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wrinkle filling system Moisturizing

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					           DIRECTIONS
           On clean and completely dry skin, apply a small amount of Fillderma DUO Silicone Serum (Step 1) all over the face including the
           eye contour wrinkles (in front, frown, and nasogenian fold). Let it work for one minute until it is completely absorbed and then apply
           fillderma DUO activating gel (Step 2) on the face.
           You may complete the treatment by applying a moisturizing cream such as DAESES (lifting/firming), ACGLICOLIC (anti-aging), JUVESES
           (Menopause), RETISES (retinol and vitamin C), BTSES (expression wrinkles).

           TREATMENT PERIOD
           Two applications per day (morning and night) for six to twelve months.
           Maintenance treatment: Three times per week. SPECIALLY AT NIGHT.
           In order to capture the maximum filling effect, periodically exfoliate prior to application of Fillderma DUO
                                                                                                                                                                                                                                                   wrinkle-filling system
           NORMAL SKIN: Abradermol Microdermabrasion Cream. Once every 10 to 15 days.
           SENSITIVE SKIN: Mandelac Scrub. One to two times per week.




             COMPLEMENTARY TREATMENTS



                                                                                                                                           Firming Facial Gel Cream




                                                                                                                                                Moisturizing Cream

                                                                                                                                                Moisturizing Cream


                                                                                                                                                                                                                                                 HYALURONIC ACID microspheres
                                                                                                                              Acglicolic Classic Forte Moisturizing Gel Cream

                                                                                                                                                          Moisturizing Cream

                                                                                                                                                                                                                                                 Low molecular weight hyaluronic acid (10-20kDa)




                                                                                                                                                        Antiwrinkle Gel Cream




           * After    fillderma DUO silicone serum (Step 1) have been absorbed.




           BIBLIOGRAPHY
           1.Pieper JS, Oosterhof A et al. Preparation and characterization of porous crosslinked collagenous matrices containing bioavailable chondroitin sulphate. Biomaterials 1999; 20: 847-58.
           2. Servaty R, Schiller J et al. Hydration of polymeric components of cartilage-an infrared spectroscopic study on hyaluronic acid and chondroitin sulfate-. Int J Biol Macromol. 2001; 28: 121-127.
           3. Pierard GE, Lapiere M. Skin in dermatosparaxis. Dermal microarchitecture and biomechanical properties. J Invest Dermatol. 1976; 66: 2-7.
           4. Daly CH, Odland GF. Age-related changes in the mechanical properties of human skin. J Invest Dermatol. 1979; 73: 84-87.
           5. Daly CH. Biomechanical properties of dermis. J Invest Dermatol. 1982; 79 Suppl 1: 17s-20s.
           6. Loden M. Urea-containing moisturizers influence barrier properties of normal skin. Arch Dermatol Res. 1996; 288: 103-107.
           7. Swanbeck G. Urea in the treatment of dry skin. Acta Derm Venereol Suppl (Stockh). 1992; 177: 7-8.
           8. Sunilkumar, Parameshwaraiah S, Shivakumar HG.Evaluation of topical formulations of aqueous extract of Centella asiatica on open wounds in rats.Indian J Exp Biol. 1998 Jun; 36(6): 569-72.
           9. Nagakawwa et al, 2002-07-24.Protective activity of green tea against free-radical and glucose-mediated protein damage. J Agric Food Chem, Apr 10, 50 (8), p 2418. 10. Negrel et al, 1989.Prostacyclin as a potent effector
           of adipose cell differentiation.Biochem J, 257, p399.
           10. Yamauchi et al, 1998.Aging and cross-linking of skin collagen.Biochem Biophys Res Commun., April, 152, (2), p898.
           11. Uitto J, Paul JL, Brockley K, Pearce RH, Clark JG. Elastic fibers in human skin: quantitation of elastic fibers by computerized digital image analyses and determination of elastin by radioimmunoassay of desmosine.Lab
           Invest. 1983 Oct;49(4): 499-505.
           12. Narayanan AS, Page RC. Biochemical characterization of collagens synthesized by fibroblasts derived from normal and diseased human gingiva. J Biol Chem. 1976 Sep 25; 251(18): 5464-71.
           13. Hsu-Wong S, Katchman SD, Ledo I, et al.Tissue-specific and developmentally regulated expression of human elastin promoter activity in transgenic mice. J Biol Chem. 1994 Jul 8; 269(27): 1 8072-5.



                                SeSDERMA S.L., Polígono Industrial Rafelbuñol.                      SeSDERMA U S A INC.                               SeSDERMA PORTUGAL
                                                                                                                                                      Rua Ilídio Sardoeira, 47
                                                                                                    42 Lenox Pointe. Atlanta. GA 30324. USA           4400-107 VILA NOVA DE GAIA
                                C/ Massamagrell, 3 - 46138 Rafelbuñol. Valencia (España)            Tel.: (1) 404 846 2044. Fax: (1) 404 846 2045     Atendimento ao cliente: (351) 223 760 402
                                www.sesderma.com • e-mail: ses@sesderma.com                         Customer line: (1) 800 796 0996                   SeSDERMA COLOMBIA
                                                                                                                                                      Carrera 49 C, 79-81 BARRANQUILLA - Colombia
                                                                                                    www.sesdermausa.com                               Atención al cliente: (57) 53 68 78 05
                                                                                                                                                                                                                     DIN EN ISO 9001:2000
                                                                                                                                                                                                                  Certificado Nº 01 100 058077
                                Customer line: 0034 961412058                                       e-mail: ses@sesdermausa.com                       e-mail: sescol@metrotel.net.co
C2103-12




