Unusual applications of lanthanides coordination complexes from by kdv77245


									Séminaires & Conférences Chimie École Doctorale 459                                       Jeudi 18 Juin 2009, 13h45
                           Salle de Cours SC-16.01 – Université Montpellier II

 Unusual applications of lanthanides coordination complexes:
      from protein crystallography to nonlinear optics
                                    Professeur Olivier MAURY
         Laboratoire de Chimie de l'École Normale Supérieure de Lyon, UMR CNRS 5182
            46 Allée d’Italie 69007 Lyon — courriel : olivier.maury@ens-lyon.fr

       In the last two decades, lanthanide complexes have been extensively used for their
   catalytic, magnetic and luminescence properties resulting in the development of
   numerous important application in particular in the field of bio-imaging as fluorescent-
   probe for fluoro-immunoassays as well as contrast agents for medical magnetic
   resonance imaging. By contrast, the study of the nonlinear optical (NLO) properties of
   lanthanides remains in its infancy and becomes currently an emerging field of
   research. Here, we will illustrate the potentialities of lanthanides for NLO and
   underline the direct contribution of f-electrons the quadratic hyperpolarisability[1] as
   well as the first example of nonlinear fluorescence microscopy imaging using
   europium, terbium or ytterbium derivatives[2] towards the design of new bio-probes as
   grafted or doped silica nanoparticles. During the course of this study, we serendipity
   discovered a new class of compounds exhibiting very strong supramolecular
   interactions with amino-acid, able to co-crystallise with a large variety of proteins and
   acting as valuable auxiliaries for proteins X-rays structures determination.[3]

   Figure. Left: Nonlinear microscopy imaging of cancer cell doped with europium complexes.[2]
           Right: luminescence imaging of lysozyme crystal co-crystallized with a terbium complex.[3]

    1. N. Tancrez, C. Feuvrie, I. Ledoux, .J Zyss, L. Toupet, H. Le Bozec, O. Maury, J. Am. Chem. Soc. 2005, 127,
          13474-13475 ; K. Sénéchal-David, A. Hemeryck, N. Tancrez, L. Toupet, J.A.G. Williams, I. Ledoux, J.
          Zyss, A. Boucekkine, J.-P. Guégan, H. Le Bozec, O. Maury, J. Am. Chem. Soc. 2006, 128, 12243-12255.
    2. A. Picot, A. D'Aléo, P.L. Baldeck, A. Grishine, A. Duperray, C. Andraud, O. Maury, J. Am. Chem. Soc.
          2008, 130(5), 1532-1533.
    3. G. Pompidor, A. D'Aléo, J. Vicat, L. Toupet, N. Giraud, R. Kahn, O. Maury, Angew. Chem. Int. Ed. 2008,
          47, 3388-3391.

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