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Curriculum vitae tweezer0

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Curriculum vitae tweezer0

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									Kellermayer: Resumé                                                                                      1
                                            CURRICULUM VITAE


Name:                 Miklós Sándor Zoltán Kellermayer
Affiliation:          University of Pécs, Medical School, Department of Biophysics
                      Pécs, Szigeti ut 12., H-7624
                      Tel: +(36-72) 326-222/2348. Fax: +(36-72) 314-017 Mobile: +(36-30) 500-5041
                      e-mail: Miklos.Kellermayer.Jr@aok.pte.hu.
                      Home page: www.pote.hu/biofizika/Molbiof/public

Place of birth:              Pécs, Hungary
Date of birth:               July 17, 1964
Family status:               Married: Dr. Gyöngyi Szántó; Five children: Zoltán, Bernát, Blanka, Dalma, Anna

Educational history:
1988                 M.D., General Medicine (No. 69-66/1988)   University of Pécs, Medical School
                     Doctoral thesis:                          Thesis advisers:
                     "Isolation and structural                 Dr. József Belágyi
                     investigation of tubulin"                 Dr. Károly Trombitás
1998                  Ph.D., Medicine (No. 117-3/1998)         University of Pécs, Medical School
                      PhD. thesis: “Dynamic cytoskeletal interactions studied with an
                      in vitro molecular model system”

Language skills:      English fluent (State exam No. Á 025526/1982)
                      Russian basic (Language exam No. POTE 170/1997)

Research experience:
1983-1988          Research Trainee                             University of Pécs, Medical School
                   Structure and molecular dynamics             Central Research Laboratory
                   of microtubules;                             Advisers:
                   EPR spectroscopy and                         Dr. József Belágyi
                   Electron microscopy                          Dr. Károly Trombitás
1988-89               Postdoctoral Research Fellowship          Uiversity of Pécs, Medical School
                      Hungarian Academy of Sciences             Department of Biophysics
                      Structure and dynamics of the             Adviser:
                      striated muscle cytoskeleton              Dr. József Tigyi
1989-91               Postdoctoral fellow                       Center for Bioengineering,
                      In vitro actomyosin motility              University of Washington
                      Fluorescence video microscopy             Seattle, Washington, USA
                                                                Adviser: Gerald H. Pollack, Ph.D
1991-93               American Heart Association                Center for Bioengineering
                      Postdoctoral Research Fellowship          University of Washington
                      Actin filament dynamics studied           Adviser: Gerald H. Pollack, Ph.D.
                      with the in vitro motility assay
1993-97               Research Associate                        University of Pécs, Medical School
                      Biological motility, electron             Central Research Laboratory
                      microscopy, digital image processing
1995-1997             Research Associate                        Dept. Veterinary Comparative
                      Molecular biophysics of titin             Anatomy, Pharmacology and
                      Development of laser trap for             Physiology, Washington State
Kellermayer: Resumé                                                                                            2
                       stretching single titin molecule          University, Pullman, WA USA
1998-2000              Assistant professor                       University of Pécs, Medical School
                                                                 Department of Biophysics
2000.01-03             Visiting professor                        Dept. Veterinary Comparative
                       Development of force-feedback             Anatomy, Pharmacology and
                       atomic force microscope for               Physiology, Washington State
                       stretching single titin molecule          University, Pullman, WA USA
2000-                  Associate professor                       Univ. Pécs, Med. Sch., Dept. Biophysics
                       Research areas:
                       Single molecule manipulation with laser tweezers
                       Actomyosin motility studied with the in vitro motility assay
                       Molecular biophysics of the giant muscle protein titin
                       Nanobiotechnology, single-molecule imaging and manipulation with AFM

