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NIB1209.qxd 11/30/09 12:11 PM Page 1 www.renalandurologynews.com DECEMBER 2009 Renal & Urology News 3 Please visit us at www.renalandurologynews.com News in Brief Fistulas, Grafts Black Men Lead RCC with Capsular Invasion Lower Mortality In PSA Testing Predicts Worse Outcomes emodialysis (HD) patients who H switch their vascular access from a catheter to a fistula or graft have A study of a large multiethnic cohort found that African-American men R enal capsular invasion in patients with localized clear-cell renal cell car- cinoma (RCC) is associated with an increased risk of cancer recurrence and improved survival, a study of 79,545 had a higher prevalence of PSA screen- cancer-related death after surgery, according to researchers at the Catholic HD patients found. Compared with ing than white and Latino men. University of Korea in Seoul. They studied 299 patients with localized clear-cell patients who continue to use cath- Researchers with Kaiser Perma- RCC who underwent radical nephrectomy or nephron-sparing surgery. Of the eters, those who convert to a fistula nente Southern California and Kaiser 299 patients, 106 (35.5%) had capsular invasion. These patients had significant- or graft have a 31% decreased risk Permanente North California studied ly lower five-year recurrence free survival (RFS) and cancer-specific survival of death, researchers reported in the 55,278 men who participated in the (CSS) rates. After a mean follow-up of 60.5 months, the five-year RFS rate was American Journal of Kidney Dis- California Men’s Health Study, which 77.7% for patients with capsular invasion and 92.3% for subjects without cap- eases (2009;54:912-921). Subjects consists of a cohort established with- sular invasion, the investigators reported in European Urology (2009; 56:1006- who switch from a fistula or graft to in these two health plans. Of the 1012). The five-year CSS rate was 85.5% and 95.7%, respectively. Capsular inva- a catheter have a twofold increased 55,278 men, 40,062 (72.5%) under- sion independently predicted a threefold increased risk of disease recurrence and risk of death. n went PSA screening. The prevalence a fourfold increased risk of cancer-related death. n of any PSA screening was 82.6% in African Americans, 73.7% in whites, Alcohol Use May and 64.8% in Latinos, according to a report in the American Journal of Medication Found to Benefit Cut Diabetes Risk Managed Care (2009;15:793-799). Men with Peyronie’s Disease Compared with white men, African- oderate alcohol consumption is American men were 66% more likely entoxifylline sustained-release (PTX-SR) may be an effective treatment M associated with a decreased risk of developing type 2 diabetes, new to undergo PSA testing and Latino men were 11% less likely, after ad- P for men suffering from early Peyronie’s disease, researchers concluded in BJU International (2009; published online ahead of print). findings confirm. justing for confounders, the re- The study, by Mohammad R. Safarinejad, MD, and collaborators at Shaheed Based on a meta-analysis of data searchers said. Modarress Hospital in Tehran, Iran, included 228 men with early Peyronie’s dis- from 20 cohort studies, researchers Additionally, compared with men ease. Subjects had a mean age of 51 years. The researchers randomized 114 found that, compared with lifetime al- who had discussed PSA testing with patients to receive 400 mg PTX-SR twice
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