Functional Food Ingredients: Probiotics Second generation probiotics DSM Food Specialties has developed second generation probiotics that are the result of extensive screening of a vast collection of micro-organisms with potential probiotic effects. LAFTI® probiotics have recently been selected using today’s scientific techniques that focus on probiotic properties that are now known to be important: stability survival proven health effects safety LAFTI®‘s unique benefits are the direct result of this Second-Generation screening Available Probiotic strains: Lactobacillus acidophilus LAFTI® L10 Bifidobacterium lactis LAFTI ® B94 Lactobacillus paracasei LAFTI ® L26 What are probiotics? A natural part of our body The literal meaning of ‘probiotics’ is ‘for life’. Probiotics are a generic term for naturally occurring ‘friendly’ bacteria that are beneficial for health, which differentiates them from the ‘bad’ bacteria such as the well known Escherichia coli and Salmonella, causing diarrhea and other intestinal problems. The most famous probiotic families are Lactobacillus and Bifidobacterium. Many different types of probiotic bacteria grow in the human digestive tract, and together with other ‘friendly’ bacteria create a complex ecosystem in our intestines called the intestinal microflora. Probiotics are thus a natural part of our body. What makes a bacteria a probiotic? Three checks Why do we need probiotics? Staying healthy What makes a bacteria a probiotic? 3. Survival of the bacteria Three checks The bacteria must be alive when reaching the 1. Safe for consumption human gut in order to provide the health benefits. The bacteria to be used as probiotic must be a It is important to note that probiotic 'friendly' bacteria that is safe. By law, only safe supplements in which the number of live bacteria are accepted on the market. However, bacteria CFU is guaranteed until the end of the law does not yet regulate the definition shelf life provide more certainty that you get a ‘probiotics’. Anyone can claim a bacteria to be a sufficient dose of 'friendly' bacteria than a probiotic bacteria. supplement that only guarantees the dose "at 2. Measurable beneficial effects on health time of manufacturing". There must be scientific evidence available demonstrating the beneficial effects of the probiotic strain on our health. Very important is that this scientific evidence must be for a specific strain. For example, there are many different Lactobacillus acidophilus strains, such as Lactobacillus acidophilus LAFTI® L10. This What are probiotics? strain is a probiotic, since there is scientific A natural part of our body evidence available demonstrating the health Why do we need probiotics? benefits for this specific strain. Staying healthy Lactobacillus acidophilus LAFTI® L10 [family] [species] [strain] Why do we need probiotics? The important balance of the many different Staying healthy types of ‘friendly’ bacteria is easily disturbed, however. External factors such Probiotic bacteria play an important role in as (antibiotic) medication, travel, changes in digesting food as well as maintaining health. diet and stress as well as internal influences They produce short chain fatty acids, which including microbial interactions and promote colonic nutrition, help the body in intestinal secretions can have a negative breaking down food, assist the absorption of effect. As a result, undesirable ‘bad’ essential vitamins, and protect against bacteria may invade, bringing symptoms attack from ‘bad’ bacteria such as E. coli such as diarrhea, constipation, and other and Salmonella. bowel problems. Supplementing the daily diet with probiotics keeps the important balance of ‘friendly’ bacteria in place and thereby helps maintain health. What are probiotics? A natural part of our body What makes a bacteria a probiotic? Three checks What are LAFTI® What makes LAFTI® probiotics special? probiotics? They bring the latest discoveries in the Second-generation field of probiotics probiotics The second-generation screening LAFTI® probiotics are strategy has resulted in unique benefits such second-generation probiotics. The first as stability, survival and probiotic health probiotic strains were isolated many effects (see picture below). decades ago without insight into strain- related characteristics and their efficacy was not always predictable or repeatable. Additionally, many ‘probiotics’ currently available in the market place lack the (strain-specific) scientific evidence to demonstrate the health benefits. Second-generation LAFTI® probiotics, conversely, have built on knowledge amassed over the years. LAFTI® probiotics are the result of sophisticated screening of a large number of bacteria with potential probiotic effects. LAFTI® second-generation probiotics have recently been selected using today’s scientific techniques that focus on probiotic properties that are now known to be important. LAFTI®’s unique benefits include: Proven health effects LAFTI® probiotics assist the immune system via Superior stability protection against ‘bad’ bacteria such as Listeria and Salmonella. Also, clinical studies in humans In order to deliver health benefits, probiotics must be alive when they arrive at their final destination: have been completed. These support LAFTI® as the intestines. Heat, moisture, long shelf life and having a beneficial effect on the general feeling of inadequate packaging of the final product can all well being and control of irritable bowel syndrome. easily inactivate probiotics, resulting in inferior Excellent survival consumer products. LAFTI® probiotics have been Before arriving at their final destination, probiotics particularly developed to minimise the difficulties must pass through the digestive system, including associated with stability. the stomach. The acidic stomach and bile in the digestive system can easily inactivate probiotics. LAFTI® second-generation probiotics have been specifically screened for acid and bile resistance and survival in the human digestive system. High concentration LAFTI® probiotics are available in very high concentrations, enabling for example dietary supplement manufacturers to create cost-effective supplements which are also efficacious. These probiotics can be blend with other ingredients such as prebiotics, vitamins and minerals, and they allow consumers to take their daily dose of probiotics in a single capsule. Safety All LAFTI® strains are safe to use in every application. Back.. Scientific information DSM’s understanding of probiotic Numerous studies have been undertaken cultures, combined with extensive and which support the positive effects of continuing in vivo and in vitro research probiotic microbial population. Choice of ensures that the LAFTI® range provides strain depends on the desired health an optimal combination of important benefits of the application. probiotic properties with data available to support product and labelling claims. To claim efficacy beyond the point of DSM will continue to provide scientific manufacture, probiotics must remain backing for all LAFTI® strains and stable throughout shelf life and in the support customers with advice and gastro-intestinal tract where they are support in product development and designed to take effect. Our studies have labeling. Literature information is shown that LAFTI ® survives well in the available human gastro-intestinal tract. from DSM upon request. Sophisticated strain selection is key to probiotic performance. DSM second- generation LAFTI® strains are specially selected and formulated to meet the dual demands of stability and survival, delivering positive probiotic effects to humans. Clinical trials have been completed which show that LAFTI® products are effective probiotics. These trials indicated promising results, for example a beneficial effect on the general feeling of well being and control of irritable bowel syndrome. Other studies have shown that all three LAFTI ® strains inhibit a range of pathogenic bacteria in vitro.