfect trip for
                                                                                                         every taste! Contact Usha Sellers,
                                                                                                         Ed.D., Program Director, at
                                                                                                         usha.sellers@tufts.edu
                                                                                                         or 800-843-2586 for our
                ur
       Vis it o
                    see                                                                                  brochure or visit our
   web  site to
              citing                                                                                     website for itineraries.
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             TRAVEL-LEARN          visit: www.tuftstravellearn.org


                                                                                                             w i nt e r 2 010 tufts medicine 37
    alumni news


                                                   Lawrence. “I’ve been mulling        for the celebration of the 35th     Vermont College of Medicine
                                                   this for three or four years,       anniversary of the partnership      and sits on the college’s admis-
                                                   and it’s time,” says Macoul.        between Baystate and Tufts          sions committee.
                                                   “I’m doing this with mixed          Medical School. “I went back to
                                                   emotions because I still have
                                                   all my talents.” He plans to
                                                   spend half the year in Methuen
                                                                                       Boston and told everyone how
                                                                                       good it was,” he said. Also at
                                                                                       the event were Tufts President
                                                                                                                           79       Alexander Hannenberg
                                                                                                                                    of Wellesley, Mass.,
                                                                                                                           became president of
                                                   and half in Tampa, Fla., where      Lawrence S. Bacow and Dean          the American Society of
                                                   he will relax with his family and   Michael Rosenblatt. The affili-     Anesthesiologists in October.

  57         Albert Hurwit of
             Hartford, Conn., was
   awarded first place out of 124
                                                   also perform surgery on mem-
                                                   bers of the Senior Professional
                                                   Golf Association tour. Macoul
                                                                                       ation was established in 1974,
                                                                                       and in 1988 Baystate became
                                                                                       the medical school’s western
                                                                                                                           He is currently the associate
                                                                                                                           chair of the Department of
                                                                                                                           Anesthesiology at Newton–
   entries in the 2009 American                    has seen many changes dur-          campus. Emery is now head of        Wellesley Hospital and a clinical
   Composer Competition. The                       ing his professional life, and      cardiovascular surgery at St.       professor of anesthesiology at
   award is sponsored by Columbia                  even contributed to them. In        Joseph’s Hospital in St. Paul,      Tufts. Hannenberg and his wife,
   Orchestra (of Maryland),                        the course of his career, he in-    Minn.                               Carol, also a physician, have
   which performed Movement                        vented the Macoul retinoscope,                                          two daughters.
   III of his Symphony No. 1 in
   early December. The 59-minute
   symphony was also scheduled
                                                   a device that enables physi-
                                                   cians to conduct eye exams on
                                                   children and patients who are
                                                                                       74       Kevin Dole of Dover,
                                                                                                Mass., an associate
                                                                                       clinical professor of pathol-
   to be performed by the Laredo                   bedridden and have other            ogy at Tufts Medical School,
   Philharmonic Orchestra (of                      debilitating diseases.              has been named the 2009
   Texas) on January 24. More                                                          Pathologist of the Year, the
   information is available at www.
   alberthurwit.com.                               71      Marc Trager of Green
                                                           Bay, Wisc., has retired
                                                   from the practice of radiol-
                                                                                       highest honor of the College
                                                                                       of American Pathologists. He
                                                                                       was recognized for his leader-

  60       Michael K. Levine,
           A56, received a lifetime
   achievement award from the
                                                   ogy after 30 years in the field.
                                                   He plans to run for the U.S.
                                                   Congress from the 8th District
                                                                                       ship of the college’s Council on
                                                                                       Membership and Professional
                                                                                       Development and for his contri-     80       Donald Driscoll of
                                                                                                                                    Concord, Mass., has
   Georgia chapter of the American                 in Wisconsin in the 2010 elec-      butions to pathology over more      been chosen by his peers to be
   Academy of Pediatrics.                          tion. He invites anyone interest-   than two decades. Dole, who         president of the medical staff at
                                                   ed to visit his website at www.     has held a variety of leadership    Emerson Hospital in Concord.

