Nano-medicine is developed with nano-biomedical nanotechnology to solve medical problems with discipline. The development of synthetic biology to develop cell or cell biology and computer robot technology, will bring a new nano-technology revolution. Nanotechnology and material of the field of medicine will bring about a profound revolution, mainly in the fight against cancer and cardiovascular disease is important.
Nanomedicine Development Centers An overview for the TCNP A X N N Nano-pointer 380 nm 500 nm X N N Grantees B Nano-tweezers David M. Balshaw, PhD N N N N X X X X 380 nm 500 nm National Institute of Environmental Health Sciences On behalf of the Nanomedicine Project Team National Institutes Department of Health Of Health and Human Services Clinical Enterprise Molecular Re-engineering the Libraries Building Blocks, Clinical Research and Imaging Biological Pathways Enterprise and Networks Structural New Pathways Public-Private Biology to Discovery Partnerships Implementation Groups Bioinformatics and Computational Biology High-risk Research Interdisciplinary Research Nanomedicine Research Teams of the Future Nanomedicine Nanomedicine Roadmap • By understanding how Biology has mastered the nanoscale we can engineer ways of ‘hijacking’ biological nanomachines for medical purposes • 8 Nanomedicine Development Centers funded (4 in 2005, 4 in 2006) – $6M in 2005 – $12M in 2006 and 2007 – $24M in 2008 and 2009 Center for Nucleoprotein Machines • PI: Gang Bao, Georgia Tech • Central focus: Probing the dynamics of protein complex assembly and function using Non-homologous end- joining as a model • Projects: – Protein tagging strategies and probes (Bao) – Structure-function in NHEJ Core (William Dynan, Medical College of Georgia) – Dynamics of nanomachine assembly at repair foci (David Spector, Cold Spring Harbor Labs) – Dimension and structure of repair foci (Dynan) – Engineering principles underlieing dsb repair (Bao) www.nucleoproteinmachines.org Center for Protein Folding Machinery • PI: Wah Chiu, Baylor • Central Focus: Understand and Control protein folding • Project/Goals – Develop experimental and computational tools to characterize in vivo protein folding – Engineer modified chaperonins as a therapeutic tool – Virtual courses in design and application of biological nanomachines http://ncmi.bcm.tmc.edu/nanomedicine • PI: Peixuan Guo • Central Focus: Understand the mechanochemical action of the phi29 DNA packing motor and harness it for engineering and medical purposes • Goals – Motor Mechanism – Motor Application http://www.vet.purdue.edu/PeixuanGuo/NDC/ • PI: Chih-Ming Ho, UCLA • Central focus: Develop biological feedback loops through tunable nanoparticle resonators • Projects: – Preventing Viral infection (Genhong Cheng) – Guide stem cell differentiation (Hong Wu) – Cancer signaling and networks (Michael Teitell) http://centerforcellcontrol.org/ Optical Control of Biological Function • PI: Ehud Isacoff, UC Berkeley/LBNL • Central focus: Using light to control receptors, channels and enzymes • Goals: – Modified amino acids for optical control of conformation – Optical nano-pointers – Optical nano-tweezers – Light gates – Viral delivery of photo-switches – Restoring light sensitivity to the retina – Light delivery to deep neurons Cell Propulsion Lab • PI: Wendell Lim, UCSF • Central Focus: develop strategies to control cell motility – guidance and force generation • Projects: – Reprogramming Cell guidance (Lim) – Alternative Force Generation (Dyche Mullins) – Engineering Synthetic motility systems (Dan Fletcher) – Cellular Control toolkit (Tanja Kortemme) – Theoretical framework (Chris Voigt) – Assays for motility and organization (Orion Weiner) www.qb3.org/cpl • PI: Michael sheetz, Columbia • Central Focus: Understanding and manipulating adhesion and mechanotransduction • Projects – Molecular components in Force sensing (Sheetz) – Force Regulation of ECM (Viola Vogel) – Focal Adhesion Network – the Adhesome (Benny Geiger) – Probes for cellular response to external cues (Joachim Spatz) – Image analysis software development (Chris Wiggins) – Spatio-temporal models of actin cytoskeleton (Ravi Iyengar) – Nanofabrication of structures for assessing response to external cues (Shalom Wind) – Developmetn of multirigidity substrates (Jim Hone) – New tools for Cell Adhesion and migration – 3D T cell stimulation (Lance Kam) – T cell Stimulation (Michael Dustin) http://www.mechanicalbiology.org • PI: Erik Jakobsson, UIUC • Central Focus: Develop a Biological Battery for implantable devices • Projects: – Design, assembly and characterization of active membranes – Simulation of membrane assembly and transport http://www.nanoconductor.org/ Areas of Common Interest • Imaging and Optical Control • Cytoskeleton –Transmembrane transport - nuclear transport • Dynamics of signaling • Computational modeling Opportunities for Collaboration • Nanomedicine ‘Ramp-up’ in FY 2009 • TCNP ‘Collaborative R01’ Program (PA- 07-266) • Joint grantee meeting??? Nanomedicine Development Centers NIH Project Team: 15 ICs Tom Aigner, NIDA Eleni Kousvelari, NIDCR David Balshaw, NIEHS Catherine Lewis, NIGMS Ravi Bassavapa, NIGMS Roger Miller, NIDCD A N N Nano-pointer John Bowers, CSR Karen Peterson, NIBIB Denis Buxton, NHLBI Joseph Pancrazio, NINDS X X N N 380 nm 500 nm B X N N X Nano-tweezers X N N X German Cavelier, NIMH Jeffery Schloss, NHGRI 380 nm 500 nm Richard Fisher, NEI Paul Sieving, NEI Daniel Gallahan, NCI Kuan Wang, NIAMS William Heetderks, NIBIB Michael Weinrich, NICHD National Institutes Department of Health Of Health and Human Services
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