BRAIN VOLUMES IN AUTISM AND DEVELOPMENTAL DELAY - A MRI STUDY by ProQuest

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									                                                                           Articles Section

Journal of Cognitive and Behavioral Psychotherapies,
Vol. 10, No. 1, March 2010, 25-38.



             BRAIN VOLUMES IN AUTISM AND
          DEVELOPMENTAL DELAY – A MRI STUDY
    Elena PREDESCU*¹, Paul SIPOS², Roxana SIPOS¹, Felicia IFTENE³,
                          Róbert BALÁZSI4
      ¹Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
                       ²Technical University of Cluj-Napoca, Romania
                           ³Queen`s University Kingston, Canada
                     4
                       Babes-Bolyai University, Cluj-Napoca, Romania

          Abstract
          The objective of this paper was to study brain volumes in children with
          autistic spectrum disorder (ASD) as compared to children with a
          developmental delay (DD). Fifteen children with autism and ten children
          with developmental delay, ages between 2 and 8 years old, were included
          in this MRI study. Total brain (TBV), grey matter (GM) and white matter
          (WM) volumes were measured using SPM5. Parents completed The Child
          Behaviour Checklist 1.5-5 (CBCL) for all the children included in the
          study. Our results do not indicate statistically significant differences
          between the two groups, but we observed a higher average of the measured
          brain volumes in the ASD group. A significant correlation was found
          between age and GM and WM volumes (for GM volumes Spearman`s
          rho=.42, DF=23, p<.05 and for WM volumes Spearman`s rho=.57, DF=23,
          p<.01). We performed a univariate descriptive statistic for CBCL subscale
          scores and a non-parametric correlation analysis between the three brain
          volumetric measures (TBV, WM and GM) and participants’ scores on
          CBCL subscales. In both groups, correlations were found between the
          measured brain volumes and the scores of the CBCL Attention
          deficit/Hyperactivity Problems and Opposition Defiant Problems subscales.
          Unlike the correlations found in the ASD group, the DD group shows only
          positive correlations. This result suggests a possible moderator role of the
          disorder, in the relation between CBCL subscales and volumetric measures
          of the brain. Our data on the measured brain volumes of the two groups
          largely overlap those described in the literature. Structural me
								
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