  62         Sherwood Gorbach,
             a professor of public
   health and community medicine
                                                   TragerforCongress.com and
                                                   lend support to his campaign.
                                                                                       positions within the profes-
                                                                                       sional organization, is the medi-
                                                                                       cal director at Caritas Medical
                                                                                                                           He is serving a two-year term
                                                                                                                           that began in October. Driscoll,
                                                                                                                           an orthopedic surgeon, has cov-
   at Tufts Medical School, was
   selected to deliver the annual
   George A. Jacoby, M.D., Lecture
                                                   73       The American
                                                            Association of
                                                   Clinical Endocrinologists
                                                                                       Laboratories and the director
                                                                                       of pathology and laboratory
                                                                                       at Carney Hospital. He is also
                                                                                                                           ered high school football games
                                                                                                                           as a sideline physician for the
                                                                                                                           past 23 years. He maintains a
   in Infectious Diseases at Lahey                 and the American College of         a trustee of Carney Hospital,       private orthopedic practice in
   Clinic. On December 3 and 4, he                 Endocrinology presented David       Martha’s Vineyard Hospital          Concord and Westwood.
   spoke on Clostridium difficile, a               Cooper with its Distinction in      and Windemere Nursing and
   potentially life-threatening bac-
   terium that causes gastrointes-
   tinal illness, and four other ill-
                                                   Clinical Endocrinology Award
                                                   during the organizations’ annual
                                                   meeting in Houston, Texas, in
                                                                                       Rehabilitation Center in Oak
                                                                                       Bluffs, Mass.
                                                                                           Ruth Uphold has been ap-
                                                                                                                           83       Mary Hart of Orlando,
                                                                                                                                    Fla., is chair of the
                                                                                                                           nuclear medicine department of
   nesses (botulism, tetanus, gas                  May 2009. Cooper called the         pointed to the board of trustees    M.D. Anderson Cancer Center
   gangrene and colitis) caused by                 honor “one of the highlights of     of Fletcher Allen Health Care,      and Orlando Health, overseeing
   the toxin-producing Clostridium                 my career.”                         the Burlington, Vt., hospital.      the department that serves the
   bacterium.                                          Robert W. Emery Jr., the        She is a clinical attending         six hospitals in the network.
                                                   very first Tufts medical student    physician and former medi-          She was recruited to join the

  65        Kenneth Marcoul, J87P,
            M91P, of Methuen,
   Mass., has laid down his pupil
                                                   to rotate through Baystate
                                                   Medical Center for his surgi-
                                                   cal training in 1972, returned
                                                                                       cal director of Fletcher Allen’s
                                                                                       emergency department, where
                                                                                       she has been practicing since
                                                                                                                           M.D. Anderson staff three
                                                                                                                           years ago after 14 years of
                                                                                                                           private practice in Clearwater,
   dilator after 40 years as an                    to the hospital in Springfield,     1981. She is also a professor       Fla. Before that, she spent
   ophthalmologist practicing in                   Mass., on November 24, 2009,        of surgery at the University of     10 years in the U.S. Army,



