Kidney Stone Disease Tied to Obesity by ProQuest


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									14 Renal & Urology News            FEBRUARY 2010

Kidney Stone Disease Tied to Obesity
During a five-year period, stones were diagnosed in 4.9% of obese and 2.6% of non-obese subjects
OBESITY IS associated with an in                 Among male subjects, those with a                                                                    “Obesity is associated with an
creased risk of kidney stone dis-              BMI of 30-34.9, 35-39.9, 40-44.9, and                                                                increased risk of kidney stone forma-
ease, researchers concluded in a               45-49.9 had a significant 2.44, 2.74,                                                                 tion, a concerning finding considering
recent study.                                  2.66, and 3.18 times increased risk of                                                               that obesity and nephrolithiasis are
  Brian R. Matlaga, MD, and his col-           kidney stone disease compared with                                                                   increasing at a great rate,” Dr. Matlaga’s

leagues at Johns Hopkins University            individuals who had a BMI below 20.                                                                  group concluded. “However, the risk
School of Medicine in Baltimore,                 Among female subjects, compared                                                                    of stone disease in the obese popula-
studied 95,598 patients, 54,572 female         with those who had a BMI below 20,                                                                   tion does remain stable with increasing
(57.1%) and 41,026 male 42.9%).                those with a BMI of 30-34.9, 35-39.9,       An x-ray of a stone in an obese patient.                 degrees of obesity as stratified by BMI
Among non-obese subjects (BMI less             40-44.9, 45-49.9, and 50 or greater                                                                  based on our present analysis. Dietary
than 30 kg/m2), 2.6% were diagnosed            had a significant 1.95, 1.84, 2.42, 2.31,    their analysis included 33,051 subjects                  modification and weight loss should be
with a kidney stone during the evalu-          and 2.54 increased risk of kidney stone     with a BMI greater than 30 and 11,413                    encouraged in the obese population to
ation period (2002-2006), compared             disease. Researchers observed no sig-       subjects with a BMI greater than 35.                     reduce stone risk.”
with 4.9% of obese patients (BMI of 30         nificantly increased risk among those          “Therefore, we can provide a robust                      In a previous study published in
or greater), according to a report in The      with a BMI of 20-24.9.                      description of the prevalence of stone                   the Journal of the American Medical
Journal of Urology (2010;183:571-575).           “What the present work uniquely adds      disease among all categories of obe-                     Association (2005;293:455-462), research-
At all stratifications of obesity, except       to our understanding of the relationship    sity,” they wrote. To their knowledge,                   ers found that a BMI of 30 or greater was
for men with a BMI greater than 50,            between obesity and kidney stone dis-       they stated, no similar report has strati-               associated with a twofold increased risk
obese patients were significantly more          ease is the subcategorization of a large    fied the effect of increasing degrees                     of kidney stone formation in women and
likely to be diagnosed with a kidney           cohort with extreme, or morbid, obe-        of obesity on stone risk, especially in                  a 33% increased risk in men compared
stone that non-obese patients.                 sity,” the authors wrote. They noted that   extremely obese patients.                                with a BMI of 21-22.9. ■

BCG Better                                     45% decreased risk of distant metasta-
                                               ses, a 24% decreased risk of all-cause
                                               mortality, and a 53% decreased risk
                                                                                            Adding ADT to Brachytherapy
For Overall                                    of death from bladder cancer. The
                                               researchers observed no significant
                                                                                            May Boost Mortality Risk
Survival                                       difference in time to progression or in
                                               non-bladder cancer mortality.
                                                                                            ADDING ANDROGEN deprivation therapy
                                                                                            (ADT) to brachytherapy for localized
                                                                                                                                                    online ahead of print). The researchers
                                                                                                                                                    observed no association between ADT
                                                 Among patients with intermediate-
                                                                                            prostate cancer may incre
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