Teaching experience:
1988-89                    Invited lecturer, Biology in English, Pécsi Apáczai Csere János Nevelési
                           Központ Gimnázium, bilingual educational program
1991                       Guest Lecturer, Cellular Biomechanics, Graduate course in Bioengineering
                           University of Washington, Seattle, WA, USA
1993-98                    Lecturer, course instructor, examiner
                           Biometrics, Medical core curriculum, University of Pécs, Medical School
1993-94                    Course instructor, Electron microscopy. Seminar and lab practice within the
                           Biophysics curriculum, University of Pécs, Medical School.
1994-                      Course instructor, Biomedical light microscopy and digital image processing
                           Credit course, University of Pécs, Medical School
1998-                      Lecturer, course instructor, examiner
                           Biophysics, Medical core curriculum, University of Pécs, Medical School.
1998-                      Course instructor, Cellular biomechanics. Cellular and molecular basis of
                           biological motion. Credit course, University of Pécs, Medical School
1998. November. 23.        Invited Ph.D. course lecturer. Biochemistry, Szent-Györgyi Albert Medical School.
1999. March. 21.           Invited Ph.D. course lecturer. Methods in molecular structure.
                           Semmelweis Medical University
1999-                      Ph.D. course instructor: Molecular biomechanics, University of Pécs, Medical School
1999-                      Ph.D. course instructor Digital Image Processing, University of Pécs, Medical School
2001. September 20.        Invited Lecturer: Workshop on Biological Structure. Abdus Salam International
                           Centre for Theoretical Physics, Trieste, Italy.
2003. February 9-12.       Invited Lecturer: Winter College on Biophotonics. Abdus Salam International
                           Centre for Theoretical Physics, Trieste, Italy.
2003. May 19.              Invited Lecturer: Muscle Physiology. Orthopedic Surgery Residency program.
                           University of Pécs, Medical School.

Honors and awards:
1981        National Honor Society of the USA Award in Chemistry
1984        I. Prize in Histology competition, University of Pécs, Medical School
1984-1988   Hungarian State Scholarship
1985        XVII. Országos TDK Konferencia (National Student Research Conference), Budapest, I. prize
1987        XVIII. Országos TDK Konferencia (National Student Research Conference), Pécs, I. prize
Kellermayer: Resumé                                                                                       3
1988          Rector’s Award for thesis, University of Pécs, Medical School
1988          Graduation with award: Summa cum laude
1988          "Verzár Frigyes" Award of the Hungarian Biological Association
1988-1989     Postdoctoral Research Fellowhip of the Hungarian Academy of Sciences
1991-1993     Postdoctoral Research Fellowship, American Heart Association, Washington Affiliate
1994          American Biophysical Society Travel Fellowship
1998          “Kovács Tibor” Award, Hungarian Immunological Society
1998          “Magyary Zoltán” Postdoctoral Fellowship, Foundation for Hungarian Higher
              Education and Research (declined award)
1998-2001     “Bolyai János” Postdoctoral Fellowhip, Hungarian Academy of Sciences
1999          American Biophysical Society Travel Fellowship
2001          Hungarian State Eötvös Fellowship
2002-2004     Széchenyi Fellowship

Society memberships:
Hungarian Microscopical Society (since 1989)
European Society for Microscopy (since 1989)
American Biophysical Society (since 1991)
American Association for the Advancement of Science (since 1995)
Hungarian Biophysical Society (since 1998)
Hungarian Biopchemical Society (since 2001)

Recent grant support:
1. European Development Grant, FEFA Project No. 3313, Subproject No. 687-6.2, 1994.
2. Hungarian Ministry of Social Welfare T-06 622/93. "Investigation of cardiac ischemia in an in vitro molecular
model system". 1993-1996, Principal Investigator.
3. World Bank funded Instrument grant, OTKA W015117, 1995, Principal Investigator.
4. Hungarian Research Foundation, OTKA F 017164. "Structural and functional reconstruction of strited muscle
myofilaments”. 1995-98, Principal Investigator.
5. Higher Education Program Financing Grant. PFP-1013/98. "Interactive teaching of molecular biophysics". 1998,
Principal Investigator.
6. NATO grant for organizing NATO Advanced Research Workshop: Biological, Biophysical and Theoretical
Aspects of Polymer Structure and Transport, Bikal, Hungary, June 15-20, 1999. (Co-Director).
7. OMFB “Mecenatúra”. OMFB-01871/98. Travel support.
8. OMFB “Mecenatúra”. OMFB-02248/98. Congress organization support.
9. Hungarian Ministry of Social Welfare T-06 021/97. "Mechanism of action of calcium-sensitizing drugs as
studied in a molecular model system using cardiac biopsy samples obtained from cardiomyopathic patients.” 1997-
1999, Principal Investigator.
10. Hungarian Research Foundation, OTKA F 025353. "Molecular biophysics of the giant protein titin". 1998-
2001, Principal Investigator.
11. Hungarian Research Foundation, OTKA T25206. "Interactions between chaperones and the cytoskeleton"
1988-2001 (Principal Investigator, Dr. Péter Csermely).
12. Hungarian Education Minisrty Instrument Grant MU-00550/2000. “Development of force-measuring laser
tweezers”