38 t u f t s m e d i c i n e w i n t e r 2 0 1 0
class notes




stationed in Washington, D.C.,            Hart adds: “Although I have lost    with the limitations of the health-   30, 2008. She is the administra-
and San Francisco. Hart says              touch with most of my class-        care system, is founder and           tive director of neurosciences
her proudest accomplishment               mates, I remember nearly every      chief medical officer of Carena, a    at Long Island Jewish Medical
is having raised three wonderful          one of them with fondness, and      Seattle-based medical services        Center.
children, Meghan, 24; Jessica,            I hope they are happy and at        company that specializes in
23; and Benjamin, 21. She
resides in Orlando with her
                                          peace in their lives.”              hour-long house calls and avail-
                                                                              ability to its patients around the    05         Susan Butler-Wu,
                                                                                                                               assistant director of the
husband of three years, Curtis
McGee, a personal trainer,
former pro football player and
                                          84       Candace Lapidus
                                                   Sloane, J80, of
                                          Barrington, R.I., is an assistant
                                                                              clock. Carena sells its personal-
                                                                              ized care services to large, self-
                                                                              insured companies. Microsoft is
                                                                                                                    Clinical Microbiology Laboratory
                                                                                                                    at the University of Washington
                                                                                                                    Medical Center in Seattle, is a
president of Blue Chip Youth              professor of dermatology and pe-    one of its largest customers.         diplomate of the American Board
Sports Foundation, a nonprofit            diatrics at Brown Medical School                                          of Medical Microbiology. To earn
assisting underprivileged high
school athletes aspiring to col-
lege scholarships. She reports
                                          and recently joined the medical
                                          school’s admissions committee.      96       Melina Jampolis, J92,
                                                                                       is the diet and fitness
                                                                              expert for CNN.com’s expanded
                                                                                                                    that credential, she met rigorous
                                                                                                                    educational and experiential
                                                                                                                    eligibility requirements and then
that her heart remains in New
England, where her father, age
80, also a physician, continues
                                          89       Paul Bettinger of
                                                   Keene, N.H., an ortho-
                                          pedic hand surgeon based at
                                                                              health website: http://www.cnn.
                                                                              com/HEALTH/diet.fitness. She
                                                                              answers consumer questions
                                                                                                                    passed a comprehensive written
                                                                                                                    examination. She has demon-
                                                                                                                    strated the knowledge and skills
to maintain his family practice           the Cheshire Medical Center in      online each week, along with          necessary to direct laboratories
in southern New Hampshire.                Keene, is enjoying family life,     doing a few podcasts and video        engaged in the microbiological
He formerly enjoyed a partner-            going to concerts and attending     podcasts.                             diagnosis of human disease.
ship of more than 35 years                professional sports events when                                           She received her Ph.D. in
with Raymond Moore, ’37, now
deceased. “These two and their
lifelong dedication to family
                                          he can. He and his wife, Alyse,
                                          have three children, Joshua, 15;
                                          Ethan, 14; and Tami, 12.
                                                                              02       Julie Chan and Do Chan,
                                                                                       M01, of Wellesley,
                                                                              Mass., welcomed Camden Ye
                                                                                                                    molecular microbiology from
                                                                                                                    the Sackler School of Graduate
                                                                                                                    Biomedical Sciences.
practice,” she writes, “have pro-                                             Sing on March 2, 2009.
vided role models for an entire
community, as well as three
generations of physicians.”
                                          90       Ted Conklin, A86, of
                                                   Seattle, Wash., a family
                                          practitioner who grew frustrated
                                                                                 Allison Doyle Roditi, MPH,
                                                                              and Randy Roditi welcomed
                                                                              Connor Grayson on November
                                                                                                                    07      Meghan Tramontozzi
                                                                                                                            and Louis Tramontozzi,
                                                                                                                    of Malden, Mass., welcomed
                                                                                                                    Sophia Margaret on June 28,
                                                                                                                    2009.

     we want to hear from you
     Fill us in on your news. Have you been getting together with classmates? Have a new
                                                                                                                    09        Michelle Long and
                                                                                                                              David Munson were
                                                                                                                    selected as 2009 Massachusetts
     job? A special project or appointment? Is your family growing? Have you moved or                               Medical Society Scholars. They
     changed your contact information recently? Keep your fellow alumni/ae posted by                                were among eight fourth-year
     dropping us a line.                                                                                            students, two from each of the
                                                                                                                    state’s four medical schools, who
                                                                                                                    demonstrated excellent academic
                                                                                                                    performance, community involve-
                                                                                                                    ment and financial need. Each
     Name
                                                                                                                    honoree receives a $10,000
     Class                                                                                                          scholarship. Both have been ac-
     Street                                                                                                         tive with the Sharewood Project,
     City             State         Zip                                                                             the Tufts-run clinic in Malden,
     E-mail address
                                                                                                                    Mass., and Munson became
                                                                                                                    clinic coordinator in 2006. Long
        CHECK HERE IF ADDRESS IS NEW.                                                                               intends to pursue a career in
     Send to:                                                                                                       academic internal medicine with
     Tufts Medical Alumni Relations, 136 Harrison Avenue,Boston, MA 02111                                           a focus on underserved popula-
     or e-mail medicine-alumni@tufts.edu                                                                            tions. Munson plans a career in
                                                                                                                    primary care, with a focus on HIV
                      CLASS noTES DEADLinE foR nExT iSSUE iS APRiL 1, 2010
                                                                                                                    medicine or infectious disease.



