GRANTS ANNOUNCEMENT Department of Paediatrics and Child Health Aga by Commonthread

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									                       GRANTS ANNOUNCEMENT
                   Department of Paediatrics and Child Health
                            Aga Khan University

Title: Evaluation of the impact of zinc and/or multiple micronutrient
supplementations on growth, intestinal function and flora and morbidity in a
representative urban and rural cohort of young children in Pakistan

Principal Investigator: Dr Zulfiqar A Bhutta
Co-investigators: Dr Mohammad Imran, Dr Sajid Soofi, Dr Anita Zaidi, Dr Qamaruddin
Nizami, Dr Zahid Larik (Nutrition Cell, Ministry of Health)
Funding Agency: The Bill & Melinda Gates Foundation
Amount: US$ 4.25 million
Collaborating Institutions: Department of Microbiology, Tufts University Boston,
London School of Hygiene & Tropical Medicine, Nutrition Cell, Ministry of Health,
Islamabad
Project Duration: 3 years
Project Description: This is the first direct grant from the Gates Foundation to Aga
Khan University (AKU) and also the single largest research grant ever awarded to AKU.
This grant will allow the establishment of an urban and rural birth cohort in Karachi and
Hala/Matiari to evaluate the effects of nutritional supplementation for two years. The
project has substantial opportunities for in-depth studies and establishment of laboratory
methods for evaluation of nutrition outcomes, morbidity and growth in community
settings. There will be the possibility for establishing improved laboratory and research
infrastructure in Hala, an established community research site of the Department.




Title: Impact of Introduction of Haemophilus influenzae type b (Hib) Vaccine in
Pakistan’s National Immunization Programme.

Principal Investigator: Dr Anita Zaidi
Co-investigators: Dr Asad Ali, Dr Sajid Soofi, Dr Zulfiqar Bhutta, Dr Rehan Hafiz (EPI
program)
Funding Agency: Global Alliance for Vaccines and Immunizations (GAVI) and the Hib
Consortium
Amount: US$ 1.24 million
Collaborating Institutions: Pakistan Expanded Programme for Immunizations, Centers
for Disease Control and Prevention (CDC), Atlanta, Georgia, London School of Hygiene
and Tropical Medicine
Project Duration: 3 years
Project Description: The grant will allow the establishment of surveillance for Hib
disease in three districts of Pakistan and conduct epidemiological analyses to measure the
impact of introduction of new vaccines in children in Pakistan.
Title: Burden and Etiology of Diarrhoeal Diseases among Children in urban and peri-
urban Karachi.

Principal Investigator: Dr Anita Zaidi
Co-investigators: Departments of Pathology/Microbiology (Dr Rumina Hasan), and
Biological and Biomedical Sciences (Dr Sohail Qureshi)
Funding Agency: Center for Vaccine Development, University of Maryland, Baltimore,
USA through a grant from the Bill & Melinda Gates Foundation
Amount: US$ 958,000
Collaborating Institutions: Center for Vaccine Development, University of Maryland,
Baltimore, USA (Myron Levine)
Project Duration: 3 years
Project Description: This project will measure the pathogen-specific population burden
of diarrhoeal diseases and conduct related epidemiological studies in order to inform
vaccine priorities for enteric diseases in children in developing countries. The project also
allows AKU to build laboratory and field infrastructure for undertaking enteric vaccine
trials.



Title: Implementation and impact assessment of a novel urban school vaccination
strategy for reducing the burden of Typhoid fever in Karachi.

Principal Investigator: Dr Zulfiqar A. Bhutta
Co-investigators: Dr Sajid Soofi, Dr Hafeez Bhutto, Dr Shakil Ahmad
Collaborating Institutions: Departments of Pathology/Microbiology, Department of
Public Health, Government of Sindh
Funding Agency: International Vaccine Institute (Seoul) through a grant from the Bill &
Melinda Gates Foundation
Amount: US$ 750,000
Collaborating Institutions: International Vaccine Institute (Seoul) through a grant from
the Bill & Melinda Gates Foundation
Project Duration: 3 years
Project Description: Following the hugely successful epidemiological studies and
demonstration projects on typhoid fever in the slum populations of Karachi (2002-2007),
this project aims to implement and evaluate the impact of a novel strategy for vaccinating
young school children with a single dose Vi vaccine and to objectively evaluate the
reduction, if any, in the overall burden of disease. The project will also allow AKU to
build and further strengthen off-campus laboratory and field infrastructure for
undertaking enteric vaccine trials.
Title: Impact of management of childhood pneumonia by community health workers in
rural Sindh.

Principal Investigator: Dr Zulfiqar A. Bhutta
Co-investigators: Dr Sajid Soofi, Dr Qamaruddin Nizami, Dr Sheraz Ahmad, Dr Khalil
Ahmad
Funding Agency: United States Agency for International Development (USAID)
Amount: US$ 1.24 million
Collaborating Institutions: Division of International Health, Boston University School
of Public Health, National Program for Primary Care, Government of Pakistan, Save the
Children USA (Pakistan), the World Health Organization (Geneva)
Project Duration: 2 years
Project Description: This project builds on several pilot studies and the recent Hala
perinatal project. Given the persistent high burden of childhood pneumonia deaths in
Pakistan, this project aims to reduce the morbidity due to childhood pneumonia and delay
in the institution of appropriate therapy through trained community health workers. If
successful, the results will have huge policy implications for the national programme for
the prevention and treatment of acute respiratory infections in developing countries in
general and Pakistan in particular.

								
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