Current grant support:
1. European Community, Framework V. Muscle and Motility EC Netwrok Grant. RTN1-1999-00419. Principal
Investigator of sub-project.
2. Hungarian Research Foundation, OTKA T032700. “Dynamic and structural characteristics of contractile
proteins” 2000-2003. (Principal Investigator, Dr. Béla Somogyi)
3. Howard Hughes Medical Institute International Research Scholar Grant. #55000314. 2001-2005. Molecular
Biophysics of the Muscle Cytoskeleton. Principal Investigator.
Kellermayer: Resumé                                                                                     4
4. FKFP pályázat, Dél-Dunántúli Kooperációs Kutatási Központ. A Nanobiotechnológiai Csoport vezetője.
5. Tematikus OTKA T037935. “Molecular mechanics of cztoskeletal muscle proteins explored with
nanobiotechnology methods". 2002-2005. Principal Investigator.
6. Hungarian Ministrz of Education. Nanobiotechnology BIO-110/2002. “Development of specific nano tweezers
for the manipulation of single biomolecules” 2003-2005. Project coordinator.
7. Hungarian Ministry of Social Welfare 440/2003. „Nanomechanics of collagen” 2003-2005. Principal
Investigator.

Seminars:
1989. October 29.   Structure and molecular dynamics of the microtubular cytoskeleton.
                    PPG seminar. University of Washington, Seattle.
1991. April 26.     In vitro motility assay for the study of actin-filament
                    dynamics. PPG seminar. University of Washington, Seattle.
1992. April 17.     Segmental behavior of actin filaments in the in vitro motility assay.
                    PPG seminar. University of Washington, Seattle.
1992. December 4. In vitro actin-filament motility at reduced ATP levels. PPG
                    seminar. University of Washington, Seattle.
1994. March 16.     After ATP pretreatment, in vitro action motility persists at nanomolar
                    ATP concentrations. Washington State University, Pullman.
1994. April 18.     Mechanisms of muscle contraction studied in an in vitro molecular system.
                    University of Pécs, Medical School. Science Lecture Series.
1995. March 22.     Effect of Triton X-100 on in vitro actomyosin motility.
                    University of Washington, Seattle.
1997. February 26.  Elastic properties of the titin molecule measured using an optical trap.
                    Washington State University, Pullman.
1997. March 17.     Folding-unfolding transitions in single titin molecules characterized with
                    force-measuring laser tweezers. University of Washington, Seattle.
1997. September 1. Mechanical manipulation of biomolecules. University of Pécs, Medical School
                    Central Research Laboratory
1997. December. 15. Stretching a single molecule with laser tweezers:
                    folding/unfolding transitions in the giant protein titin.
                    University of Pécs, Medical School. Science Lecture Series.
1998. February 10.  Cytoskeletal system of the striated muscle.
                    University of Pécs, Medical School. Department of Neurology.
1998. May 14.       Molecular mechanics of the giant muscle protein titin.
                    University of Pavia, Pavia, Italy.
1998. May 29.       Stretching a single protein molecule: mechanically driven
                    folding-unfolding transitions in the giant protein titin.
                    National Institutes of Standards and Technology,
                    Bioprocess Engineer Group, Gaithesburg, MD, USA.
1999. January 28.   Mechanical extension of the giant protein titin by using laser tweezer.
                    Semmelweis Medical University, Department of Medical Chemistry
1999. February 18.  Mechanical manipulation of the giant muscle protein titin.
                    Dept. VCAPP, Washington State University, Pullman, WA USA.
2000. February 16.  Molecular bungee in muscle.
                    Dept. Microbiology, University of Alabama, Birmigham, AL USA.
2000. October 6.    Mechanical behavior of the giant protein titin explored by imaging and
                    manipulating single molecules
                    European Laboratory for Nonlinear Spectroscopy. Florence, Italy.