                                                                                                                    w i nt e r 2 010 tufts medicine 39
    alumni news                                     obituaries




        remembering mort madoff
        the passing of our good friend and colleague dr. morton        which will allow us to make two Madoff Fellowship awards
        A. Madoff this past June reminded us of just how much Mort’s   of $3,000 each year. We are asking for your help in creating
        contributions have meant to Tufts, to the organization                     this fellowship fund. Our goal is to award the first
        and delivery of health care in Massachusetts, and to                       Madoff Fellowship in 2010.
        public health in general.                                                     We hope that you will join with us in helping to
           In think ing about ways in which we might                               memorialize Dr. Madoff ’s lifetime commitment
        memorialize Dr. Madoff ’s career, and after consul-                        to the careers of others by making a contribution
        tation with his family, we have decided to establish                       today. Contributions may be sent to Joshua Young,
        the Morton A. Madoff, M.D., M.P.H., Public Health                          Development and Alumni Relations, Tufts University
        Fellowship Fund. Intended as a career development                          School of Medicine, 136 Harrison Avenue, Boston,
        award, the fellowship fund will acknowledge and                            MA 02111. If you have any questions about making
        honor Dr. Madoff ’s contributions in promoting the Morton A. Madoff        a gift, please contact Josh by email (joshua.young@
        training and career development of students with interests in  tufts.edu) or phone (617.636.3604).
        public health, public policy and health-care management.       — dr . h a r r is be r m a n
           We have set a goal of raising $100,000 for an endowed fund,    FOR THE MORTON A. MADOFF, M.D., M.P.H., PUBLIC HEALTH FELLOWSHIP FUND COMMITTEE