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           PA N A M A · PA R AG U AY · P O L A N D · P O R T U G A L · R U S S I A · S A U D I A R A B I A · S O U T H A F R I CA · TA I WA N · U K · U N I T E D A R A B E M I R AT E S · U S A · V E N E Z U E L A
                  wrinkle-filling system                                                                                                                                     activating gel
                                                                                                                                                                             long-lasting filling from the inside

                                                                                                                                                                    Enhances the effects of the microspheres by hydrating and expanding them.
                                                                                                                                                                    Regenerates, redensifies, and restructures the skin, recovering the firmness and elasticity.
                                double wrinkle-filling without injections!                                                                                       EPIDERMIS
                                Topical system that smoothes and fills wrinkles and folds on the face.                                                           PROTEASES
                                May be used as an alternative or as a simple, painless complement to injections.                                                 Helps penetrate the active ingredients
                                Contains none of the side effects of microinjections. Immediate and long-lasting results.                                        UREA
                                                                                                                                                                 · Moisturizes, soothes, and regenerates.
                                                                                                                                                                 HYALURONIC ACID
                                                                                                                                                                 · High molecular weight: forms a hydration film. Flash effect.
                                                                                                 BEFORE                                                          · Low molecular weight (10 - 20kDa): penetrates the corneous layer and stimulates hyaluronic acid
                                                                                                           x9                                                    synthesis, inhibiting hyaluronidase-1, which improves elasticity and reduces oxidative stress on
                                                                                                                                                                 the skin.
                                   silicone serum
                                                                                                                                                                 DERMIS
                                   immediate filling - flash effect!
                                                                                                                                                                 MIMETIC PEPTIDES (PAL-KTTKS, PAL-VGVAPG, PAL-GHK)
                        CONTAINS                                                                 AFTER                                                           Regenerates the dermal matrix, stimulating the synthesis of GAGs and proteoglycans.
                        DEHYDRATED HYALURONIC ACID AND COLLAGEN                                        x30                                                       CENTELLA ASIATICA
                        MICROSPHERES                                                                                                                             Stimulates synthesis of GAG and proteoglycans.
                        The spheres increase to 30 times their original volume once water                                                                        NIACINAMIDE
                        activates them, immediately filling the wrinkle.                                                                                         Improves the functional barrier of the skin: it regulates ceramide synthesis, keratin, involucrin
                                                                                                                                                                 and filagrin. Reduces TEWL. It stimulates new collagen synthesis.
                                                                                                                                                                                                                                                                 IN VITRO
                        PROPERTIES OF MICROSPHERES                                                                                                                                                                                                               Cultivates fibroblasts by means of
                        · They capture and retain large amounts of water that increase                                                                           HYPODERMIS                                                                                      a substrate of differentiation and
                                                                                                                                                                                                                                                                 3% fermented sweet black tea
                          their volume                                                              microspheres increase their                                  FERMENTED SWEET BLACK TEA                                                                       extract. The fermented sweet black
                                                                                                                                                                                                                                                                 tea extract stimulates the
                        · Hydrate skin                                                              volume a                                                     · Lipofilling; stimulates adipocyte differentiation within                                      differentiation of the adipocytes
                                                                                                                                                                                                                                                                 and increases the activity of
                        · Immediately fill wrinkles                                                 more than before                                               the skin.                                                 Control             Adipocyte       G3PDH* by 136%.
                                                                                                                                                                 · Prevents glycation of collagen and elastine.                                differentiation   *Glyceraldehyde-3-phosphate dehydrogenase


                                                                                                                                                                 · Smoothes the skin, giving it a glowing aspect and a pink color.
C.N. 162556.4



IMMEDIATELY FILLS THE WRINKLES                                                                           Reduces wrinkles

                                                                                                                                                                                                                                                                       hydrated
                                                                                                                                                  dehydrated                                                                                                           spheres
                                                                                                 60%
                                                                                                                                                     spheres
                                                                                                                         54%
                                                                    IN VIVO: 54% of              50%                                               epidermis

                                                                      wrinkles are
                                                                                                 40%                                                  dermis                                                                                                           neocollagenesis
                                                                     smoother after                        31%
                                                                       the initial               30%                                             hypodermis
                                                                                                                                                                                                                                                                       adipocyte
                                                                      application                20%                                                                                                                                                                   proliferation
           DEHYDRATED                 HYDRATED
                                                                                                 10%
           SPHERES                    SPHERES
                                                                                                  0%
                                                                                                                                        MECHANISM              · The spheres enter the        · The spheres re-hydrate by      · The depth of wrinkles decreases by:
                                                                                                                                                                 micro-depressions and          taking up water from TWL         · Swelling of the spheres. Filling of the upper
                                                                                                                                        OF ACTION
                                                                                                          PLACEBO       HYALURONIC
                                                                                                                    ACID MICROSPHERES
                                                                                                                                                                 reach the upper epidermis.     and from the activating gel.       epidermal layers through an increase in the spheres volume.
                                                                                                                                                                                              · Hydration of epidermis           · Regeneration of epidermal, dermal and hypodermal
                        SILICONE                                                                                                                                                                increases.                         tissues induced by the activating gel.
                        Hydrophobic
                        ·Immediately fills, decreases the depth, and hides wrinkles.
                        ·Moisturizes and matifies skin (absorbs sebum) small silicon
                        particles together with silicone surface alow a sebum absorption.
                                                                                                                                        results



                        PEARLY SOFT-FOCUS PIGMENTS
                                                                                                reflects light
                        Immediate flash effect. Hides imperfections such as wrinkles
                        and scars and diminishes signs of fatigue.
                                                                                                            pigments                    Before                     After                                             Before                             After



                                                                                                                 skin

				
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Description: wrinkle filling system Moisturizing