Invited symposium lectures:
1993. September 5. Investigation of muscle contraction in a dynamic, in vitro molecular model system,
Kellermayer: Resumé                                                                                       5
                      using fluorescence video microscopy. Conference on Luminescence Sectroscopy, Pécs.
1997. September 9.    Folding-unfolding transitions in single titin molecules characterized with force-
                      measuring laser tweezers. Alpbach Workshop on Coiled Coils. Alpbach, Austria.
1998. February 26.    Elastic behavior of the cardiac titin molecule charactierized by manipulating
                      single molecules with laser tweezers. 42nd Annual Meeting of the
                      American Biophysical Society, Kansas City, MO, USA.
1999. February 13.    A molecular segment in titin is an adjustable spring. 43rd Annual Meeting
                      of the American Biophysical Society, Baltimore, MD, USA.
1999. June 23.        Mechanical extension of single molecules of the giant protein titin. Biological,
                      Biophysical and Theoretical Aspects of Polymer Structure and Transport.
                      NATO Advanced Research Workshop, Bikal.
2000. February 12     The muscular break: molecular mechanisms of regulating sarcomeric extensibility by
                      titin. Motility Subroup Meeting, 44th Annual Meeting of the American Biophysical
                      Society, New Orleans, USA
2000. February 16.    Direct visualization of the extensibility of fluorescently labeled titin molecules.
                      44th Annual Meeting of the American Biophysical Society, New Orleans, USA
2000. June 22.        Molecular Bungee in Muscle: Mechanisms of regulating sarcomeric extensibility by titin.
                      Workshop on Models of Biological Motion. Collegium Budapest, Institute for Advanced
                      Study, Budapest, Hungary. Summary about the workshop: Nature Magazine,
                      News and Views, 406, 244-245, 2000.
2000. August 12.      Mechanical properties of the giant protein titin explored by imaging and manipulating
                      single molecules. 3rd Conference on Molecular Recognition. Pécs, Hungary.
2001. February 21.    Stretch-and-release molecular force spectroscopy of titin. 45th Annual Meeting of the
                      American Biophysical Society, Boston, USA.
2001. May 15.         Studying protein folding on a single molecule. Annual Meeting of the Hungarian Society
                      for Biochemistry, Sárospatak, Hungary.
2002. October 26.     Force-driven unfolding in single protein molecules.
                      Nanobiology 2001. Atlanta, GA, USA.
2002. August 8        Imaging and mechanical manipulation of skeletal-muscle titin. World Congress on
                      Biomechanics. Calgary, Canada.
2003. May 8.          Limits of Imagination: The "Nano" World. Grastyán Endre Szakkollégium Konferenciája.
                      Opening Lecture.
2003. May 23.         Mechanical manipulation of single biomolecules. XXXIII. Membrane transport
                      Conference. May 19-23., 2003. Sümeg, Hungary
2003. May 25.         Mechanical manipulation of single molecules of titin
                      and its recombinant fragments.
                      EMBO/HHMI Central European Scientists Meeting. 25-25 May, 2003, Warsaw.

Science organizing activity:
1998. February 26.   Chairman in the Muscle Mechanics and Ultrastructure section.
                     42nd Annual Meeting of the American Biophysical Society,
                     Kansas City, MO, USA.
1999. June 20-25.    NATO Advanced Research Workshop Co-Director. Biological, Biophysical
                     and Theoretical Aspects of Polymer Structure and Transport. Bikal, Hungary.
2000. August 12-16. III. International Conference on Molecular Recognition, Pécs, Hungary.
                     Co-organizer of Cytoskeleton and Contractility section.
2001. September 5-9 European Muscle Conference. Organizer of the Elastic Filaments session.
Since January, 2003 Member of Research and Development Committee, University of Pécs, Medical School.
2005                 International FEBS Conference. Local organizer of the „Single molecule biochemistry“
                     section

Ad hoc reviewer in international journals:
Kellermayer: Resumé                            6
Biophysical Journal
Journal of Muscle Research and Cell Motility
Physical Review Letters E
Journal of Biological Chemistry
Histochemical Journal
Progress in Biophysics and Molecular Biology

								
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