   irving Showstack, ’29, of Delray                12 grandchildren and 14              practice in Portland, he was the        John J. Harrington, ’54, of
   Beach, Fla., died on November                   great-grandchildren.                 sole gastroenterologist in the          Lorain, Ohio, died on October 31,
   15, 2009, at age 103. He is                                                          state of Maine. He was on staff         2009, at age 82. He was an an-
   survived by his two children,                   Halim Habib, ’46, of Roslindale,     at Maine Medical Center and an          esthesiologist who practiced in
   Barbara and James, seven                        Mass., died on November 10,          assistant clinical professor at the     the Lorain area for many years.
   grandchildren and 13 great-                     2009. He was an obstetri-            medical school. He is survived          He is survived by his wife, Carol,
   grandchildren.                                  cian and gynecologist in West        by his wife, Anne, three daugh-         four daughters, two sons and 13
                                                   Roxbury who delivered many           ters, two sons and a number of          grandchildren.
   Robert Bolduc, ’39, of                          hundreds of babies over the          grandchildren.
   Worcester, Mass., died on                       course of his career. He had also                                            franklyn Hayford, ’54, of Scotia,
   November 16, 2009, at age 96.                   lent his time and energy to ongo-    Charles Ballou iii, ’53, of Clifton     N.Y., died on October 31, 2009,
   He had a surgical practice in                   ing research efforts as a board      Forge, Va., died in November            at age 84. He practiced internal
   Worcester from 1949 to 1984.                    member at St. Jude Children’s        2009. He was an internal medi-          medicine, with a specialty in
   He was a major in the U.S. Army                 Research Hospital in Memphis.        cine and pulmonary medicine             pulmonary disease.
   Medical Corps, serving in the                   He is survived by his four daugh-    specialist who practiced at
   South Pacific during World War                  ters, Judy, Jacqueline, Susan        several hospitals in the Alleghany      Lavius Robinson Jr., ’54, of
   II. He is survived by 15 nieces                 and Louise, and their families,      Highlands of Virginia. He enjoyed       South Killingly, Conn., died on
   and nephews and their families.                 including five grandchildren.        reading, traveling, history, football   October 30, 2009, at age 82.
                                                                                        and spending time with his wife,        Known by many as “Dr. Robbie,”
   Patrick fitzGerald, ’44, of Santa               Donald Berman, ’49, of               Bari; their sons, Jim and Sam;          he maintained a solo family prac-
   Ana, Calif., died on September                  Chelmsford, Mass., died on June      and their sons’ wives. He was           tice in Danielson, Conn., from
   5, 2009, at age 91. He practiced                26, 2009. He was retired after       devoted to his granddaughters,          1956 to 1999.
   internal medicine in Virginia and               50 years of practicing pediatrics.   Kate, Marguerite and Hannah,
   California for 41 years.                        He is survived by Dorette, his       with whom he could often be             William McDermott, ’61, of
                                                   wife of nearly 53 years, and four    seen around town.                       Narragansett, R.I., died on
   Warren Eddy Jr., ’46, of                        children, Peter, George, Cynthia                                             November 6, 2009, at age 74.
   Tucson, Ariz., died on October                  and Douglas.                         Lawrence nadeau, ’53, of                He opened the first pediatrics
   29, 2009, at age 88. He was                                                          Lewiston, Maine, died on                practice in South County, R.I.,
   an orthopedic surgeon and                       irving Poliner, ’52, of Cape         September 17, 2009, at age 84.          in 1964 and practiced for 43
   passionate gardener who had                     Elizabeth, Maine, died on            He was a radiologist at St. Mary’s      years before retiring in 2007. He
   lived in Tucson since 1956.                     September 26, 2009, at age           Regional Medical Center in              is survived by his three children,
   He is survived by six children,                 85. In 1958, when he opened a        Lewiston for more than 30 years.        William, Michael and Beth.



40 t u f t s m e d i c i n e w i n t e r 2 0 1 0
                                           “ I loved my experiences at
                                             Tufts and the School of
                                             Medicine. My sons have
                                             four Tufts degrees among
                                             them and I received schol-
                                             arships throughout my years
                                             there. Our family feels an
                                             obligation to say ‘thank you’
                                             by creating scholarships for
                                             future Tufts students.          ”
                                             Since graduating magna cum laude from
                                             both Tufts and Tufts University School of
                                             Medicine, where he was first in his class, Dr.
                                             EDwarD “TED” GorDon, a44, M47, a72P,
                                             M76P, a77P, EG77P, has always found time
                                             for the Tufts Medical alumni association.
                                             For him and his wife, Claire, medicine is a
                                             family tradition. During his 60-year career,
                                             Dr. Gordon served as chief of surgery at
                                             Quincy Hospital, an assistant clinical profes-
                                             sor of surgery at Tufts, and most recently
                                             worked in the Boston Va Healthcare System.
                                             Mrs. Gordon’s father was a physician, and
                                             in 2000, she established the Claire Gordon
                                             Lecture Series at the medical school to
                                             promote compassionate care. The Gordons’
                                             sons are all involved in the medical profes-
                                             sion: Michael, a72, M76, is a general sur-
                                             geon; Steven, a77, EG77, president of Good
                                             Samaritan Medical Center in Brockton; and
                                             John, a reproductive endocrinologist. The
                                             Gordons recently named TUSM as a benefi-
                                             ciary of their Ira, which will provide schol-
                                             arship support to future generations of
                                             medical students.


For more information please contact Tufts’ Gift Planning Office
888.748.8387 • giftplanning @ tufts.edu • www.tufts.edu/giftplanning

				
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