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14 Renal & Urology News FEBRUARY 2010 www.renalandurologynews.com Kidney Stone Disease Tied to Obesity During a ﬁve-year period, stones were diagnosed in 4.9% of obese and 2.6% of non-obese subjects OBESITY IS associated with an in Among male subjects, those with a “Obesity is associated with an creased risk of kidney stone dis- BMI of 30-34.9, 35-39.9, 40-44.9, and increased risk of kidney stone forma- ease, researchers concluded in a 45-49.9 had a signiﬁcant 2.44, 2.74, tion, a concerning ﬁnding considering recent study. 2.66, and 3.18 times increased risk of that obesity and nephrolithiasis are Brian R. Matlaga, MD, and his col- kidney stone disease compared with increasing at a great rate,” Dr. Matlaga’s ISTOCKPHOTO leagues at Johns Hopkins University individuals who had a BMI below 20. group concluded. “However, the risk School of Medicine in Baltimore, Among female subjects, compared of stone disease in the obese popula- studied 95,598 patients, 54,572 female with those who had a BMI below 20, tion does remain stable with increasing (57.1%) and 41,026 male 42.9%). those with a BMI of 30-34.9, 35-39.9, An x-ray of a stone in an obese patient. degrees of obesity as stratiﬁed by BMI Among non-obese subjects (BMI less 40-44.9, 45-49.9, and 50 or greater based on our present analysis. Dietary than 30 kg/m2), 2.6% were diagnosed had a signiﬁcant 1.95, 1.84, 2.42, 2.31, their analysis included 33,051 subjects modiﬁcation and weight loss should be with a kidney stone during the evalu- and 2.54 increased risk of kidney stone with a BMI greater than 30 and 11,413 encouraged in the obese population to ation period (2002-2006), compared disease. Researchers observed no sig- subjects with a BMI greater than 35. reduce stone risk.” with 4.9% of obese patients (BMI of 30 niﬁcantly increased risk among those “Therefore, we can provide a robust In a previous study published in or greater), according to a report in The with a BMI of 20-24.9. description of the prevalence of stone the Journal of the American Medical Journal of Urology (2010;183:571-575). “What the present work uniquely adds disease among all categories of obe- Association (2005;293:455-462), research- At all stratiﬁcations of obesity, except to our understanding of the relationship sity,” they wrote. To their knowledge, ers found that a BMI of 30 or greater was for men with a BMI greater than 50, between obesity and kidney stone dis- they stated, no similar report has strati- associated with a twofold increased risk obese patients were signiﬁcantly more ease is the subcategorization of a large ﬁed the effect of increasing degrees of kidney stone formation in women and likely to be diagnosed with a kidney cohort with extreme, or morbid, obe- of obesity on stone risk, especially in a 33% increased risk in men compared stone that non-obese patients. sity,” the authors wrote. They noted that extremely obese patients. with a BMI of 21-22.9. ■ BCG Better 45% decreased risk of distant metasta- ses, a 24% decreased risk of all-cause mortality, and a 53% decreased risk Adding ADT to Brachytherapy For Overall of death from bladder cancer. The researchers observed no significant May Boost Mortality Risk Survival difference in time to progression or in non-bladder cancer mortality. ADDING ANDROGEN deprivation therapy (ADT) to brachytherapy for localized online ahead of print). The researchers observed no association between ADT Among patients with intermediate- prostate cancer may incre
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