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Nanomedicine Development Centers of the NIH Roadmap

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					                                                              Nanomedicine Development
                                                                       Centers
                                                               An overview for the TCNP
A
    X
        N
            N
                          Nano-pointer



                             380 nm

                             500 nm
                                      X
                                              N
                                              N
                                                                       Grantees
B                         Nano-tweezers

                                                                              David M. Balshaw, PhD
                N N

                                                  N
                                                      N
                                          X               X
            X         X




                            380 nm

                            500 nm


                                                               National Institute of Environmental Health Sciences
                                                                 On behalf of the Nanomedicine Project Team




                                                                   National Institutes   Department of Health
                                                                   Of Health             and Human Services
 Clinical
 Enterprise
                                         Molecular
               Re-engineering the        Libraries     Building Blocks,
                Clinical Research       and Imaging   Biological Pathways
                    Enterprise                           and Networks




                                                         Structural
                                                                      New Pathways
         Public-Private
                                                          Biology     to Discovery
         Partnerships               Implementation
                                       Groups


                                                        Bioinformatics and
                                                       Computational Biology
          High-risk
          Research
                          Interdisciplinary
                              Research         Nanomedicine
Research
Teams of the
Future
Nanomedicine

               Nanomedicine Roadmap
    • By understanding how Biology has mastered the
      nanoscale we can engineer ways of ‘hijacking’
      biological nanomachines for medical purposes

    • 8 Nanomedicine Development Centers funded
      (4 in 2005, 4 in 2006)
        – $6M in 2005
        – $12M in 2006 and 2007
        – $24M in 2008 and 2009
           Center for Nucleoprotein Machines

• PI: Gang Bao, Georgia Tech

• Central focus: Probing the dynamics of protein complex
  assembly and function using Non-homologous end-
  joining as a model
• Projects:
   – Protein tagging strategies and probes (Bao)
   – Structure-function in NHEJ Core (William Dynan, Medical
     College of Georgia)
   – Dynamics of nanomachine assembly at repair foci (David
     Spector, Cold Spring Harbor Labs)
   – Dimension and structure of repair foci (Dynan)
   – Engineering principles underlieing dsb repair (Bao)

                   www.nucleoproteinmachines.org
                Center for Protein Folding
                        Machinery
• PI: Wah Chiu, Baylor

• Central Focus: Understand and Control protein
  folding
• Project/Goals
  – Develop experimental and computational tools to
    characterize in vivo protein folding
  – Engineer modified chaperonins as a therapeutic tool
  – Virtual courses in design and application of biological
    nanomachines

              http://ncmi.bcm.tmc.edu/nanomedicine
• PI: Peixuan Guo

• Central Focus: Understand the
  mechanochemical action of the phi29 DNA
  packing motor and harness it for
  engineering and medical purposes
• Goals
  – Motor Mechanism
  – Motor Application

         http://www.vet.purdue.edu/PeixuanGuo/NDC/
• PI: Chih-Ming Ho, UCLA

• Central focus: Develop biological feedback loops
  through tunable nanoparticle resonators
• Projects:
  – Preventing Viral infection (Genhong Cheng)
  – Guide stem cell differentiation (Hong Wu)
  – Cancer signaling and networks (Michael Teitell)

                 http://centerforcellcontrol.org/
Optical Control of Biological Function
• PI: Ehud Isacoff, UC Berkeley/LBNL

• Central focus: Using light to control receptors, channels
  and enzymes
• Goals:
   –   Modified amino acids for optical control of conformation
   –   Optical nano-pointers
   –   Optical nano-tweezers
   –   Light gates
   –   Viral delivery of photo-switches
   –   Restoring light sensitivity to the retina
   –   Light delivery to deep neurons
               Cell Propulsion Lab
• PI: Wendell Lim, UCSF

• Central Focus: develop strategies to control cell
  motility – guidance and force generation
• Projects:
  –   Reprogramming Cell guidance (Lim)
  –   Alternative Force Generation (Dyche Mullins)
  –   Engineering Synthetic motility systems (Dan Fletcher)
  –   Cellular Control toolkit (Tanja Kortemme)
  –   Theoretical framework (Chris Voigt)
  –   Assays for motility and organization (Orion Weiner)

  www.qb3.org/cpl
•   PI: Michael sheetz, Columbia

•   Central Focus: Understanding and manipulating adhesion and
    mechanotransduction
•   Projects
     – Molecular components in Force sensing (Sheetz)
     – Force Regulation of ECM (Viola Vogel)
     – Focal Adhesion Network – the Adhesome (Benny Geiger)
     – Probes for cellular response to external cues (Joachim Spatz)
     – Image analysis software development (Chris Wiggins)
     – Spatio-temporal models of actin cytoskeleton (Ravi Iyengar)
     – Nanofabrication of structures for assessing response to external cues (Shalom
       Wind)
     – Developmetn of multirigidity substrates (Jim Hone)
     – New tools for Cell Adhesion and migration – 3D T cell stimulation (Lance Kam)
     – T cell Stimulation (Michael Dustin)




                        http://www.mechanicalbiology.org
• PI: Erik Jakobsson, UIUC

• Central Focus: Develop a Biological
  Battery for implantable devices
• Projects:
  – Design, assembly and characterization of
    active membranes
  – Simulation of membrane assembly and
    transport

              http://www.nanoconductor.org/
   Areas of Common Interest
• Imaging and Optical Control
• Cytoskeleton –Transmembrane transport -
  nuclear transport
• Dynamics of signaling
• Computational modeling
 Opportunities for Collaboration
• Nanomedicine ‘Ramp-up’ in FY 2009
• TCNP ‘Collaborative R01’ Program (PA-
  07-266)

• Joint grantee meeting???
                                                                   Nanomedicine Development Centers
                                                                   NIH Project Team: 15 ICs

                                                              Tom Aigner, NIDA           Eleni Kousvelari, NIDCR
                                                              David Balshaw, NIEHS       Catherine Lewis, NIGMS
                                                              Ravi Bassavapa, NIGMS      Roger Miller, NIDCD
A       N
            N
                          Nano-pointer
                                                              John Bowers, CSR           Karen Peterson, NIBIB
                                                              Denis Buxton, NHLBI        Joseph Pancrazio, NINDS
    X                                 X
                                              N
                                              N




                             380 nm

                             500 nm


B
            X
                N N




                      X
                          Nano-tweezers
                                          X
                                                  N
                                                      N
                                                          X
                                                              German Cavelier, NIMH      Jeffery Schloss, NHGRI
                            380 nm

                            500 nm
                                                              Richard Fisher, NEI        Paul Sieving, NEI
                                                              Daniel Gallahan, NCI       Kuan Wang, NIAMS
                                                              William Heetderks, NIBIB   Michael Weinrich, NICHD



                                                                                            National Institutes   Department of Health
                                                                                            Of Health             and Human Services

				
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posted:6/27/2010
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Description: Nano-medicine is developed with nano-biomedical nanotechnology to solve medical problems with discipline. The development of synthetic biology to develop cell or cell biology and computer robot technology, will bring a new nano-technology revolution. Nanotechnology and material of the field of medicine will bring about a profound revolution, mainly in the fight against cancer and cardiovascular disease is important.