Engineering mechanics and mechanical engineering have long been present in oncology and cancer research. For instance, Arun Majumdar in the Department of Mechanical Engineering at the University of California at Berkeley used micromachined cantilever beams to provide a means for the early and accurate diagnosis of cancer from biological fluid samples. In a second example, Rakesh Jain and his team at Harvard University and Massachusetts General Hospital demonstrated that cancers and the surrounding tissues generally develop internal hydrostatic pressure distributions that oppose the transport of therapeutic drugs from the blood stream into the cancer. Lipid-based nanoparticles, or liposomes, have been used in cancer clinics for over a decade, following FDA approval in the mid-1990s of liposomal formulations of drugs such as doxorubicin and antifungal agents. Generally, nanoparticle formulations of drugs tend to concentrate in tumor lesions, thus reducing dispersion in healthy parts of the body and yielding lower adverse side effects for a given therapeutic efficacy.
INFERNAL MECHANISM Mauro Ferrari Mechanical Engineering; Mar 2010; 132, 3; Docstoc pg. 24 Reproduced with permis
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