NO LINING IN THAT SMOG IS A GOOD THING INTRODUCTION ABOUT “NO” synthesised from the amino acid L-arginine literally in cells from head to foot NO can keep us fit and healthy. nitric oxide synthases or NOS, will convert the amino acid L-arginine to L-citrulline and forming nitric oxide in the process. The molecule is short-lived constant supply is generated by endothelial cells in response to the sheer stress of the blood flow on the artery wall Govern the blood pressure Messenger between nerve cell helps the immune system's macrophages Benefiit of Nitric Oxide Fighting neurological disorders Help sickle’s cell patient Prevent pulmonary hypertension Messenger between nerve cell brain contained more of the nitric oxide synthase enzyme than any other organ the nitric oxide synthase enzyme was not confined to small areas, NO was distributed throughout the brain So, NO being involved in almost all the brain function The small size of NO made it easier to diffuses into and out of cells easily now NO is a prime candidate for the much searched for "retrograde messenger" that is the basis of memory. Govern the blood vessels The dilation of blood vessels is sustained by a steady flow of nitric oxide. Any interruption to the production of nitric oxide interferes with the tone of the smooth muscle. NO will cause penile erections by dilating blood vessels, and controls the action of almost every orifice from swallowing to defecation Its also regulator of the muscle tone of blood vessels. Helps the immune system's macrophages Macrophages are the cells in the body , activated in injury , illness to get rid of debris, when they seek out invading bacteria or cancer cells to destroy. the macrophages use the “cytotoxic properties of nitric oxide” to sweep up parasites, bacteria and other potentially infectious rubbish. NO will destroy many organisms that are difficult to kill by other means. nitric oxide can also killed the “vicious parasite” that causes Leishmaniasis ( a group of potentially fatal tropical diseases caused by parasites transmitted by the bite of sandflies) Fighting neurological disorders Nitric oxide produced in the brain by the neuronal form of the nitric oxide synthase is belive to cure “Alzheimers, Parkinsons and other neurological disorders”. This research is still going on. Maybe in 10 years time, we will truly find the cure for this kind of disease Prevent pulmonary hypertension raised blood pressure is due to the “lack of dilator tone “ lung cogestion can be relieve by “inhaling only trace of nitric oxide gas (25 parts per million) by patients with pulmonary hypertension” . NO could could “stop a painful attack of angina” (the chest pain now known to be caused when the heart muscle is short of oxygen it was too dangerous to give people nitric oxide directly, substances that released it slowly could relieve hypertension Help sickle cell’s patient NO act by “restoring the natural charge and shape” of the oxygen-carrying component of red blood cells Hemoglobin S with the help of nitric oxide “behaves like normal adult hemoglobin”, which does not sickle. NO also prevents unhealthy clustering of hemoglobin S molecules NO can also “melt the existing polymers”, leaving more hemoglobin free to do its job of oxygen delivery to the body. unwanted hemoglobin S polymers in the microcirculation when oxygen levels are lower, once hemoglobin releases its oxygen to the tissues Conclusion NO benefits to our body is truly a great achievement for science. NO contribution could increase the quality of life for the patient. In the future we hope that a lot of “new great scientific breakthrough being discovered” So, don’t judge a book by its cover!
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