J. Biomedical Science and Engineering, 2010, 3, 83-84 JBiSE
doi:10.4236/jbise.2010.31012 Published Online January 2010 (http://www.SciRP.org/journal/jbise/).
Induced-pluripotent stem cells seeded acellular peripheral
nerve graft as “autologous nerve graft”
Jiang Li1*, Guo-Dong Gao1*, Ti-Fei Yuan*
Department of Neurosurgery, Tang Du Hospital, The Forth Military Medical University, Xi’an, China.
Email: email@example.com; firstname.lastname@example.org; email@example.com
Received 27 October 2009; revised 9 November 2009; accepted 10 November 2009.
ABSTRACT 2. THE HYPOTHESIS
The hypothesis is that induced pluripotent stem cells We propose that the recent developed induced pluripo-
(iPSC) derived Schwann cells and/or macrophages can tent stem cell (iPSC) technology combined with acellu-
be transplanted into acellular nerve graft in repairing lar nerve graft transplantation can provide a novel ap-
injured nervous system. The efficiency of iPSC seeded proach to repair the injured nervous system. The iPSC-
acellular nerve graft may mimic the autologous periph- seeded acellular nerve graft from other individuals can
eral nerve graft. be functional similar to the autologous nerve grafts.
The induced pluripotent stem cells, genetically repro-
Keywords: Induced-Pluripotent Stem Cells, Peripheral grammed form any somatic cells can be theoretically
Nerve Graft; Axon Regeneration promoted into any kinds of cells [3,4,5], including Sch-
wann cells and macrophages. We propose that the iPSC
1. INTRODUCTION could be generated from somatic cells of the patients,
and induced into Schwann cells and macrophages before
Brain and spinal c