CKD in Men with BPH-Related LUTS

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      www.renalandurologynews.com                                                                                                                                                              DECEMBER 2009          Renal & Urology News 3



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     News in Brief
       Fistulas, Grafts                                                                         Black Men Lead                                                         RCC with Capsular Invasion
       Lower Mortality                                                                          In PSA Testing                                                         Predicts Worse Outcomes
            emodialysis (HD) patients who
      H     switch their vascular access from
       a catheter to a fistula or graft have                                                    A    study of a large multiethnic cohort
                                                                                                     found that African-American men                                   R    enal capsular invasion in patients with localized clear-cell renal cell car-
                                                                                                                                                                            cinoma (RCC) is associated with an increased risk of cancer recurrence and
       improved survival, a study of 79,545                                                     had a higher prevalence of PSA screen-                                 cancer-related death after surgery, according to researchers at the Catholic
       HD patients found. Compared with                                                         ing than white and Latino men.                                         University of Korea in Seoul. They studied 299 patients with localized clear-cell
       patients who continue to use cath-                                                         Researchers with Kaiser Perma-                                       RCC who underwent radical nephrectomy or nephron-sparing surgery. Of the
       eters, those who convert to a fistula                                                    nente Southern California and Kaiser                                   299 patients, 106 (35.5%) had capsular invasion. These patients had significant-
       or graft have a 31% decreased risk                                                       Permanente North California studied                                    ly lower five-year recurrence free survival (RFS) and cancer-specific survival
       of death, researchers reported in the                                                    55,278 men who participated in the                                     (CSS) rates. After a mean follow-up of 60.5 months, the five-year RFS rate was
       American Journal of Kidney Dis-                                                          California Men’s Health Study, which                                   77.7% for patients with capsular invasion and 92.3% for subjects without cap-
       eases (2009;54:912-921). Subjects                                                        consists of a cohort established with-                                 sular invasion, the investigators reported in European Urology (2009; 56:1006-
       who switch from a fistula or graft to                                                    in these two health plans. Of the                                      1012). The five-year CSS rate was 85.5% and 95.7%, respectively. Capsular inva-
       a catheter have a twofold increased                                                      55,278 men, 40,062 (72.5%) under-                                      sion independently predicted a threefold increased risk of disease recurrence and
       risk of death. n                                                                         went PSA screening. The prevalence                                     a fourfold increased risk of cancer-related death. n
                                                                                                of any PSA screening was 82.6% in
                                                                                                African Americans, 73.7% in whites,
       Alcohol Use May                                                                          and 64.8% in Latinos, according to a
                                                                                                report in the American Journal of
                                                                                                                                                                       Medication Found to Benefit
       Cut Diabetes Risk                                                                        Managed Care (2009;15:793-799).                                        Men with Peyronie’s Disease
                                                                                                Compared with white men, African-
              oderate alcohol consumption is                                                    American men were 66% more likely                                           entoxifylline sustained-release (PTX-SR) may be an effective treatment
      M       associated with a decreased risk
       of developing type 2 diabetes, new
                                                                                                to undergo PSA testing and Latino
                                                                                                men were 11% less likely, after ad-
                                                                                                                                                                       P    for men suffering from early Peyronie’s disease, researchers concluded in
                                                                                                                                                                       BJU International (2009; published online ahead of print).
       findings confirm.                                                                        justing for confounders, the re-                                         The study, by Mohammad R. Safarinejad, MD, and collaborators at Shaheed
         Based on a meta-analysis of data                                                       searchers said.                                                        Modarress Hospital in Tehran, Iran, included 228 men with early Peyronie’s dis-
       from 20 cohort studies, researchers                                                        Additionally, compared with men                                      ease. Subjects had a mean age of 51 years. The researchers randomized 114
       found that, compared with lifetime al-                                                   who had discussed PSA testing with                                     patients to receive 400 mg PTX-SR twice 
				
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