Study on efficiency of Monoclonal antibody-Palcitaxel complex as antineoplastic
Srujana.D., Durgaprasad.K., Ramchander.T., Nagaraju.G.
Mother Teresa College of Pharmacy, Ghatkesar-501301, Ranagareddy Dist,
Andhra Pradesh, India
Neoplasm is a disease when uncontrolled growth of cells occurs due to different
factors. This is of two types, malignant and benign which means of dangerous and non
dangerous forms of growth of cells. The effective treatment includes the site specific
treatment for the tumors. Here, the study involves the evaluation of efficiency of
Monoclonal antibody-Palcitaxel complex as antineoplastic agent, where the Palcitaxel
derived from the plant origin.
The monoclonal antibodies were prepared from hybridoma cells which have come
from the immunized mouse. Palcitaxel was made into micro spheres and complexed with
the monoclonal antibodies. Monoclonal antibody-Palcitaxel complex (PLT-IMS) was
evaluated against palcitaxel (PLT) and palcitaxel microspheres (PLT-MS) for
antineoplastic activity using EAC induced tumor in mice. The mice were given by PLT,
PLT-MS, and PLT-IMS after 2nd and 11th day of post infection. The tumor inhibition was
calculated by estimating the packed cell volume of EAC. In 2nd day post infection group
PLT-IMS batch showed 67.77% tumor inhibition, PLT-MS showed 50.55% and PLT
showed 42.21%. In 11th day post infection group the % tumor inhibition was 64.1, 41.27
and 24.33 for PLT-IMS, PLT-MS and PLT respectively. These results are plausible that
the PLT-IMS complex is very effective in killing the tumor cells compared to other
compounds and more efficient than other compounds in treatment of neoplasm.